#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0ABJ1	uniprotkb:P0ABI8	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	intact:EBI-2932021|ensemblbacteria:AAC73534|ensemblbacteria:BAE76211|uniprotkb:P18401|uniprotkb:Q2MBZ5	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:cyob_ecoli(display_long)|uniprotkb:cyoB(gene name)|psi-mi:cyoB(display_short)|uniprotkb:Ubiquinol oxidase polypeptide I(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 1(gene name synonym)|uniprotkb:Ubiquinol oxidase chain A(gene name synonym)|uniprotkb:Cytochrome b562-o complex subunit I(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 1"(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 1(gene name synonym)|uniprotkb:JW0421(locus name)|uniprotkb:b0431(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8697873|imex:IM-21306-1|wwpdb:1fft	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	ensemblbacteria:AAC73534(transcript)|ensemblbacteria:b0431(gene)|ensemblbacteria:BAE76211(gene)|ensemblbacteria:BAE76211(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0020037"(heme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0070469"(respirasome)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR014207(Cytochrome o ubiquinol oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR036927|rcsb pdb:1FFT|refseq:WP_000467180.1|refseq:NP_414965.1|dip:DIP-47943N	-	-	-	figure legend:Fig.s 2, 3, Table 1.|3d-resolution:3.5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	rogid:6zVn1Fm1KcCP2ml3vnTQa38nTO083333	intact-crc:EA532DF97CA06E5D|rigid:GY2Iz9Tw25wUf9RoZAH1gJjg9fE	false	his tag:c-c	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ABJ1	uniprotkb:P0ABJ3	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	intact:EBI-8697823|uniprotkb:P18402|uniprotkb:Q2MBZ6|ensemblbacteria:AAC73533|ensemblbacteria:BAE76210	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:cyoc_ecoli(display_long)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 3(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 3"(gene name synonym)|uniprotkb:Ubiquinol oxidase polypeptide III(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 3(gene name synonym)|uniprotkb:JW0420(locus name)|uniprotkb:b0430(locus name)|uniprotkb:cyoC(gene name)|psi-mi:cyoC(display_short)|uniprotkb:Ubiquinol oxidase chain C(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8697873|imex:IM-21306-1|wwpdb:1fft	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	refseq:WP_000179819.1|dip:DIP-47944N|refseq:NP_414964.1|ensemblbacteria:AAC73533(transcript)|ensemblbacteria:b0430(gene)|ensemblbacteria:BAE76210(gene)|ensemblbacteria:BAE76210(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0019646"(aerobic electron transport chain)|interpro:IPR000298(Cytochrome c oxidase, subunit III)|interpro:IPR013833(Cytochrome c oxidase, subunit III, 4-helical bundle)|interpro:IPR014206(Cytochrome o ubiquinol oxidase, subunit III)|interpro:IPR024791|interpro:IPR033946|interpro:IPR035973|rcsb pdb:1FFT	-	-	-	figure legend:Fig.s 2, 3, Table 1.|3d-resolution:3.5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	rogid:XvksIQs+RyW8W95aMO0N2DgZeUI83333	intact-crc:EA532DF97CA06E5D|rigid:GY2Iz9Tw25wUf9RoZAH1gJjg9fE	false	his tag:c-c	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ABJ1	uniprotkb:P0ABJ6	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	intact:EBI-8697850|uniprotkb:P18403|uniprotkb:P77116|uniprotkb:Q2MBZ7|ensemblbacteria:AAC73532|ensemblbacteria:BAE76209	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:cyod_ecoli(display_long)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 4(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 4"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain D(gene name synonym)|uniprotkb:Ubiquinol oxidase polypeptide IV(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 4(gene name synonym)|uniprotkb:JW0419(locus name)|uniprotkb:b0429(locus name)|uniprotkb:cyoD(gene name)|psi-mi:cyoD(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8697873|imex:IM-21306-1|wwpdb:1fft	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	refseq:WP_000019869.1|dip:DIP-48238N|refseq:NP_414963.1|ensemblbacteria:AAC73532(transcript)|ensemblbacteria:b0429(gene)|ensemblbacteria:BAE76209(gene)|ensemblbacteria:BAE76209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0019646"(aerobic electron transport chain)|interpro:IPR005171(Cytochrome C oxidase subunit IV prokaryotic)|interpro:IPR014210(Cytochrome o ubiquinol oxidase subunit IV)|rcsb pdb:1FFT	-	-	-	figure legend:Fig.s 2, 3, Table 1.|3d-resolution:3.5 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/08/27	2014/10/16	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	rogid:04X4NdEUwLqGbSvRATmD2NMhlTM83333	intact-crc:EA532DF97CA06E5D|rigid:GY2Iz9Tw25wUf9RoZAH1gJjg9fE	false	his tag:c-c	-	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ABJ1	uniprotkb:P0ABI8	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	intact:EBI-2932021|ensemblbacteria:AAC73534|ensemblbacteria:BAE76211|uniprotkb:P18401|uniprotkb:Q2MBZ5	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:cyob_ecoli(display_long)|uniprotkb:cyoB(gene name)|psi-mi:cyoB(display_short)|uniprotkb:Ubiquinol oxidase polypeptide I(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 1(gene name synonym)|uniprotkb:Ubiquinol oxidase chain A(gene name synonym)|uniprotkb:Cytochrome b562-o complex subunit I(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 1"(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 1(gene name synonym)|uniprotkb:JW0421(locus name)|uniprotkb:b0431(locus name)	psi-mi:"MI:0979"(oxidoreductase assay)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8762421|imex:IM-21306-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	ensemblbacteria:AAC73534(transcript)|ensemblbacteria:b0431(gene)|ensemblbacteria:BAE76211(gene)|ensemblbacteria:BAE76211(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0020037"(heme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0070469"(respirasome)|interpro:IPR000883(Cytochrome c oxidase, subunit I)|interpro:IPR014207(Cytochrome o ubiquinol oxidase, subunit I)|interpro:IPR023615|interpro:IPR023616|interpro:IPR036927|rcsb pdb:1FFT|refseq:WP_000467180.1|refseq:NP_414965.1|dip:DIP-47943N	go:"GO:0008827"	-	-	figure legend:Fig. 8,  Table 2.|comment:"The reaction with the WT construct was measured in two buffers: Triton-X100 with a kM of 45 uM and DM with a kM of 18 uM."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:45.0x10^-6(mol)	2013/08/27	2014/10/16	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	rogid:6zVn1Fm1KcCP2ml3vnTQa38nTO083333	intact-crc:284A3563A0A5971C	false	his tag:?-?	mutation disrupting interaction rate:71-71|mutation disrupting interaction rate:71-71|mutation disrupting interaction rate:75-75|mutation disrupting interaction rate:98-98|his tag:?-?|mutation decreasing interaction rate:101-101	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ABJ1	uniprotkb:P0ABJ3	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	intact:EBI-8697823|uniprotkb:P18402|uniprotkb:Q2MBZ6|ensemblbacteria:AAC73533|ensemblbacteria:BAE76210	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:cyoc_ecoli(display_long)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 3(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 3"(gene name synonym)|uniprotkb:Ubiquinol oxidase polypeptide III(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 3(gene name synonym)|uniprotkb:JW0420(locus name)|uniprotkb:b0430(locus name)|uniprotkb:cyoC(gene name)|psi-mi:cyoC(display_short)|uniprotkb:Ubiquinol oxidase chain C(gene name synonym)	psi-mi:"MI:0979"(oxidoreductase assay)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8762421|imex:IM-21306-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	refseq:WP_000179819.1|dip:DIP-47944N|refseq:NP_414964.1|ensemblbacteria:AAC73533(transcript)|ensemblbacteria:b0430(gene)|ensemblbacteria:BAE76210(gene)|ensemblbacteria:BAE76210(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0019646"(aerobic electron transport chain)|interpro:IPR000298(Cytochrome c oxidase, subunit III)|interpro:IPR013833(Cytochrome c oxidase, subunit III, 4-helical bundle)|interpro:IPR014206(Cytochrome o ubiquinol oxidase, subunit III)|interpro:IPR024791|interpro:IPR033946|interpro:IPR035973|rcsb pdb:1FFT	go:"GO:0008827"	-	-	figure legend:Fig. 8,  Table 2.|comment:"The reaction with the WT construct was measured in two buffers: Triton-X100 with a kM of 45 uM and DM with a kM of 18 uM."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:45.0x10^-6(mol)	2013/08/27	2014/10/16	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	rogid:XvksIQs+RyW8W95aMO0N2DgZeUI83333	intact-crc:284A3563A0A5971C	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0ABJ1	uniprotkb:P0ABJ6	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	intact:EBI-8697850|uniprotkb:P18403|uniprotkb:P77116|uniprotkb:Q2MBZ7|ensemblbacteria:AAC73532|ensemblbacteria:BAE76209	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:cyod_ecoli(display_long)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 4(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 4"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain D(gene name synonym)|uniprotkb:Ubiquinol oxidase polypeptide IV(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 4(gene name synonym)|uniprotkb:JW0419(locus name)|uniprotkb:b0429(locus name)|uniprotkb:cyoD(gene name)|psi-mi:cyoD(display_short)	psi-mi:"MI:0979"(oxidoreductase assay)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8762421|imex:IM-21306-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	refseq:WP_000019869.1|dip:DIP-48238N|refseq:NP_414963.1|ensemblbacteria:AAC73532(transcript)|ensemblbacteria:b0429(gene)|ensemblbacteria:BAE76209(gene)|ensemblbacteria:BAE76209(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0019646"(aerobic electron transport chain)|interpro:IPR005171(Cytochrome C oxidase subunit IV prokaryotic)|interpro:IPR014210(Cytochrome o ubiquinol oxidase subunit IV)|rcsb pdb:1FFT	go:"GO:0008827"	-	-	figure legend:Fig. 8,  Table 2.|comment:"The reaction with the WT construct was measured in two buffers: Triton-X100 with a kM of 45 uM and DM with a kM of 18 uM."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:45.0x10^-6(mol)	2013/08/27	2014/10/16	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	rogid:04X4NdEUwLqGbSvRATmD2NMhlTM83333	intact-crc:284A3563A0A5971C	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:26355"	uniprotkb:P0ABJ1	intact:EBI-1225103	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	psi-mi:heme b(display_short)|psi-mi:"CHEBI:26355"(display_long)	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:"MI:0979"(oxidoreductase assay)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8762421|imex:IM-21306-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	go:"GO:0008827"	-	-	figure legend:Fig. 8,  Table 2.|comment:"The reaction with the WT construct was measured in two buffers: Triton-X100 with a kM of 45 uM and DM with a kM of 18 uM."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:45.0x10^-6(mol)	2013/08/27	2014/10/16	-	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	intact-crc:284A3563A0A5971C	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:17976"	uniprotkb:P0ABJ1	intact:EBI-8697933|chebi:"CHEBI:9851"|chebi:"CHEBI:15278"|chebi:"CHEBI:27182"	intact:EBI-1116940|uniprotkb:P18400|uniprotkb:Q2MBZ4|ensemblbacteria:AAC73535|ensemblbacteria:BAE76212	psi-mi:ubiquinol(display_short)|psi-mi:"CHEBI:17976"(display_long)|intact:a ubiquinol(synonym)|intact:coenzymes QH2(synonym)|intact:CoQH2(synonym)|intact:"QH(2)"(synonym)|intact:QH2(synonym)|intact:reduced ubiquinone(synonym)|intact:Ubiquinol(synonym)|intact:ubiquinols(synonym)	psi-mi:cyoa_ecoli(display_long)|uniprotkb:Ubiquinol oxidase polypeptide II(gene name synonym)|uniprotkb:Cytochrome o ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:cyoA(gene name)|psi-mi:cyoA(display_short)|uniprotkb:Cytochrome b562-o complex subunit II(gene name synonym)|uniprotkb:"Oxidase bo(3) subunit 2"(gene name synonym)|uniprotkb:Ubiquinol oxidase chain B(gene name synonym)|uniprotkb:Ubiquinol oxidase subunit 2(gene name synonym)|uniprotkb:JW0422(locus name)|uniprotkb:b0432(locus name)	psi-mi:"MI:0979"(oxidoreductase assay)	Abramson et al. (2000)	imex:IM-21306|pubmed:11017202	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0945"(oxidoreductase activity electron transfer reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-8762421|imex:IM-21306-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:WP_001239436.1|refseq:NP_414966.1|ensemblbacteria:AAC73535(transcript)|ensemblbacteria:b0432(gene)|ensemblbacteria:BAE76212(gene)|go:"GO:0005507"(copper ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009319"(cytochrome o ubiquinol oxidase complex)|go:"GO:0009486"(cytochrome bo3 ubiquinol oxidase activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015453"(oxidoreduction-driven active transmembrane transporter activity)|go:"GO:0015990"(electron transport coupled proton transport)|go:"GO:0016682"(oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor)|go:"GO:0019646"(aerobic electron transport chain)|go:"GO:0042773"(ATP synthesis coupled electron transport)|go:"GO:0070469"(respirasome)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR002429(Cytochrome c oxidase subunit II C-terminal)|interpro:IPR006333(Cytochrome o ubiquinol oxidase subunit II)|interpro:IPR008972(Cupredoxin)|ensemblbacteria:BAE76212(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|interpro:IPR010514(COX aromatic rich)|interpro:IPR011759(Cytochrome C oxidase subunit II, transmembrane region)|interpro:IPR034227|interpro:IPR036257|rcsb pdb:1CYW|rcsb pdb:1CYX|rcsb pdb:1FFT|dip:DIP-47942N	go:"GO:0008827"	inchi key:TVLSKGDBUQMDPR-UHFFFAOYSA-N	-	figure legend:Fig. 8,  Table 2.|comment:"The reaction with the WT construct was measured in two buffers: Triton-X100 with a kM of 45 uM and DM with a kM of 18 uM."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	km:45.0x10^-6(mol)	2013/08/27	2014/10/16	-	rogid:cyUyCtdDQGcnRDwh735lzVLFHno83333	intact-crc:284A3563A0A5971C	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)