#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q86YC2	uniprotkb:Q06609	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	intact:EBI-297202|uniprotkb:Q6FHX9|ensembl:ENSP00000267868|ensembl:ENSP00000433924|uniprotkb:B0FXP0|uniprotkb:Q9BV60|intact:EBI-1059207|uniprotkb:B2R8T6|uniprotkb:Q6ZNA8	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:rad51_human(display_long)|uniprotkb:RAD51(gene name)|psi-mi:RAD51(display_short)|uniprotkb:RAD51A(gene name synonym)|uniprotkb:RECA(gene name synonym)|uniprotkb:RAD51 homolog A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615447|mint:MINT-8329250|imex:IM-16695-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8329252(identity)	interpro:IPR013632(Rad51, C-terminal)|interpro:IPR016467(DNA repair and recombination, RecA-like)|interpro:IPR020587|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:Q06609|rcsb pdb:1B22|rcsb pdb:1N0W|rcsb pdb:5H1B|rcsb pdb:5H1C|rcsb pdb:5JZC|rcsb pdb:5NP7|rcsb pdb:5NWL|rcsb pdb:7C9A|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|reactome:R-HSA-8953750|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042148"(strand invasion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:1904631"(response to glucoside)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR011941(DNA repair protein RAD51)|ensembl:ENSG00000051180(gene)|ensembl:ENST00000267868(transcript)|ensembl:ENST00000532743(transcript)|go:"GO:0000150"(DNA strand exchange activity)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000730"(DNA recombinase assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016605"(PML body)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001157742.1|refseq:NP_002866.2|refseq:NP_597994.3|refseq:XP_011520159.1|refseq:XP_011520160.1|refseq:XP_011520161.1|refseq:XP_011520162.1|refseq:XP_011520163.1|refseq:NP_001157741.1|refseq:XP_006720689.1|dip:DIP-462N|mint:MINT-8329256(identity)	-	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-eufa1341)|taxid:9606(Homo sapiens)	-	2012/03/07	2015/12/03	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	rogid:B7WPMU7tZuNcA2qjsTR+7i/OwFw9606	intact-crc:D7C2652AD143B709|rigid:uJRYMAFUQ/LaS/gIPYyf/3HLaW8	false	yellow fluorescent protein tag:?-?(MINT-8329259)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86YC2	uniprotkb:P38398	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615447|mint:MINT-8329250|imex:IM-16695-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8329252(identity)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329254(identity)	-	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-eufa1341)|taxid:9606(Homo sapiens)	-	2012/03/07	2015/12/03	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	intact-crc:D7C2652AD143B709|rigid:uJRYMAFUQ/LaS/gIPYyf/3HLaW8	false	yellow fluorescent protein tag:?-?(MINT-8329259)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86YC2	uniprotkb:P51587	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615447|mint:MINT-8329250|imex:IM-16695-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8329252(identity)	ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N|mint:MINT-8329253(identity)	-	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-eufa1341)|taxid:9606(Homo sapiens)	-	2012/03/07	2015/12/03	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606	intact-crc:D7C2652AD143B709|rigid:uJRYMAFUQ/LaS/gIPYyf/3HLaW8	false	yellow fluorescent protein tag:?-?(MINT-8329259)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q86YC2	uniprotkb:Q9UBU8	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	intact:EBI-399246|uniprotkb:O95899|uniprotkb:Q5QTS1|uniprotkb:Q6NVX8|uniprotkb:Q86YT7|uniprotkb:Q9HBP6|uniprotkb:Q9NSW5|uniprotkb:B4DKN6|uniprotkb:D3DW88|ensembl:ENSP00000331310|uniprotkb:B7Z6R1	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:mo4l1_human(display_long)|uniprotkb:HSPC008(orf name)|uniprotkb:HSPC061(orf name)|uniprotkb:PP368(orf name)|uniprotkb:MORF4L1(gene name)|psi-mi:MORF4L1(display_short)|uniprotkb:MRG15(gene name synonym)|uniprotkb:MORF-related gene 15 protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRG15(gene name synonym)|uniprotkb:Protein MSL3-1(gene name synonym)|uniprotkb:FWP006(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615447|mint:MINT-8329250|imex:IM-16695-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8329252(identity)	refseq:NP_006782.1|refseq:NP_996670.1|dip:DIP-29017N|refseq:NP_001252532.1|refseq:NP_001252533.1|refseq:NP_001252534.1|ensembl:ENSG00000185787(gene)|ensembl:ENST00000331268(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR038011|interpro:IPR038217|mint:Q9UBU8|rcsb pdb:2AQL|rcsb pdb:2EFI|rcsb pdb:2F5J|rcsb pdb:2F5K|rcsb pdb:2LKM|rcsb pdb:2N1D|rcsb pdb:6AGO|rcsb pdb:6INE|reactome:R-HSA-3214847|mint:MINT-8329255(identity)	-	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-eufa1341)|taxid:9606(Homo sapiens)	-	2012/03/07	2015/12/03	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	rogid:28GQifqUMxwR32cneTXH+lpW4gM9606	intact-crc:D7C2652AD143B709|rigid:uJRYMAFUQ/LaS/gIPYyf/3HLaW8	false	yellow fluorescent protein tag:?-?(MINT-8329259)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:P51587	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615501|mint:MINT-8329289|imex:IM-16695-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329297(identity)	ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N|mint:MINT-8329295(identity)	go:"GO:0000790"	-	-	figure legend:f3e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606	intact-crc:F9A11E1B5FAB4F4A|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:P02545	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615501|mint:MINT-8329289|imex:IM-16695-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329297(identity)	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N|mint:MINT-8329340(identity)	go:"GO:0000790"	-	-	figure legend:f3e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:F9A11E1B5FAB4F4A|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q9UBU8	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-399246|uniprotkb:O95899|uniprotkb:Q5QTS1|uniprotkb:Q6NVX8|uniprotkb:Q86YT7|uniprotkb:Q9HBP6|uniprotkb:Q9NSW5|uniprotkb:B4DKN6|uniprotkb:D3DW88|ensembl:ENSP00000331310|uniprotkb:B7Z6R1	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:mo4l1_human(display_long)|uniprotkb:HSPC008(orf name)|uniprotkb:HSPC061(orf name)|uniprotkb:PP368(orf name)|uniprotkb:MORF4L1(gene name)|psi-mi:MORF4L1(display_short)|uniprotkb:MRG15(gene name synonym)|uniprotkb:MORF-related gene 15 protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRG15(gene name synonym)|uniprotkb:Protein MSL3-1(gene name synonym)|uniprotkb:FWP006(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615501|mint:MINT-8329289|imex:IM-16695-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329297(identity)	refseq:NP_006782.1|refseq:NP_996670.1|dip:DIP-29017N|refseq:NP_001252532.1|refseq:NP_001252533.1|refseq:NP_001252534.1|ensembl:ENSG00000185787(gene)|ensembl:ENST00000331268(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR038011|interpro:IPR038217|mint:Q9UBU8|rcsb pdb:2AQL|rcsb pdb:2EFI|rcsb pdb:2F5J|rcsb pdb:2F5K|rcsb pdb:2LKM|rcsb pdb:2N1D|rcsb pdb:6AGO|rcsb pdb:6INE|reactome:R-HSA-3214847|mint:MINT-8329299(identity)	go:"GO:0000790"	-	-	figure legend:f3e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:28GQifqUMxwR32cneTXH+lpW4gM9606	intact-crc:F9A11E1B5FAB4F4A|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q86YC2	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615501|mint:MINT-8329289|imex:IM-16695-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329297(identity)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8329291(identity)	go:"GO:0000790"	-	-	figure legend:f3e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	intact-crc:F9A11E1B5FAB4F4A|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	binding-associated region:395-446(MINT-8329417)|yellow fluorescent protein tag:?-?(MINT-8329292)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q06609	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-297202|uniprotkb:Q6FHX9|ensembl:ENSP00000267868|ensembl:ENSP00000433924|uniprotkb:B0FXP0|uniprotkb:Q9BV60|intact:EBI-1059207|uniprotkb:B2R8T6|uniprotkb:Q6ZNA8	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:rad51_human(display_long)|uniprotkb:RAD51(gene name)|psi-mi:RAD51(display_short)|uniprotkb:RAD51A(gene name synonym)|uniprotkb:RECA(gene name synonym)|uniprotkb:RAD51 homolog A(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615501|mint:MINT-8329289|imex:IM-16695-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329297(identity)	interpro:IPR013632(Rad51, C-terminal)|interpro:IPR016467(DNA repair and recombination, RecA-like)|interpro:IPR020587|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:Q06609|rcsb pdb:1B22|rcsb pdb:1N0W|rcsb pdb:5H1B|rcsb pdb:5H1C|rcsb pdb:5JZC|rcsb pdb:5NP7|rcsb pdb:5NWL|rcsb pdb:7C9A|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|reactome:R-HSA-8953750|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042148"(strand invasion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:1904631"(response to glucoside)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR011941(DNA repair protein RAD51)|ensembl:ENSG00000051180(gene)|ensembl:ENST00000267868(transcript)|ensembl:ENST00000532743(transcript)|go:"GO:0000150"(DNA strand exchange activity)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000730"(DNA recombinase assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016605"(PML body)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001157742.1|refseq:NP_002866.2|refseq:NP_597994.3|refseq:XP_011520159.1|refseq:XP_011520160.1|refseq:XP_011520161.1|refseq:XP_011520162.1|refseq:XP_011520163.1|refseq:NP_001157741.1|refseq:XP_006720689.1|dip:DIP-462N|mint:MINT-8329301(identity)	go:"GO:0000790"	-	-	figure legend:f3e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:B7WPMU7tZuNcA2qjsTR+7i/OwFw9606	intact-crc:F9A11E1B5FAB4F4A|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:P51587	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615551|mint:MINT-8329389|imex:IM-16695-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329398(identity)	ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N|mint:MINT-8329396(identity)	go:"GO:0000790"	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606	intact-crc:C1480AB740F39760|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:P02545	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615551|mint:MINT-8329389|imex:IM-16695-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329398(identity)	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N|mint:MINT-8329404(identity)	go:"GO:0000790"	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:C1480AB740F39760|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q9UBU8	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-399246|uniprotkb:O95899|uniprotkb:Q5QTS1|uniprotkb:Q6NVX8|uniprotkb:Q86YT7|uniprotkb:Q9HBP6|uniprotkb:Q9NSW5|uniprotkb:B4DKN6|uniprotkb:D3DW88|ensembl:ENSP00000331310|uniprotkb:B7Z6R1	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:mo4l1_human(display_long)|uniprotkb:HSPC008(orf name)|uniprotkb:HSPC061(orf name)|uniprotkb:PP368(orf name)|uniprotkb:MORF4L1(gene name)|psi-mi:MORF4L1(display_short)|uniprotkb:MRG15(gene name synonym)|uniprotkb:MORF-related gene 15 protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRG15(gene name synonym)|uniprotkb:Protein MSL3-1(gene name synonym)|uniprotkb:FWP006(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615551|mint:MINT-8329389|imex:IM-16695-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329398(identity)	refseq:NP_006782.1|refseq:NP_996670.1|dip:DIP-29017N|refseq:NP_001252532.1|refseq:NP_001252533.1|refseq:NP_001252534.1|ensembl:ENSG00000185787(gene)|ensembl:ENST00000331268(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR038011|interpro:IPR038217|mint:Q9UBU8|rcsb pdb:2AQL|rcsb pdb:2EFI|rcsb pdb:2F5J|rcsb pdb:2F5K|rcsb pdb:2LKM|rcsb pdb:2N1D|rcsb pdb:6AGO|rcsb pdb:6INE|reactome:R-HSA-3214847|mint:MINT-8329400(identity)	go:"GO:0000790"	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:28GQifqUMxwR32cneTXH+lpW4gM9606	intact-crc:C1480AB740F39760|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	myc tag:?-?(MINT-8329411)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P38398	uniprotkb:Q86YC2	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615551|mint:MINT-8329389|imex:IM-16695-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329398(identity)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8329392(identity)	go:"GO:0000790"	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	intact-crc:C1480AB740F39760|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	yellow fluorescent protein tag:?-?(MINT-8329393)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q06609	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-297202|uniprotkb:Q6FHX9|ensembl:ENSP00000267868|ensembl:ENSP00000433924|uniprotkb:B0FXP0|uniprotkb:Q9BV60|intact:EBI-1059207|uniprotkb:B2R8T6|uniprotkb:Q6ZNA8	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:rad51_human(display_long)|uniprotkb:RAD51(gene name)|psi-mi:RAD51(display_short)|uniprotkb:RAD51A(gene name synonym)|uniprotkb:RECA(gene name synonym)|uniprotkb:RAD51 homolog A(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615551|mint:MINT-8329389|imex:IM-16695-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8329398(identity)	interpro:IPR013632(Rad51, C-terminal)|interpro:IPR016467(DNA repair and recombination, RecA-like)|interpro:IPR020587|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:Q06609|rcsb pdb:1B22|rcsb pdb:1N0W|rcsb pdb:5H1B|rcsb pdb:5H1C|rcsb pdb:5JZC|rcsb pdb:5NP7|rcsb pdb:5NWL|rcsb pdb:7C9A|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|reactome:R-HSA-8953750|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042148"(strand invasion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:1904631"(response to glucoside)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR011941(DNA repair protein RAD51)|ensembl:ENSG00000051180(gene)|ensembl:ENST00000267868(transcript)|ensembl:ENST00000532743(transcript)|go:"GO:0000150"(DNA strand exchange activity)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000730"(DNA recombinase assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016605"(PML body)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001157742.1|refseq:NP_002866.2|refseq:NP_597994.3|refseq:XP_011520159.1|refseq:XP_011520160.1|refseq:XP_011520161.1|refseq:XP_011520162.1|refseq:XP_011520163.1|refseq:NP_001157741.1|refseq:XP_006720689.1|dip:DIP-462N|mint:MINT-8329402(identity)	go:"GO:0000790"	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:B7WPMU7tZuNcA2qjsTR+7i/OwFw9606	intact-crc:C1480AB740F39760|rigid:8NGhcXDc7WomyVmwexXshtnArYM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:P51587	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-79792|ensembl:ENSP00000369497|ensembl:ENSP00000439902|uniprotkb:Q5TBJ7|uniprotkb:O00183|uniprotkb:O15008|uniprotkb:Q13879	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:brca2_human(display_long)|uniprotkb:BRCA2(gene name)|psi-mi:BRCA2(display_short)|uniprotkb:FANCD1(gene name synonym)|uniprotkb:FACD(gene name synonym)|uniprotkb:Fanconi anemia group D1 protein(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615583|mint:MINT-8361862|imex:IM-16695-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8361873(identity)	ensembl:ENSG00000139618(gene)|ensembl:ENST00000380152(transcript)|ensembl:ENST00000544455(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000800"(lateral element)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008585"(female gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010225"(response to UV-C)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030141"(secretory granule)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033593"(BRCA2-MAGE-D1 complex)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048478"(replication fork protection)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR002093(BRCA2 repeat)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR015187(BRCA2, oligonucleotide/oligosaccharide-binding 1)|interpro:IPR015188(BRCA2, oligonucleotide/oligosaccharide-binding 3)|interpro:IPR015205(Tower)|interpro:IPR015252(BRCA2, helical)|interpro:IPR015525(Breast cancer type 2 susceptibility protein)|interpro:IPR036315|mint:P51587|rcsb pdb:1N0W|rcsb pdb:3EU7|rcsb pdb:6GY2|go:"GO:0007141"(male meiosis I)|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|rcsb pdb:6HQU|refseq:NP_000050.2|dip:DIP-24214N|mint:MINT-8361871(identity)	go:"GO:0000790"	-	-	comment:homomint|comment:mint|figure legend:f2a sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:GvNlXMFXTHiRgOGT5EBlQUVh/+k9606	intact-crc:23DD6518338AF9BD|rigid:vAog3HNmKg+U/vnlp3ImIaYMs/0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:P16104	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615583|mint:MINT-8361862|imex:IM-16695-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8361873(identity)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|mint:MINT-8361881(identity)	go:"GO:0000790"	-	-	comment:homomint|comment:mint|figure legend:f2a sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	intact-crc:23DD6518338AF9BD|rigid:vAog3HNmKg+U/vnlp3ImIaYMs/0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:P02545	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615583|mint:MINT-8361862|imex:IM-16695-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8361873(identity)	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N|mint:MINT-8361879(identity)	go:"GO:0000790"	-	-	comment:homomint|comment:mint|figure legend:f2a sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:23DD6518338AF9BD|rigid:vAog3HNmKg+U/vnlp3ImIaYMs/0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q9UBU8	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-399246|uniprotkb:O95899|uniprotkb:Q5QTS1|uniprotkb:Q6NVX8|uniprotkb:Q86YT7|uniprotkb:Q9HBP6|uniprotkb:Q9NSW5|uniprotkb:B4DKN6|uniprotkb:D3DW88|ensembl:ENSP00000331310|uniprotkb:B7Z6R1	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:mo4l1_human(display_long)|uniprotkb:HSPC008(orf name)|uniprotkb:HSPC061(orf name)|uniprotkb:PP368(orf name)|uniprotkb:MORF4L1(gene name)|psi-mi:MORF4L1(display_short)|uniprotkb:MRG15(gene name synonym)|uniprotkb:MORF-related gene 15 protein(gene name synonym)|uniprotkb:Transcription factor-like protein MRG15(gene name synonym)|uniprotkb:Protein MSL3-1(gene name synonym)|uniprotkb:FWP006(orf name)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615583|mint:MINT-8361862|imex:IM-16695-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8361873(identity)	refseq:NP_006782.1|refseq:NP_996670.1|dip:DIP-29017N|refseq:NP_001252532.1|refseq:NP_001252533.1|refseq:NP_001252534.1|ensembl:ENSG00000185787(gene)|ensembl:ENST00000331268(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0047485"(protein N-terminus binding)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR038011|interpro:IPR038217|mint:Q9UBU8|rcsb pdb:2AQL|rcsb pdb:2EFI|rcsb pdb:2F5J|rcsb pdb:2F5K|rcsb pdb:2LKM|rcsb pdb:2N1D|rcsb pdb:6AGO|rcsb pdb:6INE|reactome:R-HSA-3214847|mint:MINT-8361875(identity)	go:"GO:0000790"	-	-	comment:homomint|comment:mint|figure legend:f2a sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:28GQifqUMxwR32cneTXH+lpW4gM9606	intact-crc:23DD6518338AF9BD|rigid:vAog3HNmKg+U/vnlp3ImIaYMs/0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q86YC2	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615583|mint:MINT-8361862|imex:IM-16695-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8361873(identity)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8361865(identity)	go:"GO:0000790"	-	-	comment:homomint|comment:mint|figure legend:f2a sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	intact-crc:23DD6518338AF9BD|rigid:vAog3HNmKg+U/vnlp3ImIaYMs/0	false	-	binding-associated region:395-446(MINT-8361866)|yellow fluorescent protein tag:?-?(MINT-8361868)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38398	uniprotkb:Q06609	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-297202|uniprotkb:Q6FHX9|ensembl:ENSP00000267868|ensembl:ENSP00000433924|uniprotkb:B0FXP0|uniprotkb:Q9BV60|intact:EBI-1059207|uniprotkb:B2R8T6|uniprotkb:Q6ZNA8	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:rad51_human(display_long)|uniprotkb:RAD51(gene name)|psi-mi:RAD51(display_short)|uniprotkb:RAD51A(gene name synonym)|uniprotkb:RECA(gene name synonym)|uniprotkb:RAD51 homolog A(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615583|mint:MINT-8361862|imex:IM-16695-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N|mint:MINT-8361873(identity)	interpro:IPR013632(Rad51, C-terminal)|interpro:IPR016467(DNA repair and recombination, RecA-like)|interpro:IPR020587|interpro:IPR020588|interpro:IPR027417|interpro:IPR033925|mint:Q06609|rcsb pdb:1B22|rcsb pdb:1N0W|rcsb pdb:5H1B|rcsb pdb:5H1C|rcsb pdb:5JZC|rcsb pdb:5NP7|rcsb pdb:5NWL|rcsb pdb:7C9A|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693616|reactome:R-HSA-912446|reactome:R-HSA-8953750|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042148"(strand invasion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0072719"(cellular response to cisplatin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072757"(cellular response to camptothecin)|go:"GO:1904631"(response to glucoside)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990426"(mitotic recombination-dependent replication fork processing)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010995(DNA repair Rad51/transcription factor NusA, alpha-helical)|interpro:IPR011941(DNA repair protein RAD51)|ensembl:ENSG00000051180(gene)|ensembl:ENST00000267868(transcript)|ensembl:ENST00000532743(transcript)|go:"GO:0000150"(DNA strand exchange activity)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000730"(DNA recombinase assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0016605"(PML body)|go:"GO:0017116"(single-stranded DNA helicase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001157742.1|refseq:NP_002866.2|refseq:NP_597994.3|refseq:XP_011520159.1|refseq:XP_011520160.1|refseq:XP_011520161.1|refseq:XP_011520162.1|refseq:XP_011520163.1|refseq:NP_001157741.1|refseq:XP_006720689.1|dip:DIP-462N|mint:MINT-8361877(identity)	go:"GO:0000790"	-	-	comment:homomint|comment:mint|figure legend:f2a sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/07	2015/12/03	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:B7WPMU7tZuNcA2qjsTR+7i/OwFw9606	intact-crc:23DD6518338AF9BD|rigid:vAog3HNmKg+U/vnlp3ImIaYMs/0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16104	uniprotkb:Q86YC2	intact:EBI-494830|uniprotkb:Q4ZGJ7|uniprotkb:Q6IAS5|ensembl:ENSP00000364310|ensembl:ENSP00000434024	intact:EBI-1222653|uniprotkb:Q8N7Y6|uniprotkb:Q8ND31|uniprotkb:Q9H6W1|uniprotkb:A6NIE1|ensembl:ENSP00000261584	psi-mi:h2ax_human(display_long)|uniprotkb:H2AX(gene name)|psi-mi:H2AX(display_short)|uniprotkb:H2AFX(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:palb2_human(display_long)|uniprotkb:PALB2(gene name)|psi-mi:PALB2(display_short)|uniprotkb:FANCN(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Bleuyard et al. (2012)	doi:10.1038/embor.2011.243|pubmed:22193777|imex:IM-16695|mint:MINT-8329239	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7615627|mint:MINT-8329426|imex:IM-16695-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188486(gene)|ensembl:ENST00000375167(transcript)|ensembl:ENST00000530167(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|refseq:NP_002096.1|dip:DIP-33604N|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|go:"GO:0005813"(centrosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P16104|rcsb pdb:1YDP|rcsb pdb:2AZM|rcsb pdb:2D31|rcsb pdb:2DYP|rcsb pdb:3SHV|rcsb pdb:3SQD|rcsb pdb:3SZM|rcsb pdb:3U3Z|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|mint:MINT-8329428(identity)	refseq:NP_078951.2|dip:DIP-38427N|ensembl:ENSG00000083093(gene)|ensembl:ENST00000261584(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001756"(somitogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007498"(mesoderm development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0048568"(embryonic organ development)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031920|interpro:IPR036322|interpro:IPR042417|mint:Q86YC2|rcsb pdb:2W18|rcsb pdb:3EU7|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|go:"GO:0001833"(inner cell mass cell proliferation)|mint:MINT-8329429(identity)	go:"GO:0044428"(obsolete nuclear part)	-	-	comment:homomint|comment:mint|figure legend:sf4a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line)	-	2012/03/07	2014/10/16	rogid:VQoEp3F8lEBTOj+PDDUzrJCQNZA9606	rogid:/CusSIimN2s+1JZ83gI0GtaHdz09606	intact-crc:00117E0CB365A351|rigid:rFv7S4O0h+mSknvYu93kd6XqZDI	false	-	tandem tag:?-?(MINT-8329433)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)