#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26664	uniprotkb:Q91XE4	intact:EBI-6941357|intact:MINT-97561|uniprotkb:Q9IFE5	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	psi-mi:polg_hcv1(display_long)	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Tsirulnikov et al. (2012)	pubmed:23010594|mint:MINT-8392191	taxid:11104(hcv1)|taxid:11104("Hepatitis C virus genotype 1a (isolate 1)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8066992|mint:MINT-8392201	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1RTL|rcsb pdb:2A4G|rcsb pdb:2GVF|rcsb pdb:3EYD|rcsb pdb:3HKW|rcsb pdb:3KN2|rcsb pdb:3QGH|rcsb pdb:3QGI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:3SU4|rcsb pdb:6MVO|rcsb pdb:6N4N|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR024350|mint:P26664|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR043128|mint:MINT-8392203(identity)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392204(identity)	-	function:Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation|function:"NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS"|function:NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication|function:"P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity"|function:"Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis)"|comment:mint|function:NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex|comment:homomint|function:NS5A is a component of the replication complex involved in RNA-binding. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication|function:"E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection"	comment:mint|comment:homomint	figure legend:t1|comment:homomint|comment:domino|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.1x10^-6(molar)	2012/09/10	2014/10/16	rogid:w9B7GmFhQvUZqUzLXMQN2rvAsv411104	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	intact-crc:9B44CB5799CF53B0|rigid:TFNEMxgYhkSFMKbkwOVJgVdpI+c	false	binding-associated region:1-177(MINT-8392219)|polyprotein fragment:2-191(MINT-8392217)	tag:?-?(MINT-8392212)	-	-	psi-mi:"MI:0083"(peptide synthesis)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q91XE4	uniprotkb:P26664	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	intact:EBI-6941357|intact:MINT-97561|uniprotkb:Q9IFE5	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:polg_hcv1(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Tsirulnikov et al. (2012)	pubmed:23010594|mint:MINT-8392191	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11104(hcv1)|taxid:11104("Hepatitis C virus genotype 1a (isolate 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8067015|mint:MINT-8392223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392233(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1RTL|rcsb pdb:2A4G|rcsb pdb:2GVF|rcsb pdb:3EYD|rcsb pdb:3HKW|rcsb pdb:3KN2|rcsb pdb:3QGH|rcsb pdb:3QGI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:3SU4|rcsb pdb:6MVO|rcsb pdb:6N4N|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR024350|mint:P26664|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR043128|mint:MINT-8392226(identity)	-	comment:mint|comment:homomint	function:Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation|function:"NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS"|function:NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication|function:"P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity"|function:"Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis)"|comment:mint|function:NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex|comment:homomint|function:NS5A is a component of the replication complex involved in RNA-binding. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication|function:"E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection"	figure legend:t1|comment:homomint|comment:domino|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.3x10^-3(molar)	2012/09/10	2014/10/16	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	rogid:w9B7GmFhQvUZqUzLXMQN2rvAsv411104	intact-crc:FF8BDCA8E051D0AF|rigid:TFNEMxgYhkSFMKbkwOVJgVdpI+c	false	tag:?-?(MINT-8392234)	binding-associated region:2-11(MINT-8392227)|monoacetylated residue:2-2(MINT-8392239)|polyprotein fragment:2-191(MINT-8392230)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q91XE4	uniprotkb:P26664	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	intact:EBI-6941357|intact:MINT-97561|uniprotkb:Q9IFE5	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:polg_hcv1(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Tsirulnikov et al. (2012)	pubmed:23010594|mint:MINT-8392191	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11104(hcv1)|taxid:11104("Hepatitis C virus genotype 1a (isolate 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8067082|mint:MINT-8392261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392273(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1RTL|rcsb pdb:2A4G|rcsb pdb:2GVF|rcsb pdb:3EYD|rcsb pdb:3HKW|rcsb pdb:3KN2|rcsb pdb:3QGH|rcsb pdb:3QGI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:3SU4|rcsb pdb:6MVO|rcsb pdb:6N4N|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR024350|mint:P26664|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR043128|mint:MINT-8392264(identity)	-	comment:mint|comment:homomint	function:Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation|function:"NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS"|function:NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication|function:"P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity"|function:"Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis)"|comment:mint|function:NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex|comment:homomint|function:NS5A is a component of the replication complex involved in RNA-binding. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication|function:"E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection"	figure legend:t1|comment:homomint|comment:domino|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:170.0x10^-6(molar)	2012/09/10	2014/10/16	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	rogid:w9B7GmFhQvUZqUzLXMQN2rvAsv411104	intact-crc:02A49C0802502C34|rigid:TFNEMxgYhkSFMKbkwOVJgVdpI+c	false	tag:?-?(MINT-8392274)	polyprotein fragment:2-191(MINT-8392267)|monoacetylated residue:2-2(MINT-8392265)|binding-associated region:2-27(MINT-8392269)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q91XE4	uniprotkb:P26664	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	intact:EBI-6941357|intact:MINT-97561|uniprotkb:Q9IFE5	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:polg_hcv1(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Tsirulnikov et al. (2012)	pubmed:23010594|mint:MINT-8392191	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11104(hcv1)|taxid:11104("Hepatitis C virus genotype 1a (isolate 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8067059|mint:MINT-8392242	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392254(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1RTL|rcsb pdb:2A4G|rcsb pdb:2GVF|rcsb pdb:3EYD|rcsb pdb:3HKW|rcsb pdb:3KN2|rcsb pdb:3QGH|rcsb pdb:3QGI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:3SU4|rcsb pdb:6MVO|rcsb pdb:6N4N|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR024350|mint:P26664|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR043128|mint:MINT-8392245(identity)	-	comment:mint|comment:homomint	function:Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation|function:"NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS"|function:NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication|function:"P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity"|function:"Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis)"|comment:mint|function:NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex|comment:homomint|function:NS5A is a component of the replication complex involved in RNA-binding. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication|function:"E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection"	figure legend:t1|comment:homomint|comment:domino|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.58x10^-3(molar)	2012/09/10	2014/10/16	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	rogid:w9B7GmFhQvUZqUzLXMQN2rvAsv411104	intact-crc:4D94A1FB9E5D46AF|rigid:TFNEMxgYhkSFMKbkwOVJgVdpI+c	false	tag:?-?(MINT-8392255)	binding-associated region:2-11(MINT-8392250)|polyprotein fragment:2-191(MINT-8392248)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q91XE4	uniprotkb:P26664	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	intact:EBI-6941357|intact:MINT-97561|uniprotkb:Q9IFE5	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:polg_hcv1(display_long)	psi-mi:"MI:0107"(surface plasmon resonance)	Tsirulnikov et al. (2012)	pubmed:23010594|mint:MINT-8392191	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11104(hcv1)|taxid:11104("Hepatitis C virus genotype 1a (isolate 1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8067118|mint:MINT-8392280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392292(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1RTL|rcsb pdb:2A4G|rcsb pdb:2GVF|rcsb pdb:3EYD|rcsb pdb:3HKW|rcsb pdb:3KN2|rcsb pdb:3QGH|rcsb pdb:3QGI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:3SU4|rcsb pdb:6MVO|rcsb pdb:6N4N|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR024350|mint:P26664|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR043128|mint:MINT-8392283(identity)	-	comment:mint|comment:homomint	function:Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation|function:"NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS"|function:NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication|function:"P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity"|function:"Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis)"|comment:mint|function:NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex|comment:homomint|function:NS5A is a component of the replication complex involved in RNA-binding. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication|function:"E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection"	figure legend:t1|comment:homomint|comment:domino|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:142.0x10^-6(molar)	2012/09/10	2014/10/16	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	rogid:w9B7GmFhQvUZqUzLXMQN2rvAsv411104	intact-crc:B0BBE15B7C5CBA34|rigid:TFNEMxgYhkSFMKbkwOVJgVdpI+c	false	tag:?-?(MINT-8392293)	binding-associated region:2-27(MINT-8392284)|polyprotein fragment:2-191(MINT-8392287)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:Q91XE4	uniprotkb:P26664	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	intact:EBI-6941357|intact:MINT-97561|uniprotkb:Q9IFE5	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:polg_hcv1(display_long)	psi-mi:"MI:0435"(protease assay)	Tsirulnikov et al. (2012)	pubmed:23010594|mint:MINT-8392191	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11104(hcv1)|taxid:11104("Hepatitis C virus genotype 1a (isolate 1)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8067174|mint:MINT-8392302	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392312(identity)	go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044186"(host cell lipid droplet)|go:"GO:0044191"(host cell mitochondrial membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1RTL|rcsb pdb:2A4G|rcsb pdb:2GVF|rcsb pdb:3EYD|rcsb pdb:3HKW|rcsb pdb:3KN2|rcsb pdb:3QGH|rcsb pdb:3QGI|rcsb pdb:3RC4|rcsb pdb:3RC5|rcsb pdb:3SU4|rcsb pdb:6MVO|rcsb pdb:6N4N|interpro:IPR000745(Hepatitis C virus non-structural protein NS4a)|interpro:IPR001490(Hepatitis C virus non-structural protein NS4b)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR002518(Peptidase C18, hepatitis C virus endopeptidase 2)|interpro:IPR002519(Hepatitis C virus envelope glycoprotein E1)|interpro:IPR002521(Hepatitis C virus core protein)|interpro:IPR002522(Hepatitis C virus capsid protein)|interpro:IPR002531(Hepatitis C virus non-structural protein E2/NS1)|interpro:IPR002868(Hepatitis C virus non-structural 5a protein)|interpro:IPR004109(Peptidase S29, hepatitus C polyprotein NS3)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR013192(Zinc finger, hepatitis C virus non-structural 5a-type)|interpro:IPR013193(Hepatitis C virus non-structural 5a, region 1b)|interpro:IPR027417|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR024350|mint:P26664|interpro:IPR038170|interpro:IPR038568|interpro:IPR042205|interpro:IPR042209|interpro:IPR043502|interpro:IPR043504|interpro:IPR043128|mint:MINT-8392305(identity)	-	comment:mint|comment:homomint	function:Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation|function:"NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS"|function:NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication|function:"P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity"|function:"Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis)"|comment:mint|function:NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex|comment:homomint|function:NS5A is a component of the replication complex involved in RNA-binding. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication|function:"E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection"	comment:homomint|comment:domino|comment:mint|figure legend:f3a f3b f3c f3d	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/10	2014/10/16	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	rogid:w9B7GmFhQvUZqUzLXMQN2rvAsv411104	intact-crc:B65B32D2876065EF|rigid:TFNEMxgYhkSFMKbkwOVJgVdpI+c	false	tag:?-?(MINT-8392313)	binding-associated region:2-11(MINT-8392306)|polyprotein fragment:2-191(MINT-8392309)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q91XE4	uniprotkb:Q91XE4	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	intact:EBI-7378963|intact:MINT-1869885|uniprotkb:Q9DD17|uniprotkb:Q3UP59|ensembl:ENSMUSP00000050056|ensembl:ENSMUSP00000158093|ensembl:ENSMUSP00000158512	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:acy3_mouse(display_long)|uniprotkb:Acy3(gene name)|psi-mi:Acy3(display_short)|uniprotkb:Aspa2(gene name synonym)|uniprotkb:Aminoacylase-3(gene name synonym)|uniprotkb:Aminoacylase III(gene name synonym)|uniprotkb:Acylase III(gene name synonym)|uniprotkb:Hepatitis C virus core-binding protein 1(gene name synonym)|uniprotkb:Aspartoacylase-2(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Tsirulnikov et al. (2012)	pubmed:23010594|mint:MINT-8392191	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8067200|mint:MINT-8392324	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392326(identity)	refseq:NP_001289408.1|refseq:NP_001289409.1|refseq:NP_001289410.1|refseq:NP_001289411.1|ensembl:ENSMUSG00000024866(gene)|ensembl:ENSMUST00000054030(transcript)|ensembl:ENSMUST00000235612(transcript)|ensembl:ENSMUST00000236510(transcript)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016788"(hydrolase activity, acting on ester bonds)|go:"GO:0016811"("hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides")|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR007036(Succinylglutamate desuccinylase/aspartoacylase)|interpro:IPR016708(Aspartoacylase)|mint:Q91XE4|rcsb pdb:3NFZ|rcsb pdb:3NH4|rcsb pdb:3NH5|rcsb pdb:3NH8|reactome:R-MMU-5423646|dip:DIP-44060N|mint:MINT-8392330(identity)	-	comment:mint|comment:homomint	comment:mint|comment:homomint	comment:homomint|comment:mint|figure legend:f3e f3f	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/10	2014/10/16	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	rogid:vaLqjkhOEE6W/DVCQblxUD7VcTI10090	intact-crc:1019F117F195A86D|rigid:q6f+SyQpuw1+Cd8l5Ne7MmOs3wI	false	tag:?-?(MINT-8392327)	binding-associated region:2-11(MINT-8392333)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)