#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13177	uniprotkb:P55210	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2011)	pubmed:21555521|imex:IM-17236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5326935|imex:IM-17236-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	-	-	-	figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/16	2014/10/16	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	intact-crc:20A628A3B398744A|rigid:hYl3noiAC7eqJTKpfq3gqWOKfIo	false	v5 tag:?-?	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P55210	uniprotkb:Q13177	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Li et al. (2011)	pubmed:21555521|imex:IM-17236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5326950|imex:IM-17236-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	-	-	-	figure legend:2b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2012/01/16	2014/10/16	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	intact-crc:5433BFE32DBB92E7|rigid:hYl3noiAC7eqJTKpfq3gqWOKfIo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55210	uniprotkb:Q13177	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2011)	pubmed:21555521|imex:IM-17236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5326965|imex:IM-17236-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)	-	-	figure legend:2c|comment:"The colocalization is detected in cytoplasm. Upon treatment with staurosporine (induces apoptosis), the colocalization is restricted to the nucleus."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2012/01/16	2014/10/16	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	intact-crc:0EDE58D96EDD1936|rigid:hYl3noiAC7eqJTKpfq3gqWOKfIo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q13177	-	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	-	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	-	psi-mi:"MI:0424"(protein kinase assay)	Li et al. (2011)	pubmed:21555521|imex:IM-17236	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5328384|imex:IM-17236-7	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	-	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	-	-	figure legend:3d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/16	2014/10/16	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	-	intact-crc:995CDE94C2156557	false	his tag:c-c|t7 tag:n-n|his tag:n-n	-	-	-	psi-mi:"MI:0833"(autoradiography)	-
uniprotkb:P55210	uniprotkb:Q13177	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Li et al. (2011)	pubmed:21555521|imex:IM-17236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5326979|imex:IM-17236-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:2d and 3d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/16	2014/10/16	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	intact-crc:D395A16BF8CDE018|rigid:hYl3noiAC7eqJTKpfq3gqWOKfIo	false	mutation decreasing interaction:30-30,173-173,239-239|his tag:n-n	his tag:n-n|his tag:c-c|t7 tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q13177	uniprotkb:P55210	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Li et al. (2011)	pubmed:21555521|imex:IM-17236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5327025|imex:IM-17236-6	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:3c and 3b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/16	2014/10/16	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	intact-crc:3F308775E90AFE2F|rigid:hYl3noiAC7eqJTKpfq3gqWOKfIo	false	t7 tag:n-n|his tag:c-c|his tag:n-n	sufficient binding region:235-243|sufficient binding region:169-177|sufficient binding region:26-34	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q13177	uniprotkb:P55210	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Li et al. (2011)	pubmed:21555521|imex:IM-17236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5327005|imex:IM-17236-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:3a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/16	2014/10/16	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	intact-crc:A9094EB11DB8A4DD|rigid:hYl3noiAC7eqJTKpfq3gqWOKfIo	false	his tag:n-n|t7 tag:n-n|his tag:c-c	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)