#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22413	uniprotkb:P06213	intact:EBI-3197846|ensembl:ENSP00000498074|uniprotkb:Q9UP61|uniprotkb:Q9Y6K3|uniprotkb:Q9NPZ3|uniprotkb:Q5T9R6|uniprotkb:Q9P1P6	intact:EBI-475899|uniprotkb:Q17RW0|uniprotkb:Q59H98|uniprotkb:Q9UCB7|uniprotkb:Q9UCB8|uniprotkb:Q9UCB9|ensembl:ENSP00000303830	psi-mi:enpp1_human(display_long)|uniprotkb:ENPP1(gene name)|psi-mi:ENPP1(display_short)|uniprotkb:M6S1(gene name synonym)|uniprotkb:NPPS(gene name synonym)|uniprotkb:PC1(gene name synonym)|uniprotkb:PDNP1(gene name synonym)|uniprotkb:Membrane component chromosome 6 surface marker 1(gene name synonym)|uniprotkb:Phosphodiesterase I/nucleotide pyrophosphatase 1(gene name synonym)|uniprotkb:Plasma-cell membrane glycoprotein PC-1(gene name synonym)	psi-mi:insr_human(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Costanzo et al. (2001)	pubmed:11289049|imex:IM-22128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8851990|imex:IM-22128-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6WEV|rcsb pdb:6WEW|rcsb pdb:6WFJ|reactome:R-HSA-196843|reactome:R-HSA-199220|rcsb pdb:6WEU|ensembl:ENSG00000197594(gene)|ensembl:ENST00000647893(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0004551"(nucleotide diphosphatase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009143"(nucleoside triphosphate catabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030505"(inorganic diphosphate transport)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035529"(NADH pyrophosphatase activity)|go:"GO:0036218"(dTTP diphosphatase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0050427"(3'-phosphoadenosine 5'-phosphosulfate metabolic process)|go:"GO:0050656"(3'-phosphoadenosine 5'-phosphosulfate binding)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0106177"(cyclic-GMP-AMP hydrolase activity)|go:"GO:1990787"(negative regulation of hh target transcription factor activity)|interpro:IPR001212(Somatomedin B)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR002591(Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR020436|interpro:IPR020821|interpro:IPR029890|interpro:IPR036024|mint:P22413|rcsb pdb:2YS0|rcsb pdb:6WET|refseq:NP_006199.2	refseq:NP_000199.2|refseq:NP_001073285.1|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P06213|rcsb pdb:1GAG|rcsb pdb:1I44|rcsb pdb:1IR3|rcsb pdb:1IRK|rcsb pdb:1P14|rcsb pdb:1RQQ|rcsb pdb:2AUH|rcsb pdb:2B4S|rcsb pdb:2HR7|rcsb pdb:2MFR|go:"GO:0032809"(neuronal cell body membrane)|rcsb pdb:2Z8C|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|rcsb pdb:3EKK|rcsb pdb:3EKN|dip:DIP-480N|rcsb pdb:7BW8|rcsb pdb:7BWA|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:4IBM|rcsb pdb:4OGA|rcsb pdb:4XLV|rcsb pdb:4XSS|rcsb pdb:4XST|rcsb pdb:4ZXB|rcsb pdb:5E1S|rcsb pdb:5HHW|rcsb pdb:5J3H|rcsb pdb:5KQV|rcsb pdb:5U1M|rcsb pdb:6HN4|rcsb pdb:6HN5|rcsb pdb:6PXV|rcsb pdb:3ETA|rcsb pdb:6PXW|rcsb pdb:6SOF|rcsb pdb:6VEP|rcsb pdb:6VEQ|rcsb pdb:7BW7	-	-	-	figure legend:Figure 3 A & B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2013/11/15	2014/10/16	rogid:5qr5E+tfmPJFgXtvePCm+fDs9ks9606	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	intact-crc:7A154E977F2DB042|rigid:9Dgtzg/qH4P1h4rHkkRIrk6lJg4	false	disease causing amino-acid variant:173-173(VAR_008873)	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:P06213	uniprotkb:P22413	intact:EBI-475899|uniprotkb:Q17RW0|uniprotkb:Q59H98|uniprotkb:Q9UCB7|uniprotkb:Q9UCB8|uniprotkb:Q9UCB9|ensembl:ENSP00000303830	intact:EBI-3197846|ensembl:ENSP00000498074|uniprotkb:Q9UP61|uniprotkb:Q9Y6K3|uniprotkb:Q9NPZ3|uniprotkb:Q5T9R6|uniprotkb:Q9P1P6	psi-mi:insr_human(display_long)|uniprotkb:INSR(gene name)|psi-mi:INSR(display_short)	psi-mi:enpp1_human(display_long)|uniprotkb:ENPP1(gene name)|psi-mi:ENPP1(display_short)|uniprotkb:M6S1(gene name synonym)|uniprotkb:NPPS(gene name synonym)|uniprotkb:PC1(gene name synonym)|uniprotkb:PDNP1(gene name synonym)|uniprotkb:Membrane component chromosome 6 surface marker 1(gene name synonym)|uniprotkb:Phosphodiesterase I/nucleotide pyrophosphatase 1(gene name synonym)|uniprotkb:Plasma-cell membrane glycoprotein PC-1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Costanzo et al. (2001)	pubmed:11289049|imex:IM-22128	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8851801|imex:IM-22128-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000199.2|refseq:NP_001073285.1|ensembl:ENSG00000171105(gene)|ensembl:ENST00000302850(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005009"(insulin-activated receptor activity)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005899"(insulin receptor complex)|go:"GO:0005901"(caveola)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002011(Receptor tyrosine kinase, class II, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016246(Insulin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036941|interpro:IPR040969|mint:P06213|rcsb pdb:1GAG|rcsb pdb:1I44|rcsb pdb:1IR3|rcsb pdb:1IRK|rcsb pdb:1P14|rcsb pdb:1RQQ|rcsb pdb:2AUH|rcsb pdb:2B4S|rcsb pdb:2HR7|rcsb pdb:2MFR|go:"GO:0032809"(neuronal cell body membrane)|rcsb pdb:2Z8C|rcsb pdb:3BU3|rcsb pdb:3BU5|rcsb pdb:3BU6|rcsb pdb:3EKK|rcsb pdb:3EKN|dip:DIP-480N|rcsb pdb:7BW8|rcsb pdb:7BWA|reactome:R-HSA-6811558|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-74752|reactome:R-HSA-77387|rcsb pdb:3W11|rcsb pdb:3W12|rcsb pdb:3W13|rcsb pdb:4IBM|rcsb pdb:4OGA|rcsb pdb:4XLV|rcsb pdb:4XSS|rcsb pdb:4XST|rcsb pdb:4ZXB|rcsb pdb:5E1S|rcsb pdb:5HHW|rcsb pdb:5J3H|rcsb pdb:5KQV|rcsb pdb:5U1M|rcsb pdb:6HN4|rcsb pdb:6HN5|rcsb pdb:6PXV|rcsb pdb:3ETA|rcsb pdb:6PXW|rcsb pdb:6SOF|rcsb pdb:6VEP|rcsb pdb:6VEQ|rcsb pdb:7BW7	rcsb pdb:6WEV|rcsb pdb:6WEW|rcsb pdb:6WFJ|reactome:R-HSA-196843|reactome:R-HSA-199220|rcsb pdb:6WEU|ensembl:ENSG00000197594(gene)|ensembl:ENST00000647893(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0004551"(nucleotide diphosphatase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006955"(immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009143"(nucleoside triphosphate catabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030505"(inorganic diphosphate transport)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0031214"(biomineral tissue development)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035529"(NADH pyrophosphatase activity)|go:"GO:0036218"(dTTP diphosphatase activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0050427"(3'-phosphoadenosine 5'-phosphosulfate metabolic process)|go:"GO:0050656"(3'-phosphoadenosine 5'-phosphosulfate binding)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0106177"(cyclic-GMP-AMP hydrolase activity)|go:"GO:1990787"(negative regulation of hh target transcription factor activity)|interpro:IPR001212(Somatomedin B)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR002591(Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase)|interpro:IPR017850(Alkaline-phosphatase-like, core domain)|interpro:IPR020436|interpro:IPR020821|interpro:IPR029890|interpro:IPR036024|mint:P22413|rcsb pdb:2YS0|rcsb pdb:6WET|refseq:NP_006199.2	-	-	-	figure legend:Figure 2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2013/11/15	2014/10/16	rogid:mLKbADp8yGfO+Kic/dzn3VFCZrc9606	rogid:5qr5E+tfmPJFgXtvePCm+fDs9ks9606	intact-crc:0A0696BD623DA6C0|rigid:9Dgtzg/qH4P1h4rHkkRIrk6lJg4	false	-	disease causing amino-acid variant:173-173(VAR_008873)	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)