#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q4JIM5	uniprotkb:P28693	intact:EBI-6663603	intact:EBI-6725885	psi-mi:abl2_mouse(display_long)|uniprotkb:Abl2(gene name)|psi-mi:Abl2(display_short)|uniprotkb:Arg(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)	psi-mi:ephb2_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:CEK5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663596|imex:IM-25924-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-9706369|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006909"(phagocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007612"(learning)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016322"(neuron remodeling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022414"(reproductive process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031223"(auditory behavior)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035640"(exploration behavior)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060074"(synapse maturation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0001891"(phagocytic cup)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072359"(circulatory system development)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:0002118"(aggressive behavior)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0004713"(protein tyrosine kinase activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XLI|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-60989N|reactome:R-MMU-428890	go:"GO:0001525"(angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021963"(spinothalamic tract morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|refseq:NP_996834.1|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|rcsb pdb:1SGG|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116	go:"GO:0004565"(beta-galactosidase activity)	-	-	figure legend:table1|comment:Arg C-terminal binds to EphB2 is phosphorylation-independent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2018/04/13	rogid:Cv053Jd9kWQe1IRcNPSDpsq+xJA10090	rogid:H1FT8bEj+95IFkYU4xQt3Gk2m209031	intact-crc:B7F60BBBA5D5A34D|rigid:OfpucMLedVQ2UGXroIx6IIBNkjk	false	sufficient binding region:883-975	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28693	uniprotkb:P00520	intact:EBI-6725885	intact:EBI-914519|uniprotkb:P97896|uniprotkb:Q61252|uniprotkb:Q61253|uniprotkb:Q61254|uniprotkb:Q61255|uniprotkb:Q61256|uniprotkb:Q61257|uniprotkb:Q61258|uniprotkb:Q61259|uniprotkb:Q61260|uniprotkb:Q61261|uniprotkb:Q6PCM5|uniprotkb:Q8C1X4|ensembl:ENSMUSP00000028190	psi-mi:ephb2_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:CEK5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)	psi-mi:abl1_mouse(display_long)|uniprotkb:Abl1(gene name)|psi-mi:Abl1(display_short)|uniprotkb:Abl(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663547|imex:IM-25924-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001525"(angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021963"(spinothalamic tract morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|refseq:NP_996834.1|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|rcsb pdb:1SGG|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116	refseq:NP_001269974.1|refseq:NP_001269975.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSMUSG00000026842(gene)|ensembl:ENSMUST00000028190(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|refseq:NP_001106174.1|refseq:NP_033724.2|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00520|rcsb pdb:1ABO|rcsb pdb:1ABQ|rcsb pdb:1FPU|rcsb pdb:1IEP|rcsb pdb:1M52|rcsb pdb:1OPJ|rcsb pdb:1OPK|rcsb pdb:2HZN|rcsb pdb:2QOH|rcsb pdb:2Z60|rcsb pdb:3DK3|rcsb pdb:3DK6|rcsb pdb:3DK7|rcsb pdb:3IK3|rcsb pdb:3K5V|rcsb pdb:3KF4|rcsb pdb:3KFA|rcsb pdb:3MS9|rcsb pdb:3MSS|rcsb pdb:3OXZ|rcsb pdb:3OY3|rcsb pdb:5IH2|rcsb pdb:6HD4|rcsb pdb:6HD6|reactome:R-MMU-2029482|reactome:R-MMU-428890|reactome:R-MMU-525793|reactome:R-MMU-5663213|reactome:R-MMU-5685938|reactome:R-MMU-5693565|reactome:R-MMU-69231|reactome:R-MMU-8939236	go:"GO:0004565"(beta-galactosidase activity)|go:"GO:0016310"(phosphorylation)	-	-	figure legend:table1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2018/04/13	rogid:H1FT8bEj+95IFkYU4xQt3Gk2m209031	rogid:Ua709ju5WT1NhOz3n4xzlEBD0Cw10090	intact-crc:BC0282D16C0046AF|rigid:P4HhH1dEMh3gATGW9A4ttL8XRyE	false	-	sufficient binding region:149-235	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03137	uniprotkb:P00520	intact:EBI-1539152|uniprotkb:Q80VZ2|ensembl:ENSMUSP00000027451|ensembl:ENSMUSP00000139640|ensembl:ENSMUSP00000140954	intact:EBI-914519|uniprotkb:P97896|uniprotkb:Q61252|uniprotkb:Q61253|uniprotkb:Q61254|uniprotkb:Q61255|uniprotkb:Q61256|uniprotkb:Q61257|uniprotkb:Q61258|uniprotkb:Q61259|uniprotkb:Q61260|uniprotkb:Q61261|uniprotkb:Q6PCM5|uniprotkb:Q8C1X4|ensembl:ENSMUSP00000028190	psi-mi:epha4_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor SEK-1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor MPK-3(gene name synonym)|uniprotkb:Epha4(gene name)|psi-mi:Epha4(display_short)|uniprotkb:Sek(gene name synonym)|uniprotkb:Sek1(gene name synonym)	psi-mi:abl1_mouse(display_long)|uniprotkb:Abl1(gene name)|psi-mi:Abl1(display_short)|uniprotkb:Abl(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663637|imex:IM-25924-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031962.2|dip:DIP-1019N|ensembl:ENSMUST00000027451(transcript)|ensembl:ENSMUST00000188797(transcript)|ensembl:ENSMUST00000188952(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016301"(kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048710"(regulation of astrocyte differentiation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0072178"(nephric duct morphogenesis)|go:"GO:0090102"(cochlea development)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|go:"GO:0097161"(DH domain binding)|go:"GO:0097485"(neuron projection guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098883"(synapse pruning)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106030"(neuron projection fasciculation)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903051"(negative regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|ensembl:ENSMUSG00000026235(gene)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR030602|interpro:IPR034270|interpro:IPR036116|mint:Q03137|rcsb pdb:1B0X|rcsb pdb:2HEL|rcsb pdb:2I8J|rcsb pdb:2XYU|rcsb pdb:2Y6M|rcsb pdb:2Y6O|reactome:R-MMU-2682334|reactome:R-MMU-3928663|reactome:R-MMU-3928665	refseq:NP_001269974.1|refseq:NP_001269975.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSMUSG00000026842(gene)|ensembl:ENSMUST00000028190(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|refseq:NP_001106174.1|refseq:NP_033724.2|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00520|rcsb pdb:1ABO|rcsb pdb:1ABQ|rcsb pdb:1FPU|rcsb pdb:1IEP|rcsb pdb:1M52|rcsb pdb:1OPJ|rcsb pdb:1OPK|rcsb pdb:2HZN|rcsb pdb:2QOH|rcsb pdb:2Z60|rcsb pdb:3DK3|rcsb pdb:3DK6|rcsb pdb:3DK7|rcsb pdb:3IK3|rcsb pdb:3K5V|rcsb pdb:3KF4|rcsb pdb:3KFA|rcsb pdb:3MS9|rcsb pdb:3MSS|rcsb pdb:3OXZ|rcsb pdb:3OY3|rcsb pdb:5IH2|rcsb pdb:6HD4|rcsb pdb:6HD6|reactome:R-MMU-2029482|reactome:R-MMU-428890|reactome:R-MMU-525793|reactome:R-MMU-5663213|reactome:R-MMU-5685938|reactome:R-MMU-5693565|reactome:R-MMU-69231|reactome:R-MMU-8939236	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2014/10/16	rogid:cDRUcRD/LB5owMEI7vdfcaD90uE10090	rogid:Ua709ju5WT1NhOz3n4xzlEBD0Cw10090	intact-crc:BB5C4F5CED327472|rigid:xsKy/1+QF3ntug3nvi8dy+JeDak	false	-	sufficient binding region:115-842	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q4JIM5	uniprotkb:P54763	intact:EBI-6663603	intact:EBI-537711|uniprotkb:Q9QVY4|uniprotkb:Q62213|uniprotkb:A3KG00|uniprotkb:A3KG01|uniprotkb:A3KG02|uniprotkb:A3KG89|uniprotkb:A3KG90|uniprotkb:Q6GTQ7|uniprotkb:Q6P5F1|ensembl:ENSMUSP00000101471	psi-mi:abl2_mouse(display_long)|uniprotkb:Abl2(gene name)|psi-mi:Abl2(display_short)|uniprotkb:Arg(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)	psi-mi:ephb2_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor EPH-3(gene name synonym)|uniprotkb:Neural kinase(gene name synonym)|uniprotkb:Nuk receptor tyrosine kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor SEK-3(gene name synonym)|uniprotkb:Ephb2(gene name)|psi-mi:Ephb2(display_short)|uniprotkb:Epth3(gene name synonym)|uniprotkb:Nuk(gene name synonym)|uniprotkb:Sek3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6690674|imex:IM-25924-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-9706369|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006909"(phagocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007612"(learning)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016322"(neuron remodeling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022414"(reproductive process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031223"(auditory behavior)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035640"(exploration behavior)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060074"(synapse maturation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0001891"(phagocytic cup)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0072359"(circulatory system development)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:0002118"(aggressive behavior)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0004713"(protein tyrosine kinase activity)|interpro:IPR001452(Src homology-3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XLI|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-60989N|reactome:R-MMU-428890	refseq:NP_001277682.1|refseq:NP_034272.1|refseq:XP_006538594.1|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0001655"(urogenital system development)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016310"(phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0005003"(ephrin receptor activity)|interpro:IPR011009(Protein kinase-like)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|interpro:IPR011641(GCC2 and GCC3)|go:"GO:0106028"(neuron projection retraction)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|mint:P54763|rcsb pdb:1JPA|rcsb pdb:1KGY|rcsb pdb:1NUK|interpro:IPR000719(Protein kinase, core)|rcsb pdb:1SHW|rcsb pdb:2HEN|rcsb pdb:3ETP|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|reactome:R-MMU-2682334|interpro:IPR003961(Fibronectin, type III)|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|ensembl:ENSMUSG00000028664(gene)|ensembl:ENSMUST00000105845(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001525"(angiogenesis)|dip:DIP-34917N	go:"GO:0004565"(beta-galactosidase activity)	-	-	figure legend:2|comment:"Arg SH2 domain binds to the tyrosine 611 motif of EphB2 (fig 2)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2015/11/10	rogid:Cv053Jd9kWQe1IRcNPSDpsq+xJA10090	rogid:QgDJW2yhMS13Eb5l3DR03T814gI10090	intact-crc:2EAC722481B3302F|rigid:/H5kMzMhFmFhAF8arlwNw8Paqh8	false	sufficient binding region:883-975,847-1012	mutation decreasing interaction strength:597-597	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28693	uniprotkb:P00520	intact:EBI-6725885	intact:EBI-914519|uniprotkb:P97896|uniprotkb:Q61252|uniprotkb:Q61253|uniprotkb:Q61254|uniprotkb:Q61255|uniprotkb:Q61256|uniprotkb:Q61257|uniprotkb:Q61258|uniprotkb:Q61259|uniprotkb:Q61260|uniprotkb:Q61261|uniprotkb:Q6PCM5|uniprotkb:Q8C1X4|ensembl:ENSMUSP00000028190	psi-mi:ephb2_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:CEK5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)	psi-mi:abl1_mouse(display_long)|uniprotkb:Abl1(gene name)|psi-mi:Abl1(display_short)|uniprotkb:Abl(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6690680|imex:IM-25924-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001525"(angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021963"(spinothalamic tract morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|refseq:NP_996834.1|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|rcsb pdb:1SGG|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116	refseq:NP_001269974.1|refseq:NP_001269975.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSMUSG00000026842(gene)|ensembl:ENSMUST00000028190(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|refseq:NP_001106174.1|refseq:NP_033724.2|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00520|rcsb pdb:1ABO|rcsb pdb:1ABQ|rcsb pdb:1FPU|rcsb pdb:1IEP|rcsb pdb:1M52|rcsb pdb:1OPJ|rcsb pdb:1OPK|rcsb pdb:2HZN|rcsb pdb:2QOH|rcsb pdb:2Z60|rcsb pdb:3DK3|rcsb pdb:3DK6|rcsb pdb:3DK7|rcsb pdb:3IK3|rcsb pdb:3K5V|rcsb pdb:3KF4|rcsb pdb:3KFA|rcsb pdb:3MS9|rcsb pdb:3MSS|rcsb pdb:3OXZ|rcsb pdb:3OY3|rcsb pdb:5IH2|rcsb pdb:6HD4|rcsb pdb:6HD6|reactome:R-MMU-2029482|reactome:R-MMU-428890|reactome:R-MMU-525793|reactome:R-MMU-5663213|reactome:R-MMU-5685938|reactome:R-MMU-5693565|reactome:R-MMU-69231|reactome:R-MMU-8939236	go:"GO:0004565"(beta-galactosidase activity)|go:"GO:0016310"(phosphorylation)	-	-	figure legend:2|comment:Abl SH2 domain binds to both 605 and 611 tyrosine phosphorylated motifs on EphB2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2018/04/13	rogid:H1FT8bEj+95IFkYU4xQt3Gk2m209031	rogid:Ua709ju5WT1NhOz3n4xzlEBD0Cw10090	intact-crc:D2D3182123D6F064|rigid:P4HhH1dEMh3gATGW9A4ttL8XRyE	false	mutation decreasing interaction strength:614-614|mutation decreasing interaction strength:620-620|mutation disrupting interaction strength:614-614,620-620	sufficient binding region:149-235,97-236	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00520	uniprotkb:P28693	intact:EBI-914519|uniprotkb:P97896|uniprotkb:Q61252|uniprotkb:Q61253|uniprotkb:Q61254|uniprotkb:Q61255|uniprotkb:Q61256|uniprotkb:Q61257|uniprotkb:Q61258|uniprotkb:Q61259|uniprotkb:Q61260|uniprotkb:Q61261|uniprotkb:Q6PCM5|uniprotkb:Q8C1X4|ensembl:ENSMUSP00000028190	intact:EBI-6725885	psi-mi:abl1_mouse(display_long)|uniprotkb:Abl1(gene name)|psi-mi:Abl1(display_short)|uniprotkb:Abl(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)	psi-mi:ephb2_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:CEK5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663703|imex:IM-25924-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269974.1|refseq:NP_001269975.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSMUSG00000026842(gene)|ensembl:ENSMUST00000028190(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|refseq:NP_001106174.1|refseq:NP_033724.2|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00520|rcsb pdb:1ABO|rcsb pdb:1ABQ|rcsb pdb:1FPU|rcsb pdb:1IEP|rcsb pdb:1M52|rcsb pdb:1OPJ|rcsb pdb:1OPK|rcsb pdb:2HZN|rcsb pdb:2QOH|rcsb pdb:2Z60|rcsb pdb:3DK3|rcsb pdb:3DK6|rcsb pdb:3DK7|rcsb pdb:3IK3|rcsb pdb:3K5V|rcsb pdb:3KF4|rcsb pdb:3KFA|rcsb pdb:3MS9|rcsb pdb:3MSS|rcsb pdb:3OXZ|rcsb pdb:3OY3|rcsb pdb:5IH2|rcsb pdb:6HD4|rcsb pdb:6HD6|reactome:R-MMU-2029482|reactome:R-MMU-428890|reactome:R-MMU-525793|reactome:R-MMU-5663213|reactome:R-MMU-5685938|reactome:R-MMU-5693565|reactome:R-MMU-69231|reactome:R-MMU-8939236	go:"GO:0001525"(angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021963"(spinothalamic tract morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|refseq:NP_996834.1|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|rcsb pdb:1SGG|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116	go:"GO:0016310"(phosphorylation)	-	-	figure legend:3A|comment:Abl SH2 domain binding to EphB2 require phosphorylation of tyrosines 605 and 611.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2018/04/13	rogid:Ua709ju5WT1NhOz3n4xzlEBD0Cw10090	rogid:H1FT8bEj+95IFkYU4xQt3Gk2m209031	intact-crc:1116EE786F4F78B3|rigid:P4HhH1dEMh3gATGW9A4ttL8XRyE	false	tag:?-?	mutation decreasing interaction strength:614-614,620-620	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q98946	uniprotkb:F1NHC7	intact:EBI-6663732	intact:EBI-6663549|ensembl:ENSGALP00000007541	psi-mi:q98946_chick(display_long)|uniprotkb:ABL(gene name)|psi-mi:ABL(display_short)	psi-mi:f1nhc7_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)	psi-mi:"MI:0096"(pull down)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663730|imex:IM-25924-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003407"(neural retina development)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007420"(brain development)|interpro:IPR020635|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR033221	ensembl:ENSGALG00000004741(gene)|ensembl:ENSGALT00000007553(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001655"(urogenital system development)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003407"(neural retina development)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0007411"(axon guidance)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0016301"(kinase activity)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099557"(trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission)|go:"GO:0106028"(neuron projection retraction)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116|reactome:R-GGA-2682334|reactome:R-GGA-3928662|reactome:R-GGA-3928664|reactome:R-GGA-3928665|refseq:NP_996834.1	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2017/09/02	rogid:xF98PPdqeofhi7YS1kqnfrA5SO49031	rogid:dEI9Td9b2Xg5MjMklB2G8w+kCcQ9031	intact-crc:35B7688D14BC2FD1|rigid:xuqQCpxOyIpxfFGsaVg1ZauohJo	false	tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q98946	uniprotkb:P29318	intact:EBI-6663732	intact:EBI-6663771	psi-mi:q98946_chick(display_long)|uniprotkb:ABL(gene name)|psi-mi:ABL(display_short)	psi-mi:epha3_chick(display_long)|uniprotkb:EPHA3(gene name)|psi-mi:EPHA3(display_short)|uniprotkb:CEK4(gene name synonym)|uniprotkb:ETK1(gene name synonym)|uniprotkb:EPH-like kinase 4(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor ETK1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663730|imex:IM-25924-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003407"(neural retina development)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007420"(brain development)|interpro:IPR020635|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR033221	go:"GO:0005003"(ephrin receptor activity)|go:"GO:0005004"(GPI-linked ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016477"(cell migration)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0097155"(fasciculation of sensory neuron axon)|go:"GO:0097156"(fasciculation of motor neuron axon)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|refseq:NP_990761.1|interpro:IPR027936|interpro:IPR034266|interpro:IPR036116	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/03	2017/09/02	rogid:xF98PPdqeofhi7YS1kqnfrA5SO49031	rogid:2onaOL6S8U68s9VmEhXkesIUROs9031	intact-crc:35B7688D14BC2FD1|rigid:xuqQCpxOyIpxfFGsaVg1ZauohJo	false	tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00520	uniprotkb:P28693	intact:EBI-914519|uniprotkb:P97896|uniprotkb:Q61252|uniprotkb:Q61253|uniprotkb:Q61254|uniprotkb:Q61255|uniprotkb:Q61256|uniprotkb:Q61257|uniprotkb:Q61258|uniprotkb:Q61259|uniprotkb:Q61260|uniprotkb:Q61261|uniprotkb:Q6PCM5|uniprotkb:Q8C1X4|ensembl:ENSMUSP00000028190	intact:EBI-6725885	psi-mi:abl1_mouse(display_long)|uniprotkb:Abl1(gene name)|psi-mi:Abl1(display_short)|uniprotkb:Abl(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)	psi-mi:ephb2_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:CEK5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663819|imex:IM-25924-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269974.1|refseq:NP_001269975.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSMUSG00000026842(gene)|ensembl:ENSMUST00000028190(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|refseq:NP_001106174.1|refseq:NP_033724.2|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00520|rcsb pdb:1ABO|rcsb pdb:1ABQ|rcsb pdb:1FPU|rcsb pdb:1IEP|rcsb pdb:1M52|rcsb pdb:1OPJ|rcsb pdb:1OPK|rcsb pdb:2HZN|rcsb pdb:2QOH|rcsb pdb:2Z60|rcsb pdb:3DK3|rcsb pdb:3DK6|rcsb pdb:3DK7|rcsb pdb:3IK3|rcsb pdb:3K5V|rcsb pdb:3KF4|rcsb pdb:3KFA|rcsb pdb:3MS9|rcsb pdb:3MSS|rcsb pdb:3OXZ|rcsb pdb:3OY3|rcsb pdb:5IH2|rcsb pdb:6HD4|rcsb pdb:6HD6|reactome:R-MMU-2029482|reactome:R-MMU-428890|reactome:R-MMU-525793|reactome:R-MMU-5663213|reactome:R-MMU-5685938|reactome:R-MMU-5693565|reactome:R-MMU-69231|reactome:R-MMU-8939236	go:"GO:0001525"(angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021963"(spinothalamic tract morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|refseq:NP_996834.1|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|rcsb pdb:1SGG|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116	-	-	-	figure legend:4B, 6A|comment:Abl C-terminal motif mediates binding to EphB2 in a phosphorylation-independent manner.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/05/03	2018/04/13	rogid:Ua709ju5WT1NhOz3n4xzlEBD0Cw10090	rogid:H1FT8bEj+95IFkYU4xQt3Gk2m209031	intact-crc:6915A7AC42F63FBD|rigid:P4HhH1dEMh3gATGW9A4ttL8XRyE	false	flag tag:979-980	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00520	uniprotkb:P28693	intact:EBI-914519|uniprotkb:P97896|uniprotkb:Q61252|uniprotkb:Q61253|uniprotkb:Q61254|uniprotkb:Q61255|uniprotkb:Q61256|uniprotkb:Q61257|uniprotkb:Q61258|uniprotkb:Q61259|uniprotkb:Q61260|uniprotkb:Q61261|uniprotkb:Q6PCM5|uniprotkb:Q8C1X4|ensembl:ENSMUSP00000028190	intact:EBI-6725885	psi-mi:abl1_mouse(display_long)|uniprotkb:Abl1(gene name)|psi-mi:Abl1(display_short)|uniprotkb:Abl(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 1(gene name synonym)|uniprotkb:Proto-oncogene c-Abl(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:Abelson tyrosine-protein kinase 1(gene name synonym)	psi-mi:ephb2_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:CEK5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6666566|imex:IM-25924-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269974.1|refseq:NP_001269975.1|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030035"(microspike assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|ensembl:ENSMUSG00000026842(gene)|ensembl:ENSMUST00000028190(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0001726"(ruffle)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002333"(transitional one stage B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|refseq:NP_001106174.1|refseq:NP_033724.2|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071103"(DNA conformation change)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072359"(circulatory system development)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090135"(actin filament branching)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903053"(regulation of extracellular matrix organization)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR033221|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P00520|rcsb pdb:1ABO|rcsb pdb:1ABQ|rcsb pdb:1FPU|rcsb pdb:1IEP|rcsb pdb:1M52|rcsb pdb:1OPJ|rcsb pdb:1OPK|rcsb pdb:2HZN|rcsb pdb:2QOH|rcsb pdb:2Z60|rcsb pdb:3DK3|rcsb pdb:3DK6|rcsb pdb:3DK7|rcsb pdb:3IK3|rcsb pdb:3K5V|rcsb pdb:3KF4|rcsb pdb:3KFA|rcsb pdb:3MS9|rcsb pdb:3MSS|rcsb pdb:3OXZ|rcsb pdb:3OY3|rcsb pdb:5IH2|rcsb pdb:6HD4|rcsb pdb:6HD6|reactome:R-MMU-2029482|reactome:R-MMU-428890|reactome:R-MMU-525793|reactome:R-MMU-5663213|reactome:R-MMU-5685938|reactome:R-MMU-5693565|reactome:R-MMU-69231|reactome:R-MMU-8939236	go:"GO:0001525"(angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021963"(spinothalamic tract morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|refseq:NP_996834.1|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|rcsb pdb:1SGG|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116	-	-	-	figure legend:Figs. 4A, 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/05/03	2018/04/13	rogid:Ua709ju5WT1NhOz3n4xzlEBD0Cw10090	rogid:H1FT8bEj+95IFkYU4xQt3Gk2m209031	intact-crc:F4040FADFE74434A|rigid:P4HhH1dEMh3gATGW9A4ttL8XRyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42684	uniprotkb:P28693	intact:EBI-1102694|uniprotkb:Q5T0X6|uniprotkb:Q5W0C5|uniprotkb:B7UEF2|uniprotkb:B7UEF3|uniprotkb:B7UEF4|uniprotkb:B7UEF5|uniprotkb:Q6NZY6|uniprotkb:Q7Z301|ensembl:ENSP00000427562|uniprotkb:A0M8X0	intact:EBI-6725885	psi-mi:abl2_human(display_long)|uniprotkb:Abelson tyrosine-protein kinase 2(gene name synonym)|uniprotkb:ABL2(gene name)|psi-mi:ABL2(display_short)|uniprotkb:ABLL(gene name synonym)|uniprotkb:ARG(gene name synonym)|uniprotkb:Abelson murine leukemia viral oncogene homolog 2(gene name synonym)|uniprotkb:Abelson-related gene protein(gene name synonym)|uniprotkb:Tyrosine-protein kinase ARG(gene name synonym)	psi-mi:ephb2_chick(display_long)|uniprotkb:EPHB2(gene name)|psi-mi:EPHB2(display_short)|uniprotkb:CEK5(gene name synonym)|uniprotkb:EPH-like kinase 5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yu et al. (2001)	pubmed:11494128|mint:MINT-6731333|imex:IM-25924	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-6663826|imex:IM-25924-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143322(gene)|ensembl:ENST00000502732(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035640"(exploration behavior)|go:"GO:0051015"(actin filament binding)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:2000145"(regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015015(F-actin binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035837|interpro:IPR036028|interpro:IPR036860|mint:P42684|rcsb pdb:2ECD|rcsb pdb:2KK1|rcsb pdb:2XYN|rcsb pdb:3GVU|rcsb pdb:3HMI|rcsb pdb:3ULR|rcsb pdb:4EIH|rcsb pdb:5NP3|rcsb pdb:5NP5|reactome:R-HSA-428890|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9706369|refseq:NP_001129472.1|refseq:NP_001129473.1|refseq:NP_001161708.1|refseq:NP_001161709.1|refseq:NP_001161710.1|refseq:NP_001161711.1|refseq:NP_005149.4|refseq:NP_009298.1|refseq:XP_005245145.1|dip:DIP-91N	go:"GO:0001525"(angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0021963"(spinothalamic tract morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|refseq:NP_996834.1|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011641(GCC2 and GCC3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|rcsb pdb:1SGG|interpro:IPR027936|interpro:IPR034238|interpro:IPR036116	-	crc64:ED93869BC2B14FAA	-	figure legend:4C, 5B, 6B|comment:Arg C-terminal motif is required for binding to EphB2 independently of EphB2 tyrosine phosphorylation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/05/03	2018/04/13	rogid:ct5SG4m0wewDSllBklIOi48BV7Q9606	rogid:H1FT8bEj+95IFkYU4xQt3Gk2m209031	intact-crc:4CA9A001796CB46E|rigid:bMbkiOr5iOJ0RywhxzhuVgKDX9w	false	myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)