#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q05769 uniprotkb:Q05769 intact:EBI-298933|ensembl:ENSMUSP00000035065|uniprotkb:Q543K3 intact:EBI-298933|ensembl:ENSMUSP00000035065|uniprotkb:Q543K3 psi-mi:pgh2_mouse(display_long)|uniprotkb:Ptgs2(gene name)|psi-mi:Ptgs2(display_short)|uniprotkb:Cox-2(gene name synonym)|uniprotkb:Cox2(gene name synonym)|uniprotkb:Pghs-b(gene name synonym)|uniprotkb:Tis10(gene name synonym)|uniprotkb:Gripghs(gene name synonym)|uniprotkb:TIS10 protein(gene name synonym)|uniprotkb:Macrophage activation-associated marker protein P71/73(gene name synonym)|uniprotkb:PES-2(gene name synonym)|uniprotkb:Cyclooxygenase-2(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 2(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 2(gene name synonym)|uniprotkb:PHS II(gene name synonym)|uniprotkb:Glucocorticoid-regulated inflammatory cyclooxygenase(gene name synonym) psi-mi:pgh2_mouse(display_long)|uniprotkb:Ptgs2(gene name)|psi-mi:Ptgs2(display_short)|uniprotkb:Cox-2(gene name synonym)|uniprotkb:Cox2(gene name synonym)|uniprotkb:Pghs-b(gene name synonym)|uniprotkb:Tis10(gene name synonym)|uniprotkb:Gripghs(gene name synonym)|uniprotkb:TIS10 protein(gene name synonym)|uniprotkb:Macrophage activation-associated marker protein P71/73(gene name synonym)|uniprotkb:PES-2(gene name synonym)|uniprotkb:Cyclooxygenase-2(gene name synonym)|uniprotkb:Prostaglandin-endoperoxide synthase 2(gene name synonym)|uniprotkb:Prostaglandin H2 synthase 2(gene name synonym)|uniprotkb:PHS II(gene name synonym)|uniprotkb:Glucocorticoid-regulated inflammatory cyclooxygenase(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Vecchio et al. (2010) pubmed:20463020 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-5324876|pdbe:3krk|pdbe:3hs5|pdbe:3hs6|pdbe:3hs7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030728"(ovulation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034097"(response to cytokine)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042633"(hair cycle)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046697"(decidualization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071471"(cellular response to non-ionic osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090362"(positive regulation of platelet-derived growth factor production)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029576|interpro:IPR037120|rcsb pdb:1CVU|rcsb pdb:1CX2|rcsb pdb:1DCX|rcsb pdb:1DD0|rcsb pdb:1DDX|rcsb pdb:1PXX|rcsb pdb:3HS5|rcsb pdb:3HS6|rcsb pdb:3HS7|rcsb pdb:3KRK|rcsb pdb:3LN0|rcsb pdb:3LN1|rcsb pdb:3MDL|rcsb pdb:3MQE|rcsb pdb:3NT1|rcsb pdb:3NTB|rcsb pdb:3NTG|rcsb pdb:3OLT|rcsb pdb:3OLU|rcsb pdb:3PGH|rcsb pdb:3Q7D|rcsb pdb:3QH0|rcsb pdb:3QMO|rcsb pdb:3RR3|rcsb pdb:3TZI|rcsb pdb:4COX|rcsb pdb:4E1G|rcsb pdb:4FM5|rcsb pdb:4M10|rcsb pdb:4M11|rcsb pdb:4OTJ|rcsb pdb:4OTY|rcsb pdb:4PH9|rcsb pdb:4RRW|rcsb pdb:4RRX|rcsb pdb:4RRY|rcsb pdb:4RRZ|rcsb pdb:4RS0|rcsb pdb:4RUT|rcsb pdb:4Z0L|rcsb pdb:5COX|rcsb pdb:5FDQ|rcsb pdb:5JVY|rcsb pdb:5JVZ|rcsb pdb:5JW1|rcsb pdb:5W58|rcsb pdb:6BL3|rcsb pdb:6BL4|rcsb pdb:6COX|rcsb pdb:6OFY|rcsb pdb:6V3R|reactome:R-MMU-197264|reactome:R-MMU-2142770|reactome:R-MMU-2162123|reactome:R-MMU-9018677|reactome:R-MMU-9018679|reactome:R-MMU-9025094|reactome:R-MMU-9027604|ensembl:ENSMUSG00000032487(gene)|ensembl:ENSMUST00000035065(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001525"(angiogenesis)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005901"(caveola)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009750"(response to fructose)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010942"(positive regulation of cell death)|refseq:NP_035328.2|dip:DIP-31082N go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030728"(ovulation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034097"(response to cytokine)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042493"|go:"GO:0042633"(hair cycle)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046697"(decidualization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071284"(cellular response to lead ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071471"(cellular response to non-ionic osmotic stress)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090271"(positive regulation of fibroblast growth factor production)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0090362"(positive regulation of platelet-derived growth factor production)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR010255(Haem peroxidase)|interpro:IPR019791|interpro:IPR029576|interpro:IPR037120|rcsb pdb:1CVU|rcsb pdb:1CX2|rcsb pdb:1DCX|rcsb pdb:1DD0|rcsb pdb:1DDX|rcsb pdb:1PXX|rcsb pdb:3HS5|rcsb pdb:3HS6|rcsb pdb:3HS7|rcsb pdb:3KRK|rcsb pdb:3LN0|rcsb pdb:3LN1|rcsb pdb:3MDL|rcsb pdb:3MQE|rcsb pdb:3NT1|rcsb pdb:3NTB|rcsb pdb:3NTG|rcsb pdb:3OLT|rcsb pdb:3OLU|rcsb pdb:3PGH|rcsb pdb:3Q7D|rcsb pdb:3QH0|rcsb pdb:3QMO|rcsb pdb:3RR3|rcsb pdb:3TZI|rcsb pdb:4COX|rcsb pdb:4E1G|rcsb pdb:4FM5|rcsb pdb:4M10|rcsb pdb:4M11|rcsb pdb:4OTJ|rcsb pdb:4OTY|rcsb pdb:4PH9|rcsb pdb:4RRW|rcsb pdb:4RRX|rcsb pdb:4RRY|rcsb pdb:4RRZ|rcsb pdb:4RS0|rcsb pdb:4RUT|rcsb pdb:4Z0L|rcsb pdb:5COX|rcsb pdb:5FDQ|rcsb pdb:5JVY|rcsb pdb:5JVZ|rcsb pdb:5JW1|rcsb pdb:5W58|rcsb pdb:6BL3|rcsb pdb:6BL4|rcsb pdb:6COX|rcsb pdb:6OFY|rcsb pdb:6V3R|reactome:R-MMU-197264|reactome:R-MMU-2142770|reactome:R-MMU-2162123|reactome:R-MMU-9018677|reactome:R-MMU-9018679|reactome:R-MMU-9025094|reactome:R-MMU-9027604|ensembl:ENSMUSG00000032487(gene)|ensembl:ENSMUST00000035065(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001525"(angiogenesis)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004666"(prostaglandin-endoperoxide synthase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005901"(caveola)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009750"(response to fructose)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010942"(positive regulation of cell death)|refseq:NP_035328.2|dip:DIP-31082N - "mimix:comment":not sure if the protein origin is right determined, my suggestion is based on fig.1c and 1d description "mimix:comment":not sure if the protein origin is right determined, my suggestion is based on fig.1c and 1d description 3d-r-factors:0.171 R factor for 3Hs5 0.21 free R factor for 3Hs5 0.179 R factor for 3Hs6 0.223 free R factor for 3Hs6 0.184 R factor for 3Hs7 0.234 free R factor for 3Hs7 0.182 R factor for 3krk 0.228 free R factor for 3krk|3d-resolution:2.1 A for 3hs5 2.4 A for 3hs6 2.65 A for 3hs7 2.4 A for 3krk|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/01/10 2014/10/16 rogid:qEZAEY7+mfcvc5oe6aZ25me/MsY10090 rogid:qEZAEY7+mfcvc5oe6aZ25me/MsY10090 intact-crc:DE552AF061B5965E|rigid:eQ9V0++Q6+EpCwVZrYAfNYwVowY false - - 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)