#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q90VU7	uniprotkb:Q900A7	intact:EBI-7460704|intact:MINT-5281653	intact:EBI-7460739|intact:MINT-8208185	psi-mi:q90vu7_9hiv1(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym)	psi-mi:q900a7_9hiv1(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Sugiyama et al. (2011)	pubmed:21970979|imex:IM-16787|mint:MINT-8206204|doi:10.1016/j.febslet.2011.09.029	taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1)	taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7460732|mint:MINT-8206271|imex:IM-16787-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019058"(viral life cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051117"(ATPase binding)|go:"GO:0052085"(suppression by symbiont of host T-cell mediated immune response)|go:"GO:0075528"(modulation by virus of host immune response)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|interpro:IPR027481|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|dip:DIP-43762N|mint:Q90VU7|mint:MINT-8206274(identity)	interpro:IPR036963|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|mint:MINT-8206273(identity)	go:"GO:0005737"(cytoplasm)	comment:mint	comment:mint	figure legend:f2d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/09/20	2014/10/16	rogid:/q84A6o2nxh3A2gNX5BJ1TL+Ids11676	rogid:3VV2rq2HGmWgs76aoJDZhJg4Xio11676	intact-crc:3BA53F2023550CA5|rigid:Mr3eRHg30tuxdfRovWzExasffec	false	flag tag:?-?(MINT-8206281)	v5 tag:?-?(MINT-8206277)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q900A7	uniprotkb:P08107	intact:EBI-7460739|intact:MINT-8208185	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:q900a7_9hiv1(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugiyama et al. (2011)	pubmed:21970979|imex:IM-16787|mint:MINT-8206204|doi:10.1016/j.febslet.2011.09.029	taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7460786|mint:MINT-8206740|imex:IM-16787-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR036963|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|mint:MINT-8206743(identity)	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487|mint:MINT-8206742(identity)	-	comment:mint	-	figure legend:f3d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/09/20	2014/10/16	rogid:3VV2rq2HGmWgs76aoJDZhJg4Xio11676	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:47FDA1FEE24E5199|rigid:GL7o8z+myU0M0j66dqShm15FTQk	false	v5 tag:?-?(MINT-8206827)	flag tag:?-?(MINT-8206823)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)