#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9ULM6 uniprotkb:Q9UFF9 intact:EBI-2104530|uniprotkb:D3DWR0|uniprotkb:A7MD46|ensembl:ENSP00000261951|ensembl:ENSP00000377024|ensembl:ENSP00000481893 intact:EBI-742299|uniprotkb:O95709|uniprotkb:Q7Z521|uniprotkb:Q9H6Y1|uniprotkb:D3DQI8|uniprotkb:B2RAR8|intact:EBI-10979182|uniprotkb:B0AZS3|uniprotkb:B7Z8R1|ensembl:ENSP00000285896|ensembl:ENSP00000384747|ensembl:ENSP00000430493 psi-mi:cnot6_human(display_long)|uniprotkb:CNOT6(gene name)|psi-mi:CNOT6(display_short)|uniprotkb:CCR4(gene name synonym)|uniprotkb:KIAA1194(gene name synonym)|uniprotkb:Carbon catabolite repressor protein 4 homolog(gene name synonym)|uniprotkb:CCR4 carbon catabolite repression 4-like(gene name synonym)|uniprotkb:Cytoplasmic deadenylase(gene name synonym)|uniprotkb:CCR4a(gene name synonym) psi-mi:cnot8_human(display_long)|uniprotkb:CNOT8(gene name)|psi-mi:CNOT8(display_short)|uniprotkb:CALIF(gene name synonym)|uniprotkb:POP2(gene name synonym)|uniprotkb:CCR4-associated factor 8(gene name synonym)|uniprotkb:CAF1-like protein(gene name synonym)|uniprotkb:CAF2(gene name synonym)|uniprotkb:Caf1b(gene name synonym) psi-mi:"MI:0018"(two hybrid) Dupressoir et al. (2001) pubmed:11747467|imex:IM-18695 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6553207|imex:IM-18695-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532908.1|refseq:XP_011532909.1|refseq:NP_001290170.1|refseq:XP_005266010.1|dip:DIP-46838N|ensembl:ENSG00000113300(gene)|ensembl:ENST00000261951(transcript)|ensembl:ENST00000393356(transcript)|ensembl:ENST00000618123(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR032675|interpro:IPR034966|interpro:IPR036691|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-5617472|reactome:R-HSA-6804115 refseq:NP_004770.4|refseq:XP_005268584.1|refseq:NP_001288002.1|refseq:NP_001288003.1|refseq:NP_001288004.1|refseq:NP_001288006.1|refseq:NP_001288009.1|refseq:NP_001288011.1|refseq:NP_001288012.1|refseq:NP_001288015.1|refseq:XP_011536008.1|refseq:XP_011536010.1|refseq:XP_016865537.1|refseq:XP_016865538.1|refseq:XP_016865539.1|refseq:XP_016865540.1|refseq:XP_016865541.1|refseq:XP_016865542.1|refseq:XP_016865543.1|refseq:XP_016865544.1|refseq:XP_016865545.1|refseq:XP_016865546.1|ensembl:ENSG00000155508(gene)|ensembl:ENST00000285896(transcript)|ensembl:ENST00000403027(transcript)|ensembl:ENST00000517876(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR027212|interpro:IPR036397|interpro:IPR039637|mint:Q9UFF9|reactome:R-HSA-429947|reactome:R-HSA-6804115|dip:DIP-29084N - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/02/27 2014/10/16 rogid:zxSIU+XaCoDUIUyPz5YpQycyaj49606 rogid:pjaQYzYBGJWC7z5R5s8Te+v2sRA9606 intact-crc:8D6C38465E555910|rigid:r5CFDwG1A/GgwaGhK3kSAaP8TC0 false necessary binding region:52..52-143..143(IPR001611) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIV1 uniprotkb:Q9ULM6 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 intact:EBI-2104530|uniprotkb:D3DWR0|uniprotkb:A7MD46|ensembl:ENSP00000261951|ensembl:ENSP00000377024|ensembl:ENSP00000481893 psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:cnot6_human(display_long)|uniprotkb:CNOT6(gene name)|psi-mi:CNOT6(display_short)|uniprotkb:CCR4(gene name synonym)|uniprotkb:KIAA1194(gene name synonym)|uniprotkb:Carbon catabolite repressor protein 4 homolog(gene name synonym)|uniprotkb:CCR4 carbon catabolite repression 4-like(gene name synonym)|uniprotkb:Cytoplasmic deadenylase(gene name synonym)|uniprotkb:CCR4a(gene name synonym) psi-mi:"MI:0018"(two hybrid) Dupressoir et al. (2001) pubmed:11747467|imex:IM-18695 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6553190|imex:IM-18695-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 refseq:XP_011532908.1|refseq:XP_011532909.1|refseq:NP_001290170.1|refseq:XP_005266010.1|dip:DIP-46838N|ensembl:ENSG00000113300(gene)|ensembl:ENST00000261951(transcript)|ensembl:ENST00000393356(transcript)|ensembl:ENST00000618123(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR032675|interpro:IPR034966|interpro:IPR036691|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-5617472|reactome:R-HSA-6804115 - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2013/02/27 2014/10/16 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rogid:zxSIU+XaCoDUIUyPz5YpQycyaj49606 intact-crc:82F2F453FD483B6C|rigid:A92IcKTHhU3BBVqdmGXosj0Uit4 false - necessary binding region:52..52-143..143(IPR001611) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UIV1 uniprotkb:Q9ULM6 intact:EBI-2105113|uniprotkb:A8MZM5|uniprotkb:Q7Z530|uniprotkb:D3DSP6|uniprotkb:B3KMP1|uniprotkb:B3KN35|uniprotkb:G3V108|ensembl:ENSP00000355279 intact:EBI-2104530|uniprotkb:D3DWR0|uniprotkb:A7MD46|ensembl:ENSP00000261951|ensembl:ENSP00000377024|ensembl:ENSP00000481893 psi-mi:cnot7_human(display_long)|uniprotkb:CNOT7(gene name)|psi-mi:CNOT7(display_short)|uniprotkb:CAF1(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:BTG1-binding factor 1(gene name synonym)|uniprotkb:Caf1a(gene name synonym) psi-mi:cnot6_human(display_long)|uniprotkb:CNOT6(gene name)|psi-mi:CNOT6(display_short)|uniprotkb:CCR4(gene name synonym)|uniprotkb:KIAA1194(gene name synonym)|uniprotkb:Carbon catabolite repressor protein 4 homolog(gene name synonym)|uniprotkb:CCR4 carbon catabolite repression 4-like(gene name synonym)|uniprotkb:Cytoplasmic deadenylase(gene name synonym)|uniprotkb:CCR4a(gene name synonym) psi-mi:"MI:0047"(far western blotting) Dupressoir et al. (2001) pubmed:11747467|imex:IM-18695 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6553221|imex:IM-18695-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001309026.1|refseq:NP_001309028.1|refseq:NP_001309029.1|refseq:NP_001309016.1|refseq:NP_001309017.1|refseq:NP_001309018.1|refseq:NP_001309019.1|refseq:NP_001309020.1|refseq:NP_001309021.1|refseq:NP_001309022.1|refseq:NP_001309023.1|refseq:NP_001309024.1|refseq:NP_001309025.1|refseq:NP_037486.2|refseq:NP_473367.2|refseq:XP_005273538.1|refseq:NP_001309027.1|dip:DIP-41902N|ensembl:ENSG00000198791(gene)|ensembl:ENST00000361272(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR006941(Ribonuclease CAF1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039636|interpro:IPR039637|mint:Q9UIV1|rcsb pdb:2D5R|rcsb pdb:4GMJ|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-6804115 refseq:XP_011532908.1|refseq:XP_011532909.1|refseq:NP_001290170.1|refseq:XP_005266010.1|dip:DIP-46838N|ensembl:ENSG00000113300(gene)|ensembl:ENST00000261951(transcript)|ensembl:ENST00000393356(transcript)|ensembl:ENST00000618123(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0003723"(RNA binding)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0046872"(metal ion binding)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR032675|interpro:IPR034966|interpro:IPR036691|rcsb pdb:7AX1|reactome:R-HSA-429947|reactome:R-HSA-5617472|reactome:R-HSA-6804115 - - - figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2013/02/27 2014/10/16 rogid:+bu5LFmE8SFVSqNkFf91SSN3kVI9606 rogid:zxSIU+XaCoDUIUyPz5YpQycyaj49606 intact-crc:AB22527C8409217A|rigid:A92IcKTHhU3BBVqdmGXosj0Uit4 false 35s radiolabel:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography)