#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00264	uniprotkb:P16435	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252132|imex:IM-17497-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	-	-	-	figure legend:Fig 8B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	intact-crc:CC46E9ACFE3F0319|rigid:m/tN6FE541FNTD70HTBRNkqZCuY	false	flag tag:?-?	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00264	uniprotkb:P00181	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6251864|imex:IM-17497-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	-	-	-	figure legend:Fig 1B|comment:"the chimera OEC/GFP binds much more efficiently to PGRMC1 than C1(1–29)/GFP, consistent with an interaction mediated mainly by the cytosolic domain of CYP2C2 (Fig. 1B, left)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:11C95E4AA8278A72|rigid:fcMLsttBlOnIyVvm0pmD3A77YF4	false	flag tag:?-?	green fluorescent protein tag:?-?|sufficient binding region:22-490|tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15503	uniprotkb:P00180	intact:EBI-6252425|ensembl:ENSP00000344741|uniprotkb:A8K6L0|uniprotkb:Q53XW8|uniprotkb:Q9BUV5|uniprotkb:A4D2N1	intact:EBI-6251821|uniprotkb:Q00172	psi-mi:insi1_human(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short)	psi-mi:cp2c1_rabit(display_long)|uniprotkb:CYP2C1(gene name)|psi-mi:CYP2C1(display_short)|uniprotkb:CYPIIC1(gene name synonym)|uniprotkb:Cytochrome P-450 IIC1(gene name synonym)|uniprotkb:Cytochrome P450 PBc1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252497|imex:IM-17497-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:1901303"(negative regulation of cargo loading into COPII-coated vesicle)|interpro:IPR009904(Insulin-induced)|interpro:IPR025929|mint:O15503|rcsb pdb:4J81|reactome:R-HSA-1655829|go:"GO:0070862"(negative regulation of protein exit from endoplasmic reticulum)|refseq:NP_001333519.1|refseq:NP_001333520.1|refseq:NP_001333521.1|refseq:NP_001333522.1|refseq:NP_001333523.1|refseq:NP_005533.2|refseq:NP_938150.2|refseq:NP_938151.1|dip:DIP-61157N|refseq:XP_016867666.1	go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR036396	-	-	-	figure legend:Fig 10C -2|comment:"Coimmunoprecipitation of INSIG1 and chimera C1(1–29)/GFP is more efficient than that with the cytoplasmic domain chimera OEC/GFP."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606	rogid:yXlk/zjZNzXaddjjkHsmAl6l2bc9986	intact-crc:CD3071FEB1EC318E|rigid:p7nQ3SXKf0pF0WV/tk/ysaPOr88	false	myc tag:?-?	sufficient binding region:1-29|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15503	uniprotkb:P00181	intact:EBI-6252425|ensembl:ENSP00000344741|uniprotkb:A8K6L0|uniprotkb:Q53XW8|uniprotkb:Q9BUV5|uniprotkb:A4D2N1	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:insi1_human(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252512|imex:IM-17497-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:1901303"(negative regulation of cargo loading into COPII-coated vesicle)|interpro:IPR009904(Insulin-induced)|interpro:IPR025929|mint:O15503|rcsb pdb:4J81|reactome:R-HSA-1655829|go:"GO:0070862"(negative regulation of protein exit from endoplasmic reticulum)|refseq:NP_001333519.1|refseq:NP_001333520.1|refseq:NP_001333521.1|refseq:NP_001333522.1|refseq:NP_001333523.1|refseq:NP_005533.2|refseq:NP_938150.2|refseq:NP_938151.1|dip:DIP-61157N|refseq:XP_016867666.1	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	-	-	-	figure legend:Fig 10C-3|comment:"Coimmunoprecipitation of INSIG1 and chimera C1(1–29)/GFP is more efficient than that with the cytoplasmic domain chimera OEC/GFP (Fig. 10C)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:2480E342FCAA9A55|rigid:HLld0vFYXdpzH8Mit2JE92R5bPM	false	myc tag:?-?	tag:?-?|sufficient binding region:22-490|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00264	uniprotkb:P00181	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6251623|imex:IM-17497-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	-	-	-	figure legend:Fig 1A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:22AF6B02945C498E|rigid:fcMLsttBlOnIyVvm0pmD3A77YF4	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P10632	uniprotkb:O00264	intact:EBI-2951522|ensembl:ENSP00000360317|uniprotkb:Q9UCZ9|uniprotkb:Q5VX93|uniprotkb:B0AZN2|uniprotkb:A8K9N8|uniprotkb:Q8WWB1|uniprotkb:B7Z1F6	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	psi-mi:cp2c8_human(display_long)|uniprotkb:CYP2C8(gene name)|psi-mi:CYP2C8(display_short)|uniprotkb:CYPIIC8(gene name synonym)|uniprotkb:Cytochrome P450 IIC2(gene name synonym)|uniprotkb:Cytochrome P450 MP-12(gene name synonym)|uniprotkb:Cytochrome P450 MP-20(gene name synonym)|uniprotkb:Cytochrome P450 form 1(gene name synonym)|uniprotkb:S-mephenytoin 4-hydroxylase(gene name synonym)	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6251799|imex:IM-17497-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138115(gene)|ensembl:ENST00000371270(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006082"(organic acid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008392"(arachidonic acid epoxygenase activity)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0016712"(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)|go:"GO:0017144"|go:"GO:0019373"(epoxygenase P450 pathway)|go:"GO:0020037"(heme binding)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042738"|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0070330"(aromatase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0097267"(omega-hydroxylase P450 pathway)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1PQ2|rcsb pdb:2NNH|rcsb pdb:2NNI|rcsb pdb:2NNJ|rcsb pdb:2VN0|reactome:R-HSA-211981|reactome:R-HSA-211999|reactome:R-HSA-2142670|reactome:R-HSA-2142816|reactome:R-HSA-9027307|refseq:NP_000761.3|refseq:NP_001185782.1|refseq:NP_001185783.1|refseq:NP_001185784.1	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	-	-	-	figure legend:Fig 1A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:sy4QWC5ZugTrrEVD/DQRvhGyhH09606	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	intact-crc:3790A7687738DDB5|rigid:WWGesLRdS28psVwDccMz/a5nTuA	false	flag tag:c-c|his tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00264	uniprotkb:P00181	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252113|imex:IM-17497-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	-	-	-	figure legend:Fig 8B|comment:In cells coexpressing all three proteins, there was a marked decrease in CPR binding to PGRMC1, whereas binding of PGRMC1 to CYP2C2 was little changed.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:5E25B94E1E09E612|rigid:e+LJTlBegzIxz+KJwSlk5oDhvdI	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00264	uniprotkb:P16435	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252113|imex:IM-17497-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	-	-	-	figure legend:Fig 8B|comment:In cells coexpressing all three proteins, there was a marked decrease in CPR binding to PGRMC1, whereas binding of PGRMC1 to CYP2C2 was little changed.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	intact-crc:5E25B94E1E09E612|rigid:e+LJTlBegzIxz+KJwSlk5oDhvdI	false	flag tag:?-?	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15503	uniprotkb:P00180	intact:EBI-6252425|ensembl:ENSP00000344741|uniprotkb:A8K6L0|uniprotkb:Q53XW8|uniprotkb:Q9BUV5|uniprotkb:A4D2N1	intact:EBI-6251821|uniprotkb:Q00172	psi-mi:insi1_human(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short)	psi-mi:cp2c1_rabit(display_long)|uniprotkb:CYP2C1(gene name)|psi-mi:CYP2C1(display_short)|uniprotkb:CYPIIC1(gene name synonym)|uniprotkb:Cytochrome P-450 IIC1(gene name synonym)|uniprotkb:Cytochrome P450 PBc1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252486|imex:IM-17497-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:1901303"(negative regulation of cargo loading into COPII-coated vesicle)|interpro:IPR009904(Insulin-induced)|interpro:IPR025929|mint:O15503|rcsb pdb:4J81|reactome:R-HSA-1655829|go:"GO:0070862"(negative regulation of protein exit from endoplasmic reticulum)|refseq:NP_001333519.1|refseq:NP_001333520.1|refseq:NP_001333521.1|refseq:NP_001333522.1|refseq:NP_001333523.1|refseq:NP_005533.2|refseq:NP_938150.2|refseq:NP_938151.1|dip:DIP-61157N|refseq:XP_016867666.1	go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR036396	-	-	-	figure legend:Fig 10C -1|comment:"Coimmunoprecipitation of INSIG1 and chimera C1(1–29)/GFP is more efficient than that with the cytoplasmic domain chimera OEC/GFP.  [OEC is a fusion protein assembled from the catalytic cytosolic domain (amino acids 21–490) of  CYP2C2 fused to the transmembrane domain of  epidermal growth factor receptor (EGFR- species undetermined), -which replaces the deleted  CYP2C2 signal peptide.]"|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606	rogid:yXlk/zjZNzXaddjjkHsmAl6l2bc9986	intact-crc:67C01511F570835B|rigid:p7nQ3SXKf0pF0WV/tk/ysaPOr88	false	myc tag:?-?	green fluorescent protein tag:?-?|sufficient binding region:1-29	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00181	uniprotkb:O15503	intact:EBI-4320576|uniprotkb:Q28683	intact:EBI-6252425|ensembl:ENSP00000344741|uniprotkb:A8K6L0|uniprotkb:Q53XW8|uniprotkb:Q9BUV5|uniprotkb:A4D2N1	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:insi1_human(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252414|imex:IM-17497-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:1901303"(negative regulation of cargo loading into COPII-coated vesicle)|interpro:IPR009904(Insulin-induced)|interpro:IPR025929|mint:O15503|rcsb pdb:4J81|reactome:R-HSA-1655829|go:"GO:0070862"(negative regulation of protein exit from endoplasmic reticulum)|refseq:NP_001333519.1|refseq:NP_001333520.1|refseq:NP_001333521.1|refseq:NP_001333522.1|refseq:NP_001333523.1|refseq:NP_005533.2|refseq:NP_938150.2|refseq:NP_938151.1|dip:DIP-61157N|refseq:XP_016867666.1	-	-	-	figure legend:Fig 10A|comment:binding of INSIG1 to CYP2C2 is independent of PGRMC1.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606	intact-crc:386FC00D65D257C0|rigid:HLld0vFYXdpzH8Mit2JE92R5bPM	false	flag tag:?-?|his tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00181	uniprotkb:O15503	intact:EBI-4320576|uniprotkb:Q28683	intact:EBI-6252425|ensembl:ENSP00000344741|uniprotkb:A8K6L0|uniprotkb:Q53XW8|uniprotkb:Q9BUV5|uniprotkb:A4D2N1	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:insi1_human(display_long)|uniprotkb:INSIG1(gene name)|psi-mi:INSIG1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252455|imex:IM-17497-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	ensembl:ENSG00000186480(gene)|ensembl:ENST00000340368(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:1901303"(negative regulation of cargo loading into COPII-coated vesicle)|interpro:IPR009904(Insulin-induced)|interpro:IPR025929|mint:O15503|rcsb pdb:4J81|reactome:R-HSA-1655829|go:"GO:0070862"(negative regulation of protein exit from endoplasmic reticulum)|refseq:NP_001333519.1|refseq:NP_001333520.1|refseq:NP_001333521.1|refseq:NP_001333522.1|refseq:NP_001333523.1|refseq:NP_005533.2|refseq:NP_938150.2|refseq:NP_938151.1|dip:DIP-61157N|refseq:XP_016867666.1	-	-	-	figure legend:Fig 10A|comment:Binding of INSIG1 to CYP2C2 is independent of PGRMC1.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	rogid:CePNtn7b6ienEbjTcmzRblg0FnE9606	intact-crc:14AB29D8226AF992|rigid:HLld0vFYXdpzH8Mit2JE92R5bPM	false	flag tag:?-?|his tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00181	uniprotkb:O00264	intact:EBI-4320576|uniprotkb:Q28683	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252124|imex:IM-17497-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	-	-	-	figure legend:Fig 8B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	intact-crc:47F4A805AE57A366|rigid:fcMLsttBlOnIyVvm0pmD3A77YF4	false	green fluorescent protein tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P00180	uniprotkb:O00264	intact:EBI-6251821|uniprotkb:Q00172	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	psi-mi:cp2c1_rabit(display_long)|uniprotkb:CYP2C1(gene name)|psi-mi:CYP2C1(display_short)|uniprotkb:CYPIIC1(gene name synonym)|uniprotkb:Cytochrome P-450 IIC1(gene name synonym)|uniprotkb:Cytochrome P450 PBc1(gene name synonym)	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6251812|imex:IM-17497-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|interpro:IPR036396	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	-	-	-	figure legend:Fig 1B|comment:"the chimera OEC/GFP binds much more efficiently to PGRMC1 than C1(1–29)/GFP, consistent with an interaction mediated mainly by the cytosolic domain of CYP2C2 (Fig. 1B, left)."|caution:"It is possible that  the construct \"C1(1–29)/GFP\" may have been derived from  CYP2C2 rather than CYP2C1- as entered here."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:yXlk/zjZNzXaddjjkHsmAl6l2bc9986	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	intact-crc:64E021A714F539B9|rigid:w175iR7qjkxnRkuaRE3pWa4hN2g	false	green fluorescent protein tag:?-?|sufficient binding region:1-29	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00264	uniprotkb:P08684	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6251781|imex:IM-17497-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	-	-	-	figure legend:Fig 1A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	intact-crc:D8D4B2DBA8A3FFA0|rigid:sGjI77igk+Q+nWmUxaPzOJog4SE	false	flag tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P16435	uniprotkb:P00181	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252466|imex:IM-17497-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	-	-	-	figure legend:Fig 10B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:7353D11F52B15A84|rigid:fDqDh5CwjqXcm76GMaVUSW7tHVQ	false	yellow fluorescent protein tag:c-c	flag tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O00264	uniprotkb:P00181	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252009|imex:IM-17497-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0031965"(nuclear membrane)	-	-	figure legend:Fig 2A/B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:DE16D139BDA9164C|rigid:fcMLsttBlOnIyVvm0pmD3A77YF4	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O00264	uniprotkb:P00181	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6251992|imex:IM-17497-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0031965"(nuclear membrane)	-	-	figure legend:Fig 2A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:49F4BA6063F59BD6|rigid:fcMLsttBlOnIyVvm0pmD3A77YF4	false	flag tag:?-?	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O00264	uniprotkb:P16435	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252400|imex:IM-17497-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0031965"(nuclear membrane)	-	-	figure legend:Fig 9A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	intact-crc:C5C14286048830D8|rigid:m/tN6FE541FNTD70HTBRNkqZCuY	false	flag tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O00264	uniprotkb:P08684	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	intact:EBI-3928618|uniprotkb:P05184|uniprotkb:Q9UK50|uniprotkb:Q16757|ensembl:ENSP00000498939	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:cp3a4_human(display_long)|uniprotkb:"Albendazole monooxygenase (sulfoxide-forming)"(gene name synonym)|uniprotkb:CYP3A4(gene name)|psi-mi:CYP3A4(display_short)|uniprotkb:CYP3A3(gene name synonym)|uniprotkb:Albendazole sulfoxidase(gene name synonym)|uniprotkb:CYPIIIA3(gene name synonym)|uniprotkb:CYPIIIA4(gene name synonym)|uniprotkb:Cytochrome P450 3A3(gene name synonym)|uniprotkb:Cytochrome P450 HLp(gene name synonym)|uniprotkb:Cytochrome P450 NF-25(gene name synonym)|uniprotkb:Cytochrome P450-PCN1(gene name synonym)|uniprotkb:Nifedipine oxidase(gene name synonym)|uniprotkb:Quinine 3-monooxygenase(gene name synonym)|uniprotkb:1,8-cineole 2-exo-monooxygenase(gene name synonym)|uniprotkb:Cholesterol 25-hydroxylase(gene name synonym)|uniprotkb:1,4-cineole 2-exo-monooxygenase(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252024|imex:IM-17497-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	ensembl:ENSG00000160868(gene)|ensembl:ENST00000651514(transcript)|go:"GO:0002933"(lipid hydroxylation)|go:"GO:0004497"(monooxygenase activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006706"(steroid catabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0008395"(steroid hydroxylase activity)|go:"GO:0008401"(retinoic acid 4-hydroxylase activity)|go:"GO:0009822"(alkaloid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016098"(monoterpenoid metabolic process)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0017144"|go:"GO:0019825"(oxygen binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030343"(vitamin D3 25-hydroxylase activity)|go:"GO:0034875"(caffeine oxidase activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0042572"(retinol metabolic process)|go:"GO:0042573"(retinoic acid metabolic process)|go:"GO:0042737"|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046222"(aflatoxin metabolic process)|go:"GO:0046483"(heterocycle metabolic process)|go:"GO:0050591"(quinine 3-monooxygenase activity)|go:"GO:0050649"(testosterone 6-beta-hydroxylase activity)|go:"GO:0062181"(1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity)|go:"GO:0062187"(anandamide 8,9 epoxidase activity)|go:"GO:0062188"(anandamide 11,12 epoxidase activity)|go:"GO:0062189"(anandamide 14,15 epoxidase activity)|go:"GO:0070330"(aromatase activity)|go:"GO:0070576"(vitamin D 24-hydroxylase activity)|go:"GO:0070989"(oxidative demethylation)|go:"GO:0101020"(estrogen 16-alpha-hydroxylase activity)|go:"GO:0042738"|go:"GO:0102320"(1,8-cineole 2-exo-monooxygenase activity)|interpro:IPR001128(Cytochrome P450)|interpro:IPR002402(Cytochrome P450, E-class, group II)|interpro:IPR008072(Cytochrome P450, E-class, CYP3A)|interpro:IPR017972|interpro:IPR036396|rcsb pdb:1TQN|rcsb pdb:1W0E|rcsb pdb:1W0F|rcsb pdb:1W0G|rcsb pdb:2J0D|rcsb pdb:2V0M|rcsb pdb:3NXU|rcsb pdb:3TJS|rcsb pdb:3UA1|rcsb pdb:4D6Z|rcsb pdb:4D75|rcsb pdb:4D78|rcsb pdb:4D7D|rcsb pdb:4I3Q|rcsb pdb:4I4G|rcsb pdb:4I4H|rcsb pdb:4K9T|rcsb pdb:4K9U|rcsb pdb:4K9V|rcsb pdb:4K9W|rcsb pdb:4K9X|rcsb pdb:4NY4|go:"GO:0101021"(estrogen 2-hydroxylase activity)|rcsb pdb:5A1P|rcsb pdb:5A1R|rcsb pdb:5G5J|rcsb pdb:5TE8|rcsb pdb:5VC0|rcsb pdb:5VCC|rcsb pdb:5VCD|rcsb pdb:5VCE|rcsb pdb:5VCG|rcsb pdb:6BCZ|rcsb pdb:6BD6|rcsb pdb:6BD7|rcsb pdb:6BD8|rcsb pdb:6BDH|rcsb pdb:6BDI|rcsb pdb:6BDK|rcsb pdb:6BDM|rcsb pdb:6OO9|rcsb pdb:6OOA|rcsb pdb:6OOB|rcsb pdb:7KS8|rcsb pdb:7KSA|rcsb pdb:7KVH|rcsb pdb:7KVI|rcsb pdb:7KVJ|rcsb pdb:7KVK|rcsb pdb:7KVM|rcsb pdb:7KVN|rcsb pdb:7KVO|rcsb pdb:6BD5|rcsb pdb:7KVP|rcsb pdb:7KVQ|rcsb pdb:7KVS|rcsb pdb:7LXL|reactome:R-HSA-211981|reactome:R-HSA-5423646|reactome:R-HSA-9027307|refseq:NP_001189784.1|refseq:NP_059488.2	go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0031965"(nuclear membrane)	-	-	figure legend:Fig 2A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2012/07/23	2014/10/16	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	rogid:GWcoaD9hEywHmATn5H/kjeJ+QaA9606	intact-crc:C5C14DD6048830D8|rigid:sGjI77igk+Q+nWmUxaPzOJog4SE	false	flag tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P00181	uniprotkb:P16435	intact:EBI-4320576|uniprotkb:Q28683	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252084|imex:IM-17497-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	-	-	-	figure legend:Fig 8A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	intact-crc:ACD58BAEA6EE1D21|rigid:fDqDh5CwjqXcm76GMaVUSW7tHVQ	false	flag tag:?-?|his tag:?-?	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51572	uniprotkb:P00181	intact:EBI-77683|ensembl:ENSP00000343458|ensembl:ENSP00000494052|ensembl:ENSP00000499882|uniprotkb:Q13836|uniprotkb:Q96CF0|uniprotkb:D3DWV5|uniprotkb:B3KQ79	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:bap31_human(display_long)|uniprotkb:BCAP31(gene name)|psi-mi:BCAP31(display_short)|uniprotkb:BAP31(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:6C6-AG tumor-associated antigen(gene name synonym)|uniprotkb:DXS1357E(gene name synonym)|uniprotkb:Protein CDM(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6251957|imex:IM-17497-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001132913.1|refseq:NP_005736.3|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904154"(positive regulation of retrograde protein transport, ER to cytosol)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672|mint:P51572|rcsb pdb:4JZL|rcsb pdb:4JZP|reactome:R-HSA-111465|reactome:R-HSA-75153|reactome:R-HSA-8980692|reactome:R-HSA-983170|ensembl:ENSG00000185825(gene)|ensembl:ENST00000345046(transcript)|ensembl:ENST00000647529(transcript)|ensembl:ENST00000672675(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001243376.1|refseq:NP_001132929.1	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	-	-	-	figure legend:Fig 1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:m0aN00PLZJDWA/K1vEbla1W9+S89606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:4E62AD321000F17F|rigid:0viCxIZyFCPMgF/J5bZj1U9Zq00	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16435	uniprotkb:O00264	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252073|imex:IM-17497-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	-	-	-	figure legend:Fig 8A|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	intact-crc:6D66DF24D5EA0355|rigid:m/tN6FE541FNTD70HTBRNkqZCuY	false	yellow fluorescent protein tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P00181	uniprotkb:P16435	intact:EBI-4320576|uniprotkb:Q28683	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252369|imex:IM-17497-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	-	-	-	figure legend:Fig 8C -2|comment:In cells coexpressing all three proteins, there was a marked decrease in CPR binding to PGRMC1, whereas binding of PGRMC1 to CYP2C2 was little changed.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	intact-crc:F0FBCFD2EE3427F2|rigid:fDqDh5CwjqXcm76GMaVUSW7tHVQ	false	his tag:?-?|flag tag:?-?	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16435	uniprotkb:O00264	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252349|imex:IM-17497-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1	-	-	-	figure legend:Fig 8C -1|comment:"only weak binding of PGRMC1 to CPR was observed (Fig. 8C, third panel)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606	intact-crc:CBEA1EF124EB41EB|rigid:e+LJTlBegzIxz+KJwSlk5oDhvdI	false	yellow fluorescent protein tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16435	uniprotkb:P00181	intact:EBI-726554|uniprotkb:Q9UDT3|uniprotkb:Q16455|uniprotkb:Q8N181|uniprotkb:Q9H3M8|uniprotkb:Q197M5|ensembl:ENSP00000378355|ensembl:ENSP00000389409|ensembl:ENSP00000389719|ensembl:ENSP00000390540|ensembl:ENSP00000395813|ensembl:ENSP00000399327|ensembl:ENSP00000399556|ensembl:ENSP00000404731|ensembl:ENSP00000409238|ensembl:ENSP00000414263|ensembl:ENSP00000419970	intact:EBI-4320576|uniprotkb:Q28683	psi-mi:ncpr_human(display_long)|uniprotkb:POR(gene name)|psi-mi:POR(display_short)|uniprotkb:CYPOR(gene name synonym)	psi-mi:cp2c2_rabit(display_long)|uniprotkb:CYP2C2(gene name)|psi-mi:CYP2C2(display_short)|uniprotkb:CYPIIC2(gene name synonym)|uniprotkb:Cytochrome P450 PBc2(gene name synonym)|uniprotkb:Cytochrome P450 PHP2(gene name synonym)|uniprotkb:Laurate omega-1 hydroxylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Szczesna-Skorupa et al. (2011)	imex:IM-17497|pubmed:21081644	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6252349|imex:IM-17497-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000932.3|ensembl:ENSG00000127948(gene)|ensembl:ENST00000394893(transcript)|ensembl:ENST00000412064(transcript)|ensembl:ENST00000412521(transcript)|ensembl:ENST00000414186(transcript)|ensembl:ENST00000418341(transcript)|ensembl:ENST00000432753(transcript)|ensembl:ENST00000439963(transcript)|ensembl:ENST00000449920(transcript)|ensembl:ENST00000453773(transcript)|ensembl:ENST00000454934(transcript)|ensembl:ENST00000461988(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|rcsb pdb:1B1C|rcsb pdb:3FJO|rcsb pdb:3QE2|rcsb pdb:3QFC|rcsb pdb:3QFR|rcsb pdb:3QFS|rcsb pdb:3QFT|rcsb pdb:5EMN|rcsb pdb:5FA6|reactome:R-HSA-211897|dip:DIP-29682N	interpro:IPR036396|interpro:IPR001128(Cytochrome P450)|interpro:IPR017972|interpro:IPR002401(Cytochrome P450, E-class, group I)|refseq:NP_001164584.1|go:"GO:0005506"(iron ion binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0020037"(heme binding)|go:"GO:0070330"(aromatase activity)	-	-	-	figure legend:Fig 8C -1|comment:"only weak binding of PGRMC1 to CPR was observed (Fig. 8C, third panel)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/07/23	2014/10/16	rogid:Tgl0hfwgwo16Yw+kH4JIdIaRPpM9606	rogid:nHbsBzEexhQa7Nx5Qda9Lfs30q49986	intact-crc:CBEA1EF124EB41EB|rigid:e+LJTlBegzIxz+KJwSlk5oDhvdI	false	yellow fluorescent protein tag:c-c	flag tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)