#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q61152 uniprotkb:P97814 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743 psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short) psi-mi:"MI:0096"(pull down) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654066|mint:MINT-8311311 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311312(identity)|uniprotkb:Q61152(original identifier) interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-8311319(identity)|uniprotkb:P97814(original identifier) - comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2" figure legend:F3A|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090 intact-crc:5963EFB926813A33|rigid:2lFlIZgk+b4n0xjCrf/3G6KSzNk false binding-associated region:305-453(MINT-8311315)|glutathione s tranferase tag:?-?(MINT-8311317) mutation disrupting interaction:232-232(MINT-8311322) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q61152 uniprotkb:Q99M15 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:"MI:0096"(pull down) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654043|mint:MINT-8311298 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311299(identity)|uniprotkb:Q61152(original identifier) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8311306(identity)|uniprotkb:Q99M15(original identifier) - comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton figure legend:F3A|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 intact-crc:24F8749E54551579|rigid:MYJ7b1R1LewQNL3/52vwzV5jXWQ false glutathione s tranferase tag:?-?(MINT-8311304)|binding-associated region:305-453(MINT-8311302) mutation disrupting interaction:232-232(MINT-8311309) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q61152 uniprotkb:Q99M15 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:"MI:0096"(pull down) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654106|mint:MINT-8311324 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311325(identity)|uniprotkb:Q61152(original identifier) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8311332(identity)|uniprotkb:Q99M15(original identifier) - comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton figure legend:F3B F3C|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 intact-crc:AB924BA370D9BBB7|rigid:MYJ7b1R1LewQNL3/52vwzV5jXWQ false binding-associated region:432-451(MINT-8311328)|mutation decreasing interaction:450-450(MINT-8311330) glutathione s tranferase tag:?-?(MINT-8311335) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99M15 uniprotkb:Q61152 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:"MI:0096"(pull down) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654152|mint:MINT-8311350 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8311358(identity)|uniprotkb:Q99M15(original identifier) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311351(identity)|uniprotkb:Q61152(original identifier) - comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells figure legend:F3B F3C|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 intact-crc:E770F063392E5577|rigid:MYJ7b1R1LewQNL3/52vwzV5jXWQ false glutathione s tranferase tag:?-?(MINT-8311361) mutation decreasing interaction:444-444(MINT-8311356)|binding-associated region:432-451(MINT-8311354) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q61152 uniprotkb:P97814 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743 psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short) psi-mi:"MI:0096"(pull down) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654129|mint:MINT-8311337 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311338(identity)|uniprotkb:Q61152(original identifier) interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-8311345(identity)|uniprotkb:P97814(original identifier) - comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2" figure legend:F3B F3C|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090 intact-crc:A7C068A4AE839E0C|rigid:2lFlIZgk+b4n0xjCrf/3G6KSzNk false binding-associated region:432-451(MINT-8311341)|mutation decreasing interaction:450-450(MINT-8311343) glutathione s tranferase tag:?-?(MINT-8311348) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P97814 uniprotkb:Q61152 intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short) psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:"MI:0096"(pull down) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654175|mint:MINT-8311363 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-8311371(identity)|uniprotkb:P97814(original identifier) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311364(identity)|uniprotkb:Q61152(original identifier) - comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2" comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells figure legend:F3B F3C|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 intact-crc:C57BA8ED596D5E74|rigid:2lFlIZgk+b4n0xjCrf/3G6KSzNk false glutathione s tranferase tag:?-?(MINT-8311374) mutation decreasing interaction:444-444(MINT-8311369)|binding-associated region:432-451(MINT-8311367) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P29352 uniprotkb:P97814 intact:EBI-8654263|ensembl:ENSMUSP00000029433|uniprotkb:Q7TMP9|intact:MINT-1535132 intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743 psi-mi:ptn22_mouse(display_long)|uniprotkb:Ptpn22(gene name)|psi-mi:Ptpn22(display_short)|uniprotkb:Ptpn8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short) psi-mi:"MI:0405"(competition binding) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654312|mint:MINT-8311412 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000027843(gene)|ensembl:ENSMUST00000029433(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|refseq:XP_011238343.1|refseq:XP_011238344.1|refseq:NP_033005.1|refseq:XP_006501211.1|refseq:XP_006501212.1|refseq:XP_006501213.1|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:1JEG|reactome:R-MMU-202427|reactome:R-MMU-202430|mint:MINT-8311413(identity)|uniprotkb:P29352(original identifier) interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-8311418(identity)|uniprotkb:P97814(original identifier) - comment:mint|comment:homomint|function:May be an effector and/or regulator of tyrosine-protein kinase CSK in T-cells and other hemopoietic cells comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2" figure legend:F3B|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:J/oQL2AmSxShta0Bv8oM7uMLaBM10090 rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090 intact-crc:4C4ED683E1330C8F|rigid:kJkG38B5F2enetPKfXDS/l7H+H4 false binding-associated region:781-800(MINT-8311416) glutathione s tranferase tag:?-?(MINT-8311421) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99M15 uniprotkb:P35831 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 intact:EBI-2642957|uniprotkb:Q80UM4|ensembl:ENSMUSP00000030556 psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:ptn12_mouse(display_long)|uniprotkb:Protein-tyrosine phosphatase P19(gene name synonym)|uniprotkb:Ptpn12(gene name)|psi-mi:Ptpn12(display_short)|uniprotkb:MPTP-PEST(gene name synonym) psi-mi:"MI:0405"(competition binding) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654208|mint:MINT-8311379 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8311385(identity)|uniprotkb:Q99M15(original identifier) refseq:NP_035333.2|ensembl:ENSMUSG00000028771(gene)|ensembl:ENSMUST00000030556(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P35831|reactome:R-MMU-1250196|reactome:R-MMU-182971|reactome:R-MMU-186797|reactome:R-MMU-8863795|mint:MINT-8311380(identity)|uniprotkb:P35831(original identifier) - comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton - figure legend:F3B|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 rogid:GgHiRVbQuJTf7k7PeNejGiKHybQ10090 intact-crc:E05232A1F33C98A4|rigid:A13gncwB3ynRDtwNQuMy5l+7vUE false glutathione s tranferase tag:?-?(MINT-8311388) binding-associated region:756-765(MINT-8311383) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P97814 uniprotkb:P35831 intact:EBI-7484574|uniprotkb:Q4V9R4|intact:MINT-444743 intact:EBI-2642957|uniprotkb:Q80UM4|ensembl:ENSMUSP00000030556 psi-mi:ppip1_mouse(display_long)|uniprotkb:Pstpip1(gene name)|psi-mi:Pstpip1(display_short) psi-mi:ptn12_mouse(display_long)|uniprotkb:Protein-tyrosine phosphatase P19(gene name synonym)|uniprotkb:Ptpn12(gene name)|psi-mi:Ptpn12(display_short)|uniprotkb:MPTP-PEST(gene name synonym) psi-mi:"MI:0405"(competition binding) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654227|mint:MINT-8311390 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027267|mint:P97814|interpro:IPR031160|interpro:IPR036028|refseq:NP_035323.2|interpro:IPR030777|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|go:"GO:0001725"(stress fiber)|go:"GO:0001931"(uropod)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|reactome:R-MMU-844456|mint:MINT-8311396(identity)|uniprotkb:P97814(original identifier) refseq:NP_035333.2|ensembl:ENSMUSG00000028771(gene)|ensembl:ENSMUST00000030556(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P35831|reactome:R-MMU-1250196|reactome:R-MMU-182971|reactome:R-MMU-186797|reactome:R-MMU-8863795|mint:MINT-8311391(identity)|uniprotkb:P35831(original identifier) - comment:mint|comment:homomint|function:"Involved in regulation of the actin cytoskeleton. May regulate the WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to the ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS, and allows PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymeriszation required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through coupling PTPN12 to CD2" - figure legend:F3B|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:rC2GOU2BlaFNkA4+iB9pAYHJBDI10090 rogid:GgHiRVbQuJTf7k7PeNejGiKHybQ10090 intact-crc:33E506D3105FB40C|rigid:BKpAS4EcEwTOfHRffBdcYNxkbB8 false glutathione s tranferase tag:?-?(MINT-8311399) binding-associated region:756-765(MINT-8311394) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P29352 uniprotkb:Q99M15 intact:EBI-8654263|ensembl:ENSMUSP00000029433|uniprotkb:Q7TMP9|intact:MINT-1535132 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 psi-mi:ptn22_mouse(display_long)|uniprotkb:Ptpn22(gene name)|psi-mi:Ptpn22(display_short)|uniprotkb:Ptpn8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:"MI:0405"(competition binding) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8654293|mint:MINT-8311401 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000027843(gene)|ensembl:ENSMUST00000029433(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|refseq:XP_011238343.1|refseq:XP_011238344.1|refseq:NP_033005.1|refseq:XP_006501211.1|refseq:XP_006501212.1|refseq:XP_006501213.1|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:1JEG|reactome:R-MMU-202427|reactome:R-MMU-202430|mint:MINT-8311402(identity)|uniprotkb:P29352(original identifier) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8311407(identity)|uniprotkb:Q99M15(original identifier) - comment:mint|comment:homomint|function:May be an effector and/or regulator of tyrosine-protein kinase CSK in T-cells and other hemopoietic cells comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton figure legend:F3B|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:J/oQL2AmSxShta0Bv8oM7uMLaBM10090 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 intact-crc:2B2D92594D2BF9C0|rigid:z68Hbd0x8/+39sTw+iclGMEP6kQ false binding-associated region:781-800(MINT-8311405) glutathione s tranferase tag:?-?(MINT-8311410) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q61152 uniprotkb:Q99M15 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8654370|mint:MINT-8311987 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311988(identity)|uniprotkb:Q61152(original identifier) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8311991(identity)|uniprotkb:Q99M15(original identifier) - comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton figure legend:F2|comment:homomint|comment:mint|partial coverage:partial coverage taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent) - 2012/02/13 2014/10/16 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 intact-crc:5D8C7E82AC9E8297|rigid:MYJ7b1R1LewQNL3/52vwzV5jXWQ false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q99M15 uniprotkb:Q61152 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:"MI:0405"(competition binding) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8654341|mint:MINT-8311426 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8311432(identity)|uniprotkb:Q99M15(original identifier) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311427(identity)|uniprotkb:Q61152(original identifier) - comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells figure legend:F9|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 intact-crc:C7A7A0E0E07DDD57|rigid:MYJ7b1R1LewQNL3/52vwzV5jXWQ false myc tag:?-?(MINT-8311435) ha tag:?-?(MINT-8311430) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99M15 uniprotkb:Q61152 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8654393|mint:MINT-8311997 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8312007(identity)|uniprotkb:Q99M15(original identifier) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311998(identity)|uniprotkb:Q61152(original identifier) - comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells figure legend:F4|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 intact-crc:DC2FF9BD538C3A61|rigid:MYJ7b1R1LewQNL3/52vwzV5jXWQ false myc tag:?-?(MINT-8312010) binding-associated region:432-451(MINT-8312001)|ha tag:?-?(MINT-8312005)|mutation decreasing interaction:450-450(MINT-8312003) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99M15 uniprotkb:Q61152 intact:EBI-8653964|uniprotkb:Q6GTF6|uniprotkb:Q9Z189|intact:MINT-5315607|ensembl:ENSMUSP00000110389 intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3 psi-mi:ppip2_mouse(display_long)|uniprotkb:Macrophage actin-associated tyrosine-phosphorylated protein(gene name synonym)|uniprotkb:pp37(gene name synonym)|uniprotkb:Pstpip2(gene name)|psi-mi:Pstpip2(display_short)|uniprotkb:Mayp(gene name synonym) psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Wu et al. (1998) mint:MINT-8310621|pubmed:9804817|doi:10.1074/jbc.273.46.30487 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8654419|mint:MINT-8312012 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038859.3|ensembl:ENSMUSG00000025429(gene)|ensembl:ENSMUST00000114741(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR027267|interpro:IPR030106|interpro:IPR031160|interpro:IPR042694|mint:MINT-8312020(identity)|uniprotkb:Q99M15(original identifier) ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8312013(identity)|uniprotkb:Q61152(original identifier) - comment:mint|comment:homomint|function:Binds to F-actin. May be involved in regulation of the actin cytoskeleton comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells figure legend:F6|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:HCaMbhEIbXpMe6lbJu5GKbpbok410090 rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090 intact-crc:49F3A289C17EB68F|rigid:MYJ7b1R1LewQNL3/52vwzV5jXWQ false myc tag:?-?(MINT-8312023) binding-associated region:432-451(MINT-8312016)|ha tag:?-?(MINT-8312018) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)