#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9H6B4 uniprotkb:Q9H6B4 intact:EBI-4314260|ensembl:ENSP00000405577 intact:EBI-4314260|ensembl:ENSP00000405577 psi-mi:clmp_human(display_long)|uniprotkb:CLMP(gene name)|psi-mi:CLMP(display_short)|uniprotkb:ACAM(gene name synonym)|uniprotkb:ASAM(gene name synonym)|uniprotkb:Adipocyte adhesion molecule(gene name synonym)|uniprotkb:Coxsackie- and adenovirus receptor-like membrane protein(gene name synonym)|uniprotkb:UNQ318/PRO363(orf name) psi-mi:clmp_human(display_long)|uniprotkb:CLMP(gene name)|psi-mi:CLMP(display_short)|uniprotkb:ACAM(gene name synonym)|uniprotkb:ASAM(gene name synonym)|uniprotkb:Adipocyte adhesion molecule(gene name synonym)|uniprotkb:Coxsackie- and adenovirus receptor-like membrane protein(gene name synonym)|uniprotkb:UNQ318/PRO363(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314257|imex:IM-15733-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079045.1|ensembl:ENSG00000166250(gene)|ensembl:ENST00000448775(transcript)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048565"(digestive tract development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042454 refseq:NP_079045.1|ensembl:ENSG00000166250(gene)|ensembl:ENST00000448775(transcript)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0048565"(digestive tract development)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042454 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:5.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:cKsAaFSjts9jMlqxWT3qrg/IXmo9606 rogid:cKsAaFSjts9jMlqxWT3qrg/IXmo9606 intact-crc:F9843A8457CDDCED|rigid:Q6p/5T42kGf88y5EjbYacqTGyyk false - fc-igg tag:373-373 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:P33681 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314279|imex:IM-15733-27 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:12.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 intact-crc:484B4FE775EAA558|rigid:dekVHLAYv5FV/AAjOd9C0tdWZRs false - fc-igg tag:288-288 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33681 uniprotkb:P10747 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 intact:EBI-4314301|uniprotkb:Q8WXJ2|uniprotkb:Q52M23|uniprotkb:A8KAC1|uniprotkb:Q8NI56|uniprotkb:Q9BYV0|uniprotkb:Q8NI54|uniprotkb:Q8NI55|uniprotkb:Q13964|uniprotkb:Q70WG0|ensembl:ENSP00000324890 psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:cd28_human(display_long)|uniprotkb:CD28(gene name)|psi-mi:CD28(display_short)|uniprotkb:TP44(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314298|imex:IM-15733-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N refseq:NP_001230006.1|refseq:NP_001230007.1|refseq:NP_006130.1|refseq:XP_011510496.1|refseq:XP_011510499.1|ensembl:ENSG00000178562(gene)|ensembl:ENST00000324106(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006959"(humoral immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR008093(T cell antigen CD28)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1YJD|rcsb pdb:3WA4|rcsb pdb:5AUL|rcsb pdb:5GJH|rcsb pdb:5GJI|rcsb pdb:6O8D|reactome:R-HSA-1257604|reactome:R-HSA-164939|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-6811558|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050852"(T cell receptor signaling pathway)|dip:DIP-6043N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 rogid:hXXImyYy1G/3xoStJWpisi3sIWI9606 intact-crc:F61B89E808050F17|rigid:cFNOHgcI/Oq4Aiw/ReikYtdTGX4 false fc-igg tag:288-288 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33681 uniprotkb:P16410 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653 psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314319|imex:IM-15733-25 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606 intact-crc:E86A49FDA622A173|rigid:9Maubx1fz7zswwgnBtgVx+DUHXE false fc-igg tag:288-288 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314333|imex:IM-15733-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:15.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 intact-crc:064504F073A64C46|rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false fc-igg tag:290-290 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P08138 uniprotkb:P33681 intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym) psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314270|imex:IM-15733-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563 refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:14|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 intact-crc:FC241E63904A1A70|rigid:xIMp+rvT5PMDgYhgshF89BJLrIs false - fc-igg tag:288-288 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P41217 uniprotkb:Q8TD46 intact:EBI-3910563|uniprotkb:Q6J2Q6|uniprotkb:Q9H3J3|uniprotkb:D3DN65|uniprotkb:Q8TB85|uniprotkb:Q6PIQ4|uniprotkb:B3KQI1|uniprotkb:B4DLW9 intact:EBI-4314412|uniprotkb:Q8TD44|uniprotkb:Q6WHB8|uniprotkb:Q6IS95|uniprotkb:Q6UW94|uniprotkb:Q8TD52|uniprotkb:B3KWZ9|uniprotkb:Q8TD45|uniprotkb:Q52LJ7|uniprotkb:E9PCM9|ensembl:ENSP00000311035|ensembl:ENSP00000405733|ensembl:ENSP00000418801|ensembl:ENSP00000418928 psi-mi:ox2g_human(display_long)|uniprotkb:CD200(gene name)|psi-mi:CD200(display_short)|uniprotkb:MOX1(gene name synonym)|uniprotkb:MOX2(gene name synonym)|uniprotkb:My033(orf name) psi-mi:mo2r1_human(display_long)|uniprotkb:CD200R1(gene name)|psi-mi:CD200R1(display_short)|uniprotkb:CD200R(gene name synonym)|uniprotkb:CRTR2(gene name synonym)|uniprotkb:MOX2R(gene name synonym)|uniprotkb:OX2R(gene name synonym)|uniprotkb:CD200 cell surface glycoprotein receptor(gene name synonym)|uniprotkb:Cell surface glycoprotein OX2 receptor 1(gene name synonym)|uniprotkb:UNQ2522/PRO6015(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314424|imex:IM-15733-34 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR036179|refseq:NP_001004196.2|refseq:NP_005935.4|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|reactome:R-HSA-198933|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR033321|refseq:NP_001305757.1|go:"GO:0002695"(negative regulation of leukocyte activation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0044297"(cell body)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140081"(glycosylated region protein binding)|go:"GO:0150072"(positive regulation of arginase activity)|go:"GO:0150074"(positive regulation of protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|refseq:XP_005247539.1 refseq:NP_620161.1|refseq:NP_620385.1|refseq:NP_620386.1|refseq:NP_740750.1|ensembl:ENSG00000163606(gene)|ensembl:ENST00000308611(transcript)|ensembl:ENST00000440122(transcript)|ensembl:ENST00000471858(transcript)|ensembl:ENST00000490004(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019763"(immunoglobulin receptor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0140081"(glycosylated region protein binding)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040012|reactome:R-HSA-198933|go:"GO:0150077"(regulation of neuroinflammatory response) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2021/11/30 rogid:lseLZ4Jnbb7rTJWyGZxVCr5Yy0Y9606 rogid:XHzC1UOKMRt7Yoj8QDB8vMEyC5E9606 intact-crc:3D3BBF42033C4B4D|rigid:e4Ep5c1A8/omePNbFSZtLzWqd6Y false fc-igg tag:278-278 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19256 uniprotkb:P06729 intact:EBI-718785|uniprotkb:Q96KI9|uniprotkb:Q6IB65|uniprotkb:A8K7G5|uniprotkb:Q5U053|ensembl:ENSP00000358501 intact:EBI-3912464|uniprotkb:Q96TE5|ensembl:ENSP00000358490 psi-mi:lfa3_human(display_long)|uniprotkb:Surface glycoprotein LFA-3(gene name synonym)|uniprotkb:CD58(gene name)|psi-mi:CD58(display_short)|uniprotkb:LFA3(gene name synonym) psi-mi:cd2_human(display_long)|uniprotkb:CD2(gene name)|psi-mi:CD2(display_short)|uniprotkb:SRBC(gene name synonym)|uniprotkb:Erythrocyte receptor(gene name synonym)|uniprotkb:LFA-2(gene name synonym)|uniprotkb:LFA-3 receptor(gene name synonym)|uniprotkb:Rosette receptor(gene name synonym)|uniprotkb:T-cell surface antigen T11/Leu-5(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314403|imex:IM-15733-29 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001138294.1|refseq:NP_001770.1|ensembl:ENSG00000116815(gene)|ensembl:ENST00000369489(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015714(Lymphocyte function associated antigen 3)|interpro:IPR036179|rcsb pdb:1CCZ|rcsb pdb:1CI5|rcsb pdb:1QA9|reactome:R-HSA-202733|reactome:R-HSA-6798695 refseq:NP_001758.2|ensembl:ENST00000369478(transcript)|go:"GO:0001766"(membrane raft polarization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030887"(positive regulation of myeloid dendritic cell activation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015632(CD2)|interpro:IPR036179|mint:P06729|rcsb pdb:1CDB|rcsb pdb:1GYA|rcsb pdb:1HNF|rcsb pdb:1L2Z|rcsb pdb:1QA9|rcsb pdb:2J6O|rcsb pdb:2J7I|reactome:R-HSA-202733|ensembl:ENSG00000116824(gene)|refseq:NP_001315538.1 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:5PuDi2hUh+04PO3oBvP1+OeHltE9606 rogid:GN7E4kazkOZr2RuMuSMu5WGrbsE9606 intact-crc:2333940E5DDF2DBA|rigid:LDu5bVflCxuWEUFG9Q+MPKKfSx0 false - fc-igg tag:351-351 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95971 uniprotkb:Q92956 intact:EBI-4314390|uniprotkb:A0A0B4J2A1|uniprotkb:B8PRF2|uniprotkb:Q5T2V6|ensembl:ENSP00000235933|ensembl:ENSP00000358294 intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308 psi-mi:by55_human(display_long)|uniprotkb:CD160(gene name)|psi-mi:CD160(display_short)|uniprotkb:BY55(gene name synonym)|uniprotkb:Natural killer cell receptor BY55(gene name synonym) psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314394|imex:IM-15733-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008984.1|refseq:XP_005272986.1|refseq:XP_011507406.1|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:1900280"(negative regulation of CD4-positive, alpha-beta T cell costimulation)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042385|rcsb pdb:6NG3|rcsb pdb:6NG9|rcsb pdb:6NGG|reactome:R-HSA-198933|go:"GO:0046658"(anchored component of plasma membrane)|ensembl:ENSG00000117281(gene)|ensembl:ENST00000235933(transcript)|ensembl:ENST00000369288(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002857"(positive regulation of natural killer cell mediated immune response to tumor cell)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019900"(kinase binding)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032393"(MHC class I receptor activity)|go:"GO:0032394"(MHC class Ib receptor activity)|go:"GO:0032397"(activating MHC class I receptor activity)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0043323"(positive regulation of natural killer cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity) refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:wXir0GA1xTJ9aeCKBRzrbEPdFNs9606 rogid:h0mNlFr7weiZLHYvGJofgj86y249606 intact-crc:90AC65508060BBB9|rigid:iRkj55TEu7ETEmq62xVYrSV08QE false fc-igg tag:181-181 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q6UX41 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314379|uniprotkb:Q9H730|uniprotkb:A4QMZ8|uniprotkb:B7Z409|uniprotkb:E9PEF6|uniprotkb:E9PG07|uniprotkb:A6NEX6|uniprotkb:B7Z5B1|uniprotkb:F2Z2B2|uniprotkb:F8W712|intact:EBI-28985330|ensembl:ENSP00000342197 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:btnl8_human(display_long)|uniprotkb:BTNL8(gene name)|psi-mi:BTNL8(display_short)|uniprotkb:UNQ702/PRO1347(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314376|imex:IM-15733-31 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:NP_001035552.1|refseq:NP_001153179.1|refseq:NP_001153180.1|refseq:NP_001153181.1|refseq:NP_001153182.1|refseq:NP_079126.1|ensembl:ENST00000231229|ensembl:ENSP00000231229|ensembl:ENSP00000342197|ensembl:ENST00000400707|ensembl:ENSP00000383543|ensembl:ENST00000508408|ensembl:ENSP00000424585|ensembl:ENST00000511704|ensembl:ENSP00000425207|ensembl:ENST00000533815|ensembl:ENSP00000435098|ensembl:ENST00000610640|ensembl:ENSP00000483717|ensembl:ENSG00000113303(gene)|ensembl:ENST00000340184(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043136|reactome:R-HSA-8851680 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:7.3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:Eo+M4bJU2EN6LjZqQ5pPWdiMEvo9606 intact-crc:39260AFB08F6E476|rigid:CT7zYWyNQHw2SFa/xdRIB40i97Y false - fc-igg tag:500-500 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00481 uniprotkb:P04155 intact:EBI-2809309|ensembl:ENSP00000289361|uniprotkb:Q147X5|uniprotkb:A2A278|uniprotkb:Q53F15|uniprotkb:Q99420|uniprotkb:Q0P515|uniprotkb:Q9HCY1|uniprotkb:A8K2C8|uniprotkb:B4DIQ1|uniprotkb:E9PHG8|uniprotkb:B4DRM2|uniprotkb:E9PGB4 intact:EBI-743871|ensembl:ENSP00000291527 psi-mi:bt3a1_human(display_long)|uniprotkb:BTN3A1(gene name)|psi-mi:BTN3A1(display_short)|uniprotkb:BTF5(gene name synonym) psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314367|imex:IM-15733-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000026950(gene)|ensembl:ENST00000289361(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037954|interpro:IPR043136|rcsb pdb:4F80|rcsb pdb:4F9L|rcsb pdb:4F9P|rcsb pdb:4JKW|rcsb pdb:4K55|rcsb pdb:4N7I|rcsb pdb:4N7U|rcsb pdb:4V1P|rcsb pdb:5HM7|rcsb pdb:5LYG|rcsb pdb:5LYK|rcsb pdb:5ZXK|rcsb pdb:6ISM|rcsb pdb:6ITA|rcsb pdb:6J06|rcsb pdb:6XLQ|reactome:R-HSA-8851680|refseq:NP_001138480.1|refseq:NP_001138481.1|refseq:NP_008979.3|refseq:NP_919423.1|refseq:XP_005248891.1 refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:7.4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:Qx4k0aSGUrS7rLeSZzv3QJLmM6o9606 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 intact-crc:34EB949C7B7CDCE3|rigid:oD6CDWJlhMJPPbMJ9GAtS3bCCgM false fc-igg tag:513-513 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P33681 uniprotkb:Q9NZQ7 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314342|imex:IM-15733-35 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 intact-crc:81E514FA02AF81BC|rigid:dekVHLAYv5FV/AAjOd9C0tdWZRs false - fc-igg tag:290-290 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z6A9 uniprotkb:Q92956 intact:EBI-4314354|uniprotkb:Q3B831|uniprotkb:Q6ZNH9|uniprotkb:Q3HS85|ensembl:ENSP00000333919 intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308 psi-mi:btla_human(display_long)|uniprotkb:BTLA(gene name)|psi-mi:BTLA(display_short)|uniprotkb:B- and T-lymphocyte-associated protein(gene name synonym) psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314351|imex:IM-15733-33 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001078826.1|refseq:NP_861445.3|refseq:XP_016861237.1|ensembl:ENSG00000186265(gene)|ensembl:ENST00000334529(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR039257|rcsb pdb:2AW2|rcsb pdb:6NYP|reactome:R-HSA-388841|interpro:IPR007110(Immunoglobulin-like)|dip:DIP-48795N refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:19|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:gbqGbkgr+T4Ch7scsiLAAeMdFPM9606 rogid:h0mNlFr7weiZLHYvGJofgj86y249606 intact-crc:50E0CED3ED9E2B20|rigid:HLU6uOw+CERBrCNrkHg6hsDEfRA false fc-igg tag:289-289 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13688 uniprotkb:Q16568 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 intact:EBI-4314526|uniprotkb:Q6FG92|ensembl:ENSP00000296777 psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:cart_human(display_long)|uniprotkb:CARTPT(gene name)|psi-mi:CARTPT(display_short)|uniprotkb:CART(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314523|imex:IM-15733-37 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N refseq:NP_004282.1|ensembl:ENSG00000164326(gene)|ensembl:ENST00000296777(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030141"(secretory granule)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0070253"(somatostatin secretion)|interpro:IPR009106(CART satiety factor)|interpro:IPR036722|rcsb pdb:1HY9|go:"GO:0001678"(cellular glucose homeostasis) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 rogid:N3PoYTEXZrIrABT6xed52NR63EI9606 intact-crc:DC237C551DC8F632|rigid:0lNFOAVcwK+TVjHNgobz0FMMFO0 false fc-igg tag:526-526 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13688 uniprotkb:P13688 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314514|imex:IM-15733-38 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 intact-crc:80482D565E06A734|rigid:oZd3mo1FZQdlH5dTvmntol8SNe4 false fc-igg tag:526-526 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40199 uniprotkb:P13688 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314478|imex:IM-15733-39 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.9|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 intact-crc:778A11321ADD69D5|rigid:CmTBpPgKoIBRIhA4cUz3WW4eDJw false - fc-igg tag:526-526 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q6UXZ3 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314468|ensembl:ENSP00000364501 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:clm5_human(display_long)|uniprotkb:CD300LD(gene name)|psi-mi:CD300LD(display_short)|uniprotkb:CD300D(gene name synonym)|uniprotkb:CMRF35A4(gene name synonym)|uniprotkb:CD300 antigen-like family member D(gene name synonym)|uniprotkb:CMRF35-A4(gene name synonym)|uniprotkb:UNQ9218/PRO28686(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314465|imex:IM-15733-40 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:NP_001108624.1|ensembl:ENSG00000204345(gene)|ensembl:ENST00000375352(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:4.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:Z44M8MmLNTarCE2prDhXD6/kSPY9606 intact-crc:8652FF32BAF56AD1|rigid:B5VCIF92L6Sy3McBQ7UYE6BS+r8 false - fc-igg tag:194-194 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92692 uniprotkb:Q15762 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314456|imex:IM-15733-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 intact-crc:D2BE825B477C658D|rigid:s377+2gJkdZ6edLsrVDWg3AX3go false - fc-igg tag:336-336 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8TD46 uniprotkb:P41217 intact:EBI-4314412|uniprotkb:Q8TD44|uniprotkb:Q6WHB8|uniprotkb:Q6IS95|uniprotkb:Q6UW94|uniprotkb:Q8TD52|uniprotkb:B3KWZ9|uniprotkb:Q8TD45|uniprotkb:Q52LJ7|uniprotkb:E9PCM9|ensembl:ENSP00000311035|ensembl:ENSP00000405733|ensembl:ENSP00000418801|ensembl:ENSP00000418928 intact:EBI-3910563|uniprotkb:Q6J2Q6|uniprotkb:Q9H3J3|uniprotkb:D3DN65|uniprotkb:Q8TB85|uniprotkb:Q6PIQ4|uniprotkb:B3KQI1|uniprotkb:B4DLW9 psi-mi:mo2r1_human(display_long)|uniprotkb:CD200R1(gene name)|psi-mi:CD200R1(display_short)|uniprotkb:CD200R(gene name synonym)|uniprotkb:CRTR2(gene name synonym)|uniprotkb:MOX2R(gene name synonym)|uniprotkb:OX2R(gene name synonym)|uniprotkb:CD200 cell surface glycoprotein receptor(gene name synonym)|uniprotkb:Cell surface glycoprotein OX2 receptor 1(gene name synonym)|uniprotkb:UNQ2522/PRO6015(orf name) psi-mi:ox2g_human(display_long)|uniprotkb:CD200(gene name)|psi-mi:CD200(display_short)|uniprotkb:MOX1(gene name synonym)|uniprotkb:MOX2(gene name synonym)|uniprotkb:My033(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314433|imex:IM-15733-36 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620161.1|refseq:NP_620385.1|refseq:NP_620386.1|refseq:NP_740750.1|ensembl:ENSG00000163606(gene)|ensembl:ENST00000308611(transcript)|ensembl:ENST00000440122(transcript)|ensembl:ENST00000471858(transcript)|ensembl:ENST00000490004(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019763"(immunoglobulin receptor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0140081"(glycosylated region protein binding)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040012|reactome:R-HSA-198933|go:"GO:0150077"(regulation of neuroinflammatory response) interpro:IPR036179|refseq:NP_001004196.2|refseq:NP_005935.4|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|reactome:R-HSA-198933|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR033321|refseq:NP_001305757.1|go:"GO:0002695"(negative regulation of leukocyte activation)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030424"(axon)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0044297"(cell body)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140081"(glycosylated region protein binding)|go:"GO:0150072"(positive regulation of arginase activity)|go:"GO:0150074"(positive regulation of protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|refseq:XP_005247539.1 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:15|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2021/11/30 rogid:XHzC1UOKMRt7Yoj8QDB8vMEyC5E9606 rogid:lseLZ4Jnbb7rTJWyGZxVCr5Yy0Y9606 intact-crc:9D896750CA0CC22F|rigid:e4Ep5c1A8/omePNbFSZtLzWqd6Y false fc-igg tag:325-325 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P15151 uniprotkb:Q15762 intact:EBI-3919694|uniprotkb:Q96BJ1|uniprotkb:Q15268|uniprotkb:Q15267|uniprotkb:P15152|uniprotkb:B4DTS9 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 psi-mi:pvr_human(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)|uniprotkb:Nectin-like protein 5(gene name synonym) psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314447|imex:IM-15733-42 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001618"(virus receptor activity)|mint:P15151|refseq:NP_001129240.1|refseq:NP_001129241.1|refseq:NP_006496.4|refseq:NP_001129242.2|dip:DIP-43987N|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DGI|rcsb pdb:1NN8|rcsb pdb:3EPC|rcsb pdb:3EPD|rcsb pdb:3EPF|rcsb pdb:3J8F|rcsb pdb:3J9F|rcsb pdb:3UDW|rcsb pdb:3URO|rcsb pdb:4FQP|rcsb pdb:6ARQ|rcsb pdb:6ISC|rcsb pdb:6O3O|reactome:R-HSA-198933|reactome:R-HSA-420597 refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10.3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:PsTFmeD+9vG6ieNef6MupXts60g9606 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 intact-crc:3673E71F5764A0AB|rigid:lHpaVMYVq+DrIgYv/0zBKn4xsdY false - fc-igg tag:336-336 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q14002 uniprotkb:P13688 intact:EBI-4314552|uniprotkb:O15149|uniprotkb:A8K848|uniprotkb:Q0VAC1|uniprotkb:O15148|uniprotkb:Q9UPJ2|uniprotkb:Q13983|ensembl:ENSP00000006724|ensembl:ENSP00000385932 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 psi-mi:ceam7_human(display_long)|uniprotkb:CEACAM7(gene name)|psi-mi:CEACAM7(display_short)|uniprotkb:CGM2(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM2(gene name synonym) psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314562|imex:IM-15733-47 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278414.1|refseq:NP_008821.2|ensembl:ENSG00000007306(gene)|ensembl:ENST00000006724(transcript)|ensembl:ENST00000401731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4Y89|reactome:R-HSA-163125 refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:bZ66uh+fy2EfNS0DxVaNKsuTaVs9606 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 intact-crc:310634F7329978D1|rigid:mSX7uohwkftox4ecskJMrIBhZi0 false - fc-igg tag:526-526 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13688 uniprotkb:P06731 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314571|imex:IM-15733-46 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:4.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 intact-crc:D8471426A3575262|rigid:9Gm/f2zzveVe94xMXHWscy4HG48 false fc-igg tag:526-526 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40199 uniprotkb:P31997 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336 psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314580|imex:IM-15733-45 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:16|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606 intact-crc:63790BBEB3D96F51|rigid:sJKDadsUMUiHPno0tackSfMOThA false fc-igg tag:344-344 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16568 uniprotkb:P40199 intact:EBI-4314526|uniprotkb:Q6FG92|ensembl:ENSP00000296777 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 psi-mi:cart_human(display_long)|uniprotkb:CARTPT(gene name)|psi-mi:CARTPT(display_short)|uniprotkb:CART(gene name synonym) psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314589|imex:IM-15733-44 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004282.1|ensembl:ENSG00000164326(gene)|ensembl:ENST00000296777(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030141"(secretory granule)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0070253"(somatostatin secretion)|interpro:IPR009106(CART satiety factor)|interpro:IPR036722|rcsb pdb:1HY9|go:"GO:0001678"(cellular glucose homeostasis) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:15.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:N3PoYTEXZrIrABT6xed52NR63EI9606 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 intact-crc:3F9573A44EC71211|rigid:g7bIu7kE8dUTlyO6smArGdCpB7c false - fc-igg tag:344-344 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40199 uniprotkb:P13688 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314598|imex:IM-15733-43 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:15.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 intact-crc:3DC85F3C916207F4|rigid:CmTBpPgKoIBRIhA4cUz3WW4eDJw false fc-igg tag:344-344 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40199 uniprotkb:P40199 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314607|imex:IM-15733-49 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:14.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 intact-crc:B92ED59899C0078E|rigid:hLr35VjnxfD1Fpy8eZ1GNw5VTdo false fc-igg tag:344-344 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P13688 uniprotkb:P31997 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 intact:EBI-4314540|uniprotkb:Q16574|uniprotkb:O60399|ensembl:ENSP00000244336 psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:ceam8_human(display_long)|uniprotkb:CEACAM8(gene name)|psi-mi:CEACAM8(display_short)|uniprotkb:CGM6(gene name synonym)|uniprotkb:CD67 antigen(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM6(gene name synonym)|uniprotkb:Non-specific cross-reacting antigen NCA-95(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314537|imex:IM-15733-48 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N refseq:NP_001807.2|refseq:XP_016881684.1|rcsb pdb:4WTZ|rcsb pdb:4Y88|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|ensembl:ENST00000244336(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|ensembl:ENSG00000124469(gene)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2DKS psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 rogid:Sjvo2g6fbY4WtimUow7WDjufA/c9606 intact-crc:702F654F18F52B2E|rigid:Q83w7RxId9BwMSFoc0qwFsRRFgI false fc-igg tag:526-526 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P78310 uniprotkb:P78310 intact:EBI-747931|uniprotkb:O00694|uniprotkb:Q8WWT6|uniprotkb:Q8WWT7|uniprotkb:Q8WWT8|uniprotkb:Q9UKV4|ensembl:ENSP00000284878|uniprotkb:B2R8V8|uniprotkb:B7WPI3|uniprotkb:D3YHP0 intact:EBI-747931|uniprotkb:O00694|uniprotkb:Q8WWT6|uniprotkb:Q8WWT7|uniprotkb:Q8WWT8|uniprotkb:Q9UKV4|ensembl:ENSP00000284878|uniprotkb:B2R8V8|uniprotkb:B7WPI3|uniprotkb:D3YHP0 psi-mi:cxar_human(display_long)|uniprotkb:Coxsackievirus B-adenovirus receptor(gene name synonym)|uniprotkb:HCVADR(gene name synonym)|uniprotkb:CVB3-binding protein(gene name synonym)|uniprotkb:CXADR(gene name)|psi-mi:CXADR(display_short)|uniprotkb:CAR(gene name synonym) psi-mi:cxar_human(display_long)|uniprotkb:Coxsackievirus B-adenovirus receptor(gene name synonym)|uniprotkb:HCVADR(gene name synonym)|uniprotkb:CVB3-binding protein(gene name synonym)|uniprotkb:CXADR(gene name)|psi-mi:CXADR(display_short)|uniprotkb:CAR(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314661|imex:IM-15733-56 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001329.1|refseq:NP_001193992.1|refseq:NP_001193993.1|refseq:NP_001193994.1|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070633"(transepithelial transport)|ensembl:ENSG00000154639(gene)|go:"GO:0071253"(connexin binding)|ensembl:ENST00000284878(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|refseq:XP_011527781.1|refseq:NP_001193995.1|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EAJ|rcsb pdb:1F5W|rcsb pdb:1JEW|rcsb pdb:1KAC|rcsb pdb:1P69|rcsb pdb:1P6A|rcsb pdb:1RSF|rcsb pdb:2J12|rcsb pdb:2J1K|rcsb pdb:2NPL|rcsb pdb:2W9L|rcsb pdb:2WBW|rcsb pdb:3J6L|rcsb pdb:3J6M|rcsb pdb:3J6N|rcsb pdb:3J6O|rcsb pdb:7DPZ|rcsb pdb:7DQ1|reactome:R-HSA-198933|reactome:R-HSA-202733 refseq:NP_001329.1|refseq:NP_001193992.1|refseq:NP_001193993.1|refseq:NP_001193994.1|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070633"(transepithelial transport)|ensembl:ENSG00000154639(gene)|go:"GO:0071253"(connexin binding)|ensembl:ENST00000284878(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|refseq:XP_011527781.1|refseq:NP_001193995.1|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EAJ|rcsb pdb:1F5W|rcsb pdb:1JEW|rcsb pdb:1KAC|rcsb pdb:1P69|rcsb pdb:1P6A|rcsb pdb:1RSF|rcsb pdb:2J12|rcsb pdb:2J1K|rcsb pdb:2NPL|rcsb pdb:2W9L|rcsb pdb:2WBW|rcsb pdb:3J6L|rcsb pdb:3J6M|rcsb pdb:3J6N|rcsb pdb:3J6O|rcsb pdb:7DPZ|rcsb pdb:7DQ1|reactome:R-HSA-198933|reactome:R-HSA-202733 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:5.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:rISYMOJkhS94FeOElTtG8w5p4hI9606 rogid:rISYMOJkhS94FeOElTtG8w5p4hI9606 intact-crc:3473682F770A0A99|rigid:GWv+pd0U//tbeejNjE8N/JGsfhM false - fc-igg tag:365-365 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40199 uniprotkb:Q14002 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 intact:EBI-4314552|uniprotkb:O15149|uniprotkb:A8K848|uniprotkb:Q0VAC1|uniprotkb:O15148|uniprotkb:Q9UPJ2|uniprotkb:Q13983|ensembl:ENSP00000006724|ensembl:ENSP00000385932 psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:ceam7_human(display_long)|uniprotkb:CEACAM7(gene name)|psi-mi:CEACAM7(display_short)|uniprotkb:CGM2(gene name synonym)|uniprotkb:Carcinoembryonic antigen CGM2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314616|imex:IM-15733-53 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) refseq:NP_001278414.1|refseq:NP_008821.2|ensembl:ENSG00000007306(gene)|ensembl:ENST00000006724(transcript)|ensembl:ENST00000401731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4Y89|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 rogid:bZ66uh+fy2EfNS0DxVaNKsuTaVs9606 intact-crc:8AA708B0D8439FB0|rigid:bxRIllCl4fCet4teWRO4l7jR53U false fc-igg tag:344-344 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:P40199 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314625|imex:IM-15733-52 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 intact-crc:0E212337B6F9B826|rigid:jSzXkcWlBYzLCiLU3j/u2Yu+70Q false - fc-igg tag:344-344 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16410 uniprotkb:P42081 intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653 intact:EBI-1030956|uniprotkb:A0N0P0|uniprotkb:Q13655|uniprotkb:Q6FHB1|uniprotkb:Q6GTS4|uniprotkb:Q7M4L5|ensembl:ENSP00000332049|uniprotkb:B7Z2F3|uniprotkb:B7Z702|uniprotkb:E7ETN5|uniprotkb:E9PC27 psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym) psi-mi:cd86_human(display_long)|uniprotkb:CD86(gene name)|psi-mi:CD86(display_short)|uniprotkb:CD28LG2(gene name synonym)|uniprotkb:Activation B7-2 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.2(gene name synonym)|uniprotkb:B70(gene name synonym)|uniprotkb:FUN-1(gene name synonym)|uniprotkb:BU63(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314634|imex:IM-15733-51 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|ensembl:ENSG00000114013(gene)|ensembl:ENST00000330540(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032761"(positive regulation of lymphotoxin A production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042113"(B cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037677|rcsb pdb:1I85|rcsb pdb:1NCN|rcsb pdb:5YXK|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|refseq:NP_001193853.1|refseq:NP_001193854.1|refseq:NP_008820.3|refseq:NP_787058.4|refseq:NP_795711.1|dip:DIP-35606N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:7.3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606 rogid:VMDr9AcMwoSX2JyeGy7C0IcHXnY9606 intact-crc:FEAF714430F5A4EC|rigid:v01YRYbnjRx9qgVVGBEQn9vwRKI false fc-igg tag:223-223 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P16410 uniprotkb:P33681 intact:EBI-1030991|uniprotkb:Q53TD5|uniprotkb:Q8WXJ1|uniprotkb:Q96P43|uniprotkb:Q9UKN9|ensembl:ENSP00000497102|uniprotkb:A0N1S0|uniprotkb:E9PDH0|uniprotkb:Q0PP65|uniprotkb:Q52MC1|uniprotkb:Q5S005|uniprotkb:O95653 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 psi-mi:ctla4_human(display_long)|uniprotkb:CTLA4(gene name)|psi-mi:CTLA4(display_short)|uniprotkb:CD152(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte-associated antigen 4(gene name synonym) psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314643|imex:IM-15733-50 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000648405(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|ensembl:ENSG00000163599(gene)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR008096(Cytotoxic T-lymphocyte antigen 4)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1AH1|rcsb pdb:1H6E|rcsb pdb:1I85|rcsb pdb:1I8L|rcsb pdb:2X44|rcsb pdb:3BX7|rcsb pdb:3OSK|rcsb pdb:5GGV|rcsb pdb:5TRU|rcsb pdb:5XJ3|rcsb pdb:6RP8|rcsb pdb:6RPJ|rcsb pdb:6RQM|rcsb pdb:6XY2|rcsb pdb:7CIO|rcsb pdb:7ELX|reactome:R-HSA-389513|reactome:R-HSA-8877330|refseq:NP_001032720.1|refseq:NP_005205.2|dip:DIP-35607N refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:PeBR/2EG/cFzR4DKWuX80TsgBw49606 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 intact-crc:FC96F68E816BE037|rigid:9Maubx1fz7zswwgnBtgVx+DUHXE false fc-igg tag:223-223 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P78310 uniprotkb:Q86YT9 intact:EBI-747931|uniprotkb:O00694|uniprotkb:Q8WWT6|uniprotkb:Q8WWT7|uniprotkb:Q8WWT8|uniprotkb:Q9UKV4|ensembl:ENSP00000284878|uniprotkb:B2R8V8|uniprotkb:B7WPI3|uniprotkb:D3YHP0 intact:EBI-2816560|uniprotkb:Q496M1|uniprotkb:Q8NF70|uniprotkb:Q8N9I7|uniprotkb:Q7Z499|uniprotkb:B0YIV1|uniprotkb:B0YIV2|uniprotkb:Q5DTC6|ensembl:ENSP00000348635 psi-mi:cxar_human(display_long)|uniprotkb:Coxsackievirus B-adenovirus receptor(gene name synonym)|uniprotkb:HCVADR(gene name synonym)|uniprotkb:CVB3-binding protein(gene name synonym)|uniprotkb:CXADR(gene name)|psi-mi:CXADR(display_short)|uniprotkb:CAR(gene name synonym) psi-mi:jaml_human(display_long)|uniprotkb:JAML(gene name)|psi-mi:JAML(display_short)|uniprotkb:AMICA1(gene name synonym)|uniprotkb:Adhesion molecule interacting with CXADR antigen 1(gene name synonym)|uniprotkb:Dendritic cell-specific protein CREA7-1(gene name synonym)|uniprotkb:UNQ722/PRO1387(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314652|imex:IM-15733-54 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001329.1|refseq:NP_001193992.1|refseq:NP_001193993.1|refseq:NP_001193994.1|go:"GO:0045121"(membrane raft)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070633"(transepithelial transport)|ensembl:ENSG00000154639(gene)|go:"GO:0071253"(connexin binding)|ensembl:ENST00000284878(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008354"(germ cell migration)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0014704"(intercalated disc)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|refseq:XP_011527781.1|refseq:NP_001193995.1|go:"GO:0086067"(AV node cell to bundle of His cell communication)|go:"GO:0086072"(AV node cell-bundle of His cell adhesion involved in cell communication)|go:"GO:0086082"(cell adhesive protein binding involved in AV node cell-bundle of His cell communication)|go:"GO:0098904"(regulation of AV node cell action potential)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1EAJ|rcsb pdb:1F5W|rcsb pdb:1JEW|rcsb pdb:1KAC|rcsb pdb:1P69|rcsb pdb:1P6A|rcsb pdb:1RSF|rcsb pdb:2J12|rcsb pdb:2J1K|rcsb pdb:2NPL|rcsb pdb:2W9L|rcsb pdb:2WBW|rcsb pdb:3J6L|rcsb pdb:3J6M|rcsb pdb:3J6N|rcsb pdb:3J6O|rcsb pdb:7DPZ|rcsb pdb:7DQ1|reactome:R-HSA-198933|reactome:R-HSA-202733 refseq:NP_001273500.1|refseq:NP_001091996.1|refseq:NP_694938.2|refseq:NP_001273499.1|ensembl:ENSG00000160593(gene)|ensembl:ENST00000356289(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060054"(positive regulation of epithelial cell proliferation involved in wound healing)|go:"GO:0072672"(neutrophil extravasation)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029871|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-202733 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:5.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:rISYMOJkhS94FeOElTtG8w5p4hI9606 rogid:YIYLdTPIX+q/c0mPOTVUhT0vNUA9606 intact-crc:2502393180EBBA74|rigid:zjc9DnDXo45fDd7hj9iV5COMfZU false fc-igg tag:365-365 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96AP7 uniprotkb:Q96AP7 intact:EBI-4314670|uniprotkb:Q96T50|uniprotkb:B4DVN8|ensembl:ENSP00000278927 intact:EBI-4314670|uniprotkb:Q96T50|uniprotkb:B4DVN8|ensembl:ENSP00000278927 psi-mi:esam_human(display_long)|uniprotkb:ESAM(gene name)|psi-mi:ESAM(display_short)|uniprotkb:UNQ220/PRO246(orf name) psi-mi:esam_human(display_long)|uniprotkb:ESAM(gene name)|psi-mi:ESAM(display_short)|uniprotkb:UNQ220/PRO246(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314675|imex:IM-15733-55 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_620411.2|ensembl:ENSG00000149564(gene)|ensembl:ENST00000278927(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042757|reactome:R-HSA-202733|go:"GO:0070830"(bicellular tight junction assembly) refseq:NP_620411.2|ensembl:ENSG00000149564(gene)|ensembl:ENST00000278927(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042757|reactome:R-HSA-202733|go:"GO:0070830"(bicellular tight junction assembly) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:UHG5qvwlMzactPnrryZQcnEGzIs9606 rogid:UHG5qvwlMzactPnrryZQcnEGzIs9606 intact-crc:A7C46D61C6667636|rigid:tl3UMSskCeqxujMfreAhlKD8iME false fc-igg tag:390-390 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PJ5 uniprotkb:P04155 intact:EBI-4314687|uniprotkb:Q96RE0|uniprotkb:Q96PJ3|ensembl:ENSP00000271532 intact:EBI-743871|ensembl:ENSP00000291527 psi-mi:fcrl4_human(display_long)|uniprotkb:FCRL4(gene name)|psi-mi:FCRL4(display_short)|uniprotkb:FCRH4(gene name synonym)|uniprotkb:IFGP2(gene name synonym)|uniprotkb:IRTA1(gene name synonym)|uniprotkb:Fc receptor homolog 4(gene name synonym)|uniprotkb:IFGP family protein 2(gene name synonym)|uniprotkb:Immune receptor translocation-associated protein 1(gene name synonym) psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314684|imex:IM-15733-59 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112572.1|ensembl:ENSG00000163518(gene)|ensembl:ENST00000271532(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:4roUvQm/vS0uROX51uF7KYoPo5g9606 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 intact-crc:9FEA6A9669770910|rigid:PzZPxtieBxfkIhOQs79I7Ugn5tQ false fc-igg tag:515-515 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BX67 uniprotkb:P57087 intact:EBI-4314733|uniprotkb:Q8WWL8|uniprotkb:Q96FL1|uniprotkb:B3KWG9|ensembl:ENSP00000299106 intact:EBI-3918416|ensembl:ENSP00000420419|uniprotkb:B2R6T9|uniprotkb:Q6UXG6|uniprotkb:Q6YNC1|uniprotkb:B4DGT9 psi-mi:jam3_human(display_long)|uniprotkb:JAM3(gene name)|psi-mi:JAM3(display_short)|uniprotkb:JAM-2(gene name synonym)|uniprotkb:Junctional adhesion molecule 3(gene name synonym)|uniprotkb:UNQ859/PRO1868(orf name) psi-mi:jam2_human(display_long)|uniprotkb:JAM2(gene name)|psi-mi:JAM2(display_short)|uniprotkb:C21orf43(gene name synonym)|uniprotkb:VEJAM(gene name synonym)|uniprotkb:Junctional adhesion molecule 2(gene name synonym)|uniprotkb:Vascular endothelial junction-associated molecule(gene name synonym)|uniprotkb:UNQ219/PRO245(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314730|imex:IM-15733-58 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116190.3|refseq:NP_001192258.1|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030057"(desmosome)|go:"GO:0031103"(axon regeneration)|go:"GO:0031941"(filamentous actin)|go:"GO:0033010"(paranodal junction)|go:"GO:0033624"(negative regulation of integrin activation)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045176"(apical protein localization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070160"(tight junction)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:0090138"(regulation of actin cytoskeleton organization by cell-cell adhesion)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905710"(positive regulation of membrane permeability)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042974|mint:Q9BX67|reactome:R-HSA-202733|reactome:R-HSA-216083|ensembl:ENSG00000166086(gene)|ensembl:ENST00000299106(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0002250"(adaptive immune response) ensembl:ENSG00000154721(gene)|ensembl:ENST00000480456(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007286"(spermatid development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045123"(cellular extravasation)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070160"(tight junction)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:2000403"(positive regulation of lymphocyte migration)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042625|mint:P57087|reactome:R-HSA-202733|reactome:R-HSA-216083|refseq:NP_067042.1|refseq:NP_001257337.1|refseq:NP_001257336.1 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:12.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:EQBYrNTCG/k3qICRf5Yk89PZfGU9606 rogid:Mx7EwHDBvAswRaXWfK84V7MoDP89606 intact-crc:01AEF047B0F1FCDA|rigid:wodmJXvsmnd4TuASaQAxAobueyk false - fc-igg tag:298-298 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P57087 uniprotkb:P57087 intact:EBI-3918416|ensembl:ENSP00000420419|uniprotkb:B2R6T9|uniprotkb:Q6UXG6|uniprotkb:Q6YNC1|uniprotkb:B4DGT9 intact:EBI-3918416|ensembl:ENSP00000420419|uniprotkb:B2R6T9|uniprotkb:Q6UXG6|uniprotkb:Q6YNC1|uniprotkb:B4DGT9 psi-mi:jam2_human(display_long)|uniprotkb:JAM2(gene name)|psi-mi:JAM2(display_short)|uniprotkb:C21orf43(gene name synonym)|uniprotkb:VEJAM(gene name synonym)|uniprotkb:Junctional adhesion molecule 2(gene name synonym)|uniprotkb:Vascular endothelial junction-associated molecule(gene name synonym)|uniprotkb:UNQ219/PRO245(orf name) psi-mi:jam2_human(display_long)|uniprotkb:JAM2(gene name)|psi-mi:JAM2(display_short)|uniprotkb:C21orf43(gene name synonym)|uniprotkb:VEJAM(gene name synonym)|uniprotkb:Junctional adhesion molecule 2(gene name synonym)|uniprotkb:Vascular endothelial junction-associated molecule(gene name synonym)|uniprotkb:UNQ219/PRO245(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314745|imex:IM-15733-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154721(gene)|ensembl:ENST00000480456(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007286"(spermatid development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045123"(cellular extravasation)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070160"(tight junction)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:2000403"(positive regulation of lymphocyte migration)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042625|mint:P57087|reactome:R-HSA-202733|reactome:R-HSA-216083|refseq:NP_067042.1|refseq:NP_001257337.1|refseq:NP_001257336.1 ensembl:ENSG00000154721(gene)|ensembl:ENST00000480456(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007286"(spermatid development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045123"(cellular extravasation)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070160"(tight junction)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:2000403"(positive regulation of lymphocyte migration)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042625|mint:P57087|reactome:R-HSA-202733|reactome:R-HSA-216083|refseq:NP_067042.1|refseq:NP_001257337.1|refseq:NP_001257336.1 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:7.5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:Mx7EwHDBvAswRaXWfK84V7MoDP89606 rogid:Mx7EwHDBvAswRaXWfK84V7MoDP89606 intact-crc:1D6D328A01809847|rigid:k4m0WfBZCmYR7an8vUXLzpIKfhM false fc-igg tag:298-298 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5DX21 uniprotkb:Q5DX21 intact:EBI-4314713|uniprotkb:C9JZN0|uniprotkb:Q8N4F1|uniprotkb:Q8NDD2|uniprotkb:Q8N7T8|ensembl:ENSP00000377370 intact:EBI-4314713|uniprotkb:C9JZN0|uniprotkb:Q8N4F1|uniprotkb:Q8NDD2|uniprotkb:Q8N7T8|ensembl:ENSP00000377370 psi-mi:igs11_human(display_long)|uniprotkb:IGSF11(gene name)|psi-mi:IGSF11(display_short)|uniprotkb:BTIGSF(gene name synonym)|uniprotkb:CXADRL1(gene name synonym)|uniprotkb:VSIG3(gene name synonym)|uniprotkb:Brain and testis-specific immunoglobulin superfamily protein(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 3(gene name synonym) psi-mi:igs11_human(display_long)|uniprotkb:IGSF11(gene name)|psi-mi:IGSF11(display_short)|uniprotkb:BTIGSF(gene name synonym)|uniprotkb:CXADRL1(gene name synonym)|uniprotkb:VSIG3(gene name synonym)|uniprotkb:Brain and testis-specific immunoglobulin superfamily protein(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314721|imex:IM-15733-61 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001015887.1|refseq:NP_689751.2|refseq:XP_011510772.1|refseq:XP_011510774.1|refseq:XP_011510771.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042758|ensembl:ENSG00000144847(gene)|ensembl:ENST00000393775(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0014069"(postsynaptic density) refseq:NP_001015887.1|refseq:NP_689751.2|refseq:XP_011510772.1|refseq:XP_011510774.1|refseq:XP_011510771.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042758|ensembl:ENSG00000144847(gene)|ensembl:ENST00000393775(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0014069"(postsynaptic density) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:QtUCO0H3xHVhT0BxYqYqhCa97nc9606 rogid:QtUCO0H3xHVhT0BxYqYqhCa97nc9606 intact-crc:52199496E3932BB8|rigid:5j8ARecXZKWFSm315xbEJY0BDgk false fc-igg tag:431-431 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PJ5 uniprotkb:Q03403 intact:EBI-4314687|uniprotkb:Q96RE0|uniprotkb:Q96PJ3|ensembl:ENSP00000271532 intact:EBI-4314702|uniprotkb:Q15854|ensembl:ENSP00000291526 psi-mi:fcrl4_human(display_long)|uniprotkb:FCRL4(gene name)|psi-mi:FCRL4(display_short)|uniprotkb:FCRH4(gene name synonym)|uniprotkb:IFGP2(gene name synonym)|uniprotkb:IRTA1(gene name synonym)|uniprotkb:Fc receptor homolog 4(gene name synonym)|uniprotkb:IFGP family protein 2(gene name synonym)|uniprotkb:Immune receptor translocation-associated protein 1(gene name synonym) psi-mi:tff2_human(display_long)|uniprotkb:TFF2(gene name)|psi-mi:TFF2(display_short)|uniprotkb:SML1(gene name synonym)|uniprotkb:Spasmolysin(gene name synonym)|uniprotkb:Spasmolytic polypeptide(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314699|imex:IM-15733-60 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112572.1|ensembl:ENSG00000163518(gene)|ensembl:ENST00000271532(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 refseq:NP_005414.1|ensembl:ENSG00000160181(gene)|ensembl:ENST00000291526(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0031723"(CXCR4 chemokine receptor binding)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:4roUvQm/vS0uROX51uF7KYoPo5g9606 rogid:8r4uay1usoNmDm2uNdZTK2Iglqc9606 intact-crc:179300185765CDC8|rigid:pIHysof2DOlLBQwtK2L0orej5Kw false fc-igg tag:515-515 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q495A1 uniprotkb:Q96NY8 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-4314784|uniprotkb:Q96K15|uniprotkb:B4DQW3|ensembl:ENSP00000356991 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:nect4_human(display_long)|uniprotkb:NECTIN4(gene name)|psi-mi:NECTIN4(display_short)|uniprotkb:Ig superfamily receptor LNIR(gene name synonym)|uniprotkb:LNIR(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 4(gene name synonym)|uniprotkb:PRR4(gene name synonym)|uniprotkb:PVRL4(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 4(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314804|imex:IM-15733-66 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 refseq:NP_112178.2|ensembl:ENSG00000143217(gene)|ensembl:ENST00000368012(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033320|interpro:IPR036179|rcsb pdb:4FRW|rcsb pdb:4GJT|rcsb pdb:4JJH|reactome:R-HSA-418990|reactome:R-HSA-420597|dip:DIP-41492N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:4.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:xh33OK0Z4RsYD8uJZYbmnGfs/TQ9606 intact-crc:976D2BD5E15F545B|rigid:bheluMUmLx+bfcAzg9g+dfy+qJc false - fc-igg tag:510-510 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92692 uniprotkb:Q96NY8 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 intact:EBI-4314784|uniprotkb:Q96K15|uniprotkb:B4DQW3|ensembl:ENSP00000356991 psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:nect4_human(display_long)|uniprotkb:NECTIN4(gene name)|psi-mi:NECTIN4(display_short)|uniprotkb:Ig superfamily receptor LNIR(gene name synonym)|uniprotkb:LNIR(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 4(gene name synonym)|uniprotkb:PRR4(gene name synonym)|uniprotkb:PVRL4(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 4(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314795|imex:IM-15733-62 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N refseq:NP_112178.2|ensembl:ENSG00000143217(gene)|ensembl:ENST00000368012(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033320|interpro:IPR036179|rcsb pdb:4FRW|rcsb pdb:4GJT|rcsb pdb:4JJH|reactome:R-HSA-418990|reactome:R-HSA-420597|dip:DIP-41492N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 rogid:xh33OK0Z4RsYD8uJZYbmnGfs/TQ9606 intact-crc:2D8B7B05D993AD04|rigid:JIxzTnlbsV8iryp0QMid7Bnhaas false - fc-igg tag:510-510 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96NY8 uniprotkb:Q15223 intact:EBI-4314784|uniprotkb:Q96K15|uniprotkb:B4DQW3|ensembl:ENSP00000356991 intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 psi-mi:nect4_human(display_long)|uniprotkb:NECTIN4(gene name)|psi-mi:NECTIN4(display_short)|uniprotkb:Ig superfamily receptor LNIR(gene name synonym)|uniprotkb:LNIR(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 4(gene name synonym)|uniprotkb:PRR4(gene name synonym)|uniprotkb:PVRL4(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 4(gene name synonym) psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314781|imex:IM-15733-63 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112178.2|ensembl:ENSG00000143217(gene)|ensembl:ENST00000368012(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033320|interpro:IPR036179|rcsb pdb:4FRW|rcsb pdb:4GJT|rcsb pdb:4JJH|reactome:R-HSA-418990|reactome:R-HSA-420597|dip:DIP-41492N refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:11.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xh33OK0Z4RsYD8uJZYbmnGfs/TQ9606 rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 intact-crc:C2748E9E14D87C46|rigid:hRMxaFNfMrQX1Np++7ViMPL0jdQ false fc-igg tag:510-510 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6GTX8 uniprotkb:Q6GTX8 intact:EBI-965864|ensembl:ENSP00000301193|ensembl:ENSP00000375622|ensembl:ENSP00000418998|ensembl:ENSP00000479133|ensembl:ENSP00000479682|ensembl:ENSP00000479707 intact:EBI-965864|ensembl:ENSP00000301193|ensembl:ENSP00000375622|ensembl:ENSP00000418998|ensembl:ENSP00000479133|ensembl:ENSP00000479682|ensembl:ENSP00000479707 psi-mi:lair1_human(display_long)|uniprotkb:LAIR1(gene name)|psi-mi:LAIR1(display_short)|uniprotkb:CD305(gene name synonym) psi-mi:lair1_human(display_long)|uniprotkb:LAIR1(gene name)|psi-mi:LAIR1(display_short)|uniprotkb:CD305(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314772|imex:IM-15733-64 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275954.2|ensembl:ENSG00000167613(gene)|ensembl:ENSG00000274110(gene)|ensembl:ENSG00000276053(gene)|ensembl:ENSG00000278154(gene)|ensembl:ENST00000348231(transcript)|ensembl:ENST00000391742(transcript)|ensembl:ENST00000474878(transcript)|ensembl:ENST00000616612(transcript)|ensembl:ENST00000618434(transcript)|ensembl:ENST00000619717(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KGR|rcsb pdb:3RP1|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001275952.2|refseq:NP_002278.2|refseq:NP_068352.2 refseq:NP_001275954.2|ensembl:ENSG00000167613(gene)|ensembl:ENSG00000274110(gene)|ensembl:ENSG00000276053(gene)|ensembl:ENSG00000278154(gene)|ensembl:ENST00000348231(transcript)|ensembl:ENST00000391742(transcript)|ensembl:ENST00000474878(transcript)|ensembl:ENST00000616612(transcript)|ensembl:ENST00000618434(transcript)|ensembl:ENST00000619717(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3KGR|rcsb pdb:3RP1|reactome:R-HSA-198933|reactome:R-HSA-6798695|refseq:NP_001275952.2|refseq:NP_002278.2|refseq:NP_068352.2 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:uwpvGL79EvmpZPhLt+8D+cq8x/c9606 rogid:uwpvGL79EvmpZPhLt+8D+cq8x/c9606 intact-crc:3DBC1A8FDC49548E|rigid:nsltI468rTUJkFlTf/4fqt6Qv0I false fc-igg tag:287-287 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P57087 uniprotkb:Q9BX67 intact:EBI-3918416|ensembl:ENSP00000420419|uniprotkb:B2R6T9|uniprotkb:Q6UXG6|uniprotkb:Q6YNC1|uniprotkb:B4DGT9 intact:EBI-4314733|uniprotkb:Q8WWL8|uniprotkb:Q96FL1|uniprotkb:B3KWG9|ensembl:ENSP00000299106 psi-mi:jam2_human(display_long)|uniprotkb:JAM2(gene name)|psi-mi:JAM2(display_short)|uniprotkb:C21orf43(gene name synonym)|uniprotkb:VEJAM(gene name synonym)|uniprotkb:Junctional adhesion molecule 2(gene name synonym)|uniprotkb:Vascular endothelial junction-associated molecule(gene name synonym)|uniprotkb:UNQ219/PRO245(orf name) psi-mi:jam3_human(display_long)|uniprotkb:JAM3(gene name)|psi-mi:JAM3(display_short)|uniprotkb:JAM-2(gene name synonym)|uniprotkb:Junctional adhesion molecule 3(gene name synonym)|uniprotkb:UNQ859/PRO1868(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314754|imex:IM-15733-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154721(gene)|ensembl:ENST00000480456(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007286"(spermatid development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045123"(cellular extravasation)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0070160"(tight junction)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:2000403"(positive regulation of lymphocyte migration)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042625|mint:P57087|reactome:R-HSA-202733|reactome:R-HSA-216083|refseq:NP_067042.1|refseq:NP_001257337.1|refseq:NP_001257336.1 refseq:NP_116190.3|refseq:NP_001192258.1|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030057"(desmosome)|go:"GO:0031103"(axon regeneration)|go:"GO:0031941"(filamentous actin)|go:"GO:0033010"(paranodal junction)|go:"GO:0033624"(negative regulation of integrin activation)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045176"(apical protein localization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070160"(tight junction)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:0090138"(regulation of actin cytoskeleton organization by cell-cell adhesion)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905710"(positive regulation of membrane permeability)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042974|mint:Q9BX67|reactome:R-HSA-202733|reactome:R-HSA-216083|ensembl:ENSG00000166086(gene)|ensembl:ENST00000299106(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0002250"(adaptive immune response) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:Mx7EwHDBvAswRaXWfK84V7MoDP89606 rogid:EQBYrNTCG/k3qICRf5Yk89PZfGU9606 intact-crc:EF652982A637D114|rigid:wodmJXvsmnd4TuASaQAxAobueyk false - fc-igg tag:310-310 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BX67 uniprotkb:Q9BX67 intact:EBI-4314733|uniprotkb:Q8WWL8|uniprotkb:Q96FL1|uniprotkb:B3KWG9|ensembl:ENSP00000299106 intact:EBI-4314733|uniprotkb:Q8WWL8|uniprotkb:Q96FL1|uniprotkb:B3KWG9|ensembl:ENSP00000299106 psi-mi:jam3_human(display_long)|uniprotkb:JAM3(gene name)|psi-mi:JAM3(display_short)|uniprotkb:JAM-2(gene name synonym)|uniprotkb:Junctional adhesion molecule 3(gene name synonym)|uniprotkb:UNQ859/PRO1868(orf name) psi-mi:jam3_human(display_long)|uniprotkb:JAM3(gene name)|psi-mi:JAM3(display_short)|uniprotkb:JAM-2(gene name synonym)|uniprotkb:Junctional adhesion molecule 3(gene name synonym)|uniprotkb:UNQ859/PRO1868(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314763|imex:IM-15733-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_116190.3|refseq:NP_001192258.1|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030057"(desmosome)|go:"GO:0031103"(axon regeneration)|go:"GO:0031941"(filamentous actin)|go:"GO:0033010"(paranodal junction)|go:"GO:0033624"(negative regulation of integrin activation)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045176"(apical protein localization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070160"(tight junction)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:0090138"(regulation of actin cytoskeleton organization by cell-cell adhesion)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905710"(positive regulation of membrane permeability)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042974|mint:Q9BX67|reactome:R-HSA-202733|reactome:R-HSA-216083|ensembl:ENSG00000166086(gene)|ensembl:ENST00000299106(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0002250"(adaptive immune response) refseq:NP_116190.3|refseq:NP_001192258.1|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002693"(positive regulation of cellular extravasation)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007286"(spermatid development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030057"(desmosome)|go:"GO:0031103"(axon regeneration)|go:"GO:0031941"(filamentous actin)|go:"GO:0033010"(paranodal junction)|go:"GO:0033624"(negative regulation of integrin activation)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045176"(apical protein localization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070160"(tight junction)|go:"GO:0090022"(regulation of neutrophil chemotaxis)|go:"GO:0090138"(regulation of actin cytoskeleton organization by cell-cell adhesion)|go:"GO:0097241"(hematopoietic stem cell migration to bone marrow)|go:"GO:0097530"(granulocyte migration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:0098636"(protein complex involved in cell adhesion)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1905710"(positive regulation of membrane permeability)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042974|mint:Q9BX67|reactome:R-HSA-202733|reactome:R-HSA-216083|ensembl:ENSG00000166086(gene)|ensembl:ENST00000299106(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0002250"(adaptive immune response) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:EQBYrNTCG/k3qICRf5Yk89PZfGU9606 rogid:EQBYrNTCG/k3qICRf5Yk89PZfGU9606 intact-crc:716039442712F13B|rigid:q7LnM8muU+WNfv+I5PD1L46sDwE false - fc-igg tag:310-310 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15116 uniprotkb:Q9NZQ7 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314882|imex:IM-15733-72 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 intact-crc:DD7CD7EC4E469FC7|rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false fc-igg tag:288-288 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3B1 uniprotkb:Q7Z3B1 intact:EBI-4314838|uniprotkb:Q5VT21|uniprotkb:Q6UY06|uniprotkb:Q8NAQ3|uniprotkb:Q8N440|ensembl:ENSP00000350364 intact:EBI-4314838|uniprotkb:Q5VT21|uniprotkb:Q6UY06|uniprotkb:Q8NAQ3|uniprotkb:Q8N440|ensembl:ENSP00000350364 psi-mi:negr1_human(display_long)|uniprotkb:NEGR1(gene name)|psi-mi:NEGR1(display_short)|uniprotkb:IGLON4(gene name synonym)|uniprotkb:IgLON family member 4(gene name synonym)|uniprotkb:UNQ2433/PRO4993(orf name) psi-mi:negr1_human(display_long)|uniprotkb:NEGR1(gene name)|psi-mi:NEGR1(display_short)|uniprotkb:IGLON4(gene name synonym)|uniprotkb:IgLON family member 4(gene name synonym)|uniprotkb:UNQ2433/PRO4993(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314864|imex:IM-15733-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776169.2|ensembl:ENSG00000172260(gene)|ensembl:ENST00000357731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLD|rcsb pdb:6U6T|reactome:R-HSA-163125 refseq:NP_776169.2|ensembl:ENSG00000172260(gene)|ensembl:ENST00000357731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLD|rcsb pdb:6U6T|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:7aOTGGmWmxCluRrwEyosmc2h/Bo9606 rogid:7aOTGGmWmxCluRrwEyosmc2h/Bo9606 intact-crc:E1540C86E4A3B7C6|rigid:5X6tlcKwT2nl4pkoOy1885lBLhI false - fc-igg tag:354-354 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UWV2 uniprotkb:O60487 intact:EBI-4314854|uniprotkb:B4DLD5|uniprotkb:B4E2I8|uniprotkb:A8K025|ensembl:ENSP00000278949 intact:EBI-3906725|uniprotkb:A8K2R1|ensembl:ENSP00000278937|ensembl:ENSP00000408362 psi-mi:mpzl3_human(display_long)|uniprotkb:MPZL3(gene name)|psi-mi:MPZL3(display_short)|uniprotkb:UNQ2966/PRO7425(orf name) psi-mi:mpzl2_human(display_long)|uniprotkb:MPZL2(gene name)|psi-mi:MPZL2(display_short)|uniprotkb:EVA(gene name synonym)|uniprotkb:EVA1(gene name synonym)|uniprotkb:Epithelial V-like antigen 1(gene name synonym)|uniprotkb:UNQ606/PRO1192(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314851|imex:IM-15733-68 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273081.1|refseq:NP_938016.1|ensembl:ENSG00000160588(gene)|ensembl:ENST00000278949(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042633"(hair cycle)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029862|interpro:IPR036179 refseq:NP_005788.1|refseq:NP_658911.1|ensembl:ENSG00000149573(gene)|ensembl:ENST00000278937(transcript)|ensembl:ENST00000438295(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029863|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:5.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:4u0ZnfuMMmBw2AhVxPwPHO6THYI9606 rogid:YQHXvM5xiVw8HV97MnJ67T4/D5E9606 intact-crc:A88D322D1B6367A8|rigid:NGcs8l+D+pOcbKQWzIU3ctzYVcw false fc-igg tag:235-235 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13449 uniprotkb:Q7Z3B1 intact:EBI-4314821|uniprotkb:Q8IV49|intact:EBI-28974729|ensembl:ENSP00000419000 intact:EBI-4314838|uniprotkb:Q5VT21|uniprotkb:Q6UY06|uniprotkb:Q8NAQ3|uniprotkb:Q8N440|ensembl:ENSP00000350364 psi-mi:lsamp_human(display_long)|uniprotkb:LSAMP(gene name)|psi-mi:LSAMP(display_short)|uniprotkb:IGLON3(gene name synonym)|uniprotkb:LAMP(gene name synonym)|uniprotkb:IgLON family member 3(gene name synonym) psi-mi:negr1_human(display_long)|uniprotkb:NEGR1(gene name)|psi-mi:NEGR1(display_short)|uniprotkb:IGLON4(gene name synonym)|uniprotkb:IgLON family member 4(gene name synonym)|uniprotkb:UNQ2433/PRO4993(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314835|imex:IM-15733-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001305844.1|ensembl:ENSP00000419000|refseq:NP_002329.2|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-163125|ensembl:ENSG00000185565(gene)|ensembl:ENST00000490035(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development) refseq:NP_776169.2|ensembl:ENSG00000172260(gene)|ensembl:ENST00000357731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLD|rcsb pdb:6U6T|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:c8shRvRirX5fyHhOpOMn9W93HXk9606 rogid:7aOTGGmWmxCluRrwEyosmc2h/Bo9606 intact-crc:758287A27981700F|rigid:wy+HDUDJt4OuyJj1qXu4pYvMNqM false fc-igg tag:338-338 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13449 uniprotkb:Q13449 intact:EBI-4314821|uniprotkb:Q8IV49|intact:EBI-28974729|ensembl:ENSP00000419000 intact:EBI-4314821|uniprotkb:Q8IV49|intact:EBI-28974729|ensembl:ENSP00000419000 psi-mi:lsamp_human(display_long)|uniprotkb:LSAMP(gene name)|psi-mi:LSAMP(display_short)|uniprotkb:IGLON3(gene name synonym)|uniprotkb:LAMP(gene name synonym)|uniprotkb:IgLON family member 3(gene name synonym) psi-mi:lsamp_human(display_long)|uniprotkb:LSAMP(gene name)|psi-mi:LSAMP(display_short)|uniprotkb:IGLON3(gene name synonym)|uniprotkb:LAMP(gene name synonym)|uniprotkb:IgLON family member 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314826|imex:IM-15733-70 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001305844.1|ensembl:ENSP00000419000|refseq:NP_002329.2|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-163125|ensembl:ENSG00000185565(gene)|ensembl:ENST00000490035(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development) refseq:NP_001305844.1|ensembl:ENSP00000419000|refseq:NP_002329.2|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-163125|ensembl:ENSG00000185565(gene)|ensembl:ENST00000490035(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:c8shRvRirX5fyHhOpOMn9W93HXk9606 rogid:c8shRvRirX5fyHhOpOMn9W93HXk9606 intact-crc:E7943CEB486A50BB|rigid:6bTPx4vCdXMXe4t4ZYdPcN644mQ false fc-igg tag:338-338 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13449 uniprotkb:Q7Z3B1 intact:EBI-4314821|uniprotkb:Q8IV49|intact:EBI-28974729|ensembl:ENSP00000419000 intact:EBI-4314838|uniprotkb:Q5VT21|uniprotkb:Q6UY06|uniprotkb:Q8NAQ3|uniprotkb:Q8N440|ensembl:ENSP00000350364 psi-mi:lsamp_human(display_long)|uniprotkb:LSAMP(gene name)|psi-mi:LSAMP(display_short)|uniprotkb:IGLON3(gene name synonym)|uniprotkb:LAMP(gene name synonym)|uniprotkb:IgLON family member 3(gene name synonym) psi-mi:negr1_human(display_long)|uniprotkb:NEGR1(gene name)|psi-mi:NEGR1(display_short)|uniprotkb:IGLON4(gene name synonym)|uniprotkb:IgLON family member 4(gene name synonym)|uniprotkb:UNQ2433/PRO4993(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314873|imex:IM-15733-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001305844.1|ensembl:ENSP00000419000|refseq:NP_002329.2|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-163125|ensembl:ENSG00000185565(gene)|ensembl:ENST00000490035(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development) refseq:NP_776169.2|ensembl:ENSG00000172260(gene)|ensembl:ENST00000357731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLD|rcsb pdb:6U6T|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:c8shRvRirX5fyHhOpOMn9W93HXk9606 rogid:7aOTGGmWmxCluRrwEyosmc2h/Bo9606 intact-crc:9282F959D529F36F|rigid:wy+HDUDJt4OuyJj1qXu4pYvMNqM false - fc-igg tag:354-354 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQS3 uniprotkb:Q92692 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314943|imex:IM-15733-79 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:13.8|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 intact-crc:B878EA84877A07E8|rigid:2MoijzgNZRUk313cy0s/crul6GU false - fc-igg tag:538-538 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92692 uniprotkb:Q15762 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 intact:EBI-4314442|uniprotkb:B2R818|ensembl:ENSP00000280200|ensembl:ENSP00000461947 psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:cd226_human(display_long)|uniprotkb:CD226(gene name)|psi-mi:CD226(display_short)|uniprotkb:DNAM1(gene name synonym)|uniprotkb:DNAX accessory molecule 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314934|imex:IM-15733-78 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N refseq:NP_006557.2|refseq:XP_005266699.1|refseq:NP_001290547.1|ensembl:ENSG00000150637(gene)|ensembl:ENST00000280200(transcript)|ensembl:ENST00000582621(transcript)|go:"GO:0002729"(positive regulation of natural killer cell cytokine production)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008037"(cell recognition)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0045121"(membrane raft)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042842|rcsb pdb:6ISB|rcsb pdb:6O3O|reactome:R-HSA-198933|go:"GO:0005886"(plasma membrane) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:14.3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 rogid:yDpdwh/pOZFHScLOiLxzuZCE0f09606 intact-crc:F19953721D174A11|rigid:s377+2gJkdZ6edLsrVDWg3AX3go false fc-igg tag:538-538 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15223 uniprotkb:Q15223 intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314925|imex:IM-15733-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:7.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 intact-crc:3EED5A153D7127AD|rigid:U5T4eog3v1KBYDTHgqG9QujW/RA false fc-igg tag:517-517 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15223 uniprotkb:Q9NQS3 intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314916|imex:IM-15733-76 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 intact-crc:F7803AA5B9E9D2A9|rigid:cdl/8sOs9TPvDFm+TMyCSPkuSHw false fc-igg tag:517-517 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15223 uniprotkb:Q96NY8 intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 intact:EBI-4314784|uniprotkb:Q96K15|uniprotkb:B4DQW3|ensembl:ENSP00000356991 psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:nect4_human(display_long)|uniprotkb:NECTIN4(gene name)|psi-mi:NECTIN4(display_short)|uniprotkb:Ig superfamily receptor LNIR(gene name synonym)|uniprotkb:LNIR(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 4(gene name synonym)|uniprotkb:PRR4(gene name synonym)|uniprotkb:PVRL4(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 4(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314907|imex:IM-15733-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 refseq:NP_112178.2|ensembl:ENSG00000143217(gene)|ensembl:ENST00000368012(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033320|interpro:IPR036179|rcsb pdb:4FRW|rcsb pdb:4GJT|rcsb pdb:4JJH|reactome:R-HSA-418990|reactome:R-HSA-420597|dip:DIP-41492N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 rogid:xh33OK0Z4RsYD8uJZYbmnGfs/TQ9606 intact-crc:7F804041AC5DEEFD|rigid:hRMxaFNfMrQX1Np++7ViMPL0jdQ false fc-igg tag:517-517 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92692 uniprotkb:Q92692 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314952|imex:IM-15733-80 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 intact-crc:764CC7EA01888AC4|rigid:fbKgdsL+oGRVlBLBpGVQqQJ0vAw false fc-igg tag:538-538 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35590 uniprotkb:Q15238 intact:EBI-2256865|uniprotkb:B5A949|uniprotkb:B5A950|ensembl:ENSP00000361554 intact:EBI-4314891|uniprotkb:Q15239|uniprotkb:Q96QJ1|uniprotkb:Q9UQ75|ensembl:ENSP00000344413|ensembl:ENSP00000382334|ensembl:ENSP00000386008 psi-mi:tie1_human(display_long)|uniprotkb:TIE1(gene name)|psi-mi:TIE1(display_short)|uniprotkb:TIE(gene name synonym) psi-mi:psg5_human(display_long)|uniprotkb:PSG5(gene name)|psi-mi:PSG5(display_short)|uniprotkb:Fetal liver non-specific cross-reactive antigen 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314898|imex:IM-15733-74 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005415.1|ensembl:ENSG00000066056(gene)|ensembl:ENST00000372476(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P35590|rcsb pdb:5N06 refseq:NP_001123486.1|refseq:NP_002772.3|refseq:XP_016882492.1|ensembl:ENSG00000204941(gene)|ensembl:ENST00000342951(transcript)|ensembl:ENST00000366175(transcript)|ensembl:ENST00000407356(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-202733 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:4.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:/tuK6SwU9CCcxFhdQo/rlvlPZRg9606 rogid:O5maHM77+s2CWMD1oFv4jzy80G49606 intact-crc:C5F7D3A5C463C583|rigid:T8WUk3Tln8eBkZcu+9lL4X+UxJg false - fc-igg tag:335-335 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q9NYZ4 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314991|uniprotkb:Q7Z728|ensembl:ENSP00000321077 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:sigl8_human(display_long)|uniprotkb:SIGLEC8(gene name)|psi-mi:SIGLEC8(display_short)|uniprotkb:SAF2(gene name synonym)|uniprotkb:Sialoadhesin family member 2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314988|imex:IM-15733-84 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:XP_011525037.1|refseq:NP_055257.2|ensembl:ENSG00000105366(gene)|ensembl:ENST00000321424(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2N7A|rcsb pdb:2N7B|reactome:R-HSA-198933 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:4.9|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:lMlEum1EMluaa51lEgk7PLijfY89606 intact-crc:A391D01B41765100|rigid:PdjX8OrNlRbeckQn8MLT+BRuajE false - fc-igg tag:499-499 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13291 uniprotkb:Q13291 intact:EBI-4315002|uniprotkb:Q5W172|uniprotkb:Q9HBE8|uniprotkb:W0HKK7|ensembl:ENSP00000306190 intact:EBI-4315002|uniprotkb:Q5W172|uniprotkb:Q9HBE8|uniprotkb:W0HKK7|ensembl:ENSP00000306190 psi-mi:slaf1_human(display_long)|uniprotkb:SLAMF1(gene name)|psi-mi:SLAMF1(display_short)|uniprotkb:SLAM family member 1(gene name synonym)|uniprotkb:SLAM(gene name synonym)|uniprotkb:CDw150(gene name synonym)|uniprotkb:IPO-3(gene name synonym) psi-mi:slaf1_human(display_long)|uniprotkb:SLAMF1(gene name)|psi-mi:SLAMF1(display_short)|uniprotkb:SLAM family member 1(gene name synonym)|uniprotkb:SLAM(gene name synonym)|uniprotkb:CDw150(gene name synonym)|uniprotkb:IPO-3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315007|imex:IM-15733-85 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005245513.1|refseq:NP_003028.1|refseq:NP_001317683.1|ensembl:ENSG00000117090(gene)|ensembl:ENST00000302035(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001779"(natural killer cell differentiation)|interpro:IPR036179|rcsb pdb:1D4T|rcsb pdb:1D4W|rcsb pdb:1I3Z|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|rcsb pdb:2DZF|rcsb pdb:2IE9|rcsb pdb:2IFL|rcsb pdb:2IG5|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003823"(antigen binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010407(Signaling lymphocytic activation molecule, N-terminal)|go:"GO:0001787"(natural killer cell proliferation)|dip:DIP-40767N refseq:XP_005245513.1|refseq:NP_003028.1|refseq:NP_001317683.1|ensembl:ENSG00000117090(gene)|ensembl:ENST00000302035(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001779"(natural killer cell differentiation)|interpro:IPR036179|rcsb pdb:1D4T|rcsb pdb:1D4W|rcsb pdb:1I3Z|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|rcsb pdb:2DZF|rcsb pdb:2IE9|rcsb pdb:2IFL|rcsb pdb:2IG5|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003823"(antigen binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031338"(regulation of vesicle fusion)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010407(Signaling lymphocytic activation molecule, N-terminal)|go:"GO:0001787"(natural killer cell proliferation)|dip:DIP-40767N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:7.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:DduZeT4BxhSno9xA/om9mkV1rpI9606 rogid:DduZeT4BxhSno9xA/om9mkV1rpI9606 intact-crc:1360DAFD17FB28AE|rigid:46bJyQ5VSTNv4bJqLTSzEQnt8D0 false fc-igg tag:335-335 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQS3 uniprotkb:Q15223 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025 psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314961|imex:IM-15733-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:18.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606 intact-crc:9CCEF2A92997A202|rigid:cdl/8sOs9TPvDFm+TMyCSPkuSHw false fc-igg tag:549-549 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQ25 uniprotkb:Q9NQ25 intact:EBI-3916159|uniprotkb:A8K3U1|uniprotkb:B4DPY3|uniprotkb:B4DPU4|uniprotkb:B4DWA3|uniprotkb:Q9NY08|uniprotkb:Q8ND32|uniprotkb:Q9NY23|uniprotkb:Q8N6Y8|ensembl:ENSP00000357022 intact:EBI-3916159|uniprotkb:A8K3U1|uniprotkb:B4DPY3|uniprotkb:B4DPU4|uniprotkb:B4DWA3|uniprotkb:Q9NY08|uniprotkb:Q8ND32|uniprotkb:Q9NY23|uniprotkb:Q8N6Y8|ensembl:ENSP00000357022 psi-mi:slaf7_human(display_long)|uniprotkb:SLAMF7(gene name)|psi-mi:SLAMF7(display_short)|uniprotkb:CS1(gene name synonym)|uniprotkb:CD2 subset 1(gene name synonym)|uniprotkb:CD2-like receptor-activating cytotoxic cells(gene name synonym)|uniprotkb:Membrane protein FOAP-12(gene name synonym)|uniprotkb:Novel Ly9(gene name synonym)|uniprotkb:Protein 19A(gene name synonym)|uniprotkb:UNQ576/PRO1138(orf name) psi-mi:slaf7_human(display_long)|uniprotkb:SLAMF7(gene name)|psi-mi:SLAMF7(display_short)|uniprotkb:CS1(gene name synonym)|uniprotkb:CD2 subset 1(gene name synonym)|uniprotkb:CD2-like receptor-activating cytotoxic cells(gene name synonym)|uniprotkb:Membrane protein FOAP-12(gene name synonym)|uniprotkb:Novel Ly9(gene name synonym)|uniprotkb:Protein 19A(gene name synonym)|uniprotkb:UNQ576/PRO1138(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315016|imex:IM-15733-86 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001269519.1|refseq:NP_001269521.1|refseq:NP_001269524.1|refseq:NP_001269517.1|refseq:NP_067004.3|refseq:NP_001269518.1|refseq:NP_001269520.1|ensembl:ENST00000368043(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|ensembl:ENSG00000026751(gene) refseq:NP_001269519.1|refseq:NP_001269521.1|refseq:NP_001269524.1|refseq:NP_001269517.1|refseq:NP_067004.3|refseq:NP_001269518.1|refseq:NP_001269520.1|ensembl:ENST00000368043(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|ensembl:ENSG00000026751(gene) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:5.6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:7ybNNE/UXAZs2qxMUL/dPbSAza09606 rogid:7ybNNE/UXAZs2qxMUL/dPbSAza09606 intact-crc:F606942BA8F16BDB|rigid:jHsMwhu90xBN//fsC1wZNGN0br8 false fc-igg tag:335-335 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NQS3 uniprotkb:Q92692 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314970|imex:IM-15733-82 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:16.1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 intact-crc:127505C684A64DE9|rigid:2MoijzgNZRUk313cy0s/crul6GU false fc-igg tag:549-549 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q495A1 uniprotkb:Q9NQS3 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4314979|imex:IM-15733-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:7.9|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 intact-crc:390E40DA7E81103C|rigid:cUpU3FS5beVL+FtP02aLxziavzc false - fc-igg tag:549-549 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P121 uniprotkb:Q9P121 intact:EBI-4315078|uniprotkb:Q6UXJ3|uniprotkb:A0MTT2|uniprotkb:Q86VJ9|ensembl:ENSP00000363918 intact:EBI-4315078|uniprotkb:Q6UXJ3|uniprotkb:A0MTT2|uniprotkb:Q86VJ9|ensembl:ENSP00000363918 psi-mi:ntri_human(display_long)|uniprotkb:NTM(gene name)|psi-mi:NTM(display_short)|uniprotkb:IGLON2(gene name synonym)|uniprotkb:NT(gene name synonym)|uniprotkb:IgLON family member 2(gene name synonym)|uniprotkb:UNQ297/PRO337(orf name) psi-mi:ntri_human(display_long)|uniprotkb:NTM(gene name)|psi-mi:NTM(display_short)|uniprotkb:IGLON2(gene name synonym)|uniprotkb:NT(gene name synonym)|uniprotkb:IgLON family member 2(gene name synonym)|uniprotkb:UNQ297/PRO337(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315116|imex:IM-15733-93 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041674.1|refseq:NP_001137530.1|refseq:NP_001137531.1|refseq:NP_057606.1|ensembl:ENSG00000182667(gene)|ensembl:ENST00000374786(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008038"(neuron recognition)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLF|reactome:R-HSA-163125 refseq:NP_001041674.1|refseq:NP_001137530.1|refseq:NP_001137531.1|refseq:NP_057606.1|ensembl:ENSG00000182667(gene)|ensembl:ENST00000374786(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008038"(neuron recognition)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLF|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:6.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:SGoCfe3DYp/3jFAAT7qlTf9yb5s9606 rogid:SGoCfe3DYp/3jFAAT7qlTf9yb5s9606 intact-crc:2606E6DC232CD841|rigid:Doqzot+L3BZ6S78BePM3bvcc2e4 false - fc-igg tag:344-344 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P121 uniprotkb:Q7Z3B1 intact:EBI-4315078|uniprotkb:Q6UXJ3|uniprotkb:A0MTT2|uniprotkb:Q86VJ9|ensembl:ENSP00000363918 intact:EBI-4314838|uniprotkb:Q5VT21|uniprotkb:Q6UY06|uniprotkb:Q8NAQ3|uniprotkb:Q8N440|ensembl:ENSP00000350364 psi-mi:ntri_human(display_long)|uniprotkb:NTM(gene name)|psi-mi:NTM(display_short)|uniprotkb:IGLON2(gene name synonym)|uniprotkb:NT(gene name synonym)|uniprotkb:IgLON family member 2(gene name synonym)|uniprotkb:UNQ297/PRO337(orf name) psi-mi:negr1_human(display_long)|uniprotkb:NEGR1(gene name)|psi-mi:NEGR1(display_short)|uniprotkb:IGLON4(gene name synonym)|uniprotkb:IgLON family member 4(gene name synonym)|uniprotkb:UNQ2433/PRO4993(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315094|imex:IM-15733-92 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041674.1|refseq:NP_001137530.1|refseq:NP_001137531.1|refseq:NP_057606.1|ensembl:ENSG00000182667(gene)|ensembl:ENST00000374786(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008038"(neuron recognition)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLF|reactome:R-HSA-163125 refseq:NP_776169.2|ensembl:ENSG00000172260(gene)|ensembl:ENST00000357731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLD|rcsb pdb:6U6T|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:9.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:SGoCfe3DYp/3jFAAT7qlTf9yb5s9606 rogid:7aOTGGmWmxCluRrwEyosmc2h/Bo9606 intact-crc:0CBDBDBF25DBBC55|rigid:hEnMFyzSGp2nu71kXPocYaW8424 false fc-igg tag:344-344 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q495A1 uniprotkb:P15151 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-3919694|uniprotkb:Q96BJ1|uniprotkb:Q15268|uniprotkb:Q15267|uniprotkb:P15152|uniprotkb:B4DTS9 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:pvr_human(display_long)|uniprotkb:PVR(gene name)|psi-mi:PVR(display_short)|uniprotkb:PVS(gene name synonym)|uniprotkb:Nectin-like protein 5(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315069|imex:IM-15733-91 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 go:"GO:0001618"(virus receptor activity)|mint:P15151|refseq:NP_001129240.1|refseq:NP_001129241.1|refseq:NP_006496.4|refseq:NP_001129242.2|dip:DIP-43987N|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DGI|rcsb pdb:1NN8|rcsb pdb:3EPC|rcsb pdb:3EPD|rcsb pdb:3EPF|rcsb pdb:3J8F|rcsb pdb:3J9F|rcsb pdb:3UDW|rcsb pdb:3URO|rcsb pdb:4FQP|rcsb pdb:6ARQ|rcsb pdb:6ISC|rcsb pdb:6O3O|reactome:R-HSA-198933|reactome:R-HSA-420597 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10.4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:PsTFmeD+9vG6ieNef6MupXts60g9606 intact-crc:EF309F1719861C9E|rigid:HESoHVPaMFFSxeBqFQYcjZEHCwU false fc-igg tag:244-244 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q495A1 uniprotkb:Q96NY8 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-4314784|uniprotkb:Q96K15|uniprotkb:B4DQW3|ensembl:ENSP00000356991 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:nect4_human(display_long)|uniprotkb:NECTIN4(gene name)|psi-mi:NECTIN4(display_short)|uniprotkb:Ig superfamily receptor LNIR(gene name synonym)|uniprotkb:LNIR(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 4(gene name synonym)|uniprotkb:PRR4(gene name synonym)|uniprotkb:PVRL4(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 4(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315043|imex:IM-15733-90 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 refseq:NP_112178.2|ensembl:ENSG00000143217(gene)|ensembl:ENST00000368012(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033320|interpro:IPR036179|rcsb pdb:4FRW|rcsb pdb:4GJT|rcsb pdb:4JJH|reactome:R-HSA-418990|reactome:R-HSA-420597|dip:DIP-41492N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:14|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:xh33OK0Z4RsYD8uJZYbmnGfs/TQ9606 intact-crc:BFAB9E3B599377B8|rigid:bheluMUmLx+bfcAzg9g+dfy+qJc false fc-igg tag:244-244 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q495A1 uniprotkb:Q9NQS3 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 intact:EBI-2826725|uniprotkb:Q8WVU4|uniprotkb:Q6NVZ3|uniprotkb:Q9Y412|uniprotkb:Q9BVA9|ensembl:ENSP00000418070|uniprotkb:E9PFR0|uniprotkb:Q8NC05 psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:nect3_human(display_long)|uniprotkb:NECTIN3(gene name)|psi-mi:NECTIN3(display_short)|uniprotkb:CDw113(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 3(gene name synonym)|uniprotkb:PRR3(gene name synonym)|uniprotkb:PVRL3(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315034|imex:IM-15733-89 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 refseq:NP_001230215.1|refseq:NP_056295.1|ensembl:ENSG00000177707(gene)|ensembl:ENST00000485303(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0009566"(fertilization)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060042"(retina morphogenesis in camera-type eye)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|reactome:R-HSA-420597|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033319|interpro:IPR036179|rcsb pdb:4FOM|reactome:R-HSA-418990|refseq:NP_001230217.1|dip:DIP-41491N psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:15.5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 rogid:lzSScehKhxTPj0E6EmL+P+XXjB09606 intact-crc:7ECA3D70CB9EEDAF|rigid:cUpU3FS5beVL+FtP02aLxziavzc false fc-igg tag:244-244 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q92692 uniprotkb:Q495A1 intact:EBI-718419|uniprotkb:A8K5L5|uniprotkb:O75455|uniprotkb:Q96J29|uniprotkb:Q6IBI6|ensembl:ENSP00000252483 intact:EBI-4314807|uniprotkb:Q495A3|uniprotkb:Q5JPD8|uniprotkb:Q8N877|uniprotkb:Q6MZS2|ensembl:ENSP00000373167|ensembl:ENSP00000419085 psi-mi:nect2_human(display_long)|uniprotkb:NECTIN2(gene name)|psi-mi:NECTIN2(display_short)|uniprotkb:HVEB(gene name synonym)|uniprotkb:Herpes virus entry mediator B(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 2(gene name synonym)|uniprotkb:PRR2(gene name synonym)|uniprotkb:PVRL2(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 2(gene name synonym) psi-mi:tigit_human(display_long)|uniprotkb:TIGIT(gene name)|psi-mi:TIGIT(display_short)|uniprotkb:VSIG9(gene name synonym)|uniprotkb:VSTM3(gene name synonym)|uniprotkb:V-set and immunoglobulin domain-containing protein 9(gene name synonym)|uniprotkb:V-set and transmembrane domain-containing protein 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315025|imex:IM-15733-88 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036189.1|refseq:NP_002847.1|ensembl:ENSG00000130202(gene)|ensembl:ENST00000252483(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001675"(acrosome assembly)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002891"(positive regulation of immunoglobulin mediated immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007286"(spermatid development)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0030382"(sperm mitochondrion organization)|go:"GO:0032990"(cell part morphogenesis)|go:"GO:0033005"(positive regulation of mast cell activation)|go:"GO:0042271"(susceptibility to natural killer cell mediated cytotoxicity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044406"(adhesion of symbiont to host)|go:"GO:0044782"(cilium organization)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046814"(coreceptor-mediated virion attachment to host cell)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0060370"(susceptibility to T cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033318|interpro:IPR036179|rcsb pdb:3R0N|rcsb pdb:4DFH|rcsb pdb:4DFI|rcsb pdb:4HZA|rcsb pdb:5V52|reactome:R-HSA-198933|reactome:R-HSA-418990|reactome:R-HSA-420597|go:"GO:0042803"(protein homodimerization activity)|dip:DIP-41043N refseq:NP_776160.2|ensembl:ENSG00000181847(gene)|ensembl:ENST00000383671(transcript)|ensembl:ENST00000486257(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0042802"(identical protein binding)|go:"GO:0050868"(negative regulation of T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042948|rcsb pdb:3Q0H|rcsb pdb:3RQ3|rcsb pdb:3UCR|rcsb pdb:3UDW|rcsb pdb:5V52 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:17.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xGLJch8JXc+urj11GXKFPgBLYuc9606 rogid:smL4hP5CUhRUZJAd5SnEBU7S6kc9606 intact-crc:B0F3901FFD6C6083|rigid:Wuu5gGFOG58uNfn3nysHP/VZshc false - fc-igg tag:244-244 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P121 uniprotkb:Q13449 intact:EBI-4315078|uniprotkb:Q6UXJ3|uniprotkb:A0MTT2|uniprotkb:Q86VJ9|ensembl:ENSP00000363918 intact:EBI-4314821|uniprotkb:Q8IV49|intact:EBI-28974729|ensembl:ENSP00000419000 psi-mi:ntri_human(display_long)|uniprotkb:NTM(gene name)|psi-mi:NTM(display_short)|uniprotkb:IGLON2(gene name synonym)|uniprotkb:NT(gene name synonym)|uniprotkb:IgLON family member 2(gene name synonym)|uniprotkb:UNQ297/PRO337(orf name) psi-mi:lsamp_human(display_long)|uniprotkb:LSAMP(gene name)|psi-mi:LSAMP(display_short)|uniprotkb:IGLON3(gene name synonym)|uniprotkb:LAMP(gene name synonym)|uniprotkb:IgLON family member 3(gene name synonym) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315085|imex:IM-15733-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001041674.1|refseq:NP_001137530.1|refseq:NP_001137531.1|refseq:NP_057606.1|ensembl:ENSG00000182667(gene)|ensembl:ENST00000374786(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008038"(neuron recognition)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLF|reactome:R-HSA-163125 refseq:NP_001305844.1|ensembl:ENSP00000419000|refseq:NP_002329.2|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-163125|ensembl:ENSG00000185565(gene)|ensembl:ENST00000490035(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development) psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:10.7|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:SGoCfe3DYp/3jFAAT7qlTf9yb5s9606 rogid:c8shRvRirX5fyHhOpOMn9W93HXk9606 intact-crc:DB9E1119FCE0DBCC|rigid:bYUwh2DNLI8FW9Xy48vdQx7UplE false fc-igg tag:344-344 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13449 uniprotkb:Q9P121 intact:EBI-4314821|uniprotkb:Q8IV49|intact:EBI-28974729|ensembl:ENSP00000419000 intact:EBI-4315078|uniprotkb:Q6UXJ3|uniprotkb:A0MTT2|uniprotkb:Q86VJ9|ensembl:ENSP00000363918 psi-mi:lsamp_human(display_long)|uniprotkb:LSAMP(gene name)|psi-mi:LSAMP(display_short)|uniprotkb:IGLON3(gene name synonym)|uniprotkb:LAMP(gene name synonym)|uniprotkb:IgLON family member 3(gene name synonym) psi-mi:ntri_human(display_long)|uniprotkb:NTM(gene name)|psi-mi:NTM(display_short)|uniprotkb:IGLON2(gene name synonym)|uniprotkb:NT(gene name synonym)|uniprotkb:IgLON family member 2(gene name synonym)|uniprotkb:UNQ297/PRO337(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315125|imex:IM-15733-95 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001305844.1|ensembl:ENSP00000419000|refseq:NP_002329.2|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-163125|ensembl:ENSG00000185565(gene)|ensembl:ENST00000490035(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development) refseq:NP_001041674.1|refseq:NP_001137530.1|refseq:NP_001137531.1|refseq:NP_057606.1|ensembl:ENSG00000182667(gene)|ensembl:ENST00000374786(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008038"(neuron recognition)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLF|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:11.4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:c8shRvRirX5fyHhOpOMn9W93HXk9606 rogid:SGoCfe3DYp/3jFAAT7qlTf9yb5s9606 intact-crc:512B1BE4F6E72AD8|rigid:bYUwh2DNLI8FW9Xy48vdQx7UplE false fc-igg tag:338-338 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7Z3B1 uniprotkb:Q9P121 intact:EBI-4314838|uniprotkb:Q5VT21|uniprotkb:Q6UY06|uniprotkb:Q8NAQ3|uniprotkb:Q8N440|ensembl:ENSP00000350364 intact:EBI-4315078|uniprotkb:Q6UXJ3|uniprotkb:A0MTT2|uniprotkb:Q86VJ9|ensembl:ENSP00000363918 psi-mi:negr1_human(display_long)|uniprotkb:NEGR1(gene name)|psi-mi:NEGR1(display_short)|uniprotkb:IGLON4(gene name synonym)|uniprotkb:IgLON family member 4(gene name synonym)|uniprotkb:UNQ2433/PRO4993(orf name) psi-mi:ntri_human(display_long)|uniprotkb:NTM(gene name)|psi-mi:NTM(display_short)|uniprotkb:IGLON2(gene name synonym)|uniprotkb:NT(gene name synonym)|uniprotkb:IgLON family member 2(gene name synonym)|uniprotkb:UNQ297/PRO337(orf name) psi-mi:"MI:0089"(protein array) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-4315143|imex:IM-15733-94 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_776169.2|ensembl:ENSG00000172260(gene)|ensembl:ENST00000357731(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007626"(locomotory behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLD|rcsb pdb:6U6T|reactome:R-HSA-163125 refseq:NP_001041674.1|refseq:NP_001137530.1|refseq:NP_001137531.1|refseq:NP_057606.1|ensembl:ENSG00000182667(gene)|ensembl:ENST00000374786(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008038"(neuron recognition)|go:"GO:0031225"(anchored component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6DLF|reactome:R-HSA-163125 psi-mi:"MI:0469"(intact) - - figure legend:Table 2, Figure 5|author-confidence:8.2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:7aOTGGmWmxCluRrwEyosmc2h/Bo9606 rogid:SGoCfe3DYp/3jFAAT7qlTf9yb5s9606 intact-crc:E0BF3B0DD42B1657|rigid:hEnMFyzSGp2nu71kXPocYaW8424 false fc-igg tag:354-354 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P08138 uniprotkb:P33681 intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym) psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316445|imex:IM-15733-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563 refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 intact-crc:0E81CA2AC409F69F|rigid:xIMp+rvT5PMDgYhgshF89BJLrIs false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P08138 uniprotkb:P33681 intact:EBI-1387782|uniprotkb:B2R961|uniprotkb:B4E096|ensembl:ENSP00000172229 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 psi-mi:tnr16_human(display_long)|uniprotkb:NGFR(gene name)|psi-mi:NGFR(display_short)|uniprotkb:TNFRSF16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym) psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568137|imex:IM-15733-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002498.1|dip:DIP-406N|ensembl:ENSG00000064300(gene)|ensembl:ENST00000172229(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005035"(death receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0021675"(nerve development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:P08138|rcsb pdb:2N80|rcsb pdb:2N83|rcsb pdb:2N97|rcsb pdb:3EWV|rcsb pdb:5ZGG|reactome:R-HSA-193634|reactome:R-HSA-193648|reactome:R-HSA-193670|reactome:R-HSA-193681|reactome:R-HSA-193692|reactome:R-HSA-205017|reactome:R-HSA-205025|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-209563 refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:xoP55XGR3zC9f2ClOxgUWU3xnzk9606 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 intact-crc:2B2BA6E0F6BDE2EC|rigid:xIMp+rvT5PMDgYhgshF89BJLrIs false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:O00481 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-2809309|ensembl:ENSP00000289361|uniprotkb:Q147X5|uniprotkb:A2A278|uniprotkb:Q53F15|uniprotkb:Q99420|uniprotkb:Q0P515|uniprotkb:Q9HCY1|uniprotkb:A8K2C8|uniprotkb:B4DIQ1|uniprotkb:E9PHG8|uniprotkb:B4DRM2|uniprotkb:E9PGB4 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:bt3a1_human(display_long)|uniprotkb:BTN3A1(gene name)|psi-mi:BTN3A1(display_short)|uniprotkb:BTF5(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568123|imex:IM-15733-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 ensembl:ENSG00000026950(gene)|ensembl:ENST00000289361(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037954|interpro:IPR043136|rcsb pdb:4F80|rcsb pdb:4F9L|rcsb pdb:4F9P|rcsb pdb:4JKW|rcsb pdb:4K55|rcsb pdb:4N7I|rcsb pdb:4N7U|rcsb pdb:4V1P|rcsb pdb:5HM7|rcsb pdb:5LYG|rcsb pdb:5LYK|rcsb pdb:5ZXK|rcsb pdb:6ISM|rcsb pdb:6ITA|rcsb pdb:6J06|rcsb pdb:6XLQ|reactome:R-HSA-8851680|refseq:NP_001138480.1|refseq:NP_001138481.1|refseq:NP_008979.3|refseq:NP_919423.1|refseq:XP_005248891.1 psi-mi:"MI:0469"(intact) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:Qx4k0aSGUrS7rLeSZzv3QJLmM6o9606 intact-crc:535E566A360AAC4F|rigid:oD6CDWJlhMJPPbMJ9GAtS3bCCgM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O00481 uniprotkb:P04155 intact:EBI-2809309|ensembl:ENSP00000289361|uniprotkb:Q147X5|uniprotkb:A2A278|uniprotkb:Q53F15|uniprotkb:Q99420|uniprotkb:Q0P515|uniprotkb:Q9HCY1|uniprotkb:A8K2C8|uniprotkb:B4DIQ1|uniprotkb:E9PHG8|uniprotkb:B4DRM2|uniprotkb:E9PGB4 intact:EBI-743871|ensembl:ENSP00000291527 psi-mi:bt3a1_human(display_long)|uniprotkb:BTN3A1(gene name)|psi-mi:BTN3A1(display_short)|uniprotkb:BTF5(gene name synonym) psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316558|imex:IM-15733-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000026950(gene)|ensembl:ENST00000289361(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037954|interpro:IPR043136|rcsb pdb:4F80|rcsb pdb:4F9L|rcsb pdb:4F9P|rcsb pdb:4JKW|rcsb pdb:4K55|rcsb pdb:4N7I|rcsb pdb:4N7U|rcsb pdb:4V1P|rcsb pdb:5HM7|rcsb pdb:5LYG|rcsb pdb:5LYK|rcsb pdb:5ZXK|rcsb pdb:6ISM|rcsb pdb:6ITA|rcsb pdb:6J06|rcsb pdb:6XLQ|reactome:R-HSA-8851680|refseq:NP_001138480.1|refseq:NP_001138481.1|refseq:NP_008979.3|refseq:NP_919423.1|refseq:XP_005248891.1 refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 psi-mi:"MI:0469"(intact) - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:Qx4k0aSGUrS7rLeSZzv3QJLmM6o9606 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 intact-crc:4C01F2A467DDE113|rigid:oD6CDWJlhMJPPbMJ9GAtS3bCCgM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15238 uniprotkb:P35590 intact:EBI-4314891|uniprotkb:Q15239|uniprotkb:Q96QJ1|uniprotkb:Q9UQ75|ensembl:ENSP00000344413|ensembl:ENSP00000382334|ensembl:ENSP00000386008 intact:EBI-2256865|uniprotkb:B5A949|uniprotkb:B5A950|ensembl:ENSP00000361554 psi-mi:psg5_human(display_long)|uniprotkb:PSG5(gene name)|psi-mi:PSG5(display_short)|uniprotkb:Fetal liver non-specific cross-reactive antigen 3(gene name synonym) psi-mi:tie1_human(display_long)|uniprotkb:TIE1(gene name)|psi-mi:TIE1(display_short)|uniprotkb:TIE(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316690|imex:IM-15733-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123486.1|refseq:NP_002772.3|refseq:XP_016882492.1|ensembl:ENSG00000204941(gene)|ensembl:ENST00000342951(transcript)|ensembl:ENST00000366175(transcript)|ensembl:ENST00000407356(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-202733 refseq:NP_005415.1|ensembl:ENSG00000066056(gene)|ensembl:ENST00000372476(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P35590|rcsb pdb:5N06 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:O5maHM77+s2CWMD1oFv4jzy80G49606 rogid:/tuK6SwU9CCcxFhdQo/rlvlPZRg9606 intact-crc:900F5EF84F43FFEB|rigid:T8WUk3Tln8eBkZcu+9lL4X+UxJg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16568 uniprotkb:P13688 intact:EBI-4314526|uniprotkb:Q6FG92|ensembl:ENSP00000296777 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 psi-mi:cart_human(display_long)|uniprotkb:CARTPT(gene name)|psi-mi:CARTPT(display_short)|uniprotkb:CART(gene name synonym) psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316604|imex:IM-15733-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004282.1|ensembl:ENSG00000164326(gene)|ensembl:ENST00000296777(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030141"(secretory granule)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0070253"(somatostatin secretion)|interpro:IPR009106(CART satiety factor)|interpro:IPR036722|rcsb pdb:1HY9|go:"GO:0001678"(cellular glucose homeostasis) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:N3PoYTEXZrIrABT6xed52NR63EI9606 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 intact-crc:5061E30EB3479908|rigid:0lNFOAVcwK+TVjHNgobz0FMMFO0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q9NYZ4 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314991|uniprotkb:Q7Z728|ensembl:ENSP00000321077 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:sigl8_human(display_long)|uniprotkb:SIGLEC8(gene name)|psi-mi:SIGLEC8(display_short)|uniprotkb:SAF2(gene name synonym)|uniprotkb:Sialoadhesin family member 2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316598|imex:IM-15733-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:XP_011525037.1|refseq:NP_055257.2|ensembl:ENSG00000105366(gene)|ensembl:ENST00000321424(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2N7A|rcsb pdb:2N7B|reactome:R-HSA-198933 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:lMlEum1EMluaa51lEgk7PLijfY89606 intact-crc:BD4F95CF8FB8219D|rigid:PdjX8OrNlRbeckQn8MLT+BRuajE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60487 uniprotkb:Q6UWV2 intact:EBI-3906725|uniprotkb:A8K2R1|ensembl:ENSP00000278937|ensembl:ENSP00000408362 intact:EBI-4314854|uniprotkb:B4DLD5|uniprotkb:B4E2I8|uniprotkb:A8K025|ensembl:ENSP00000278949 psi-mi:mpzl2_human(display_long)|uniprotkb:MPZL2(gene name)|psi-mi:MPZL2(display_short)|uniprotkb:EVA(gene name synonym)|uniprotkb:EVA1(gene name synonym)|uniprotkb:Epithelial V-like antigen 1(gene name synonym)|uniprotkb:UNQ606/PRO1192(orf name) psi-mi:mpzl3_human(display_long)|uniprotkb:MPZL3(gene name)|psi-mi:MPZL3(display_short)|uniprotkb:UNQ2966/PRO7425(orf name) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568111|imex:IM-15733-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005788.1|refseq:NP_658911.1|ensembl:ENSG00000149573(gene)|ensembl:ENST00000278937(transcript)|ensembl:ENST00000438295(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029863|interpro:IPR036179 refseq:NP_001273081.1|refseq:NP_938016.1|ensembl:ENSG00000160588(gene)|ensembl:ENST00000278949(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042633"(hair cycle)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029862|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:YQHXvM5xiVw8HV97MnJ67T4/D5E9606 rogid:4u0ZnfuMMmBw2AhVxPwPHO6THYI9606 intact-crc:26B67AEDC5AF366F|rigid:NGcs8l+D+pOcbKQWzIU3ctzYVcw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UWV2 uniprotkb:O60487 intact:EBI-4314854|uniprotkb:B4DLD5|uniprotkb:B4E2I8|uniprotkb:A8K025|ensembl:ENSP00000278949 intact:EBI-3906725|uniprotkb:A8K2R1|ensembl:ENSP00000278937|ensembl:ENSP00000408362 psi-mi:mpzl3_human(display_long)|uniprotkb:MPZL3(gene name)|psi-mi:MPZL3(display_short)|uniprotkb:UNQ2966/PRO7425(orf name) psi-mi:mpzl2_human(display_long)|uniprotkb:MPZL2(gene name)|psi-mi:MPZL2(display_short)|uniprotkb:EVA(gene name synonym)|uniprotkb:EVA1(gene name synonym)|uniprotkb:Epithelial V-like antigen 1(gene name synonym)|uniprotkb:UNQ606/PRO1192(orf name) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316666|imex:IM-15733-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273081.1|refseq:NP_938016.1|ensembl:ENSG00000160588(gene)|ensembl:ENST00000278949(transcript)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042633"(hair cycle)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029862|interpro:IPR036179 refseq:NP_005788.1|refseq:NP_658911.1|ensembl:ENSG00000149573(gene)|ensembl:ENST00000278937(transcript)|ensembl:ENST00000438295(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000920(Myelin P0 protein)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR029863|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:4u0ZnfuMMmBw2AhVxPwPHO6THYI9606 rogid:YQHXvM5xiVw8HV97MnJ67T4/D5E9606 intact-crc:031C1627F71B221C|rigid:NGcs8l+D+pOcbKQWzIU3ctzYVcw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40199 uniprotkb:Q16568 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 intact:EBI-4314526|uniprotkb:Q6FG92|ensembl:ENSP00000296777 psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:cart_human(display_long)|uniprotkb:CARTPT(gene name)|psi-mi:CARTPT(display_short)|uniprotkb:CART(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316626|imex:IM-15733-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) refseq:NP_004282.1|ensembl:ENSG00000164326(gene)|ensembl:ENST00000296777(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030141"(secretory granule)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0070253"(somatostatin secretion)|interpro:IPR009106(CART satiety factor)|interpro:IPR036722|rcsb pdb:1HY9|go:"GO:0001678"(cellular glucose homeostasis) psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 rogid:N3PoYTEXZrIrABT6xed52NR63EI9606 intact-crc:48E04DA354EAE800|rigid:g7bIu7kE8dUTlyO6smArGdCpB7c false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q9NYZ4 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314991|uniprotkb:Q7Z728|ensembl:ENSP00000321077 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:sigl8_human(display_long)|uniprotkb:SIGLEC8(gene name)|psi-mi:SIGLEC8(display_short)|uniprotkb:SAF2(gene name synonym)|uniprotkb:Sialoadhesin family member 2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568101|imex:IM-15733-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:XP_011525037.1|refseq:NP_055257.2|ensembl:ENSG00000105366(gene)|ensembl:ENST00000321424(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033691"(sialic acid binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2N7A|rcsb pdb:2N7B|reactome:R-HSA-198933 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:lMlEum1EMluaa51lEgk7PLijfY89606 intact-crc:98E5F905BD0C35EE|rigid:PdjX8OrNlRbeckQn8MLT+BRuajE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q6UXZ3 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314468|ensembl:ENSP00000364501 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:clm5_human(display_long)|uniprotkb:CD300LD(gene name)|psi-mi:CD300LD(display_short)|uniprotkb:CD300D(gene name synonym)|uniprotkb:CMRF35A4(gene name synonym)|uniprotkb:CD300 antigen-like family member D(gene name synonym)|uniprotkb:CMRF35-A4(gene name synonym)|uniprotkb:UNQ9218/PRO28686(orf name) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568141|imex:IM-15733-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:NP_001108624.1|ensembl:ENSG00000204345(gene)|ensembl:ENST00000375352(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:Z44M8MmLNTarCE2prDhXD6/kSPY9606 intact-crc:A9D43CEEFDC38D16|rigid:B5VCIF92L6Sy3McBQ7UYE6BS+r8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q6UX41 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314379|uniprotkb:Q9H730|uniprotkb:A4QMZ8|uniprotkb:B7Z409|uniprotkb:E9PEF6|uniprotkb:E9PG07|uniprotkb:A6NEX6|uniprotkb:B7Z5B1|uniprotkb:F2Z2B2|uniprotkb:F8W712|intact:EBI-28985330|ensembl:ENSP00000342197 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:btnl8_human(display_long)|uniprotkb:BTNL8(gene name)|psi-mi:BTNL8(display_short)|uniprotkb:UNQ702/PRO1347(orf name) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316581|imex:IM-15733-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:NP_001035552.1|refseq:NP_001153179.1|refseq:NP_001153180.1|refseq:NP_001153181.1|refseq:NP_001153182.1|refseq:NP_079126.1|ensembl:ENST00000231229|ensembl:ENSP00000231229|ensembl:ENSP00000342197|ensembl:ENST00000400707|ensembl:ENSP00000383543|ensembl:ENST00000508408|ensembl:ENSP00000424585|ensembl:ENST00000511704|ensembl:ENSP00000425207|ensembl:ENST00000533815|ensembl:ENSP00000435098|ensembl:ENST00000610640|ensembl:ENSP00000483717|ensembl:ENSG00000113303(gene)|ensembl:ENST00000340184(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043136|reactome:R-HSA-8851680 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:Eo+M4bJU2EN6LjZqQ5pPWdiMEvo9606 intact-crc:6F63FF8405BA0854|rigid:CT7zYWyNQHw2SFa/xdRIB40i97Y false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03403 uniprotkb:Q96PJ5 intact:EBI-4314702|uniprotkb:Q15854|ensembl:ENSP00000291526 intact:EBI-4314687|uniprotkb:Q96RE0|uniprotkb:Q96PJ3|ensembl:ENSP00000271532 psi-mi:tff2_human(display_long)|uniprotkb:TFF2(gene name)|psi-mi:TFF2(display_short)|uniprotkb:SML1(gene name synonym)|uniprotkb:Spasmolysin(gene name synonym)|uniprotkb:Spasmolytic polypeptide(gene name synonym) psi-mi:fcrl4_human(display_long)|uniprotkb:FCRL4(gene name)|psi-mi:FCRL4(display_short)|uniprotkb:FCRH4(gene name synonym)|uniprotkb:IFGP2(gene name synonym)|uniprotkb:IRTA1(gene name synonym)|uniprotkb:Fc receptor homolog 4(gene name synonym)|uniprotkb:IFGP family protein 2(gene name synonym)|uniprotkb:Immune receptor translocation-associated protein 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316655|imex:IM-15733-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005414.1|ensembl:ENSG00000160181(gene)|ensembl:ENST00000291526(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0031723"(CXCR4 chemokine receptor binding)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994 refseq:NP_112572.1|ensembl:ENSG00000163518(gene)|ensembl:ENST00000271532(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:8r4uay1usoNmDm2uNdZTK2Iglqc9606 rogid:4roUvQm/vS0uROX51uF7KYoPo5g9606 intact-crc:0E392A5D2A013CFE|rigid:pIHysof2DOlLBQwtK2L0orej5Kw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16568 uniprotkb:P13688 intact:EBI-4314526|uniprotkb:Q6FG92|ensembl:ENSP00000296777 intact:EBI-4314481|uniprotkb:Q13858|uniprotkb:Q13857|uniprotkb:Q13859|uniprotkb:Q15600|uniprotkb:Q069I7|uniprotkb:O60430|uniprotkb:A6NE38|uniprotkb:Q13860|uniprotkb:A8MY49|uniprotkb:Q13854|uniprotkb:Q15601|uniprotkb:Q96CA7|uniprotkb:Q5UB49|uniprotkb:Q7KYP5|uniprotkb:Q16170|uniprotkb:Q9UQV9|ensembl:ENSP00000161559 psi-mi:cart_human(display_long)|uniprotkb:CARTPT(gene name)|psi-mi:CARTPT(display_short)|uniprotkb:CART(gene name synonym) psi-mi:ceam1_human(display_long)|uniprotkb:CEACAM1(gene name)|psi-mi:CEACAM1(display_short)|uniprotkb:BGP(gene name synonym)|uniprotkb:BGP1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568077|imex:IM-15733-18 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004282.1|ensembl:ENSG00000164326(gene)|ensembl:ENST00000296777(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030141"(secretory granule)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0070253"(somatostatin secretion)|interpro:IPR009106(CART satiety factor)|interpro:IPR036722|rcsb pdb:1HY9|go:"GO:0001678"(cellular glucose homeostasis) refseq:NP_001020083.1|refseq:NP_001171742.1|refseq:NP_001171744.1|refseq:NP_001171745.1|refseq:NP_001192273.1|refseq:NP_001703.2|go:"GO:0031528"(microvillus membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0031005"(filamin binding)|reactome:R-HSA-202733|reactome:R-HSA-6798695|reactome:R-HSA-1566977|refseq:XP_011525508.1|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P13688|rcsb pdb:2GK2|rcsb pdb:4QXW|rcsb pdb:4WHD|rcsb pdb:5DZL|rcsb pdb:6AW2|rcsb pdb:6GBG|rcsb pdb:6GBH|rcsb pdb:6V3P|rcsb pdb:6XNO|rcsb pdb:6XNT|rcsb pdb:6XNW|rcsb pdb:6XO1|ensembl:ENSG00000079385(gene)|ensembl:ENST00000161559(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|dip:DIP-42683N psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:N3PoYTEXZrIrABT6xed52NR63EI9606 rogid:M1gnNv8yCTCddhfx20lHL7WFvf49606 intact-crc:75CB8FC481F38D7B|rigid:0lNFOAVcwK+TVjHNgobz0FMMFO0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q16568 uniprotkb:P40199 intact:EBI-4314526|uniprotkb:Q6FG92|ensembl:ENSP00000296777 intact:EBI-4314501|uniprotkb:Q13774|uniprotkb:Q53XP7|uniprotkb:Q14920|ensembl:ENSP00000199764 psi-mi:cart_human(display_long)|uniprotkb:CARTPT(gene name)|psi-mi:CARTPT(display_short)|uniprotkb:CART(gene name synonym) psi-mi:ceam6_human(display_long)|uniprotkb:CEACAM6(gene name)|psi-mi:CEACAM6(display_short)|uniprotkb:NCA(gene name synonym)|uniprotkb:Non-specific crossreacting antigen(gene name synonym)|uniprotkb:Normal cross-reacting antigen(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568119|imex:IM-15733-19 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004282.1|ensembl:ENSG00000164326(gene)|ensembl:ENST00000296777(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0030141"(secretory granule)|go:"GO:0032099"(negative regulation of appetite)|go:"GO:0032812"(positive regulation of epinephrine secretion)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051971"(positive regulation of transmission of nerve impulse)|go:"GO:0070093"(negative regulation of glucagon secretion)|go:"GO:0070253"(somatostatin secretion)|interpro:IPR009106(CART satiety factor)|interpro:IPR036722|rcsb pdb:1HY9|go:"GO:0001678"(cellular glucose homeostasis) refseq:NP_002474.4|ensembl:ENSG00000086548(gene)|ensembl:ENST00000199764(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1904906"(positive regulation of endothelial cell-matrix adhesion via fibronectin)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4WHC|rcsb pdb:4WTZ|rcsb pdb:4Y8A|rcsb pdb:4YIQ|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-6798695|go:"GO:0030335"(positive regulation of cell migration) psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:N3PoYTEXZrIrABT6xed52NR63EI9606 rogid:F8d9EpjNi+/H+9akR4K9HpV/btY9606 intact-crc:6D4A2169665EFC73|rigid:g7bIu7kE8dUTlyO6smArGdCpB7c false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15238 uniprotkb:P35590 intact:EBI-4314891|uniprotkb:Q15239|uniprotkb:Q96QJ1|uniprotkb:Q9UQ75|ensembl:ENSP00000344413|ensembl:ENSP00000382334|ensembl:ENSP00000386008 intact:EBI-2256865|uniprotkb:B5A949|uniprotkb:B5A950|ensembl:ENSP00000361554 psi-mi:psg5_human(display_long)|uniprotkb:PSG5(gene name)|psi-mi:PSG5(display_short)|uniprotkb:Fetal liver non-specific cross-reactive antigen 3(gene name synonym) psi-mi:tie1_human(display_long)|uniprotkb:TIE1(gene name)|psi-mi:TIE1(display_short)|uniprotkb:TIE(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568107|imex:IM-15733-22 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001123486.1|refseq:NP_002772.3|refseq:XP_016882492.1|ensembl:ENSG00000204941(gene)|ensembl:ENST00000342951(transcript)|ensembl:ENST00000366175(transcript)|ensembl:ENST00000407356(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0007565"(female pregnancy)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-202733 refseq:NP_005415.1|ensembl:ENSG00000066056(gene)|ensembl:ENST00000372476(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007498"(mesoderm development)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060854"(branching involved in lymph vessel morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036116|interpro:IPR036179|mint:P35590|rcsb pdb:5N06 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:O5maHM77+s2CWMD1oFv4jzy80G49606 rogid:/tuK6SwU9CCcxFhdQo/rlvlPZRg9606 intact-crc:B5A532327DF7EB98|rigid:T8WUk3Tln8eBkZcu+9lL4X+UxJg false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P04155 uniprotkb:Q96PJ5 intact:EBI-743871|ensembl:ENSP00000291527 intact:EBI-4314687|uniprotkb:Q96RE0|uniprotkb:Q96PJ3|ensembl:ENSP00000271532 psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:fcrl4_human(display_long)|uniprotkb:FCRL4(gene name)|psi-mi:FCRL4(display_short)|uniprotkb:FCRH4(gene name synonym)|uniprotkb:IFGP2(gene name synonym)|uniprotkb:IRTA1(gene name synonym)|uniprotkb:Fc receptor homolog 4(gene name synonym)|uniprotkb:IFGP family protein 2(gene name synonym)|uniprotkb:Immune receptor translocation-associated protein 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316592|imex:IM-15733-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 refseq:NP_112572.1|ensembl:ENSG00000163518(gene)|ensembl:ENST00000271532(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 rogid:4roUvQm/vS0uROX51uF7KYoPo5g9606 intact-crc:0CF4B1E55F06F39F|rigid:PzZPxtieBxfkIhOQs79I7Ugn5tQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q96PJ5 uniprotkb:P04155 intact:EBI-4314687|uniprotkb:Q96RE0|uniprotkb:Q96PJ3|ensembl:ENSP00000271532 intact:EBI-743871|ensembl:ENSP00000291527 psi-mi:fcrl4_human(display_long)|uniprotkb:FCRL4(gene name)|psi-mi:FCRL4(display_short)|uniprotkb:FCRH4(gene name synonym)|uniprotkb:IFGP2(gene name synonym)|uniprotkb:IRTA1(gene name synonym)|uniprotkb:Fc receptor homolog 4(gene name synonym)|uniprotkb:IFGP family protein 2(gene name synonym)|uniprotkb:Immune receptor translocation-associated protein 1(gene name synonym) psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568086|imex:IM-15733-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_112572.1|ensembl:ENSG00000163518(gene)|ensembl:ENST00000271532(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:4roUvQm/vS0uROX51uF7KYoPo5g9606 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 intact-crc:295EDD2F6DB2E7EC|rigid:PzZPxtieBxfkIhOQs79I7Ugn5tQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UX41 uniprotkb:P04155 intact:EBI-4314379|uniprotkb:Q9H730|uniprotkb:A4QMZ8|uniprotkb:B7Z409|uniprotkb:E9PEF6|uniprotkb:E9PG07|uniprotkb:A6NEX6|uniprotkb:B7Z5B1|uniprotkb:F2Z2B2|uniprotkb:F8W712|intact:EBI-28985330|ensembl:ENSP00000342197 intact:EBI-743871|ensembl:ENSP00000291527 psi-mi:btnl8_human(display_long)|uniprotkb:BTNL8(gene name)|psi-mi:BTNL8(display_short)|uniprotkb:UNQ702/PRO1347(orf name) psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568115|imex:IM-15733-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035552.1|refseq:NP_001153179.1|refseq:NP_001153180.1|refseq:NP_001153181.1|refseq:NP_001153182.1|refseq:NP_079126.1|ensembl:ENST00000231229|ensembl:ENSP00000231229|ensembl:ENSP00000342197|ensembl:ENST00000400707|ensembl:ENSP00000383543|ensembl:ENST00000508408|ensembl:ENSP00000424585|ensembl:ENST00000511704|ensembl:ENSP00000425207|ensembl:ENST00000533815|ensembl:ENSP00000435098|ensembl:ENST00000610640|ensembl:ENSP00000483717|ensembl:ENSG00000113303(gene)|ensembl:ENST00000340184(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043136|reactome:R-HSA-8851680 refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:Eo+M4bJU2EN6LjZqQ5pPWdiMEvo9606 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 intact-crc:4AC9934E370E1C27|rigid:CT7zYWyNQHw2SFa/xdRIB40i97Y false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXZ3 uniprotkb:P04155 intact:EBI-4314468|ensembl:ENSP00000364501 intact:EBI-743871|ensembl:ENSP00000291527 psi-mi:clm5_human(display_long)|uniprotkb:CD300LD(gene name)|psi-mi:CD300LD(display_short)|uniprotkb:CD300D(gene name synonym)|uniprotkb:CMRF35A4(gene name synonym)|uniprotkb:CD300 antigen-like family member D(gene name synonym)|uniprotkb:CMRF35-A4(gene name synonym)|uniprotkb:UNQ9218/PRO28686(orf name) psi-mi:tff1_human(display_long)|uniprotkb:Protein pS2(gene name synonym)|uniprotkb:Polypeptide P1.A(gene name synonym)|uniprotkb:Breast cancer estrogen-inducible protein(gene name synonym)|uniprotkb:PNR-2(gene name synonym)|uniprotkb:TFF1(gene name)|psi-mi:TFF1(display_short)|uniprotkb:BCEI(gene name synonym)|uniprotkb:PS2(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4316586|imex:IM-15733-20 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001108624.1|ensembl:ENSG00000204345(gene)|ensembl:ENST00000375352(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933 refseq:NP_003216.1|ensembl:ENSG00000160182(gene)|ensembl:ENST00000291527(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010039"(response to iron ion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0043434"(response to peptide hormone)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994|rcsb pdb:1HI7|rcsb pdb:1PS2|rcsb pdb:6V1D|reactome:R-HSA-9018519 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:Z44M8MmLNTarCE2prDhXD6/kSPY9606 rogid:AsrVoDgxWupA7lG87+LMvc23BWM9606 intact-crc:8C7E5024CF779965|rigid:B5VCIF92L6Sy3McBQ7UYE6BS+r8 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03403 uniprotkb:Q96PJ5 intact:EBI-4314702|uniprotkb:Q15854|ensembl:ENSP00000291526 intact:EBI-4314687|uniprotkb:Q96RE0|uniprotkb:Q96PJ3|ensembl:ENSP00000271532 psi-mi:tff2_human(display_long)|uniprotkb:TFF2(gene name)|psi-mi:TFF2(display_short)|uniprotkb:SML1(gene name synonym)|uniprotkb:Spasmolysin(gene name synonym)|uniprotkb:Spasmolytic polypeptide(gene name synonym) psi-mi:fcrl4_human(display_long)|uniprotkb:FCRL4(gene name)|psi-mi:FCRL4(display_short)|uniprotkb:FCRH4(gene name synonym)|uniprotkb:IFGP2(gene name synonym)|uniprotkb:IRTA1(gene name synonym)|uniprotkb:Fc receptor homolog 4(gene name synonym)|uniprotkb:IFGP family protein 2(gene name synonym)|uniprotkb:Immune receptor translocation-associated protein 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) S et al. (2011) imex:IM-15733|pubmed:21982860 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-4568081|imex:IM-15733-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005414.1|ensembl:ENSG00000160181(gene)|ensembl:ENST00000291526(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0031723"(CXCR4 chemokine receptor binding)|go:"GO:0060455"(negative regulation of gastric acid secretion)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR000519(P-type trefoil)|interpro:IPR017957|interpro:IPR017994 refseq:NP_112572.1|ensembl:ENSG00000163518(gene)|ensembl:ENST00000271532(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009986"(cell surface)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:Table 2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/08/01 2014/10/16 rogid:8r4uay1usoNmDm2uNdZTK2Iglqc9606 rogid:4roUvQm/vS0uROX51uF7KYoPo5g9606 intact-crc:2B93469718B5288D|rigid:pIHysof2DOlLBQwtK2L0orej5Kw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)