#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P57078	uniprotkb:P98170	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422332|imex:IM-16958-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	intact-crc:43BE9478865295B1|rigid:JlUXeN+nTzekvKeoRniHhLLZTKo	false	vsv tag:?-?|35s radiolabel:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:P57078	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422342|imex:IM-16958-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	intact-crc:EBEDA876F9C94E30|rigid:exAKQzPbNftbU91H1hzYiq0V3Mo	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:Q9Y572	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422298|imex:IM-16958-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:32B76CCF9601A55D|rigid:HoalwVhwi+aW74/EcvpO7OS52+g	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?|vsv tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P98170	uniprotkb:Q9Y572	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422278|imex:IM-16958-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:1FBE91868CD26CD0|rigid:D++WHgn5vzXn2FjDik/HKhVajtY	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:O43353	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422223|imex:IM-16958-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	-	-	-	figure legend:1a, 1b|antagonist:SMAC mimetic compound BV6 disrupts this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	intact-crc:CCA675BC2C27A541|rigid:3HPNw88WGjVSkffhFMGQvfukQVg	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?|vsv tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P98170	uniprotkb:O43353	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422268|imex:IM-16958-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	intact-crc:8F57715BC4F0F017|rigid:LcFQoHYHLDW6RSJtlsbQUVFtZRM	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:Q13546	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422178|imex:IM-16958-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	-	-	-	figure legend:1a, 1b|antagonist:SMAC mimetic compound BV6 disrupts this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:6B40124ADE7681B2|rigid:05ArXQ+S9U+QWylo9Fcuz95z2nI	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?|vsv tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:Q9Y572	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422288|imex:IM-16958-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:55A3F7CB4001A79C|rigid:4WBIYMTKPqy8Nksjh2mmBnY++uc	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?|vsv tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P57078	uniprotkb:Q13490	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422352|imex:IM-16958-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:D67B0B4B08D064CA|rigid:CC2QGrReWjxuO8u6YpQ7QNLcRyQ	false	35s radiolabel:?-?|vsv tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13546	uniprotkb:P98170	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422257|imex:IM-16958-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	-	-	-	figure legend:1a, 1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	intact-crc:BD7F78918CD77A03|rigid:mc8cmVTNtc+U1napPI1TsC6SoD0	false	35s radiolabel:?-?|vsv tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:O43353	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422234|imex:IM-16958-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	-	-	-	figure legend:1a, 1b|antagonist:SMAC mimetic compound BV6 disrupts this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	intact-crc:DAFF1B0CA7518DA5|rigid:qgOnWZ4AbxP1BTdGZIu2WSuAJc4	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?|vsv tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13546	uniprotkb:Q13489	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422246|imex:IM-16958-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	-	-	-	figure legend:1a, 1b|antagonist:SMAC mimetic compound BV6 disrupts this interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2014/10/16	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	intact-crc:290394AE871B9396|rigid:YkuspKUOR0jP5KJ3I8/jKBFt2XU	false	35s radiolabel:?-?|vsv tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P57078	uniprotkb:Q13489	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422612|imex:IM-16958-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	-	-	-	figure legend:S1, 2b and 1d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	intact-crc:5BDCC892D7B55E2D|rigid:exAKQzPbNftbU91H1hzYiq0V3Mo	false	vsv tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13489	uniprotkb:Q13546	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422424|imex:IM-16958-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	-	-	-	figure legend:1d and S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:F11BCD5D27F6F938|rigid:YkuspKUOR0jP5KJ3I8/jKBFt2XU	false	myc tag:?-?	vsv tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y572	uniprotkb:Q13489	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422604|imex:IM-16958-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	-	-	-	figure legend:S1, 2b and 1d|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	intact-crc:C9E0938A297990CC|rigid:HoalwVhwi+aW74/EcvpO7OS52+g	false	vsv tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13546	uniprotkb:Q13490	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422369|imex:IM-16958-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:7E7888B2FA55A669|rigid:05ArXQ+S9U+QWylo9Fcuz95z2nI	false	vsv tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57078	uniprotkb:Q13490	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422432|imex:IM-16958-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:A1BC9C34F5A95E54|rigid:CC2QGrReWjxuO8u6YpQ7QNLcRyQ	false	vsv tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y572	uniprotkb:Q13490	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422389|imex:IM-16958-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	intact-crc:F538B2E6039F4D2C|rigid:4WBIYMTKPqy8Nksjh2mmBnY++uc	false	vsv tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13490	uniprotkb:O43353	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422381|imex:IM-16958-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	-	-	-	figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	intact-crc:AA226E30D1612E05|rigid:3HPNw88WGjVSkffhFMGQvfukQVg	false	flag tag:?-?	vsv tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43353	uniprotkb:Q13489	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422596|imex:IM-16958-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	-	-	-	figure legend:1d and S1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/10/04	2014/10/16	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	intact-crc:45F65FBF83B496C5|rigid:qgOnWZ4AbxP1BTdGZIu2WSuAJc4	false	vsv tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P57078	uniprotkb:P51668	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422575|imex:IM-16958-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:P98170 is required for ubiquitination of P57078|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:E9ECDC8C23ADD1E4|rigid:g8gDXZvxgEZ2c7ajURPkhTmG6PE	false	35s radiolabel:?-?|vsv tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P57078	uniprotkb:P98170	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422575|imex:IM-16958-26	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:P98170 is required for ubiquitination of P57078|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	intact-crc:E9ECDC8C23ADD1E4|rigid:g8gDXZvxgEZ2c7ajURPkhTmG6PE	false	35s radiolabel:?-?|vsv tag:?-?	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:P57078	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422562|imex:IM-16958-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13490 is required for ubiquitination of P57078|figure legend:2a, 3b, 3c, 3d and 5d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	intact-crc:2E00996D6F1ADC22|rigid:pkXAAdVIMSlfHS6pg2ByiRRaGd0	false	glutathione s tranferase tag:n-n	mutation decreasing interaction:51-51|vsv tag:?-?|35s radiolabel:?-?|mutation decreasing interaction:145-145	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:P51668	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422562|imex:IM-16958-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13490 is required for ubiquitination of P57078|figure legend:2a, 3b, 3c, 3d and 5d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:2E00996D6F1ADC22|rigid:pkXAAdVIMSlfHS6pg2ByiRRaGd0	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:P57078	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-4422308|uniprotkb:Q96KH0|ensembl:ENSP00000330161	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk4_human(display_long)|uniprotkb:RIPK4(gene name)|psi-mi:RIPK4(display_short)|uniprotkb:ANKRD3(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 3(gene name synonym)|uniprotkb:PKC-delta-interacting protein kinase(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422549|imex:IM-16958-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	dip:DIP-40722N|ensembl:ENSG00000183421(gene)|ensembl:ENST00000352483(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR002110(Ankyrin)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020683|interpro:IPR036770	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	causality statement:Q13489 is required for ubiquitination of P57078|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:1jgoEgfCkjhbVu3jpg/+ZHroZyM9606	intact-crc:9BB18B908265F83A|rigid:gzYy6F0kQpF0D3CwUNnS7R9EnuU	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:P51668	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422549|imex:IM-16958-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	causality statement:Q13489 is required for ubiquitination of P57078|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:9BB18B908265F83A|rigid:gzYy6F0kQpF0D3CwUNnS7R9EnuU	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:Q9Y572	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422536|imex:IM-16958-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	causality statement:Q13489 is required for ubiquitination of Q9Y572|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:5B95975670A304CD|rigid:jl9akAIJll6TI6HGmdwDAAyR8Do	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:P51668	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422536|imex:IM-16958-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	causality statement:Q13489 is required for ubiquitination of Q9Y572|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:5B95975670A304CD|rigid:jl9akAIJll6TI6HGmdwDAAyR8Do	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:O43353	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422471|imex:IM-16958-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13489 is required for ubiquitination of O43353|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	intact-crc:A342B12D9282DB60|rigid:K/mz+LwF0/k+Q9sLIlVA9T4BsEE	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:P51668	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422471|imex:IM-16958-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13489 is required for ubiquitination of O43353|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:A342B12D9282DB60|rigid:K/mz+LwF0/k+Q9sLIlVA9T4BsEE	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:O43353	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-358522|uniprotkb:Q6UWF0|uniprotkb:B7Z748|ensembl:ENSP00000220751	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk2_human(display_long)|uniprotkb:RIPK2(gene name)|psi-mi:RIPK2(display_short)|uniprotkb:CARDIAK(gene name synonym)|uniprotkb:RICK(gene name synonym)|uniprotkb:RIP2(gene name synonym)|uniprotkb:UNQ277/PRO314/PRO34092(orf name)|uniprotkb:RIP-like-interacting CLARP kinase(gene name synonym)|uniprotkb:Receptor-interacting protein 2(gene name synonym)|uniprotkb:CARD-containing interleukin-1 beta-converting enzyme-associated kinase(gene name synonym)|uniprotkb:Tyrosine-protein kinase RIPK2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422507|imex:IM-16958-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	refseq:NP_003812.1|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0006954"(inflammatory response)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033091"(positive regulation of immature T cell proliferation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0030274"(LIM domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|ensembl:ENSG00000104312(gene)|ensembl:ENST00000220751(transcript)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017322(Receptor-interacting serine/threonine-protein kinase 2)|interpro:IPR042149|mint:O43353|rcsb pdb:2N7Z|rcsb pdb:2N83|rcsb pdb:4C8B|rcsb pdb:5AR2|rcsb pdb:5AR3|rcsb pdb:5AR4|rcsb pdb:5AR5|rcsb pdb:5AR7|go:"GO:0070673"(response to interleukin-18)|rcsb pdb:5AR8|rcsb pdb:5J79|rcsb pdb:5J7B|rcsb pdb:5NG0|rcsb pdb:5NG2|rcsb pdb:5NG3|rcsb pdb:5W5J|rcsb pdb:5W5O|rcsb pdb:5YRN|rcsb pdb:6ES0|rcsb pdb:6FU5|rcsb pdb:6GFJ|rcsb pdb:6GGS|rcsb pdb:6HMX|rcsb pdb:6RN8|rcsb pdb:6RNA|rcsb pdb:6S1F|rcsb pdb:6SZE|rcsb pdb:6SZJ|rcsb pdb:6UL8|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5689896|reactome:R-HSA-9020702|refseq:XP_005251149.1|dip:DIP-27518N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13490 is required for ubiquitination of O43353|figure legend:2a, 3b, 3c and 3d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:vmVxb58HgNLVE3AgNkPsG0i7OXo9606	intact-crc:8C3ED91768FD3F2D|rigid:zIlalCfgIwcAi0X900qBtafkEJg	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:P51668	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422507|imex:IM-16958-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13490 is required for ubiquitination of O43353|figure legend:2a, 3b, 3c and 3d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:8C3ED91768FD3F2D|rigid:zIlalCfgIwcAi0X900qBtafkEJg	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:Q13546	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422493|imex:IM-16958-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13489 is required for ubiquitination of Q13546|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:449FC57CDE18A69E|rigid:GyZ7OV+mxKzV8jXFqM5f+xxZZg0	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13489	uniprotkb:P51668	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422493|imex:IM-16958-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13489 is required for ubiquitination of Q13546|figure legend:2a|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:449FC57CDE18A69E|rigid:GyZ7OV+mxKzV8jXFqM5f+xxZZg0	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:Q13546	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-358507|uniprotkb:A0AV89|uniprotkb:B2RAG1|uniprotkb:B4E3F9|uniprotkb:Q59H33|uniprotkb:Q13180|ensembl:ENSP00000259808	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk1_human(display_long)|uniprotkb:RIPK1(gene name)|psi-mi:RIPK1(display_short)|uniprotkb:RIP(gene name synonym)|uniprotkb:Cell death protein RIP(gene name synonym)|uniprotkb:RIP1(gene name synonym)|uniprotkb:Receptor-interacting protein 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422458|imex:IM-16958-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	refseq:NP_003795.2|refseq:XP_005249514.2|dip:DIP-433N|ensembl:ENSG00000137275(gene)|ensembl:ENST00000259808(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0010008"(endosome membrane)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070105"(positive regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070231"(T cell apoptotic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070513"(death domain binding)|go:"GO:0070926"("regulation of ATP:ADP antiporter activity")|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097342"(ripoptosome)|go:"GO:0097343"(ripoptosome assembly)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905206"(positive regulation of hydrogen peroxide-induced cell death)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR025735|interpro:IPR037934|mint:Q13546|rcsb pdb:4ITH|rcsb pdb:4ITI|rcsb pdb:4ITJ|rcsb pdb:4NEU|rcsb pdb:5HX6|rcsb pdb:5TX5|rcsb pdb:5V7Z|rcsb pdb:6AC5|rcsb pdb:6C3E|rcsb pdb:6C4D|rcsb pdb:6HHO|rcsb pdb:6NW2|rcsb pdb:6NYH|rcsb pdb:6OCQ|rcsb pdb:6R5F|rcsb pdb:6RLN|reactome:R-HSA-140534|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-937041|reactome:R-HSA-9679191|reactome:R-HSA-9686347|reactome:R-HSA-9693928|go:"GO:0070266"(necroptotic process)	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	causality statement:Q13490 is required for ubiquitination of Q13546|figure legend:2a, 3b, 3c and 3d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:P1pQanTLVGi2Oic1QNeELpcdL2M9606	intact-crc:B4A517466F3EF19B|rigid:ByX7yPutehKSNn2FGO9ZrZqZ368	false	glutathione s tranferase tag:n-n	vsv tag:?-?|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:P51668	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422458|imex:IM-16958-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0016567"(protein ubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	causality statement:Q13490 is required for ubiquitination of Q13546|figure legend:2a, 3b, 3c and 3d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:B4A517466F3EF19B|rigid:ByX7yPutehKSNn2FGO9ZrZqZ368	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:Q9Y572	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-298250|intact:EBI-358587|uniprotkb:C4AM87|uniprotkb:Q5J795|uniprotkb:Q5J796|uniprotkb:Q6P5Y1|uniprotkb:B4DJL9|ensembl:ENSP00000216274|ensembl:ENSP00000495490	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ripk3_human(display_long)|uniprotkb:RIPK3(gene name)|psi-mi:RIPK3(display_short)|uniprotkb:RIP3(gene name synonym)|uniprotkb:RIP-like protein kinase 3(gene name synonym)|uniprotkb:Receptor-interacting protein 3(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422523|imex:IM-16958-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	refseq:NP_006862.2|dip:DIP-27519N|ensembl:ENSG00000129465(gene)|ensembl:ENSG00000285379(gene)|ensembl:ENST00000216274(transcript)|ensembl:ENST00000646516(transcript)|go:"GO:0001914"(regulation of T cell mediated cytotoxicity)|go:"GO:0002819"(regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046006"(regulation of activated T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051351"(positive regulation of ligase activity)|go:"GO:0051353"(positive regulation of oxidoreductase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060545"(positive regulation of necroptotic process)|go:"GO:0070235"(regulation of activation-induced cell death of T cells)|go:"GO:0070266"(necroptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0097528"(execution phase of necroptosis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000452"(regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025735|mint:Q9Y572|rcsb pdb:5V7Z|rcsb pdb:5ZCK|rcsb pdb:7DAC|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-3295583|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-9013957|reactome:R-HSA-937041|reactome:R-HSA-9686347|rcsb pdb:7DA4	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13490 is required for ubiquitination of Q9Y572|figure legend:2a, 3b, 3c and 3d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:UgojU4aAUAG5RCZ55KR39AelO249606	intact-crc:021A1232F0B1D9B4|rigid:LD5tpr3MIysY8aLWDu8vDxsB1g0	false	glutathione s tranferase tag:n-n	35s radiolabel:?-?|vsv tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13490	uniprotkb:P51668	intact:EBI-514538|uniprotkb:Q16516|uniprotkb:Q4TTG0|uniprotkb:B4E026|ensembl:ENSP00000227758|ensembl:ENSP00000477613	intact:EBI-743540|ensembl:ENSP00000363019|uniprotkb:A6NLF6|uniprotkb:A8K786	psi-mi:birc2_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 2(gene name synonym)|uniprotkb:IAP homolog B(gene name synonym)|uniprotkb:RING finger protein 48(gene name synonym)|uniprotkb:BIRC2(gene name)|psi-mi:BIRC2(display_short)|uniprotkb:API1(gene name synonym)|uniprotkb:MIHB(gene name synonym)|uniprotkb:RNF48(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)	psi-mi:ub2d1_human(display_long)|uniprotkb:Ubiquitin-protein ligase D1(gene name synonym)|uniprotkb:Ubiquitin carrier protein D1(gene name synonym)|uniprotkb:UbcH5(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 1(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 1"(gene name synonym)|uniprotkb:UBC4/5 homolog(gene name synonym)|uniprotkb:Stimulator of Fe transport(gene name synonym)|uniprotkb:UBE2D1(gene name)|psi-mi:UBE2D1(display_short)|uniprotkb:UBCH5(gene name synonym)|uniprotkb:UBCH5A(gene name synonym)|uniprotkb:SFT(gene name synonym)|uniprotkb:UBC5A(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Bertrand et al. (2011)	pubmed:21931591|imex:IM-16958	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4422523|imex:IM-16958-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157.1|refseq:NP_001243095.1|refseq:NP_001243092.1|dip:DIP-33485N|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q13490|rcsb pdb:1QBH|rcsb pdb:2L9M|rcsb pdb:3D9T|rcsb pdb:3D9U|rcsb pdb:3M1D|rcsb pdb:3MUP|rcsb pdb:3OZ1|rcsb pdb:3T6P|rcsb pdb:3UW4|rcsb pdb:4EB9|rcsb pdb:4HY4|rcsb pdb:4HY5|rcsb pdb:4KMN|rcsb pdb:4LGE|rcsb pdb:4LGU|rcsb pdb:4MTI|rcsb pdb:4MU7|rcsb pdb:5M6N|rcsb pdb:6EXW|rcsb pdb:6HPR|rcsb pdb:6W74|rcsb pdb:6W7O|rcsb pdb:6W8I|reactome:R-HSA-111465|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041|ensembl:ENSG00000110330(gene)|ensembl:ENST00000227758(transcript)|ensembl:ENST00000613397(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)	ensembl:ENSG00000072401(gene)|ensembl:ENST00000373910(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|refseq:NP_003329.1|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P51668|rcsb pdb:2C4P|rcsb pdb:2YHO|rcsb pdb:3OJ4|rcsb pdb:3PTF|rcsb pdb:4AP4|rcsb pdb:4QPL|rcsb pdb:5FER|rcsb pdb:5TUT|rcsb pdb:6D4P|reactome:R-HSA-1234176|reactome:R-HSA-141430|reactome:R-HSA-168927|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-201451|reactome:R-HSA-202424|reactome:R-HSA-2173795|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-8866654|reactome:R-HSA-2871837|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9687136|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-5607764|reactome:R-HSA-5689896|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|dip:DIP-44088N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	causality statement:Q13490 is required for ubiquitination of Q9Y572|figure legend:2a, 3b, 3c and 3d|comment:"The ubiquitylation assay tested positive for different types of ubiqutylation: K48 and K63 chains (fig. 3b), head and tail ubiquitylation (fig. 3c) and mono-ubiquitylation (fig. 3d)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Crohn's disease - Interactions of proteins identified as having a link to Crohn's disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/10/04	2015/01/08	rogid:FOikzyDyDtlv2l69i/WNDNq674A9606	rogid:5BHbufBexJFsiV5kEhqOvdTfvio9606	intact-crc:021A1232F0B1D9B4|rigid:LD5tpr3MIysY8aLWDu8vDxsB1g0	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)