#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H254	uniprotkb:Q16849	intact:EBI-308543|uniprotkb:Q9H1K7|uniprotkb:Q9H1K8|uniprotkb:Q9H1K9|uniprotkb:Q9H3G8|uniprotkb:Q9HCD0|uniprotkb:E9PGQ5|uniprotkb:Q9H253|ensembl:ENSP00000263373|ensembl:ENSP00000469242	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:sptn4_human(display_long)|uniprotkb:SPTBN4(gene name)|psi-mi:SPTBN4(display_short)|uniprotkb:KIAA1642(gene name synonym)|uniprotkb:SPTBN3(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 3(gene name synonym)|uniprotkb:Beta-IV spectrin(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Berghs et al. (2000)	pubmed:11086001|imex:IM-22147	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8773252|imex:IM-22147-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066022.2|refseq:NP_079489.2|ensembl:ENSP00000263373|ensembl:ENST00000392023|ensembl:ENSP00000375877|ensembl:ENSP00000469242|refseq:XP_016882538.1|ensembl:ENSG00000160460(gene)|ensembl:ENST00000352632(transcript)|ensembl:ENST00000598249(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008091"(spectrin)|go:"GO:0009566"(fertilization)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043203"(axon hillock)|go:"GO:0051693"(actin filament capping)|go:"GO:0061337"(cardiac conduction)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070852"(cell body fiber)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	figure legend:Fig 1F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2013/09/26	2014/10/16	rogid:E/nwpJwY5fu0lc0nCgwV14bgyrs9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:E2A69C0CCD11C882|rigid:uWi+9M7+vY9kAjR0HBCjjuYK+t8	false	sufficient binding region:2068-2559|ha tag:n-n	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q9H254	uniprotkb:Q92932	intact:EBI-308543|uniprotkb:Q9H1K7|uniprotkb:Q9H1K8|uniprotkb:Q9H1K9|uniprotkb:Q9H3G8|uniprotkb:Q9HCD0|uniprotkb:E9PGQ5|uniprotkb:Q9H253|ensembl:ENSP00000263373|ensembl:ENSP00000469242	intact:EBI-310576|uniprotkb:Q8N4I5|uniprotkb:Q92662|intact:EBI-947109|uniprotkb:Q9Y4F8|uniprotkb:E9PC57|uniprotkb:Q9Y4I6|ensembl:ENSP00000374069	psi-mi:sptn4_human(display_long)|uniprotkb:SPTBN4(gene name)|psi-mi:SPTBN4(display_short)|uniprotkb:KIAA1642(gene name synonym)|uniprotkb:SPTBN3(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 3(gene name synonym)|uniprotkb:Beta-IV spectrin(gene name synonym)	psi-mi:ptpr2_human(display_long)|uniprotkb:PTPRN2(gene name)|psi-mi:PTPRN2(display_short)|uniprotkb:KIAA0387(gene name synonym)|uniprotkb:Islet cell autoantigen-related protein(gene name synonym)|uniprotkb:Phogrin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Berghs et al. (2000)	pubmed:11086001|imex:IM-22147	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8773185|imex:IM-22147-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066022.2|refseq:NP_079489.2|ensembl:ENSP00000263373|ensembl:ENST00000392023|ensembl:ENSP00000375877|ensembl:ENSP00000469242|refseq:XP_016882538.1|ensembl:ENSG00000160460(gene)|ensembl:ENST00000352632(transcript)|ensembl:ENST00000598249(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008091"(spectrin)|go:"GO:0009566"(fertilization)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043203"(axon hillock)|go:"GO:0051693"(actin filament capping)|go:"GO:0061337"(cardiac conduction)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070852"(cell body fiber)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878	refseq:NP_002838.2|refseq:NP_570857.2|refseq:NP_570858.2|refseq:NP_001295196.1|refseq:NP_001295197.1|ensembl:ENSG00000155093(gene)|ensembl:ENST00000389418(transcript)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|rcsb pdb:2QEP|rcsb pdb:4HTI|rcsb pdb:4HTJ|reactome:R-HSA-6798695	-	-	-	figure legend:Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/09/26	2014/10/16	rogid:E/nwpJwY5fu0lc0nCgwV14bgyrs9606	rogid:afvWmPT2RuvhMQ0X8iCHpp/ouF09606	intact-crc:DBA66E598DF81E61|rigid:QJrwURhMKyz7nVIB10Lav/349rU	false	sufficient binding region:2068-2559	sufficient binding region:640-1015(IPR000242)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H254	uniprotkb:Q16849	intact:EBI-308543|uniprotkb:Q9H1K7|uniprotkb:Q9H1K8|uniprotkb:Q9H1K9|uniprotkb:Q9H3G8|uniprotkb:Q9HCD0|uniprotkb:E9PGQ5|uniprotkb:Q9H253|ensembl:ENSP00000263373|ensembl:ENSP00000469242	intact:EBI-728153|uniprotkb:Q08319|uniprotkb:Q53QD6|uniprotkb:Q6NSL1|uniprotkb:B4DK12|uniprotkb:F5GZS3|ensembl:ENSP00000295718	psi-mi:sptn4_human(display_long)|uniprotkb:SPTBN4(gene name)|psi-mi:SPTBN4(display_short)|uniprotkb:KIAA1642(gene name synonym)|uniprotkb:SPTBN3(gene name synonym)|uniprotkb:Spectrin, non-erythroid beta chain 3(gene name synonym)|uniprotkb:Beta-IV spectrin(gene name synonym)	psi-mi:ptprn_human(display_long)|uniprotkb:PTPRN(gene name)|psi-mi:PTPRN(display_short)|uniprotkb:ICA3(gene name synonym)|uniprotkb:ICA512(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym)|uniprotkb:Islet cell antigen 512(gene name synonym)|uniprotkb:Islet cell autoantigen 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Berghs et al. (2000)	pubmed:11086001|imex:IM-22147	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8773172|imex:IM-22147-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066022.2|refseq:NP_079489.2|ensembl:ENSP00000263373|ensembl:ENST00000392023|ensembl:ENSP00000375877|ensembl:ENSP00000469242|refseq:XP_016882538.1|ensembl:ENSG00000160460(gene)|ensembl:ENST00000352632(transcript)|ensembl:ENST00000598249(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008091"(spectrin)|go:"GO:0009566"(fertilization)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043203"(axon hillock)|go:"GO:0051693"(actin filament capping)|go:"GO:0061337"(cardiac conduction)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070852"(cell body fiber)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878	refseq:NP_002837.1|refseq:NP_001186692.1|refseq:NP_001186693.1|ensembl:ENSG00000054356(gene)|ensembl:ENST00000295718(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043627"(response to estrogen)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:0051591"(response to cAMP)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|mint:Q16849|rcsb pdb:2I1Y|rcsb pdb:2QT7|rcsb pdb:3N01|rcsb pdb:3N4W|rcsb pdb:3NG8|rcsb pdb:3NP5	-	-	-	figure legend:Fig 1B and 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/09/26	2014/10/16	rogid:E/nwpJwY5fu0lc0nCgwV14bgyrs9606	rogid:tcloEPzsWu3GJ03BlPeLfgZgAjA9606	intact-crc:E90EAAFDBC2A2E6B|rigid:uWi+9M7+vY9kAjR0HBCjjuYK+t8	false	sufficient binding region:2068-2559	sufficient binding region:601-979(IPR000242)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)