#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26231	uniprotkb:O35889	intact:EBI-647895|ensembl:ENSMUSP00000049007	intact:EBI-6654073|uniprotkb:O35890	psi-mi:ctna1_mouse(display_long)|uniprotkb:102 kDa cadherin-associated protein(gene name synonym)|uniprotkb:CAP102(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Ctnna1(gene name)|psi-mi:Ctnna1(display_short)|uniprotkb:Catna1(gene name synonym)	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tachibana et al. (2000)	pubmed:10974003|imex:IM-21681	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-8843757|imex:IM-21681-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033948.1|refseq:XP_011245120.1|dip:DIP-35299N|ensembl:ENSMUSG00000037815(gene)|ensembl:ENSMUST00000042345(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P26231|rcsb pdb:1DOV|rcsb pdb:1DOW|rcsb pdb:1L7C|rcsb pdb:4E17|rcsb pdb:4E18|rcsb pdb:4K1N|rcsb pdb:5Y04|rcsb pdb:6DV1|rcsb pdb:6O3E|rcsb pdb:6WVT|reactome:R-MMU-418990|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	-	-	-	figure legend:Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/11/06	2014/10/16	rogid:2GScCoVKWPHfjBJE6Gm6yVmO/IA10090	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	intact-crc:1369BAEE636AB184|rigid:x1qHK3c0UvxxKW4pCPIAVVWC01c	false	necessary binding region:509-906|ha tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32507-2	uniprotkb:O35889	intact:EBI-8844104|ensembl:ENSMUSP00000104089	intact:EBI-6654073|uniprotkb:O35890	psi-mi:p32507-2(display_long)|uniprotkb:Nectin2(gene name)|psi-mi:Nectin2(display_short)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Mph(gene name synonym)|uniprotkb:Murine herpes virus entry protein B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:Poliovirus receptor homolog(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym)|uniprotkb:Pvr(gene name synonym)|uniprotkb:Pvrl2(gene name synonym)|uniprotkb:Pvs(gene name synonym)	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tachibana et al. (2000)	pubmed:10974003|imex:IM-21681	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-8843767|imex:IM-21681-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-8758399(isoform-parent)|ensembl:ENSMUSG00000062300(gene)|ensembl:ENSMUST00000108450(transcript)	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	-	-	-	figure legend:Table 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2013/11/06	2014/10/16	rogid:fCuDZiVCuP5zAS8IxPjZBMERkYs10090	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	intact-crc:E70D26D2D4D6A931|rigid:vueL1Sjuj+gTXBa0WseGcClXCE8	false	ha tag:n-n|sufficient binding region:387-467	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26231	uniprotkb:O35889	intact:EBI-647895|ensembl:ENSMUSP00000049007	intact:EBI-6654073|uniprotkb:O35890	psi-mi:ctna1_mouse(display_long)|uniprotkb:102 kDa cadherin-associated protein(gene name synonym)|uniprotkb:CAP102(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Ctnna1(gene name)|psi-mi:Ctnna1(display_short)|uniprotkb:Catna1(gene name synonym)	psi-mi:afad_rat(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Tachibana et al. (2000)	pubmed:10974003|imex:IM-21681	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-8843948|imex:IM-21681-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033948.1|refseq:XP_011245120.1|dip:DIP-35299N|ensembl:ENSMUSG00000037815(gene)|ensembl:ENSMUST00000042345(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P26231|rcsb pdb:1DOV|rcsb pdb:1DOW|rcsb pdb:1L7C|rcsb pdb:4E17|rcsb pdb:4E18|rcsb pdb:4K1N|rcsb pdb:5Y04|rcsb pdb:6DV1|rcsb pdb:6O3E|rcsb pdb:6WVT|reactome:R-MMU-418990|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467	go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007165"(signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0043296"(apical junction complex)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|go:"GO:0070160"(tight junction)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140059"(dendrite arborization)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR037977|refseq:NP_037349.1|interpro:IPR002710(Dilute)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000159(Ras-association)|interpro:IPR008984(SMAD/FHA domain)|rgd:708561|interpro:IPR029071|interpro:IPR036034|reactome:R-RNO-418990	-	-	-	figure legend:Fig 6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/11/06	2014/10/16	rogid:2GScCoVKWPHfjBJE6Gm6yVmO/IA10090	rogid:67y2afwVZA7bevsJsuxILrTbjic10116	intact-crc:10840C66F92F7010|rigid:x1qHK3c0UvxxKW4pCPIAVVWC01c	false	glutathione s tranferase tag:n-n|necessary binding region:509-906	myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P32507	uniprotkb:Q9QZQ1-2	intact:EBI-8758399|uniprotkb:Q62096|ensembl:ENSMUSP00000074898	intact:EBI-8844150|ensembl:ENSMUSP00000122447	psi-mi:nect2_mouse(display_long)|uniprotkb:Nectin2(gene name)|psi-mi:Nectin2(display_short)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Mph(gene name synonym)|uniprotkb:Murine herpes virus entry protein B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:Poliovirus receptor homolog(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym)|uniprotkb:Pvr(gene name synonym)|uniprotkb:Pvrl2(gene name synonym)|uniprotkb:Pvs(gene name synonym)	psi-mi:q9qzq1-2(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)|uniprotkb:l-afadin(isoform synonym)	psi-mi:"MI:0663"(confocal microscopy)	Tachibana et al. (2000)	pubmed:10974003|imex:IM-21681	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-8844148|imex:IM-21681-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153196.1|refseq:NP_033016.3|ensembl:ENSMUSG00000062300(gene)|ensembl:ENSMUST00000075447(transcript)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:4FMK|rcsb pdb:4FN0|go:"GO:0009986"(cell surface)|rcsb pdb:4FS0|reactome:R-MMU-198933|reactome:R-MMU-418990|reactome:R-MMU-420597|dip:DIP-59964N	ensembl:ENSMUSG00000068036(gene)|ensembl:ENSMUST00000150848(transcript)|intact:EBI-6673595(isoform-parent)	go:"GO:0016337"	-	-	figure legend:Fig 2A.|comment:"Nectin-2 and l-Afadin colocalized at cell-cell adhesion sites only in cells transfected with alpha-catenin and not in untransfected cells (Fig 2A, 2B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-f9)|taxid:10090(Mus musculus)	-	2013/11/06	2014/10/16	rogid:RmZUQkH0KDDR4AUQy2np1pXtIl810090	rogid:3MY6xEX3bYTPTFllHdmCveVxbBo10090	intact-crc:8C4ABD6309203390|rigid:5+D0UHYh1O78uNrLdNAjxyFW2Sk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P32507	uniprotkb:Q9QZQ1-2	intact:EBI-8758399|uniprotkb:Q62096|ensembl:ENSMUSP00000074898	intact:EBI-8844150|ensembl:ENSMUSP00000122447	psi-mi:nect2_mouse(display_long)|uniprotkb:Nectin2(gene name)|psi-mi:Nectin2(display_short)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Mph(gene name synonym)|uniprotkb:Murine herpes virus entry protein B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:Poliovirus receptor homolog(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym)|uniprotkb:Pvr(gene name synonym)|uniprotkb:Pvrl2(gene name synonym)|uniprotkb:Pvs(gene name synonym)	psi-mi:q9qzq1-2(display_long)|uniprotkb:Afdn(gene name)|psi-mi:Afdn(display_short)|uniprotkb:Af6(gene name synonym)|uniprotkb:Afadin adherens junction formation factor(gene name synonym)|uniprotkb:Mllt4(gene name synonym)|uniprotkb:Protein Af-6(gene name synonym)|uniprotkb:l-afadin(isoform synonym)	psi-mi:"MI:0663"(confocal microscopy)	Tachibana et al. (2000)	pubmed:10974003|imex:IM-21681	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-8844210|imex:IM-21681-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153196.1|refseq:NP_033016.3|ensembl:ENSMUSG00000062300(gene)|ensembl:ENSMUST00000075447(transcript)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:4FMK|rcsb pdb:4FN0|go:"GO:0009986"(cell surface)|rcsb pdb:4FS0|reactome:R-MMU-198933|reactome:R-MMU-418990|reactome:R-MMU-420597|dip:DIP-59964N	ensembl:ENSMUSG00000068036(gene)|ensembl:ENSMUST00000150848(transcript)|intact:EBI-6673595(isoform-parent)	go:"GO:0016337"	-	-	figure legend:Fig 3A, 5A, 7.|comment:"Nectin-2 colocalized with l-Afadin at cell-cell adhesion sites even in the absence of beta-catenin. ie., in cells transfected with a chimeric protein, where an E-cadherin lacking the beta-catenin binding domain is fused to full length alpha-catenin (Fig 3A). Nectin-2 colocalized with l-Afadin at cell-cell adhesion sites even in the absence of vinculin and ponsin, ie., in cells transfected with a chimeric protein, where E-cadherin is fused to the C-terminal region of alpha-catenin, which lacks binding to vinculin and ponsin (Fig 5A). l-Afadin colocalized with Nectin-2 at cell-cell adhesion sites in cells transfected with full length Nectin-2alpha, but not in cells transfected with mutant Nectin-2alpha with the last the last 4 carboxyl terminus residues deleted (Fig 7)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-l cells)|taxid:10090(Mus musculus embryo fibroblast, Moloney Sarcoma Virus transformed)	-	2013/11/06	2014/10/16	rogid:RmZUQkH0KDDR4AUQy2np1pXtIl810090	rogid:3MY6xEX3bYTPTFllHdmCveVxbBo10090	intact-crc:14AC25BAAC058E11|rigid:5+D0UHYh1O78uNrLdNAjxyFW2Sk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)