#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O55222	uniprotkb:P48059	intact:EBI-6690138|uniprotkb:Q78KK2|ensembl:ENSMUSP00000033182|ensembl:ENSMUSP00000130341	intact:EBI-306928|uniprotkb:Q53TE0|ensembl:ENSP00000331775|ensembl:ENSP00000376987|uniprotkb:Q9BS44|uniprotkb:B2RAJ4|uniprotkb:B7Z483|uniprotkb:B7Z7R3|uniprotkb:B7Z907	psi-mi:ilk_mouse(display_long)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:Ilk(gene name)|psi-mi:Ilk(display_short)	psi-mi:lims1_human(display_long)|uniprotkb:LIMS1(gene name)|psi-mi:LIMS1(display_short)|uniprotkb:Particularly interesting new Cys-His protein 1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-48(gene name synonym)|uniprotkb:PINCH(gene name synonym)|uniprotkb:PINCH1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (1999)	imex:IM-20835|pubmed:10574708	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6690778|imex:IM-20835-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155196.1|refseq:NP_034692.2|ensembl:ENSMUSG00000030890(gene)|ensembl:ENSMUST00000033182(transcript)|ensembl:ENSMUST00000163389(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043034"(costamere)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:O55222|reactome:R-MMU-446343|reactome:R-MMU-446353|dip:DIP-41971N	ensembl:ENSG00000169756(gene)|ensembl:ENST00000332345(transcript)|ensembl:ENST00000393310(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017351(PINCH)|mint:P48059|rcsb pdb:1G47|rcsb pdb:1NYP|rcsb pdb:1U5S|rcsb pdb:2COR|rcsb pdb:2D8X|rcsb pdb:2KBX|rcsb pdb:3F6Q|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIF|rcsb pdb:7D2S|rcsb pdb:7D2T|rcsb pdb:7D2U|rcsb pdb:7LT9|reactome:R-HSA-446353|reactome:R-HSA-446388|refseq:NP_001180417.1|refseq:NP_004978.2|refseq:NP_001180411.1|refseq:NP_001180413.1|refseq:NP_001180414.1|refseq:NP_001180412.1|dip:DIP-40671N	-	-	-	figure legend:Fig 5.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/23	2014/10/16	rogid:9kMagkwUrtq1XaI+9PXPJ21hHY810090	rogid:LzyCXdAH+qg5n0paw0Stf7+CK2w9606	intact-crc:731B683CA9004F60|rigid:C38MobBynKXb5JHTMRGxZlw5KWE	false	sufficient binding region:1-189|glutathione s tranferase tag:n-n	his tag:n-n|necessary binding region:11-38	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:O43639	uniprotkb:P48059	intact:EBI-713635|uniprotkb:Q9BWN9|uniprotkb:Q9UIC3|ensembl:ENSP00000233154|ensembl:ENSP00000377018|uniprotkb:D3DVK1	intact:EBI-306928|uniprotkb:Q53TE0|ensembl:ENSP00000331775|ensembl:ENSP00000376987|uniprotkb:Q9BS44|uniprotkb:B2RAJ4|uniprotkb:B7Z483|uniprotkb:B7Z7R3|uniprotkb:B7Z907	psi-mi:nck2_human(display_long)|uniprotkb:NCK adaptor protein 2(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-beta(gene name synonym)|uniprotkb:NCK2(gene name)|psi-mi:NCK2(display_short)|uniprotkb:GRB4(gene name synonym)|uniprotkb:Growth factor receptor-bound protein 4(gene name synonym)	psi-mi:lims1_human(display_long)|uniprotkb:LIMS1(gene name)|psi-mi:LIMS1(display_short)|uniprotkb:Particularly interesting new Cys-His protein 1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-48(gene name synonym)|uniprotkb:PINCH(gene name synonym)|uniprotkb:PINCH1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (1999)	imex:IM-20835|pubmed:10574708	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6690790|imex:IM-20835-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006712860.1|refseq:NP_001004720.1|refseq:NP_003572.2|ensembl:ENSG00000071051(gene)|ensembl:ENST00000233154(transcript)|ensembl:ENST00000393349(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016477"(cell migration)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0060996"(dendritic spine development)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028524|interpro:IPR035559|interpro:IPR035560|interpro:IPR035561|interpro:IPR035883|interpro:IPR036028|interpro:IPR036860|mint:O43639|rcsb pdb:1U5S|rcsb pdb:1WX6|rcsb pdb:1Z3K|rcsb pdb:2B86|rcsb pdb:2CIA|rcsb pdb:2FRW|rcsb pdb:2FRY|rcsb pdb:2JXB|rcsb pdb:4E6R|reactome:R-HSA-186763|reactome:R-HSA-373753|reactome:R-HSA-3928664|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-8985801|reactome:R-HSA-9013420|reactome:R-HSA-9013424|refseq:XP_016860592.1|refseq:XP_016860593.1|refseq:XP_016860594.1|refseq:XP_011510293.1	ensembl:ENSG00000169756(gene)|ensembl:ENST00000332345(transcript)|ensembl:ENST00000393310(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017351(PINCH)|mint:P48059|rcsb pdb:1G47|rcsb pdb:1NYP|rcsb pdb:1U5S|rcsb pdb:2COR|rcsb pdb:2D8X|rcsb pdb:2KBX|rcsb pdb:3F6Q|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIF|rcsb pdb:7D2S|rcsb pdb:7D2T|rcsb pdb:7D2U|rcsb pdb:7LT9|reactome:R-HSA-446353|reactome:R-HSA-446388|refseq:NP_001180417.1|refseq:NP_004978.2|refseq:NP_001180411.1|refseq:NP_001180413.1|refseq:NP_001180414.1|refseq:NP_001180412.1|dip:DIP-40671N	-	-	-	figure legend:Fig 5.|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/23	2014/10/16	rogid:WV9nJ78Im/ga5KQlRuSN2ODzWpQ9606	rogid:LzyCXdAH+qg5n0paw0Stf7+CK2w9606	intact-crc:C738AE478B782732|rigid:42up3aj4p9QCv1SkonUf/mxEEIs	false	glutathione s tranferase tag:n-n	necessary binding region:11-38|his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P48059	uniprotkb:O55222	intact:EBI-306928|uniprotkb:Q53TE0|ensembl:ENSP00000331775|ensembl:ENSP00000376987|uniprotkb:Q9BS44|uniprotkb:B2RAJ4|uniprotkb:B7Z483|uniprotkb:B7Z7R3|uniprotkb:B7Z907	intact:EBI-6690138|uniprotkb:Q78KK2|ensembl:ENSMUSP00000033182|ensembl:ENSMUSP00000130341	psi-mi:lims1_human(display_long)|uniprotkb:LIMS1(gene name)|psi-mi:LIMS1(display_short)|uniprotkb:Particularly interesting new Cys-His protein 1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-48(gene name synonym)|uniprotkb:PINCH(gene name synonym)|uniprotkb:PINCH1(gene name synonym)	psi-mi:ilk_mouse(display_long)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:Ilk(gene name)|psi-mi:Ilk(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Li et al. (1999)	imex:IM-20835|pubmed:10574708	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6690800|imex:IM-20835-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169756(gene)|ensembl:ENST00000332345(transcript)|ensembl:ENST00000393310(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007569"(cell aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017351(PINCH)|mint:P48059|rcsb pdb:1G47|rcsb pdb:1NYP|rcsb pdb:1U5S|rcsb pdb:2COR|rcsb pdb:2D8X|rcsb pdb:2KBX|rcsb pdb:3F6Q|rcsb pdb:4HI8|rcsb pdb:4HI9|rcsb pdb:6MIF|rcsb pdb:7D2S|rcsb pdb:7D2T|rcsb pdb:7D2U|rcsb pdb:7LT9|reactome:R-HSA-446353|reactome:R-HSA-446388|refseq:NP_001180417.1|refseq:NP_004978.2|refseq:NP_001180411.1|refseq:NP_001180413.1|refseq:NP_001180414.1|refseq:NP_001180412.1|dip:DIP-40671N	refseq:NP_001155196.1|refseq:NP_034692.2|ensembl:ENSMUSG00000030890(gene)|ensembl:ENSMUST00000033182(transcript)|ensembl:ENSMUST00000163389(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043034"(costamere)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:O55222|reactome:R-MMU-446343|reactome:R-MMU-446353|dip:DIP-41971N	-	-	-	figure legend:Fig 6A.|comment:The deletion of the first Ankyrin repeat from ILK [66-452] abolished the interaction between ILK and PINCH.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/23	2014/10/16	rogid:LzyCXdAH+qg5n0paw0Stf7+CK2w9606	rogid:9kMagkwUrtq1XaI+9PXPJ21hHY810090	intact-crc:2DBC292A52703553|rigid:C38MobBynKXb5JHTMRGxZlw5KWE	false	maltose binding protein tag:n-n	necessary binding region:1-65(IPR002110)|his tag:n-n	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:G3HJ13	uniprotkb:O55222	intact:EBI-6690821	intact:EBI-6690138|uniprotkb:Q78KK2|ensembl:ENSMUSP00000033182|ensembl:ENSMUSP00000130341	psi-mi:g3hj13_crigr(display_long)|uniprotkb:I79_010647(orf name)	psi-mi:ilk_mouse(display_long)|uniprotkb:59 kDa serine/threonine-protein kinase(gene name synonym)|uniprotkb:Beta-integrin-linked kinase(gene name synonym)|uniprotkb:ILK-1(gene name synonym)|uniprotkb:ILK-2(gene name synonym)|uniprotkb:ILK1(gene name synonym)|uniprotkb:ILK2(gene name synonym)|uniprotkb:p59ILK(gene name synonym)|uniprotkb:Ilk(gene name)|psi-mi:Ilk(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (1999)	imex:IM-20835|pubmed:10574708	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6690819|imex:IM-20835-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017351(PINCH)|interpro:IPR001781(Zinc finger, LIM-type)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0046872"(metal ion binding)	refseq:NP_001155196.1|refseq:NP_034692.2|ensembl:ENSMUSG00000030890(gene)|ensembl:ENSMUST00000033182(transcript)|ensembl:ENSMUST00000163389(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010761"(fibroblast migration)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032288"(myelin assembly)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043034"(costamere)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002110(Ankyrin)|interpro:IPR011009(Protein kinase-like)|interpro:IPR020683|interpro:IPR035692|interpro:IPR036770|mint:O55222|reactome:R-MMU-446343|reactome:R-MMU-446353|dip:DIP-41971N	-	-	-	figure legend:Fig 7B.|comment:Though the Ankyrin repeats region of ILK [1-230] was sufficient to interact with PINCH, the interaction was considerably less compared to wild type ILK.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2013/05/23	2014/10/16	rogid:KTYc2we+V9tfkFJPubCR8wJ7Z2410029	rogid:9kMagkwUrtq1XaI+9PXPJ21hHY810090	intact-crc:BCF427070EDFE80F|rigid:3+8AoTQLhm0rn8IwdK8OXkgWuvo	false	-	flag tag:n-n|sufficient binding region:1-230	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)