#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14640	uniprotkb:P49674	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857746|imex:IM-21248-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 4a, Fig. 4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:2D8EC8737F232821|rigid:WMxantXeSaraUl2rqExj20JkE0s	false	necessary binding region:336-519|ha tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	uniprotkb:O70239	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	intact:EBI-6857773	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857771|imex:IM-21248-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 5a, Fig. 5b|caution:"The authors claim that this interaction could not be demonstrated in an in vitro pull down experiment using MBP-tagged human Kc1e as bait and GST-tagged rat Axin1 (residues 298-832) as prey."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:435A68E4B8D26F14|rigid:ZzeuIpCFAfTcCgMatVXPuvuBw84	false	enhanced green fluorescent protein tag:?-?	myc tag:?-?|necessary binding region:298-529	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-6876714	uniprotkb:O70239	-	intact:EBI-6857773	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877706|imex:IM-21248-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	comment:Similar to P49841.	crc64:BB1EE9CCECF6D487	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	-	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:4C98998C584F4DBE	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70239	intact:EBI-6876714	intact:EBI-6857773	-	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877734|imex:IM-21248-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	comment:Similar to P49841.	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	-	intact-crc:F49AB52231474304	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70239	uniprotkb:O14640	intact:EBI-6857773	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877734|imex:IM-21248-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	crc64:BB1EE9CCECF6D487	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:F49AB52231474304	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70239	uniprotkb:P49674	intact:EBI-6857773	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877743|imex:IM-21248-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	crc64:BB1EE9CCECF6D487	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:8DFEC6857D5EB2E8	false	myc tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70239	uniprotkb:O14640	intact:EBI-6857773	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877743|imex:IM-21248-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	crc64:BB1EE9CCECF6D487	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:8DFEC6857D5EB2E8	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70239	intact:EBI-6876714	intact:EBI-6857773	-	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877743|imex:IM-21248-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	comment:Similar to P49841.	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	-	intact-crc:8DFEC6857D5EB2E8	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70239	uniprotkb:P49674	intact:EBI-6857773	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877755|imex:IM-21248-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	crc64:BB1EE9CCECF6D487	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:F6B1BE68E0899DA3	false	myc tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70239	intact:EBI-6876714	intact:EBI-6857773	-	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877755|imex:IM-21248-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	comment:Similar to P49841.	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	-	intact-crc:F6B1BE68E0899DA3	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14640	uniprotkb:O70239	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-6857773	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877765|imex:IM-21248-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:401066F2F9B361A2	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14640	intact:EBI-6876714	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	-	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877765|imex:IM-21248-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	-	-	comment:Similar to P49841.	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	-	intact-crc:401066F2F9B361A2	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14640	uniprotkb:O70239	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-6857773	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877774|imex:IM-21248-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:04F5248789575064	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14640	intact:EBI-6876714	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	-	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877774|imex:IM-21248-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	-	-	comment:Similar to P49841.	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	-	intact-crc:04F5248789575064	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14640	uniprotkb:P49674	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877774|imex:IM-21248-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:04F5248789575064	false	ha tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	intact:EBI-6876714	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	-	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877786|imex:IM-21248-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	comment:Similar to P49841.	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	-	intact-crc:9E1FBCCE67CA2F9B	false	enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	uniprotkb:O70239	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	intact:EBI-6857773	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877786|imex:IM-21248-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:9E1FBCCE67CA2F9B	false	enhanced green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	uniprotkb:O14640	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877795|imex:IM-21248-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:5638742C5BD0E7B0	false	enhanced green fluorescent protein tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	intact:EBI-6876714	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	-	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877795|imex:IM-21248-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	comment:Similar to P49841.	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	-	intact-crc:5638742C5BD0E7B0	false	enhanced green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	uniprotkb:O70239	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	intact:EBI-6857773	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877795|imex:IM-21248-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:5638742C5BD0E7B0	false	enhanced green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876712	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:ctnb1_chlae_protein(display_short)|psi-mi:EBI-6876712(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877969|imex:IM-21248-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P35222.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:4A3335A920D1DABD	false	myc tag:?-?|sufficient binding region:1211-2075	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876714	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877975|imex:IM-21248-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P49841.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:C385680057DF4D2C	false	myc tag:?-?|sufficient binding region:1211-2075	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876712	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:ctnb1_chlae_protein(display_short)|psi-mi:EBI-6876712(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877975|imex:IM-21248-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P35222.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:C385680057DF4D2C	false	myc tag:?-?|sufficient binding region:1211-2075	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:O70239	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-6857773	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877975|imex:IM-21248-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:C385680057DF4D2C	false	myc tag:?-?|sufficient binding region:1211-2075	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:P49674	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877993|imex:IM-21248-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:2B13626CD6A294E9	false	myc tag:?-?|sufficient binding region:1211-2075	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876712	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:ctnb1_chlae_protein(display_short)|psi-mi:EBI-6876712(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6877993|imex:IM-21248-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P35222.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:2B13626CD6A294E9	false	myc tag:?-?|sufficient binding region:1211-2075	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:P49674	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878028|imex:IM-21248-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:6F82E51E362A2CB8	false	myc tag:?-?|sufficient binding region:1211-2075	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:O14640	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878028|imex:IM-21248-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:6F82E51E362A2CB8	false	myc tag:?-?|sufficient binding region:1211-2075	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876712	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:ctnb1_chlae_protein(display_short)|psi-mi:EBI-6876712(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878028|imex:IM-21248-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P35222.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:6F82E51E362A2CB8	false	myc tag:?-?|sufficient binding region:1211-2075	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876714	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878058|imex:IM-21248-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P49841.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:CE927FCF172B91CE	false	myc tag:?-?|sufficient binding region:1211-2075	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:O70239	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-6857773	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878058|imex:IM-21248-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:CE927FCF172B91CE	false	myc tag:?-?|sufficient binding region:1211-2075	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876712	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:ctnb1_chlae_protein(display_short)|psi-mi:EBI-6876712(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878058|imex:IM-21248-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P35222.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:CE927FCF172B91CE	false	myc tag:?-?|sufficient binding region:1211-2075	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:P49674	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878058|imex:IM-21248-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:CE927FCF172B91CE	false	myc tag:?-?|sufficient binding region:1211-2075	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876712	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:ctnb1_chlae_protein(display_short)|psi-mi:EBI-6876712(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878085|imex:IM-21248-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P35222.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:A99CBE90DFA19BB7	false	sufficient binding region:1211-2075|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:P49674	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878085|imex:IM-21248-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:A99CBE90DFA19BB7	false	sufficient binding region:1211-2075|myc tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:O14640	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878085|imex:IM-21248-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:A99CBE90DFA19BB7	false	sufficient binding region:1211-2075|myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:O70239	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-6857773	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878085|imex:IM-21248-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	-	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:A99CBE90DFA19BB7	false	sufficient binding region:1211-2075|myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	intact:EBI-6876714	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	-	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:gsk3b_chlae_protein(display_short)|psi-mi:EBI-6876714(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878085|imex:IM-21248-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	comment:Similar to P49841.	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	intact-crc:A99CBE90DFA19BB7	false	sufficient binding region:1211-2075|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49674	uniprotkb:O14640	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6857763|imex:IM-21248-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	-	-	-	figure legend:Fig. 4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	intact-crc:91591FE7112B1542|rigid:WMxantXeSaraUl2rqExj20JkE0s	false	maltose binding protein tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P49674	uniprotkb:O70239	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	intact:EBI-6857773	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6860379|imex:IM-21248-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	crc64:BB1EE9CCECF6D487	figure legend:Fig. 3b|caution:"Coexpression of Csnk1e in COS cells did not affect the mobility of rAxin1 in SDS-PAGE (Fig. 3a)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	intact-crc:B77C248478821EF2|rigid:ZzeuIpCFAfTcCgMatVXPuvuBw84	false	his tag:?-?	maltose binding protein tag:?-?|phosphorylated residue:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O14640	uniprotkb:P49674	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6860389|imex:IM-21248-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:C383DD7E9479597B|rigid:WMxantXeSaraUl2rqExj20JkE0s	false	maltose binding protein tag:?-?|phosphorylated residue:?-?	his tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P35222	uniprotkb:P49674	intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6860399|imex:IM-21248-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 3b|caution:"The authors claim that coexpression of Csnk1e in COS cells did not affect the mobility of Ctnnb1 in SDS-PAGE (data not shown in paper)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:8BCF06640FD43ADD|rigid:HZ+aSIm8J0wTPfsjfCXdFLSCBRc	false	glutathione s tranferase tag:?-?|phosphorylated residue:?-?	his tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P49674	uniprotkb:P25054	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6860409|imex:IM-21248-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	intact-crc:4E94858E73DC931F|rigid:SHSydUIXtjJB9RwQ4a8qbOAfCM4	false	his tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1211-2075|phosphorylated residue:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O14640	uniprotkb:P49674	intact:EBI-723489|ensembl:ENSP00000368166|uniprotkb:Q5TA33|uniprotkb:Q5TA35	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:dvl1_human(display_long)|uniprotkb:DVL1(gene name)|psi-mi:DVL1(display_short)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878298|imex:IM-21248-22	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004412.2|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|ensembl:ENSG00000107404(gene)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|ensembl:ENST00000378888(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0042802"(identical protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0043005"(neuron projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0099054"(presynapse assembly)|go:"GO:0043113"(receptor clustering)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1905386"(positive regulation of protein localization to presynapse)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|go:"GO:0043197"(dendritic spine)|interpro:IPR008339(Dishevelled region)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008340(Dishevelled-1 protein)|go:"GO:0048668"(collateral sprouting)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14640|rcsb pdb:6LCB|rcsb pdb:6TTK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324|rcsb pdb:6LCA|refseq:NP_001317240.1|dip:DIP-40773N	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:YavBFKCYghbedonh2KpEgBcF2Co9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:1ED9672CFE9E72C8|rigid:WMxantXeSaraUl2rqExj20JkE0s	false	glutathione s tranferase tag:?-?|phosphorylated residue:?-?	his tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P25054	uniprotkb:P49674	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878313|imex:IM-21248-23	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	-	-	figure legend:Fig. 3c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:1C933BFD56783CBA|rigid:SHSydUIXtjJB9RwQ4a8qbOAfCM4	false	glutathione s tranferase tag:?-?|phosphorylated residue:?-?	his tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O70239	uniprotkb:P49674	intact:EBI-6857773	intact:EBI-749343|ensembl:ENSP00000352929|ensembl:ENSP00000380044|ensembl:ENSP00000384074	psi-mi:axin1_rat(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)	psi-mi:kc1e_human(display_long)|uniprotkb:CSNK1E(gene name)|psi-mi:CSNK1E(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Kishida et al. (2001)	pubmed:11425858|imex:IM-21248	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6878323|imex:IM-21248-24	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050877"(nervous system process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1WSP|rcsb pdb:2D5G|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|rgd:620859|refseq:NP_077381.1|dip:DIP-29400N	refseq:NP_001885.1|refseq:NP_689407.1|refseq:NP_001276841.1|dip:DIP-38050N|ensembl:ENSG00000213923(gene)|ensembl:ENST00000359867(transcript)|ensembl:ENST00000396832(transcript)|ensembl:ENST00000403904(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903827"|go:"GO:0005829"(cytosol)|go:"GO:1905426"(positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-400253|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-HSA-5620912|reactome:R-HSA-6791226|reactome:R-HSA-8854518|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49674|rcsb pdb:4HNI|rcsb pdb:4HOK|reactome:R-HSA-201688|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320	-	crc64:BB1EE9CCECF6D487	-	figure legend:Fig. 3c|caution:"Coexpression of Csnk1e in COS cells did not affect the mobility of rAxin1 in SDS-PAGE (Fig. 3a)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/05	2014/10/16	rogid:SyDwhbKdwM2kp9MMCySzL57N08410116	rogid:evdzz03ba4MFWavN9xRae/Wxwio9606	intact-crc:600745F2017CAFCB|rigid:ZzeuIpCFAfTcCgMatVXPuvuBw84	false	maltose binding protein tag:?-?|phosphorylated residue:?-?	his tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)