#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15382	uniprotkb:A6HIS0	intact:EBI-7043557|ensembl:ENSP00000337255|ensembl:ENSP00000382225|ensembl:ENSP00000382226|ensembl:ENSP00000382228|ensembl:ENSP00000412498|ensembl:ENSP00000416258|ensembl:ENSP00000478215|ensembl:ENSP00000483895|uniprotkb:Q91Z94|intact:MINT-7297782|uniprotkb:Q8N709|uniprotkb:A5H1P2	intact:EBI-8784724	psi-mi:kcne1_human(display_long)|uniprotkb:KCNE1(gene name)|psi-mi:KCNE1(display_short)|uniprotkb:IKs producing slow voltage-gated potassium channel subunit beta Mink(gene name synonym)|uniprotkb:Minimal potassium channel(gene name synonym)|uniprotkb:Delayed rectifier potassium channel subunit IsK(gene name synonym)	psi-mi:a6his0_rat(display_long)|uniprotkb:Tcap(gene name)|psi-mi:Tcap(display_short)|uniprotkb:rCG_32667(orf name)	psi-mi:"MI:0018"(two hybrid)	Furukawa et al. (2001)	pubmed:11697903|imex:IM-22105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8784727|imex:IM-22105-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180509(gene)|ensembl:ENST00000337385(transcript)|ensembl:ENST00000399284(transcript)|ensembl:ENST00000399286(transcript)|ensembl:ENST00000399289(transcript)|ensembl:ENST00000416357(transcript)|ensembl:ENST00000432085(transcript)|ensembl:ENST00000611936(transcript)|ensembl:ENST00000621601(transcript)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0031433"(telethonin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|interpro:IPR000369(Potassium channel, voltage-dependent, beta subunit, KCNE)|interpro:IPR005424(Potassium channel, voltage-dependent, beta subunit, KCNE1)|mint:P15382|rcsb pdb:2K21|reactome:R-HSA-5576890|reactome:R-HSA-5576893|refseq:NP_001121141.1|refseq:NP_001121140.1|refseq:NP_000210.2|refseq:NP_001257334.1|refseq:NP_001257331.1|refseq:NP_001257333.1|refseq:NP_001257332.1|refseq:NP_001121142.1	interpro:IPR015667(Telethonin)|interpro:IPR023111|refseq:NP_001258206.1|rgd:1592387|go:"GO:0001756"(somitogenesis)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036122"(BMP binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0051373"(FATZ binding)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070080"(titin Z domain binding)	-	comment:mint	-	figure legend:Fig 1b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/09/27	2014/10/16	rogid:y68EBvBKDIRCu+MDWcaRVBtBoH09606	rogid:8Z77A+WDvpbdWbnDfA6MOPYbuYM10116	intact-crc:677277F650F2ED8F|rigid:bUOXYfa3htCIDRZ7F6H6/Oj1Es8	false	sufficient binding region:67-129	sufficient binding region:152-167	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15382	uniprotkb:A6HIS0	intact:EBI-7043557|ensembl:ENSP00000337255|ensembl:ENSP00000382225|ensembl:ENSP00000382226|ensembl:ENSP00000382228|ensembl:ENSP00000412498|ensembl:ENSP00000416258|ensembl:ENSP00000478215|ensembl:ENSP00000483895|uniprotkb:Q91Z94|intact:MINT-7297782|uniprotkb:Q8N709|uniprotkb:A5H1P2	intact:EBI-8784724	psi-mi:kcne1_human(display_long)|uniprotkb:KCNE1(gene name)|psi-mi:KCNE1(display_short)|uniprotkb:IKs producing slow voltage-gated potassium channel subunit beta Mink(gene name synonym)|uniprotkb:Minimal potassium channel(gene name synonym)|uniprotkb:Delayed rectifier potassium channel subunit IsK(gene name synonym)	psi-mi:a6his0_rat(display_long)|uniprotkb:Tcap(gene name)|psi-mi:Tcap(display_short)|uniprotkb:rCG_32667(orf name)	psi-mi:"MI:0096"(pull down)	Furukawa et al. (2001)	pubmed:11697903|imex:IM-22105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8784915|imex:IM-22105-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180509(gene)|ensembl:ENST00000337385(transcript)|ensembl:ENST00000399284(transcript)|ensembl:ENST00000399286(transcript)|ensembl:ENST00000399289(transcript)|ensembl:ENST00000416357(transcript)|ensembl:ENST00000432085(transcript)|ensembl:ENST00000611936(transcript)|ensembl:ENST00000621601(transcript)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0031433"(telethonin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|interpro:IPR000369(Potassium channel, voltage-dependent, beta subunit, KCNE)|interpro:IPR005424(Potassium channel, voltage-dependent, beta subunit, KCNE1)|mint:P15382|rcsb pdb:2K21|reactome:R-HSA-5576890|reactome:R-HSA-5576893|refseq:NP_001121141.1|refseq:NP_001121140.1|refseq:NP_000210.2|refseq:NP_001257334.1|refseq:NP_001257331.1|refseq:NP_001257333.1|refseq:NP_001257332.1|refseq:NP_001121142.1	interpro:IPR015667(Telethonin)|interpro:IPR023111|refseq:NP_001258206.1|rgd:1592387|go:"GO:0001756"(somitogenesis)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036122"(BMP binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0051373"(FATZ binding)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070080"(titin Z domain binding)	-	comment:mint	-	figure legend:Fig 3|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/09/27	2014/10/16	rogid:y68EBvBKDIRCu+MDWcaRVBtBoH09606	rogid:8Z77A+WDvpbdWbnDfA6MOPYbuYM10116	intact-crc:574F15CFD5F69E0F|rigid:bUOXYfa3htCIDRZ7F6H6/Oj1Es8	false	sufficient binding region:67-129|35s radiolabel:?-?	his tag:?-?|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P15382	uniprotkb:A6HIS0	intact:EBI-7043557|ensembl:ENSP00000337255|ensembl:ENSP00000382225|ensembl:ENSP00000382226|ensembl:ENSP00000382228|ensembl:ENSP00000412498|ensembl:ENSP00000416258|ensembl:ENSP00000478215|ensembl:ENSP00000483895|uniprotkb:Q91Z94|intact:MINT-7297782|uniprotkb:Q8N709|uniprotkb:A5H1P2	intact:EBI-8784724	psi-mi:kcne1_human(display_long)|uniprotkb:KCNE1(gene name)|psi-mi:KCNE1(display_short)|uniprotkb:IKs producing slow voltage-gated potassium channel subunit beta Mink(gene name synonym)|uniprotkb:Minimal potassium channel(gene name synonym)|uniprotkb:Delayed rectifier potassium channel subunit IsK(gene name synonym)	psi-mi:a6his0_rat(display_long)|uniprotkb:Tcap(gene name)|psi-mi:Tcap(display_short)|uniprotkb:rCG_32667(orf name)	psi-mi:"MI:0018"(two hybrid)	Furukawa et al. (2001)	pubmed:11697903|imex:IM-22105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8795702|imex:IM-22105-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000180509(gene)|ensembl:ENST00000337385(transcript)|ensembl:ENST00000399284(transcript)|ensembl:ENST00000399286(transcript)|ensembl:ENST00000399289(transcript)|ensembl:ENST00000416357(transcript)|ensembl:ENST00000432085(transcript)|ensembl:ENST00000611936(transcript)|ensembl:ENST00000621601(transcript)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0009986"(cell surface)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0031433"(telethonin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0086002"(cardiac muscle cell action potential involved in contraction)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086009"(membrane repolarization)|go:"GO:0086011"(membrane repolarization during action potential)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090315"(negative regulation of protein targeting to membrane)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0098915"(membrane repolarization during ventricular cardiac muscle cell action potential)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902259"(regulation of delayed rectifier potassium channel activity)|go:"GO:1902260"(negative regulation of delayed rectifier potassium channel activity)|interpro:IPR000369(Potassium channel, voltage-dependent, beta subunit, KCNE)|interpro:IPR005424(Potassium channel, voltage-dependent, beta subunit, KCNE1)|mint:P15382|rcsb pdb:2K21|reactome:R-HSA-5576890|reactome:R-HSA-5576893|refseq:NP_001121141.1|refseq:NP_001121140.1|refseq:NP_000210.2|refseq:NP_001257334.1|refseq:NP_001257331.1|refseq:NP_001257333.1|refseq:NP_001257332.1|refseq:NP_001121142.1	interpro:IPR015667(Telethonin)|interpro:IPR023111|refseq:NP_001258206.1|rgd:1592387|go:"GO:0001756"(somitogenesis)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0007512"(adult heart development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0030018"(Z disc)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0030241"(skeletal muscle myosin thick filament assembly)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031432"(titin binding)|go:"GO:0031674"(I band)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036122"(BMP binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048769"(sarcomerogenesis)|go:"GO:0051373"(FATZ binding)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070080"(titin Z domain binding)	-	comment:mint	-	figure legend:Fig 2a, 2b, 4b, 4c|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/09/27	2014/10/16	rogid:y68EBvBKDIRCu+MDWcaRVBtBoH09606	rogid:8Z77A+WDvpbdWbnDfA6MOPYbuYM10116	intact-crc:212182D9042508A2|rigid:bUOXYfa3htCIDRZ7F6H6/Oj1Es8	false	sufficient binding region:67-129	mutation decreasing interaction:157-157|mutation increasing interaction:157-157|mutation decreasing interaction:157-157|sufficient binding region:152-167|necessary binding region:160-167|mutation disrupting interaction strength:155-155,157-157,159-159	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)