#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75969	uniprotkb:Q9BZX4	intact:EBI-9033101|uniprotkb:O75945|uniprotkb:Q86X01|uniprotkb:Q9UM61|ensembl:ENSP00000228850|ensembl:ENSP00000440994	intact:EBI-9033148|uniprotkb:D3DNA6|uniprotkb:Q96BM7|ensembl:ENSP00000251776|ensembl:ENSP00000426271	psi-mi:akap3_human(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:SOB1(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Cancer/testis antigen 82(gene name synonym)|uniprotkb:Fibrous sheath protein of 95 kDa(gene name synonym)|uniprotkb:Fibrousheathin I(gene name synonym)|uniprotkb:Fibrousheathin-1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:Sperm oocyte-binding protein(gene name synonym)	psi-mi:rop1b_human(display_long)|uniprotkb:ROPN1B(gene name)|psi-mi:ROPN1B(display_short)|uniprotkb:Rhophilin-associated protein 1B(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Carr et al. (2001)	imex:IM-22057|pubmed:11278869	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-9033135|imex:IM-22057-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519210.1|refseq:XP_011519211.1|refseq:XP_011519212.1|refseq:NP_001265238.1|refseq:NP_006413.3|refseq:XP_005253721.1|ensembl:ENSG00000111254(gene)|ensembl:ENST00000228850(transcript)|ensembl:ENST00000545990(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008104"(protein localization)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	refseq:NP_001012337.1|refseq:XP_005247195.1|refseq:NP_001295242.1|refseq:XP_006713576.1|ensembl:ENSG00000114547(gene)|ensembl:ENST00000251776(transcript)|ensembl:ENST00000514116(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0044782"(cilium organization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048240"(sperm capacitation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098609"(cell-cell adhesion)	-	-	-	figure legend:fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/12/12	2014/10/16	rogid:EInmydTsabZBmiDEYQRofcg4zy49606	rogid:sKZ+GjDooBv+QIypUJtTN9oQXuc9606	intact-crc:D0B8CCCEE634B48C|rigid:A4jrMaNLEwjrqd7zCwS71BZaZL4	false	sufficient binding region:1-350	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q96C74	uniprotkb:O75969	intact:EBI-9033237|uniprotkb:D3DTC9|uniprotkb:Q9BZX0|ensembl:ENSP00000274134|ensembl:ENSP00000421405	intact:EBI-9033101|uniprotkb:O75945|uniprotkb:Q86X01|uniprotkb:Q9UM61|ensembl:ENSP00000228850|ensembl:ENSP00000440994	psi-mi:rop1l_human(display_long)|uniprotkb:RSPH11(gene name synonym)|uniprotkb:ROPN1L(gene name)|psi-mi:ROPN1L(display_short)|uniprotkb:ASP(gene name synonym)|uniprotkb:AKAP-associated sperm protein(gene name synonym)	psi-mi:akap3_human(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:SOB1(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Cancer/testis antigen 82(gene name synonym)|uniprotkb:Fibrous sheath protein of 95 kDa(gene name synonym)|uniprotkb:Fibrousheathin I(gene name synonym)|uniprotkb:Fibrousheathin-1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:Sperm oocyte-binding protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Carr et al. (2001)	imex:IM-22057|pubmed:11278869	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-9033235|imex:IM-22057-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001188395.1|refseq:NP_114122.2|ensembl:ENSG00000145491(gene)|ensembl:ENST00000274134(transcript)|ensembl:ENST00000503804(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003351"(epithelial cilium movement involved in extracellular fluid movement)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0031514"(motile cilium)|go:"GO:0042802"(identical protein binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0030317"(flagellated sperm motility)	refseq:XP_011519210.1|refseq:XP_011519211.1|refseq:XP_011519212.1|refseq:NP_001265238.1|refseq:NP_006413.3|refseq:XP_005253721.1|ensembl:ENSG00000111254(gene)|ensembl:ENST00000228850(transcript)|ensembl:ENST00000545990(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008104"(protein localization)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	-	-	-	figure legend:fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/12/12	2014/10/16	rogid:77ZjRCzDDMn2zVN/iaK0Z6ZwToY9606	rogid:EInmydTsabZBmiDEYQRofcg4zy49606	intact-crc:C15F48F0E899EDAE|rigid:HggBGVAG1Xpb+D2eZ1IKbsAW+LY	false	-	sufficient binding region:1-350	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P13861	uniprotkb:O75969	intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724	intact:EBI-9033101|uniprotkb:O75945|uniprotkb:Q86X01|uniprotkb:Q9UM61|ensembl:ENSP00000228850|ensembl:ENSP00000440994	psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short)	psi-mi:akap3_human(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:SOB1(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Cancer/testis antigen 82(gene name synonym)|uniprotkb:Fibrous sheath protein of 95 kDa(gene name synonym)|uniprotkb:Fibrousheathin I(gene name synonym)|uniprotkb:Fibrousheathin-1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:Sperm oocyte-binding protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Carr et al. (2001)	imex:IM-22057|pubmed:11278869	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-9033266|imex:IM-22057-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1	refseq:XP_011519210.1|refseq:XP_011519211.1|refseq:XP_011519212.1|refseq:NP_001265238.1|refseq:NP_006413.3|refseq:XP_005253721.1|ensembl:ENSG00000111254(gene)|ensembl:ENST00000228850(transcript)|ensembl:ENST00000545990(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008104"(protein localization)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	-	-	-	figure legend:Fig 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/12/12	2014/10/16	rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606	rogid:EInmydTsabZBmiDEYQRofcg4zy49606	intact-crc:AC054B4E8DF1A108|rigid:tQlcTbrKaeX0jZJhoXQJCqrZ7io	false	-	sufficient binding region:1-350	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9BZX4	uniprotkb:O75969	intact:EBI-9033148|uniprotkb:D3DNA6|uniprotkb:Q96BM7|ensembl:ENSP00000251776|ensembl:ENSP00000426271	intact:EBI-9033101|uniprotkb:O75945|uniprotkb:Q86X01|uniprotkb:Q9UM61|ensembl:ENSP00000228850|ensembl:ENSP00000440994	psi-mi:rop1b_human(display_long)|uniprotkb:ROPN1B(gene name)|psi-mi:ROPN1B(display_short)|uniprotkb:Rhophilin-associated protein 1B(gene name synonym)	psi-mi:akap3_human(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:SOB1(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Cancer/testis antigen 82(gene name synonym)|uniprotkb:Fibrous sheath protein of 95 kDa(gene name synonym)|uniprotkb:Fibrousheathin I(gene name synonym)|uniprotkb:Fibrousheathin-1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:Sperm oocyte-binding protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Carr et al. (2001)	imex:IM-22057|pubmed:11278869	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-9033292|imex:IM-22057-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012337.1|refseq:XP_005247195.1|refseq:NP_001295242.1|refseq:XP_006713576.1|ensembl:ENSG00000114547(gene)|ensembl:ENST00000251776(transcript)|ensembl:ENST00000514116(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007340"(acrosome reaction)|go:"GO:0007342"(fusion of sperm to egg plasma membrane involved in single fertilization)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0044782"(cilium organization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048240"(sperm capacitation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098609"(cell-cell adhesion)	refseq:XP_011519210.1|refseq:XP_011519211.1|refseq:XP_011519212.1|refseq:NP_001265238.1|refseq:NP_006413.3|refseq:XP_005253721.1|ensembl:ENSG00000111254(gene)|ensembl:ENST00000228850(transcript)|ensembl:ENST00000545990(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008104"(protein localization)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	-	-	-	figure legend:Fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/12	2014/10/16	rogid:sKZ+GjDooBv+QIypUJtTN9oQXuc9606	rogid:EInmydTsabZBmiDEYQRofcg4zy49606	intact-crc:67D8652C4B23F964|rigid:A4jrMaNLEwjrqd7zCwS71BZaZL4	false	his tag:n-n|mutation decreasing interaction:18-18	glutathione s tranferase tag:n-n|mutation decreasing interaction:131-131	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75969	uniprotkb:P13861	intact:EBI-9033101|uniprotkb:O75945|uniprotkb:Q86X01|uniprotkb:Q9UM61|ensembl:ENSP00000228850|ensembl:ENSP00000440994	intact:EBI-2556122|intact:EBI-6116682|uniprotkb:Q9BUB1|uniprotkb:Q16823|ensembl:ENSP00000265563|ensembl:ENSP00000394041|intact:EBI-10961724	psi-mi:akap3_human(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:SOB1(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Cancer/testis antigen 82(gene name synonym)|uniprotkb:Fibrous sheath protein of 95 kDa(gene name synonym)|uniprotkb:Fibrousheathin I(gene name synonym)|uniprotkb:Fibrousheathin-1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:Sperm oocyte-binding protein(gene name synonym)	psi-mi:kap2_human(display_long)|uniprotkb:PKR2(gene name synonym)|uniprotkb:PRKAR2(gene name synonym)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short)	psi-mi:"MI:0096"(pull down)	Carr et al. (2001)	imex:IM-22057|pubmed:11278869	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1262"(I2D)	intact:EBI-9033299|imex:IM-22057-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011519210.1|refseq:XP_011519211.1|refseq:XP_011519212.1|refseq:NP_001265238.1|refseq:NP_006413.3|refseq:XP_005253721.1|ensembl:ENSG00000111254(gene)|ensembl:ENST00000228850(transcript)|ensembl:ENST00000545990(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008104"(protein localization)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	dip:DIP-552N|refseq:XP_011532244.1|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P13861|rcsb pdb:2IZX|rcsb pdb:2KYG|rcsb pdb:4ZP3|rcsb pdb:5H78|rcsb pdb:5XBY|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-381676|reactome:R-HSA-432040|reactome:R-HSA-442720|reactome:R-HSA-5610787|reactome:R-HSA-9010642|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|ensembl:ENSG00000114302(gene)|ensembl:ENST00000265563(transcript)|ensembl:ENST00000454963(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097546"(ciliary base)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|refseq:NP_001308911.1|refseq:NP_001308912.1|refseq:NP_004148.1|refseq:XP_016862304.1	-	-	-	figure legend:Fig 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/12/12	2014/10/16	rogid:EInmydTsabZBmiDEYQRofcg4zy49606	rogid:9Jf7EDZ9CZjeRERWwLAR0NyqFGQ9606	intact-crc:97BF9FB6C112A986|rigid:tQlcTbrKaeX0jZJhoXQJCqrZ7io	false	mutation decreasing interaction:131-131|glutathione s tranferase tag:1-350	mutation decreasing interaction:14-14	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9ESG2	uniprotkb:O88987	intact:EBI-7153495|ensembl:ENSMUSP00000023530|uniprotkb:Q3TVG5|intact:MINT-112356	intact:EBI-9033539|uniprotkb:Q497M9|ensembl:ENSMUSP00000093091|ensembl:ENSMUSP00000143794|ensembl:ENSMUSP00000144405	psi-mi:rop1_mouse(display_long)|uniprotkb:Ropn1(gene name)|psi-mi:Ropn1(display_short)|uniprotkb:Rhophilin-associated protein 1(gene name synonym)|uniprotkb:Rhophilin-associated 'oppo' protein(gene name synonym)	psi-mi:akap3_mouse(display_long)|uniprotkb:Akap3(gene name)|psi-mi:Akap3(display_short)|uniprotkb:Akap110(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carr et al. (2001)	imex:IM-22057|pubmed:11278869	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1262"(I2D)	intact:EBI-9033538|imex:IM-22057-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006522761.1|ensembl:ENSMUST00000023530(transcript)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0042802"(identical protein binding)|go:"GO:0044782"(cilium organization)|go:"GO:0048240"(sperm capacitation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097598"(sperm cytoplasmic droplet)|ensembl:ENSMUSG00000022832(gene)|refseq:NP_109669.1	refseq:NP_033780.2|ensembl:ENSMUSG00000030344(gene)|ensembl:ENSMUST00000095440(transcript)|ensembl:ENSMUST00000202574(transcript)|ensembl:ENSMUST00000202878(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005737"(cytoplasm)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0008104"(protein localization)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097228"(sperm principal piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799	-	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-spermatocyte)|taxid:10090(Mus musculus)	-	2013/12/12	2014/10/16	rogid:a076CGb+HyS8tMFlJqshPvRBCe410090	rogid:jG+5Gjkz6rF8vIz3hr1dnHzhjOI10090	intact-crc:E337EC5F4FF64745|rigid:INCQ3dgmcbWVmBjlaclNFtCSWOk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)