#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q12888	uniprotkb:Q99986	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6139156|imex:IM-15883-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	-	-	figure legend:2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-a_549)|taxid:9606(Homo sapiens Caucasian lung carcinoma cell line)	-	2011/09/28	2014/10/16	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	intact-crc:2C61A370C2D0C74A|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12888	uniprotkb:Q99986	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6138358|imex:IM-15883-10	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	intact-crc:011B3D47E96A771F|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	sufficient binding region:1-346|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q13315	uniprotkb:Q12888	intact:EBI-495465|uniprotkb:O15429|uniprotkb:Q12758|uniprotkb:Q16551|uniprotkb:Q93007|uniprotkb:Q9NP02|uniprotkb:Q9UCX7|intact:EBI-1059333|uniprotkb:B2RNX5|intact:EBI-28985245|ensembl:ENSP00000278616|ensembl:ENSP00000388058|ensembl:ENSP00000501606	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:atm_human(display_long)|uniprotkb:ATM(gene name)|psi-mi:ATM(display_short)|uniprotkb:Ataxia telangiectasia mutated(gene name synonym)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6138268|imex:IM-15883-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000042.3|refseq:XP_011541142.1|ensembl:ENSP00000501606|ensembl:ENSP00000278616|ensembl:ENSP00000388058|refseq:XP_005271618.2|refseq:XP_005271619.2|refseq:XP_006718906.1|refseq:XP_006718908.1|dip:DIP-182N|refseq:XP_016873278.1|refseq:XP_016873279.1|ensembl:ENSG00000149311(gene)|ensembl:ENST00000452508(transcript)|ensembl:ENST00000675843(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0002331"(pre-B cell allelic exclusion)|go:"GO:0003677"(DNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007165"(signal transduction)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071500"(cellular response to nitrosative stress)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:1904354"(negative regulation of telomere capping)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|go:"GO:1990391"(DNA repair complex)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR015519(Ataxia-Telangiectasia Mutated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021668|interpro:IPR036940|interpro:IPR044107|ensembl:ENST00000278616(transcript)|mint:Q13315|rcsb pdb:5NP0|rcsb pdb:5NP1|rcsb pdb:6HKA|rcsb pdb:6K9K|rcsb pdb:6K9L|reactome:R-HSA-2559586|reactome:R-HSA-3371453|reactome:R-HSA-349425|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803207|reactome:R-HSA-6804756|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-912446|reactome:R-HSA-9664873|reactome:R-HSA-6804757	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:d/FYo7KdBblfR/inXUZpFlWTfoo9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	intact-crc:2D0EFC51AA729925|rigid:9sZNcOFBytE1gJkqEqhRCWymTlM	false	-	sufficient binding region:1-346|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q12888	uniprotkb:Q99986	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6138340|imex:IM-15883-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	intact-crc:2DBDC148E0A43E24|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	glutathione s tranferase tag:?-?|sufficient binding region:1-346	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q99986	-	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	-	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	-	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6138206|imex:IM-15883-4	-	-	psi-mi:"MI:0502"(enzyme target)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	-	-	-	figure legend:1B, 1A|agonist:IR2 Gy increased phosphorylation levels.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	-	intact-crc:547D57C86BEDA791	false	-	-	-	-	psi-mi:"MI:0833"(autoradiography)	-
uniprotkb:Q99986	uniprotkb:Q12888	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6138258|imex:IM-15883-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	intact-crc:D157DAD1B31C00EF|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	glutathione s tranferase tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-346	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q12888	uniprotkb:Q99986	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6139161|imex:IM-15883-12	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	-	-	-	figure legend:2B|comment:Fragment 339-671 showed reduced interaction when compared with fragment 1-346.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	intact-crc:F05BE82629D0B6C1|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	glutathione s tranferase tag:?-?|sufficient binding region:339-671|sufficient binding region:1-346	his tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q99986	uniprotkb:Q12888	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4414144|imex:IM-15883-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	intact-crc:7C631B621D5727B3|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	glutathione s tranferase tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q99986	uniprotkb:Q12888	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4414164|imex:IM-15883-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:1B, 2C, 1A|agonist:IR2 Gy irradiation resulted in increased phosphorylation of the P53 AA1-85 fragment.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	intact-crc:66FBFE78CB59D884|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	-	sufficient binding region:1-346|glutathione s tranferase tag:?-?|sufficient binding region:1-85	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q99986	uniprotkb:Q12888	intact:EBI-1769146|uniprotkb:Q3SYL2|ensembl:ENSP00000216639|ensembl:ENSP00000506151|ensembl:ENSP00000506214|ensembl:ENSP00000506525|ensembl:ENSP00000506648	intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86	psi-mi:vrk1_human(display_long)|uniprotkb:Vaccinia-related kinase 1(gene name synonym)|uniprotkb:VRK1(gene name)|psi-mi:VRK1(display_short)	psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short)	psi-mi:"MI:0096"(pull down)	Sanz-Garcia et al. (2012)	imex:IM-15883|pubmed:22621922	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6138229|imex:IM-15883-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003375.1|ensembl:ENSG00000100749(gene)|ensembl:ENST00000216639(transcript)|ensembl:ENST00000679816(transcript)|ensembl:ENST00000680756(transcript)|ensembl:ENST00000681344(transcript)|ensembl:ENST00000681355(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005795"(Golgi stack)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0035175"("histone kinase activity (H3-S10 specific)")|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051301"(cell division)|go:"GO:0072354"("histone kinase activity (H3-T3 specific)")|go:"GO:0072355"(histone H3-T3 phosphorylation)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q99986|rcsb pdb:2KTY|rcsb pdb:2KUL|rcsb pdb:2LAV|rcsb pdb:2RSV|rcsb pdb:3OP5|rcsb pdb:5UKF|rcsb pdb:5UVF|rcsb pdb:6AC9|rcsb pdb:6BP0|rcsb pdb:6BRU|rcsb pdb:6BTW|rcsb pdb:6BU6|rcsb pdb:6CFM|rcsb pdb:6CMM|rcsb pdb:6CNX|rcsb pdb:6CQH|rcsb pdb:6CSW|rcsb pdb:6DD4|rcsb pdb:6NPN|rcsb pdb:6VXU|rcsb pdb:6VZH|rcsb pdb:7M10|reactome:R-HSA-2980766|reactome:R-HSA-2995383	refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N	-	-	-	figure legend:2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/28	2014/10/16	rogid:yT5v4RDikIcBEDKbg0m9H1el82o9606	rogid:QRksPL7aJniN+0thiLfIdeythoU9606	intact-crc:78CAFA9AD08B087E|rigid:VsA4YOa8aHu9aK67lbZJ013PFjg	false	his tag:?-?	sufficient binding region:956-1354|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)