#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03004	uniprotkb:P0ACB0	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	intact:EBI-548978|uniprotkb:P03005|uniprotkb:Q2M6Q2|ensemblbacteria:AAC77022|ensemblbacteria:BAE78054	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:dnab_ecoli(display_long)|uniprotkb:dnaB(gene name)|psi-mi:dnaB(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpA(gene name synonym)|uniprotkb:b4052(locus name)|uniprotkb:JW4012(locus name)	psi-mi:"MI:0892"(solid phase assay)	Seitz et al. (2000)	imex:IM-18650|pubmed:10972842	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6508350|imex:IM-18650-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	refseq:NP_418476.1|refseq:WP_000918363.1|dip:DIP-9456N|ensemblbacteria:AAC77022(transcript)|ensemblbacteria:b4052(gene)|ensemblbacteria:BAE78054(gene)|ensemblbacteria:BAE78054(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990077"(primosome complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007692(DNA helicase, DnaB type)|interpro:IPR007693(DNA helicase, DnaB-like, N-terminal)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR016136(DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal)|interpro:IPR027417|interpro:IPR036185|rcsb pdb:1B79|rcsb pdb:1JWE|rcsb pdb:6BBM|rcsb pdb:6KZA|rcsb pdb:6QEL|rcsb pdb:6QEM	go:"GO:0006268"(DNA unwinding involved in DNA replication)	-	-	figure legend:Tab. 1b, Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/05	2014/10/16	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	rogid:czmOnQQpFov7eFmCjLGjNhkbJ7M83333	intact-crc:803038363C77764C|rigid:88GY8TWoUPd+8GcT1ZoqnFfD8RA	false	necessary binding region:24-56|biotin tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03004	uniprotkb:P0ACB0	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	intact:EBI-548978|uniprotkb:P03005|uniprotkb:Q2M6Q2|ensemblbacteria:AAC77022|ensemblbacteria:BAE78054	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:dnab_ecoli(display_long)|uniprotkb:dnaB(gene name)|psi-mi:dnaB(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpA(gene name synonym)|uniprotkb:b4052(locus name)|uniprotkb:JW4012(locus name)	psi-mi:"MI:0892"(solid phase assay)	Seitz et al. (2000)	imex:IM-18650|pubmed:10972842	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6508320|imex:IM-18650-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	refseq:NP_418476.1|refseq:WP_000918363.1|dip:DIP-9456N|ensemblbacteria:AAC77022(transcript)|ensemblbacteria:b4052(gene)|ensemblbacteria:BAE78054(gene)|ensemblbacteria:BAE78054(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990077"(primosome complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007692(DNA helicase, DnaB type)|interpro:IPR007693(DNA helicase, DnaB-like, N-terminal)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR016136(DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal)|interpro:IPR027417|interpro:IPR036185|rcsb pdb:1B79|rcsb pdb:1JWE|rcsb pdb:6BBM|rcsb pdb:6KZA|rcsb pdb:6QEL|rcsb pdb:6QEM	go:"GO:0006268"(DNA unwinding involved in DNA replication)	-	-	figure legend:Tab. 1a|comment:"Full length DnaB does not interact with N-terminal DnaA 1-87 but does interact with DnaA missing aa135-148 (EBI-6508243)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/05	2018/05/08	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	rogid:czmOnQQpFov7eFmCjLGjNhkbJ7M83333	intact-crc:C10568644CAE70B0|rigid:88GY8TWoUPd+8GcT1ZoqnFfD8RA	false	necessary binding region:135-148	biotin tag:c-c|sufficient binding region:1-156	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03004	uniprotkb:P0ACB0	intact:EBI-548951|uniprotkb:P78122|uniprotkb:Q2M814|ensemblbacteria:AAC76725|ensemblbacteria:BAE77592	intact:EBI-548978|uniprotkb:P03005|uniprotkb:Q2M6Q2|ensemblbacteria:AAC77022|ensemblbacteria:BAE78054	psi-mi:dnaa_ecoli(display_long)|uniprotkb:dnaA(gene name)|psi-mi:dnaA(display_short)|uniprotkb:b3702(locus name)|uniprotkb:JW3679(locus name)	psi-mi:dnab_ecoli(display_long)|uniprotkb:dnaB(gene name)|psi-mi:dnaB(display_short)|uniprotkb:groP(gene name synonym)|uniprotkb:grpA(gene name synonym)|uniprotkb:b4052(locus name)|uniprotkb:JW4012(locus name)	psi-mi:"MI:0892"(solid phase assay)	Seitz et al. (2000)	imex:IM-18650|pubmed:10972842	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6508243|imex:IM-18650-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_418157.1|refseq:WP_000059111.1|dip:DIP-9455N|ensemblbacteria:AAC76725(transcript)|ensemblbacteria:b3702(gene)|ensemblbacteria:BAE77592(gene)|ensemblbacteria:BAE77592(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010921(Trp repressor/replication initiator)|interpro:IPR013159(Chromosomal replication initiator, DnaA C-terminal)|interpro:IPR013317(Chromosomal replication initiator, DnaA)|interpro:IPR018312|interpro:IPR020591|interpro:IPR024633|interpro:IPR027417|interpro:IPR038454|rcsb pdb:1J1V|rcsb pdb:2E0G|interpro:IPR001957(Bacterial chromosomal replication initiator protein, DnaA)	refseq:NP_418476.1|refseq:WP_000918363.1|dip:DIP-9456N|ensemblbacteria:AAC77022(transcript)|ensemblbacteria:b4052(gene)|ensemblbacteria:BAE78054(gene)|ensemblbacteria:BAE78054(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990077"(primosome complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007692(DNA helicase, DnaB type)|interpro:IPR007693(DNA helicase, DnaB-like, N-terminal)|interpro:IPR007694(DNA helicase, DnaB-like, C-terminal)|interpro:IPR016136(DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal)|interpro:IPR027417|interpro:IPR036185|rcsb pdb:1B79|rcsb pdb:1JWE|rcsb pdb:6BBM|rcsb pdb:6KZA|rcsb pdb:6QEL|rcsb pdb:6QEM	go:"GO:0006268"(DNA unwinding involved in DNA replication)	-	-	figure legend:Tab. 1a|comment:"N-terminal region of DnaB (1-156aa) does interact with N-terminal region of DnaA (1-86aa) but not with deletion mutant DnaA missing aa135-148 (EBI-6508320)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/02/05	2014/10/16	rogid:p07cXpfl7bzSh/kImTD/+Zr0Ma883333	rogid:czmOnQQpFov7eFmCjLGjNhkbJ7M83333	intact-crc:CBAA313BE1BA6BF1|rigid:88GY8TWoUPd+8GcT1ZoqnFfD8RA	false	necessary binding region:1-86	biotin tag:n-n|sufficient binding region:154-206	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)