#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99835	uniprotkb:Q13635	intact:EBI-766024|uniprotkb:A4D1K5|ensembl:ENSP00000249373	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:smo_human(display_long)|uniprotkb:Protein Gx(gene name synonym)|uniprotkb:SMO(gene name)|psi-mi:SMO(display_short)|uniprotkb:SMOH(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Karpen et al. (2001)	pubmed:11278759|imex:IM-22143	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8776494|imex:IM-22143-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005622.1|dip:DIP-34574N|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0040018"(positive regulation of multicellular organism growth)|ensembl:ENSG00000128602(gene)|ensembl:ENST00000249373(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007494"(midgut development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0007417"(central nervous system development)|rcsb pdb:6OT0|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5620922|reactome:R-HSA-5632684|reactome:R-HSA-5635838|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|mint:Q99835|rcsb pdb:4JKV|rcsb pdb:4N4W|rcsb pdb:4O9R|rcsb pdb:4QIM|rcsb pdb:4QIN|rcsb pdb:5L7D|rcsb pdb:5L7I|rcsb pdb:5V56|rcsb pdb:5V57	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	-	-	figure legend:Fig 3B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2013/09/26	2014/10/16	rogid:U/2EljQsTdy+9hVvzURz0CkburQ9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	intact-crc:E88B27D0AEEAA8CA|rigid:LBWgAYOLbjoYF+SNJKt0YmOyCRU	false	flag tag:c-c	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:G3H9I8	uniprotkb:Q13635	intact:EBI-8775494	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:g3h9i8_crigr(display_long)|uniprotkb:I79_007062(orf name)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Karpen et al. (2001)	pubmed:11278759|imex:IM-22143	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8775503|imex:IM-22143-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015504(Caveolin-1)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0002095"(caveolar macromolecular signaling complex)|go:"GO:0002931"(response to ischemia)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0005938"(cell cortex)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0001666"(response to hypoxia)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007595"(lactation)|go:"GO:0009617"(response to bacterium)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015031"(protein transport)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019217"(regulation of fatty acid metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0030193"(regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033484"(nitric oxide homeostasis)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|interpro:IPR001612(Caveolin)|interpro:IPR018361|refseq:XP_007631544.1|refseq:XP_007639694.1|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051899"(membrane depolarization)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070320"(inward rectifier potassium channel inhibitor activity)|go:"GO:0070836"(caveola assembly)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098903"(regulation of membrane repolarization during action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900085"(negative regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903609"(negative regulation of inward rectifier potassium channel activity)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	-	-	figure legend:Fig 1A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2013/09/26	2014/10/16	rogid:F+Q0csPMPDpbNg1rnN6jiLGeCSk10029	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	intact-crc:5AEFD3C7290F012D|rigid:ihzQyAKwIrJ+PkORSdXaL6BipgY	false	-	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q99835	uniprotkb:Q13635	intact:EBI-766024|uniprotkb:A4D1K5|ensembl:ENSP00000249373	intact:EBI-8775406|uniprotkb:A3KBI9|uniprotkb:E9PEJ8|uniprotkb:Q13463|uniprotkb:Q5R1U7|uniprotkb:Q5R1U9|uniprotkb:Q5R1V0|uniprotkb:Q5VZC0|uniprotkb:Q5VZC2|uniprotkb:Q86XG7|ensembl:ENSP00000332353	psi-mi:smo_human(display_long)|uniprotkb:Protein Gx(gene name synonym)|uniprotkb:SMO(gene name)|psi-mi:SMO(display_short)|uniprotkb:SMOH(gene name synonym)	psi-mi:ptc1_human(display_long)|uniprotkb:PTCH1(gene name)|psi-mi:PTCH1(display_short)|uniprotkb:PTCH(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Karpen et al. (2001)	pubmed:11278759|imex:IM-22143	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8776033|imex:IM-22143-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005622.1|dip:DIP-34574N|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0040018"(positive regulation of multicellular organism growth)|ensembl:ENSG00000128602(gene)|ensembl:ENST00000249373(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007494"(midgut development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0007417"(central nervous system development)|rcsb pdb:6OT0|rcsb pdb:6XBJ|rcsb pdb:6XBK|rcsb pdb:6XBL|rcsb pdb:6XBM|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5620922|reactome:R-HSA-5632684|reactome:R-HSA-5635838|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097542"(ciliary tip)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|mint:Q99835|rcsb pdb:4JKV|rcsb pdb:4N4W|rcsb pdb:4O9R|rcsb pdb:4QIM|rcsb pdb:4QIN|rcsb pdb:5L7D|rcsb pdb:5L7I|rcsb pdb:5V56|rcsb pdb:5V57	ensembl:ENSP00000389744|ensembl:ENSP00000332353|ensembl:ENST00000429896|ensembl:ENSP00000414823|ensembl:ENST00000430669|ensembl:ENSP00000410287|ensembl:ENST00000437951|refseq:NP_000255.2|refseq:NP_001077071.1|refseq:NP_001077072.1|refseq:NP_001077073.1|refseq:NP_001077074.1|refseq:NP_001077075.1|refseq:NP_001077076.1|ensembl:ENSG00000185920(gene)|ensembl:ENST00000331920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005119"(smoothened binding)|go:"GO:0005634"(nucleus)|go:"GO:0005113"(patched binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007420"(brain development)|go:"GO:0008158"(hedgehog receptor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009957"(epidermal cell fate specification)|go:"GO:0010157"(response to chlorate)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021532"(neural tube patterning)|go:"GO:0021997"(neural plate axis specification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030850"(prostate gland development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043616"(keratinocyte proliferation)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051782"(negative regulation of cell division)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061005"(cell differentiation involved in kidney development)|go:"GO:0061053"(somite development)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072203"(cell proliferation involved in metanephros development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097108"(hedgehog family protein binding)|go:"GO:0097421"(liver regeneration)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004766(Transmembrane receptor, patched)|rcsb pdb:6DMB|rcsb pdb:6DMO|rcsb pdb:6DMY|rcsb pdb:6E1H|rcsb pdb:6N7G|rcsb pdb:6N7H|rcsb pdb:6N7K|rcsb pdb:6OEU|rcsb pdb:6OEV|rcsb pdb:6RMG|rcsb pdb:6RTW|rcsb pdb:6RTX|rcsb pdb:6RTY|rcsb pdb:6RVC|rcsb pdb:6RVD|reactome:R-HSA-373080|reactome:R-HSA-5610787|reactome:R-HSA-5632681|reactome:R-HSA-5632684|reactome:R-HSA-5635838|dip:DIP-44940N	-	-	-	figure legend:Fig 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2013/09/26	2014/10/16	rogid:U/2EljQsTdy+9hVvzURz0CkburQ9606	rogid:lzmz15M3+odaIrWzlERDHUiG7mw9606	intact-crc:9D7BA2794549B4D7|rigid:LBWgAYOLbjoYF+SNJKt0YmOyCRU	false	flag tag:c-c	green fluorescent protein tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:1200"(immunocytochemistry)