#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N474	uniprotkb:O60353	intact:EBI-3940687|uniprotkb:O00546|uniprotkb:O14779|ensembl:ENSP00000220772	intact:EBI-8754490|uniprotkb:B4DRN0|uniprotkb:Q6N0A5|uniprotkb:Q6P9C3|uniprotkb:Q8WXR9|ensembl:ENSP00000351605|ensembl:ENSP00000429055	psi-mi:sfrp1_human(display_long)|uniprotkb:SFRP1(gene name)|psi-mi:SFRP1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:FRP1(gene name synonym)|uniprotkb:SARP2(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 2(gene name synonym)	psi-mi:fzd6_human(display_long)|uniprotkb:FZD6(gene name)|psi-mi:FZD6(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bafico et al. (1999)	pubmed:10347172|imex:IM-22169	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8754482|imex:IM-22169-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044345"(stromal-epithelial cell signaling involved in prostate gland development)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090246"(convergent extension involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:2000080"(negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026559|interpro:IPR036790|interpro:IPR041760|reactome:R-HSA-201681|reactome:R-HSA-3772470|ensembl:ENSG00000104332(gene)|ensembl:ENST00000220772(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010564"(regulation of cell cycle process)|refseq:NP_003003.3	refseq:NP_001304725.1|refseq:NP_001158087.1|refseq:NP_001158088.1|refseq:NP_003497.2|ensembl:ENSG00000164930(gene)|ensembl:ENST00000358755(transcript)|ensembl:ENST00000522566(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001942"(hair follicle development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904693"(midbrain morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026543|interpro:IPR036790|interpro:IPR041770|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4086400|reactome:R-HSA-4641263|reactome:R-HSA-5340588|dip:DIP-59893N	-	-	-	figure legend:Fig. 9B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/03	2014/10/16	rogid:2liKDFxsXQxCRLSVkE10xMGaglA9606	rogid:vBccj/vFYRExa+isZOvQLQXm4409606	intact-crc:B4C1CAA521D469B8|rigid:yPpchJvDn2J+Mmlk0SjFqRj88x0	false	ha tag:c-c|sufficient binding region:1..1-186..186	sufficient binding region:1..1-200..200|flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N474	uniprotkb:Q8N474	intact:EBI-3940687|uniprotkb:O00546|uniprotkb:O14779|ensembl:ENSP00000220772	intact:EBI-3940687|uniprotkb:O00546|uniprotkb:O14779|ensembl:ENSP00000220772	psi-mi:sfrp1_human(display_long)|uniprotkb:SFRP1(gene name)|psi-mi:SFRP1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:FRP1(gene name synonym)|uniprotkb:SARP2(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 2(gene name synonym)	psi-mi:sfrp1_human(display_long)|uniprotkb:SFRP1(gene name)|psi-mi:SFRP1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:FRP1(gene name synonym)|uniprotkb:SARP2(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bafico et al. (1999)	pubmed:10347172|imex:IM-22169	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8754430|imex:IM-22169-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044345"(stromal-epithelial cell signaling involved in prostate gland development)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090246"(convergent extension involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:2000080"(negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026559|interpro:IPR036790|interpro:IPR041760|reactome:R-HSA-201681|reactome:R-HSA-3772470|ensembl:ENSG00000104332(gene)|ensembl:ENST00000220772(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010564"(regulation of cell cycle process)|refseq:NP_003003.3	go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044345"(stromal-epithelial cell signaling involved in prostate gland development)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090246"(convergent extension involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:2000080"(negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026559|interpro:IPR036790|interpro:IPR041760|reactome:R-HSA-201681|reactome:R-HSA-3772470|ensembl:ENSG00000104332(gene)|ensembl:ENST00000220772(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010564"(regulation of cell cycle process)|refseq:NP_003003.3	-	-	-	figure legend:Fig. 8|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/03	2014/10/16	rogid:2liKDFxsXQxCRLSVkE10xMGaglA9606	rogid:2liKDFxsXQxCRLSVkE10xMGaglA9606	intact-crc:8938ADC712725B63|rigid:tQFdA8zXPj8R0mBK0VtFXV5nGq4	false	flag tag:c-c	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N474	uniprotkb:P09544	intact:EBI-3940687|uniprotkb:O00546|uniprotkb:O14779|ensembl:ENSP00000220772	intact:EBI-3905552|uniprotkb:A4D0V1|uniprotkb:Q9UDP9|uniprotkb:Q75N05|ensembl:ENSP00000265441	psi-mi:sfrp1_human(display_long)|uniprotkb:SFRP1(gene name)|psi-mi:SFRP1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:FRP1(gene name synonym)|uniprotkb:SARP2(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 2(gene name synonym)	psi-mi:wnt2_human(display_long)|uniprotkb:WNT2(gene name)|psi-mi:WNT2(display_short)|uniprotkb:INT1L1(gene name synonym)|uniprotkb:IRP(gene name synonym)|uniprotkb:Int-1-like protein 1(gene name synonym)|uniprotkb:Int-1-related protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bafico et al. (1999)	pubmed:10347172|imex:IM-22169	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8754343|imex:IM-22169-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044345"(stromal-epithelial cell signaling involved in prostate gland development)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090246"(convergent extension involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:2000080"(negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026559|interpro:IPR036790|interpro:IPR041760|reactome:R-HSA-201681|reactome:R-HSA-3772470|ensembl:ENSG00000104332(gene)|ensembl:ENST00000220772(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010564"(regulation of cell cycle process)|refseq:NP_003003.3	refseq:NP_003382.1|ensembl:ENSG00000105989(gene)|ensembl:ENST00000265441(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060492"(lung induction)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009140(Wnt-2 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-HSA-3238698|reactome:R-HSA-373080	-	-	-	figure legend:Fig. 6A, B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/03	2014/10/16	rogid:2liKDFxsXQxCRLSVkE10xMGaglA9606	rogid:s7zeq9zUdM0OpxzumJTFXYgLNh09606	intact-crc:58654D5D15E9FC4B|rigid:aoArAiivG0cBMqsekMyU9Q7aZGo	false	sufficient binding region:1..1-186..186|flag tag:c-c	fusion protein:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60353	uniprotkb:Q8N474	intact:EBI-8754490|uniprotkb:B4DRN0|uniprotkb:Q6N0A5|uniprotkb:Q6P9C3|uniprotkb:Q8WXR9|ensembl:ENSP00000351605|ensembl:ENSP00000429055	intact:EBI-3940687|uniprotkb:O00546|uniprotkb:O14779|ensembl:ENSP00000220772	psi-mi:fzd6_human(display_long)|uniprotkb:FZD6(gene name)|psi-mi:FZD6(display_short)	psi-mi:sfrp1_human(display_long)|uniprotkb:SFRP1(gene name)|psi-mi:SFRP1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:FRP1(gene name synonym)|uniprotkb:SARP2(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bafico et al. (1999)	pubmed:10347172|imex:IM-22169	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8754576|imex:IM-22169-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304725.1|refseq:NP_001158087.1|refseq:NP_001158088.1|refseq:NP_003497.2|ensembl:ENSG00000164930(gene)|ensembl:ENST00000358755(transcript)|ensembl:ENST00000522566(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001942"(hair follicle development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904693"(midbrain morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026543|interpro:IPR036790|interpro:IPR041770|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4086400|reactome:R-HSA-4641263|reactome:R-HSA-5340588|dip:DIP-59893N	go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044345"(stromal-epithelial cell signaling involved in prostate gland development)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090246"(convergent extension involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:2000080"(negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026559|interpro:IPR036790|interpro:IPR041760|reactome:R-HSA-201681|reactome:R-HSA-3772470|ensembl:ENSG00000104332(gene)|ensembl:ENST00000220772(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010564"(regulation of cell cycle process)|refseq:NP_003003.3	-	-	-	figure legend:Fig. 10|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/03	2014/10/16	rogid:vBccj/vFYRExa+isZOvQLQXm4409606	rogid:2liKDFxsXQxCRLSVkE10xMGaglA9606	intact-crc:8D26822C7C5D8A6B|rigid:yPpchJvDn2J+Mmlk0SjFqRj88x0	false	35s radiolabel:?-?|sufficient binding region:1..1-200..200|flag tag:c-c	ha tag:c-c|35s radiolabel:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O60353	uniprotkb:Q8N474	intact:EBI-8754490|uniprotkb:B4DRN0|uniprotkb:Q6N0A5|uniprotkb:Q6P9C3|uniprotkb:Q8WXR9|ensembl:ENSP00000351605|ensembl:ENSP00000429055	intact:EBI-3940687|uniprotkb:O00546|uniprotkb:O14779|ensembl:ENSP00000220772	psi-mi:fzd6_human(display_long)|uniprotkb:FZD6(gene name)|psi-mi:FZD6(display_short)	psi-mi:sfrp1_human(display_long)|uniprotkb:SFRP1(gene name)|psi-mi:SFRP1(display_short)|uniprotkb:FRP(gene name synonym)|uniprotkb:FRP1(gene name synonym)|uniprotkb:SARP2(gene name synonym)|uniprotkb:Secreted apoptosis-related protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bafico et al. (1999)	pubmed:10347172|imex:IM-22169	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8754760|imex:IM-22169-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304725.1|refseq:NP_001158087.1|refseq:NP_001158088.1|refseq:NP_003497.2|ensembl:ENSG00000164930(gene)|ensembl:ENST00000358755(transcript)|ensembl:ENST00000522566(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001942"(hair follicle development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904693"(midbrain morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026543|interpro:IPR036790|interpro:IPR041770|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4086400|reactome:R-HSA-4641263|reactome:R-HSA-5340588|dip:DIP-59893N	go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014034"(neural crest cell fate commitment)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044345"(stromal-epithelial cell signaling involved in prostate gland development)|go:"GO:0045578"(negative regulation of B cell differentiation)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090246"(convergent extension involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904956"(regulation of midbrain dopaminergic neuron differentiation)|go:"GO:2000041"(negative regulation of planar cell polarity pathway involved in axis elongation)|go:"GO:2000052"(positive regulation of non-canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|go:"GO:2000080"(negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015526(Frizzled related)|interpro:IPR018933|interpro:IPR020067|interpro:IPR026559|interpro:IPR036790|interpro:IPR041760|reactome:R-HSA-201681|reactome:R-HSA-3772470|ensembl:ENSG00000104332(gene)|ensembl:ENST00000220772(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009986"(cell surface)|go:"GO:0010564"(regulation of cell cycle process)|refseq:NP_003003.3	-	-	-	figure legend:Fig. 10|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2013/09/03	2014/10/16	rogid:vBccj/vFYRExa+isZOvQLQXm4409606	rogid:2liKDFxsXQxCRLSVkE10xMGaglA9606	intact-crc:1264A8AD2D48C6E5|rigid:yPpchJvDn2J+Mmlk0SjFqRj88x0	false	flag tag:c-c|35s radiolabel:?-?|sufficient binding region:1..1-200..200	35s radiolabel:?-?|ha tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)