#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P29117 uniprotkb:P49950 intact:EBI-6454979|ensembl:ENSRNOP00000014382 intact:EBI-79006|uniprotkb:Q62837|uniprotkb:Q64032 psi-mi:ppif_rat(display_long)|uniprotkb:Cyclophilin D(gene name synonym)|uniprotkb:Ppif(gene name)|psi-mi:Ppif(display_short)|uniprotkb:Cyclophilin F(gene name synonym)|uniprotkb:Rotamase F(gene name synonym) psi-mi:bcl2_rat(display_long)|uniprotkb:Bcl2(gene name)|psi-mi:Bcl2(display_short)|uniprotkb:Bcl-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Eliseev et al. (2009) pubmed:19228691|imex:IM-18580 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6465491|imex:IM-18580-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000010558(gene)|ensembl:ENSRNOT00000014382(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0002931"(response to ischemia)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0005737"(cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902686"(mitochondrial outer membrane permeabilization involved in programmed cell death)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|rcsb pdb:4TOT|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010849"(regulation of proton-transporting ATPase activity, rotational mechanism)|go:"GO:0010939"(regulation of necrotic cell death)|go:"GO:0016018"(cyclosporin A binding)|refseq:NP_758443.1|rgd:628670 go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002520"(immune system development)|go:"GO:0002931"(response to ischemia)|go:"GO:0003014"(renal system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009408"(response to heat)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031000"(response to caffeine)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032868"(response to insulin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034284"(response to monosaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0036017"(response to erythropoietin)|go:"GO:0040008"(regulation of growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043473"(pigmentation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045471"(response to ethanol)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0046688"(response to copper ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048599"(oocyte development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051400"(BH domain binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051593"(response to folic acid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0080184"(response to phenylpropanoid)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097421"(liver regeneration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902618"(cellular response to fluoride)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rgd:2199|refseq:NP_058689.1|reactome:R-RNO-111447|reactome:R-RNO-111453|reactome:R-RNO-844455|dip:DIP-30849N go:"GO:0005739"(mitochondrion) - - figure legend:1A, 2B, 2D|antagonist:cyclosporin A|comment:Calcium has no effect on the association|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-liver)|taxid:10116(rattus norvegicus liver) - 2012/12/18 2014/10/16 rogid:erVXqkKJG1Su/VgHy/O5qzC2aVs10116 rogid:WVpo/E3f4v7XQtAlqYuUk8plUCU10116 intact-crc:37F5573FF0136223|rigid:m51GDLrPS3XrtX3FqMCWkjnVsIQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10415 uniprotkb:P29117 intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5 intact:EBI-6454979|ensembl:ENSRNOP00000014382 psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short) psi-mi:ppif_rat(display_long)|uniprotkb:Cyclophilin D(gene name synonym)|uniprotkb:Ppif(gene name)|psi-mi:Ppif(display_short)|uniprotkb:Cyclophilin F(gene name synonym)|uniprotkb:Rotamase F(gene name synonym) psi-mi:"MI:0096"(pull down) Eliseev et al. (2009) pubmed:19228691|imex:IM-18580 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6465503|imex:IM-18580-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2 ensembl:ENSRNOG00000010558(gene)|ensembl:ENSRNOT00000014382(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0002931"(response to ischemia)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0005737"(cytoplasm)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0005739"(mitochondrion)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902686"(mitochondrial outer membrane permeabilization involved in programmed cell death)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|rcsb pdb:4TOT|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010849"(regulation of proton-transporting ATPase activity, rotational mechanism)|go:"GO:0010939"(regulation of necrotic cell death)|go:"GO:0016018"(cyclosporin A binding)|refseq:NP_758443.1|rgd:628670 - - comment:Mitochondrial protein extracts have been used. figure legend:1B, 2C, 2E|comment:Calcium had no affect on the pull-down.|antagonist:Cyclosporine A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/18 2014/10/16 rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606 rogid:erVXqkKJG1Su/VgHy/O5qzC2aVs10116 intact-crc:6D4284C48D9AFAC6|rigid:T3NtUmnUbiYx+sY0FV2ISfZXnZI false maltose binding protein tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P30405 uniprotkb:P10415 intact:EBI-5544229|uniprotkb:Q2YDB7|uniprotkb:Q5W131|ensembl:ENSP00000225174 intact:EBI-77694|ensembl:ENSP00000329623|ensembl:ENSP00000381185|uniprotkb:P10416|uniprotkb:Q13842|uniprotkb:Q16197|uniprotkb:C9JHD5 psi-mi:ppif_human(display_long)|uniprotkb:PPIF(gene name)|psi-mi:PPIF(display_short)|uniprotkb:CYP3(gene name synonym)|uniprotkb:Cyclophilin F(gene name synonym)|uniprotkb:Rotamase F(gene name synonym)|uniprotkb:Cyclophilin D(gene name synonym)|uniprotkb:Mitochondrial cyclophilin(gene name synonym) psi-mi:bcl2_human(display_long)|uniprotkb:BCL2(gene name)|psi-mi:BCL2(display_short) psi-mi:"MI:0018"(two hybrid) Eliseev et al. (2009) pubmed:19228691|imex:IM-18580 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6465542|imex:IM-18580-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005720.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010849"(regulation of proton-transporting ATPase activity, rotational mechanism)|go:"GO:0010939"(regulation of necrotic cell death)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0070266"(necroptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:1902445"(regulation of mitochondrial membrane permeability involved in programmed necrotic cell death)|go:"GO:1902686"(mitochondrial outer membrane permeabilization involved in programmed cell death)|go:"GO:2000276"(negative regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P30405|rcsb pdb:2BIT|rcsb pdb:2BIU|rcsb pdb:2Z6W|rcsb pdb:3QYU|rcsb pdb:3R49|rcsb pdb:3R4G|rcsb pdb:3R54|rcsb pdb:3R56|rcsb pdb:3R57|rcsb pdb:3R59|rcsb pdb:3RCF|rcsb pdb:3RCG|rcsb pdb:3RCI|rcsb pdb:3RCK|rcsb pdb:3RCL|rcsb pdb:3RD9|rcsb pdb:3RDA|rcsb pdb:3RDB|rcsb pdb:3RDC|rcsb pdb:4J58|rcsb pdb:4J59|rcsb pdb:4J5A|rcsb pdb:4J5B|rcsb pdb:4J5C|rcsb pdb:4J5D|rcsb pdb:4J5E|rcsb pdb:4O8H|rcsb pdb:4O8I|rcsb pdb:4XNC|rcsb pdb:4ZSC|rcsb pdb:4ZSD|rcsb pdb:5A0E|rcsb pdb:5CBT|rcsb pdb:5CBU|rcsb pdb:5CBV|rcsb pdb:5CBW|rcsb pdb:5CCN|rcsb pdb:5CCQ|rcsb pdb:5CCR|rcsb pdb:5CCS|rcsb pdb:6R8L|rcsb pdb:6R8O|rcsb pdb:6R8W|rcsb pdb:6R9S|rcsb pdb:6R9U|rcsb pdb:6R9X|rcsb pdb:6RA1|rcsb pdb:6Y3E|rcsb pdb:6YBM|ensembl:ENSG00000108179(gene)|ensembl:ENST00000225174(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0002931"(response to ischemia)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding) interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:4LVT|rcsb pdb:4LXD|rcsb pdb:4MAN|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5FCG|rcsb pdb:5JSN|rcsb pdb:5VAU|rcsb pdb:5VAX|rcsb pdb:5VAY|rcsb pdb:6GL8|rcsb pdb:6IWB|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:7LHB|reactome:R-HSA-111447|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9018519|reactome:R-HSA-9634638|mint:P10415|rcsb pdb:1G5M|rcsb pdb:1GJH|rcsb pdb:1YSW|rcsb pdb:2O21|rcsb pdb:2O22|rcsb pdb:2O2F|rcsb pdb:2W3L|rcsb pdb:2XA0|rcsb pdb:4AQ3|rcsb pdb:4IEH|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|ensembl:ENSG00000171791(gene)|ensembl:ENST00000333681(transcript)|ensembl:ENST00000398117(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002931"(response to ischemia)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0003014"(renal system process)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007565"(female pregnancy)|go:"GO:0007569"(cell aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009314"(response to radiation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010039"(response to iron ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048536"(spleen development)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0048538"(thymus development)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0048599"(oocyte development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0043583"(ear development)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|go:"GO:0051924"(regulation of calcium ion transport)|refseq:NP_000624.2|dip:DIP-1043N|refseq:NP_000648.2 - - - figure legend:1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/12/18 2014/10/16 rogid:5sa9mIaCM/Fo9PA4NgA1p4c4WIg9606 rogid:XC215VuR7Wf2ACXOm1pTyyuimSU9606 intact-crc:C680E7273E065734|rigid:6f09uQ5Dmc9Z1vBWCty30mQqBso false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)