#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17612	uniprotkb:Q92736	intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940	intact:EBI-1170425|uniprotkb:Q15411|uniprotkb:Q546N8|uniprotkb:Q5T3P2|ensembl:ENSP00000355533	psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym)	psi-mi:ryr2_human(display_long)|uniprotkb:RYR2(gene name)|psi-mi:RYR2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Marx et al. (2000)	pubmed:10830164|imex:IM-22137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8753282|imex:IM-22137-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N	refseq:NP_001026.2|refseq:XP_006711868.1|ensembl:ENSG00000198626(gene)|ensembl:ENST00000366574(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043924"(suramin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:4JKQ|rcsb pdb:6Y4O|rcsb pdb:6Y4P|rcsb pdb:7KL5|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-38325N	-	-	-	figure legend:Fig 2A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heart)|taxid:9606(Homo sapiens)	-	2013/09/02	2014/10/16	rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606	rogid:Z3eTbcvvaCLOKWelrdkxMso6IT89606	intact-crc:21C231D52220CB11|rigid:GEeLcZFHiEjDMMNqrHBcU0KEoLw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92736	uniprotkb:P68106	intact:EBI-1170425|uniprotkb:Q15411|uniprotkb:Q546N8|uniprotkb:Q5T3P2|ensembl:ENSP00000355533	intact:EBI-6693977|uniprotkb:Q13664|uniprotkb:Q16645|uniprotkb:Q53TM2|uniprotkb:Q9BQ40|ensembl:ENSP00000370373	psi-mi:ryr2_human(display_long)|uniprotkb:RYR2(gene name)|psi-mi:RYR2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:fkb1b_human(display_long)|uniprotkb:FKBP1B(gene name)|psi-mi:FKBP1B(display_short)|uniprotkb:FKBP12.6(gene name synonym)|uniprotkb:FKBP1L(gene name synonym)|uniprotkb:FKBP9(gene name synonym)|uniprotkb:OTK4(gene name synonym)|uniprotkb:12.6 kDa FK506-binding protein(gene name synonym)|uniprotkb:FK506-binding protein 1B(gene name synonym)|uniprotkb:Immunophilin FKBP12.6(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:h-FKBP-12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Marx et al. (2000)	pubmed:10830164|imex:IM-22137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8758150|imex:IM-22137-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026.2|refseq:XP_006711868.1|ensembl:ENSG00000198626(gene)|ensembl:ENST00000366574(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043924"(suramin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:4JKQ|rcsb pdb:6Y4O|rcsb pdb:6Y4P|rcsb pdb:7KL5|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-38325N	refseq:NP_004107.1|refseq:NP_473374.1|ensembl:ENSG00000119782(gene)|ensembl:ENST00000380986(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0009749"(response to glucose)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042026"(protein refolding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1C9H|rcsb pdb:4C02|rcsb pdb:4IQ2|rcsb pdb:4IQC|rcsb pdb:5HKG|rcsb pdb:5L1D|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6JGZ|rcsb pdb:6JH6|rcsb pdb:6JHN|rcsb pdb:6JI0|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRR|rcsb pdb:6JRS|rcsb pdb:6M2W|rcsb pdb:6W1N|rcsb pdb:6WOT|rcsb pdb:6WOU|rcsb pdb:6WOV|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X34|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:7CF9|rcsb pdb:7JMF|rcsb pdb:7JMG|rcsb pdb:6PV6|rcsb pdb:7JMH|rcsb pdb:7JMI|rcsb pdb:7JMJ|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-48796N	-	-	-	figure legend:Fig 4A and 4B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heart)|taxid:9606(Homo sapiens)	-	2013/09/02	2014/10/16	rogid:Z3eTbcvvaCLOKWelrdkxMso6IT89606	rogid:n8ztvcTI/NJmcWSVyVusxO2BEXY9606	intact-crc:E206C22728CC362A|rigid:rK9qDqDeym6rdWxEtiL/RoIyams	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q92736	uniprotkb:P68106	intact:EBI-1170425|uniprotkb:Q15411|uniprotkb:Q546N8|uniprotkb:Q5T3P2|ensembl:ENSP00000355533	intact:EBI-6693977|uniprotkb:Q13664|uniprotkb:Q16645|uniprotkb:Q53TM2|uniprotkb:Q9BQ40|ensembl:ENSP00000370373	psi-mi:ryr2_human(display_long)|uniprotkb:RYR2(gene name)|psi-mi:RYR2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:fkb1b_human(display_long)|uniprotkb:FKBP1B(gene name)|psi-mi:FKBP1B(display_short)|uniprotkb:FKBP12.6(gene name synonym)|uniprotkb:FKBP1L(gene name synonym)|uniprotkb:FKBP9(gene name synonym)|uniprotkb:OTK4(gene name synonym)|uniprotkb:12.6 kDa FK506-binding protein(gene name synonym)|uniprotkb:FK506-binding protein 1B(gene name synonym)|uniprotkb:Immunophilin FKBP12.6(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:h-FKBP-12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Marx et al. (2000)	pubmed:10830164|imex:IM-22137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8753396|imex:IM-22137-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026.2|refseq:XP_006711868.1|ensembl:ENSG00000198626(gene)|ensembl:ENST00000366574(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043924"(suramin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:4JKQ|rcsb pdb:6Y4O|rcsb pdb:6Y4P|rcsb pdb:7KL5|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-38325N	refseq:NP_004107.1|refseq:NP_473374.1|ensembl:ENSG00000119782(gene)|ensembl:ENST00000380986(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0009749"(response to glucose)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030073"(insulin secretion)|go:"GO:0030551"(cyclic nucleotide binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042026"(protein refolding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|rcsb pdb:1C9H|rcsb pdb:4C02|rcsb pdb:4IQ2|rcsb pdb:4IQC|rcsb pdb:5HKG|rcsb pdb:5L1D|rcsb pdb:5T15|rcsb pdb:5T9M|rcsb pdb:5T9N|rcsb pdb:5T9R|rcsb pdb:5T9S|rcsb pdb:5T9V|rcsb pdb:5TA3|rcsb pdb:5TAL|rcsb pdb:5TAM|rcsb pdb:5TAN|rcsb pdb:5TAP|rcsb pdb:5TAQ|rcsb pdb:5TAS|rcsb pdb:5TAT|rcsb pdb:5TAU|rcsb pdb:5TAV|rcsb pdb:5TAW|rcsb pdb:5TAX|rcsb pdb:5TAY|rcsb pdb:5TAZ|rcsb pdb:5TB0|rcsb pdb:5TB1|rcsb pdb:5TB2|rcsb pdb:5TB3|rcsb pdb:5TB4|rcsb pdb:6JGZ|rcsb pdb:6JH6|rcsb pdb:6JHN|rcsb pdb:6JI0|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRR|rcsb pdb:6JRS|rcsb pdb:6M2W|rcsb pdb:6W1N|rcsb pdb:6WOT|rcsb pdb:6WOU|rcsb pdb:6WOV|rcsb pdb:6X32|rcsb pdb:6X33|rcsb pdb:6X34|rcsb pdb:6X35|rcsb pdb:6X36|rcsb pdb:7CF9|rcsb pdb:7JMF|rcsb pdb:7JMG|rcsb pdb:6PV6|rcsb pdb:7JMH|rcsb pdb:7JMI|rcsb pdb:7JMJ|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-48796N	-	-	-	figure legend:Fig 3A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2013/09/02	2014/10/16	rogid:Z3eTbcvvaCLOKWelrdkxMso6IT89606	rogid:n8ztvcTI/NJmcWSVyVusxO2BEXY9606	intact-crc:A905ACCF5521BF4D|rigid:rK9qDqDeym6rdWxEtiL/RoIyams	false	sufficient binding region:2361-2496	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92736	uniprotkb:Q13023	intact:EBI-1170425|uniprotkb:Q15411|uniprotkb:Q546N8|uniprotkb:Q5T3P2|ensembl:ENSP00000355533	intact:EBI-1056102|uniprotkb:O15028|uniprotkb:A7E2D4|uniprotkb:A7E242|ensembl:ENSP00000280979	psi-mi:ryr2_human(display_long)|uniprotkb:RYR2(gene name)|psi-mi:RYR2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:akap6_human(display_long)|uniprotkb:KIAA0311(gene name synonym)|uniprotkb:AKAP6(gene name)|psi-mi:AKAP6(display_short)|uniprotkb:AKAP100(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 6(gene name synonym)|uniprotkb:A-kinase anchor protein 100 kDa(gene name synonym)|uniprotkb:mAKAP(gene name synonym)	psi-mi:"MI:0426"(light microscopy)	Marx et al. (2000)	pubmed:10830164|imex:IM-22137	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8758107|imex:IM-22137-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026.2|refseq:XP_006711868.1|ensembl:ENSG00000198626(gene)|ensembl:ENST00000366574(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043924"(suramin binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|rcsb pdb:4JKQ|rcsb pdb:6Y4O|rcsb pdb:6Y4P|rcsb pdb:7KL5|reactome:R-HSA-2672351|reactome:R-HSA-5578775|dip:DIP-38325N	refseq:NP_004265.3|ensembl:ENSG00000151320(gene)|ensembl:ENST00000280979(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|go:"GO:0006605"(protein targeting)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|interpro:IPR018159|mint:Q13023	go:"GO:0016529"(sarcoplasmic reticulum)	-	-	figure legend:Fig 3C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-heart)|taxid:9606(Homo sapiens)	-	2013/09/02	2014/10/16	rogid:Z3eTbcvvaCLOKWelrdkxMso6IT89606	rogid:N0OdGKZGo4mR8XfkEGELhmoAGlA9606	intact-crc:F1E8CB0ACC245EA4|rigid:u5oTdvZyEDjyHRoY49qeX5dYC5A	false	-	-	-	-	psi-mi:"MI:1198"(immunohistochemistry)	psi-mi:"MI:1198"(immunohistochemistry)|psi-mi:"MI:0709"(polyclonal antibody immunostaining)