#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q29983 uniprotkb:P17931 intact:EBI-1031130|uniprotkb:Q9TQK8|uniprotkb:Q9TQK9|uniprotkb:Q9TQL0|uniprotkb:Q9TQL1|uniprotkb:Q9TQL2|uniprotkb:Q9TQL3|uniprotkb:Q9TQL4|uniprotkb:Q9UE04|uniprotkb:Q9UE05|uniprotkb:Q9UE06|uniprotkb:Q9UE11|uniprotkb:Q5XM81|uniprotkb:Q70I48|uniprotkb:Q70I49|uniprotkb:Q7JFH9|uniprotkb:Q7JFI0|uniprotkb:Q7JFI1|uniprotkb:Q7JFI2|uniprotkb:Q7YQ98|uniprotkb:Q861I1|uniprotkb:Q95464|uniprotkb:Q95HA2|uniprotkb:Q95HD6|uniprotkb:Q95HN4|uniprotkb:Q95HN6|uniprotkb:Q95IB2|uniprotkb:Q95IY7|uniprotkb:Q95HN5|uniprotkb:Q9TQ92|uniprotkb:O97992|uniprotkb:P79507|uniprotkb:P79508|uniprotkb:P79509|uniprotkb:O97993|uniprotkb:O97994|uniprotkb:O97995|uniprotkb:O98234|uniprotkb:O98235|uniprotkb:O98236|uniprotkb:O98237|uniprotkb:O98238|uniprotkb:P79506|uniprotkb:A8KQR0|uniprotkb:Q99692|uniprotkb:Q9BCR3|uniprotkb:Q9BCR4|uniprotkb:Q9BCR5|uniprotkb:Q9BCS4|uniprotkb:Q9BD20|uniprotkb:Q9GIZ1|uniprotkb:Q9GIZ2|uniprotkb:Q9BCR6|uniprotkb:Q9BCR7|uniprotkb:Q9BCR8|uniprotkb:Q9BCR9|uniprotkb:Q9BCS0|uniprotkb:Q9BCS1|uniprotkb:Q9BCS2|uniprotkb:Q9BCS3|uniprotkb:A9LRW5|uniprotkb:A9QVE0|uniprotkb:B1VJF1|uniprotkb:O60917|uniprotkb:O60918|uniprotkb:O60919|uniprotkb:O60920|uniprotkb:O60933|uniprotkb:O77956|uniprotkb:O78150|uniprotkb:O78151|uniprotkb:O78152|uniprotkb:O78153|uniprotkb:O97987|uniprotkb:O97988|uniprotkb:O97989|uniprotkb:O97990|uniprotkb:O97991|uniprotkb:P79510|uniprotkb:Q9GJ08|uniprotkb:Q9GIZ3|uniprotkb:Q9GIZ4|uniprotkb:Q9GIZ5|uniprotkb:Q9GIZ6|uniprotkb:Q9GJ01|uniprotkb:Q9GJ02|uniprotkb:Q9GJ03|uniprotkb:Q9GJ04|uniprotkb:Q9GJ05|uniprotkb:Q9GJ06|uniprotkb:Q9GJ07|uniprotkb:P79511|uniprotkb:P79512|uniprotkb:P79513|uniprotkb:P79514|uniprotkb:P79515|uniprotkb:P79516|uniprotkb:P79517|uniprotkb:P79518|uniprotkb:P79519|uniprotkb:P79520|uniprotkb:Q5C9P8|uniprotkb:P79521|uniprotkb:Q9GJ09|uniprotkb:Q9MY21|uniprotkb:Q9TQ86|uniprotkb:Q9TQ87|uniprotkb:Q9TQ88|uniprotkb:Q9TQ89|uniprotkb:Q9TQ93|uniprotkb:Q9TQ94|uniprotkb:Q9TQ95|uniprotkb:Q9TQ96|uniprotkb:Q9TQ97|uniprotkb:Q9TQ98|uniprotkb:Q9TQ99|uniprotkb:Q9TQA0|uniprotkb:Q9TQA1|uniprotkb:Q9TQA2|uniprotkb:Q9TQA3|uniprotkb:Q9TQA4|uniprotkb:Q9TQI9|uniprotkb:Q9TQJ0|uniprotkb:Q9TQJ1|uniprotkb:Q9TQJ9|uniprotkb:Q9TQK0|uniprotkb:Q9TQK1|uniprotkb:Q9TQK2|ensembl:ENSP00000383179|ensembl:ENSP00000402134|ensembl:ENSP00000446963 intact:EBI-1170392|uniprotkb:Q16005|uniprotkb:Q96J47|uniprotkb:B2RC38|uniprotkb:Q6IBA7|ensembl:ENSP00000254301 psi-mi:mica_human(display_long)|uniprotkb:MICA(gene name)|psi-mi:MICA(display_short)|uniprotkb:PERB11.1(gene name synonym) psi-mi:leg3_human(display_long)|uniprotkb:LGALS3(gene name)|psi-mi:LGALS3(display_short)|uniprotkb:MAC2(gene name synonym)|uniprotkb:Galactose-specific lectin 3(gene name synonym)|uniprotkb:Mac-2 antigen(gene name synonym)|uniprotkb:IgE-binding protein(gene name synonym)|uniprotkb:35 kDa lectin(gene name synonym)|uniprotkb:Carbohydrate-binding protein 35(gene name synonym)|uniprotkb:Laminin-binding protein(gene name synonym)|uniprotkb:Lectin L-29(gene name synonym)|uniprotkb:L-31(gene name synonym)|uniprotkb:Galactoside-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Tsuboi et al. (2011) pubmed:21712812|imex:IM-16259|mint:MINT-8214391|doi:10.1038/emboj.2011.215 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6998296|mint:MINT-8214577|imex:IM-16259-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000238.1|ensembl:ENSG00000183214(gene)|ensembl:ENSG00000235233(gene)|ensembl:ENST00000400325(transcript)|ensembl:ENST00000418465(transcript)|ensembl:ENST00000547609(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019835"(cytolysis)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1B3J|rcsb pdb:1HYR|reactome:R-HSA-198933|dip:DIP-29681N|mint:MINT-8214581(identity) refseq:NP_002297.2|ensembl:ENSG00000131981(gene)|ensembl:ENST00000254301(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003723"(RNA binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019863"(IgE binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043236"(laminin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070232"(regulation of T cell apoptotic process)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:0071674"(mononuclear cell migration)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903614"(negative regulation of protein tyrosine phosphatase activity)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015534(Galectin-3)|interpro:IPR044156|mint:P17931|rcsb pdb:1A3K|rcsb pdb:1KJL|rcsb pdb:1KJR|rcsb pdb:2NMN|rcsb pdb:2NMO|rcsb pdb:2NN8|rcsb pdb:2XG3|rcsb pdb:3AYA|rcsb pdb:3AYC|rcsb pdb:3AYD|rcsb pdb:3AYE|rcsb pdb:3T1L|rcsb pdb:3T1M|rcsb pdb:3ZSJ|rcsb pdb:3ZSK|rcsb pdb:3ZSL|rcsb pdb:3ZSM|rcsb pdb:4BLI|rcsb pdb:4BLJ|rcsb pdb:4BM8|rcsb pdb:4JC1|rcsb pdb:4JCK|rcsb pdb:4LBJ|rcsb pdb:4LBK|rcsb pdb:4LBL|rcsb pdb:4LBM|rcsb pdb:4LBN|rcsb pdb:4LBO|rcsb pdb:4R9A|rcsb pdb:4R9B|rcsb pdb:4R9C|rcsb pdb:4R9D|rcsb pdb:4RL7|rcsb pdb:4XBN|rcsb pdb:5E88|rcsb pdb:5E89|rcsb pdb:5E8A|rcsb pdb:5EXO|rcsb pdb:5H9P|rcsb pdb:5H9R|rcsb pdb:5IUQ|rcsb pdb:5NF7|rcsb pdb:5NF9|rcsb pdb:5NFA|rcsb pdb:5NFB|rcsb pdb:5NFC|rcsb pdb:5OAX|rcsb pdb:5ODY|rcsb pdb:6B8K|rcsb pdb:6EOG|rcsb pdb:6EOL|rcsb pdb:6EXY|rcsb pdb:6EYM|rcsb pdb:6F2Q|rcsb pdb:6F6Y|rcsb pdb:6FK2|rcsb pdb:6FOF|rcsb pdb:6G0V|rcsb pdb:6H64|rcsb pdb:6I74|rcsb pdb:6I75|rcsb pdb:6I76|rcsb pdb:6I77|rcsb pdb:6I78|rcsb pdb:6KXA|rcsb pdb:6KXB|rcsb pdb:6Q0Q|rcsb pdb:6Q17|rcsb pdb:6QGE|rcsb pdb:6QGF|rcsb pdb:6QLN|rcsb pdb:6QLO|rcsb pdb:6QLP|rcsb pdb:6QLQ|rcsb pdb:6QLR|rcsb pdb:6QLS|rcsb pdb:6QLT|rcsb pdb:6QLU|rcsb pdb:6RHL|rcsb pdb:6RHM|rcsb pdb:6RZF|rcsb pdb:6RZG|rcsb pdb:6RZH|rcsb pdb:6RZI|rcsb pdb:6RZJ|rcsb pdb:6RZK|rcsb pdb:6RZL|rcsb pdb:6RZM|rcsb pdb:6TF6|rcsb pdb:6TF7|rcsb pdb:6Y4C|rcsb pdb:6Y78|rcsb pdb:6ZVF|rcsb pdb:7BE3|rcsb pdb:7DF5|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-8939246|reactome:R-HSA-8941333|dip:DIP-45623N|mint:MINT-8214579(identity) - - - comment:homomint|comment:mint|figure legend:sf12d|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-kk-47-c2)|taxid:9606(Homo sapiens) - 2011/10/12 2014/10/16 rogid:rBIu0nHHyVgNhLmPsQ4pTFy0Xj89606 rogid:5FijxEN6irEGIg4AtAdn6DB03e49606 intact-crc:79558B661C5DAB5C|rigid:cCP5mNn9uMhxtCk6hRU2+iKrqIc false flag tag:?-?(MINT-8214593)|binding-associated region:24-200(MINT-8214595) - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P17931 uniprotkb:Q29983 intact:EBI-1170392|uniprotkb:Q16005|uniprotkb:Q96J47|uniprotkb:B2RC38|uniprotkb:Q6IBA7|ensembl:ENSP00000254301 intact:EBI-1031130|uniprotkb:Q9TQK8|uniprotkb:Q9TQK9|uniprotkb:Q9TQL0|uniprotkb:Q9TQL1|uniprotkb:Q9TQL2|uniprotkb:Q9TQL3|uniprotkb:Q9TQL4|uniprotkb:Q9UE04|uniprotkb:Q9UE05|uniprotkb:Q9UE06|uniprotkb:Q9UE11|uniprotkb:Q5XM81|uniprotkb:Q70I48|uniprotkb:Q70I49|uniprotkb:Q7JFH9|uniprotkb:Q7JFI0|uniprotkb:Q7JFI1|uniprotkb:Q7JFI2|uniprotkb:Q7YQ98|uniprotkb:Q861I1|uniprotkb:Q95464|uniprotkb:Q95HA2|uniprotkb:Q95HD6|uniprotkb:Q95HN4|uniprotkb:Q95HN6|uniprotkb:Q95IB2|uniprotkb:Q95IY7|uniprotkb:Q95HN5|uniprotkb:Q9TQ92|uniprotkb:O97992|uniprotkb:P79507|uniprotkb:P79508|uniprotkb:P79509|uniprotkb:O97993|uniprotkb:O97994|uniprotkb:O97995|uniprotkb:O98234|uniprotkb:O98235|uniprotkb:O98236|uniprotkb:O98237|uniprotkb:O98238|uniprotkb:P79506|uniprotkb:A8KQR0|uniprotkb:Q99692|uniprotkb:Q9BCR3|uniprotkb:Q9BCR4|uniprotkb:Q9BCR5|uniprotkb:Q9BCS4|uniprotkb:Q9BD20|uniprotkb:Q9GIZ1|uniprotkb:Q9GIZ2|uniprotkb:Q9BCR6|uniprotkb:Q9BCR7|uniprotkb:Q9BCR8|uniprotkb:Q9BCR9|uniprotkb:Q9BCS0|uniprotkb:Q9BCS1|uniprotkb:Q9BCS2|uniprotkb:Q9BCS3|uniprotkb:A9LRW5|uniprotkb:A9QVE0|uniprotkb:B1VJF1|uniprotkb:O60917|uniprotkb:O60918|uniprotkb:O60919|uniprotkb:O60920|uniprotkb:O60933|uniprotkb:O77956|uniprotkb:O78150|uniprotkb:O78151|uniprotkb:O78152|uniprotkb:O78153|uniprotkb:O97987|uniprotkb:O97988|uniprotkb:O97989|uniprotkb:O97990|uniprotkb:O97991|uniprotkb:P79510|uniprotkb:Q9GJ08|uniprotkb:Q9GIZ3|uniprotkb:Q9GIZ4|uniprotkb:Q9GIZ5|uniprotkb:Q9GIZ6|uniprotkb:Q9GJ01|uniprotkb:Q9GJ02|uniprotkb:Q9GJ03|uniprotkb:Q9GJ04|uniprotkb:Q9GJ05|uniprotkb:Q9GJ06|uniprotkb:Q9GJ07|uniprotkb:P79511|uniprotkb:P79512|uniprotkb:P79513|uniprotkb:P79514|uniprotkb:P79515|uniprotkb:P79516|uniprotkb:P79517|uniprotkb:P79518|uniprotkb:P79519|uniprotkb:P79520|uniprotkb:Q5C9P8|uniprotkb:P79521|uniprotkb:Q9GJ09|uniprotkb:Q9MY21|uniprotkb:Q9TQ86|uniprotkb:Q9TQ87|uniprotkb:Q9TQ88|uniprotkb:Q9TQ89|uniprotkb:Q9TQ93|uniprotkb:Q9TQ94|uniprotkb:Q9TQ95|uniprotkb:Q9TQ96|uniprotkb:Q9TQ97|uniprotkb:Q9TQ98|uniprotkb:Q9TQ99|uniprotkb:Q9TQA0|uniprotkb:Q9TQA1|uniprotkb:Q9TQA2|uniprotkb:Q9TQA3|uniprotkb:Q9TQA4|uniprotkb:Q9TQI9|uniprotkb:Q9TQJ0|uniprotkb:Q9TQJ1|uniprotkb:Q9TQJ9|uniprotkb:Q9TQK0|uniprotkb:Q9TQK1|uniprotkb:Q9TQK2|ensembl:ENSP00000383179|ensembl:ENSP00000402134|ensembl:ENSP00000446963 psi-mi:leg3_human(display_long)|uniprotkb:LGALS3(gene name)|psi-mi:LGALS3(display_short)|uniprotkb:MAC2(gene name synonym)|uniprotkb:Galactose-specific lectin 3(gene name synonym)|uniprotkb:Mac-2 antigen(gene name synonym)|uniprotkb:IgE-binding protein(gene name synonym)|uniprotkb:35 kDa lectin(gene name synonym)|uniprotkb:Carbohydrate-binding protein 35(gene name synonym)|uniprotkb:Laminin-binding protein(gene name synonym)|uniprotkb:Lectin L-29(gene name synonym)|uniprotkb:L-31(gene name synonym)|uniprotkb:Galactoside-binding protein(gene name synonym) psi-mi:mica_human(display_long)|uniprotkb:MICA(gene name)|psi-mi:MICA(display_short)|uniprotkb:PERB11.1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Tsuboi et al. (2011) pubmed:21712812|imex:IM-16259|mint:MINT-8214391|doi:10.1038/emboj.2011.215 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6998324|mint:MINT-8214455|imex:IM-16259-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002297.2|ensembl:ENSG00000131981(gene)|ensembl:ENST00000254301(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003723"(RNA binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0019863"(IgE binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043236"(laminin binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070232"(regulation of T cell apoptotic process)|go:"GO:0070492"(oligosaccharide binding)|go:"GO:0071674"(mononuclear cell migration)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903614"(negative regulation of protein tyrosine phosphatase activity)|go:"GO:2000521"(negative regulation of immunological synapse formation)|go:"GO:2001189"(negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015534(Galectin-3)|interpro:IPR044156|mint:P17931|rcsb pdb:1A3K|rcsb pdb:1KJL|rcsb pdb:1KJR|rcsb pdb:2NMN|rcsb pdb:2NMO|rcsb pdb:2NN8|rcsb pdb:2XG3|rcsb pdb:3AYA|rcsb pdb:3AYC|rcsb pdb:3AYD|rcsb pdb:3AYE|rcsb pdb:3T1L|rcsb pdb:3T1M|rcsb pdb:3ZSJ|rcsb pdb:3ZSK|rcsb pdb:3ZSL|rcsb pdb:3ZSM|rcsb pdb:4BLI|rcsb pdb:4BLJ|rcsb pdb:4BM8|rcsb pdb:4JC1|rcsb pdb:4JCK|rcsb pdb:4LBJ|rcsb pdb:4LBK|rcsb pdb:4LBL|rcsb pdb:4LBM|rcsb pdb:4LBN|rcsb pdb:4LBO|rcsb pdb:4R9A|rcsb pdb:4R9B|rcsb pdb:4R9C|rcsb pdb:4R9D|rcsb pdb:4RL7|rcsb pdb:4XBN|rcsb pdb:5E88|rcsb pdb:5E89|rcsb pdb:5E8A|rcsb pdb:5EXO|rcsb pdb:5H9P|rcsb pdb:5H9R|rcsb pdb:5IUQ|rcsb pdb:5NF7|rcsb pdb:5NF9|rcsb pdb:5NFA|rcsb pdb:5NFB|rcsb pdb:5NFC|rcsb pdb:5OAX|rcsb pdb:5ODY|rcsb pdb:6B8K|rcsb pdb:6EOG|rcsb pdb:6EOL|rcsb pdb:6EXY|rcsb pdb:6EYM|rcsb pdb:6F2Q|rcsb pdb:6F6Y|rcsb pdb:6FK2|rcsb pdb:6FOF|rcsb pdb:6G0V|rcsb pdb:6H64|rcsb pdb:6I74|rcsb pdb:6I75|rcsb pdb:6I76|rcsb pdb:6I77|rcsb pdb:6I78|rcsb pdb:6KXA|rcsb pdb:6KXB|rcsb pdb:6Q0Q|rcsb pdb:6Q17|rcsb pdb:6QGE|rcsb pdb:6QGF|rcsb pdb:6QLN|rcsb pdb:6QLO|rcsb pdb:6QLP|rcsb pdb:6QLQ|rcsb pdb:6QLR|rcsb pdb:6QLS|rcsb pdb:6QLT|rcsb pdb:6QLU|rcsb pdb:6RHL|rcsb pdb:6RHM|rcsb pdb:6RZF|rcsb pdb:6RZG|rcsb pdb:6RZH|rcsb pdb:6RZI|rcsb pdb:6RZJ|rcsb pdb:6RZK|rcsb pdb:6RZL|rcsb pdb:6RZM|rcsb pdb:6TF6|rcsb pdb:6TF7|rcsb pdb:6Y4C|rcsb pdb:6Y78|rcsb pdb:6ZVF|rcsb pdb:7BE3|rcsb pdb:7DF5|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-8939246|reactome:R-HSA-8941333|dip:DIP-45623N|mint:MINT-8214457(identity) refseq:NP_000238.1|ensembl:ENSG00000183214(gene)|ensembl:ENSG00000235233(gene)|ensembl:ENST00000400325(transcript)|ensembl:ENST00000418465(transcript)|ensembl:ENST00000547609(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019835"(cytolysis)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1B3J|rcsb pdb:1HYR|reactome:R-HSA-198933|dip:DIP-29681N|mint:MINT-8214507(identity) - - - comment:homomint|comment:mint|figure legend:f4k f4l f5b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-kk-47-c2)|taxid:9606(Homo sapiens) - 2011/10/12 2014/10/16 rogid:5FijxEN6irEGIg4AtAdn6DB03e49606 rogid:rBIu0nHHyVgNhLmPsQ4pTFy0Xj89606 intact-crc:DDEC761293ACC7B4|rigid:cCP5mNn9uMhxtCk6hRU2+iKrqIc false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q29983 uniprotkb:P26718 intact:EBI-1031130|uniprotkb:Q9TQK8|uniprotkb:Q9TQK9|uniprotkb:Q9TQL0|uniprotkb:Q9TQL1|uniprotkb:Q9TQL2|uniprotkb:Q9TQL3|uniprotkb:Q9TQL4|uniprotkb:Q9UE04|uniprotkb:Q9UE05|uniprotkb:Q9UE06|uniprotkb:Q9UE11|uniprotkb:Q5XM81|uniprotkb:Q70I48|uniprotkb:Q70I49|uniprotkb:Q7JFH9|uniprotkb:Q7JFI0|uniprotkb:Q7JFI1|uniprotkb:Q7JFI2|uniprotkb:Q7YQ98|uniprotkb:Q861I1|uniprotkb:Q95464|uniprotkb:Q95HA2|uniprotkb:Q95HD6|uniprotkb:Q95HN4|uniprotkb:Q95HN6|uniprotkb:Q95IB2|uniprotkb:Q95IY7|uniprotkb:Q95HN5|uniprotkb:Q9TQ92|uniprotkb:O97992|uniprotkb:P79507|uniprotkb:P79508|uniprotkb:P79509|uniprotkb:O97993|uniprotkb:O97994|uniprotkb:O97995|uniprotkb:O98234|uniprotkb:O98235|uniprotkb:O98236|uniprotkb:O98237|uniprotkb:O98238|uniprotkb:P79506|uniprotkb:A8KQR0|uniprotkb:Q99692|uniprotkb:Q9BCR3|uniprotkb:Q9BCR4|uniprotkb:Q9BCR5|uniprotkb:Q9BCS4|uniprotkb:Q9BD20|uniprotkb:Q9GIZ1|uniprotkb:Q9GIZ2|uniprotkb:Q9BCR6|uniprotkb:Q9BCR7|uniprotkb:Q9BCR8|uniprotkb:Q9BCR9|uniprotkb:Q9BCS0|uniprotkb:Q9BCS1|uniprotkb:Q9BCS2|uniprotkb:Q9BCS3|uniprotkb:A9LRW5|uniprotkb:A9QVE0|uniprotkb:B1VJF1|uniprotkb:O60917|uniprotkb:O60918|uniprotkb:O60919|uniprotkb:O60920|uniprotkb:O60933|uniprotkb:O77956|uniprotkb:O78150|uniprotkb:O78151|uniprotkb:O78152|uniprotkb:O78153|uniprotkb:O97987|uniprotkb:O97988|uniprotkb:O97989|uniprotkb:O97990|uniprotkb:O97991|uniprotkb:P79510|uniprotkb:Q9GJ08|uniprotkb:Q9GIZ3|uniprotkb:Q9GIZ4|uniprotkb:Q9GIZ5|uniprotkb:Q9GIZ6|uniprotkb:Q9GJ01|uniprotkb:Q9GJ02|uniprotkb:Q9GJ03|uniprotkb:Q9GJ04|uniprotkb:Q9GJ05|uniprotkb:Q9GJ06|uniprotkb:Q9GJ07|uniprotkb:P79511|uniprotkb:P79512|uniprotkb:P79513|uniprotkb:P79514|uniprotkb:P79515|uniprotkb:P79516|uniprotkb:P79517|uniprotkb:P79518|uniprotkb:P79519|uniprotkb:P79520|uniprotkb:Q5C9P8|uniprotkb:P79521|uniprotkb:Q9GJ09|uniprotkb:Q9MY21|uniprotkb:Q9TQ86|uniprotkb:Q9TQ87|uniprotkb:Q9TQ88|uniprotkb:Q9TQ89|uniprotkb:Q9TQ93|uniprotkb:Q9TQ94|uniprotkb:Q9TQ95|uniprotkb:Q9TQ96|uniprotkb:Q9TQ97|uniprotkb:Q9TQ98|uniprotkb:Q9TQ99|uniprotkb:Q9TQA0|uniprotkb:Q9TQA1|uniprotkb:Q9TQA2|uniprotkb:Q9TQA3|uniprotkb:Q9TQA4|uniprotkb:Q9TQI9|uniprotkb:Q9TQJ0|uniprotkb:Q9TQJ1|uniprotkb:Q9TQJ9|uniprotkb:Q9TQK0|uniprotkb:Q9TQK1|uniprotkb:Q9TQK2|ensembl:ENSP00000383179|ensembl:ENSP00000402134|ensembl:ENSP00000446963 intact:EBI-458344|ensembl:ENSP00000240618|ensembl:ENSP00000446003|uniprotkb:Q9NR41|uniprotkb:A8K7K5|uniprotkb:A8K7P4 psi-mi:mica_human(display_long)|uniprotkb:MICA(gene name)|psi-mi:MICA(display_short)|uniprotkb:PERB11.1(gene name synonym) psi-mi:nkg2d_human(display_long)|uniprotkb:KLRK1(gene name)|psi-mi:KLRK1(display_short)|uniprotkb:NKG2D(gene name synonym)|uniprotkb:NKG2-D-activating NK receptor(gene name synonym)|uniprotkb:NK cell receptor D(gene name synonym)|uniprotkb:Killer cell lectin-like receptor subfamily K member 1(gene name synonym)|uniprotkb:D12S2489E(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Tsuboi et al. (2011) pubmed:21712812|imex:IM-16259|mint:MINT-8214391|doi:10.1038/emboj.2011.215 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-6998347|mint:MINT-8214603|imex:IM-16259-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000238.1|ensembl:ENSG00000183214(gene)|ensembl:ENSG00000235233(gene)|ensembl:ENST00000400325(transcript)|ensembl:ENST00000418465(transcript)|ensembl:ENST00000547609(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0002418"(immune response to tumor cell)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009408"(response to heat)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0019835"(cytolysis)|go:"GO:0032815"(negative regulation of natural killer cell activation)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046703"(natural killer cell lectin-like receptor binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|rcsb pdb:1B3J|rcsb pdb:1HYR|reactome:R-HSA-198933|dip:DIP-29681N|mint:MINT-8214607(identity) reactome:R-HSA-2424491|reactome:R-HSA-2172127|ensembl:ENSG00000213809(gene)|ensembl:ENST00000540818(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR033992|interpro:IPR042169|rcsb pdb:1HYR|rcsb pdb:1KCG|rcsb pdb:1MPU|rcsb pdb:4PDC|rcsb pdb:4S0U|ensembl:ENST00000240618(transcript)|reactome:R-HSA-198933|refseq:NP_001186734.1|refseq:NP_031386.2|dip:DIP-31100N|mint:MINT-8214605(identity) - - - comment:homomint|comment:mint|figure legend:sf14b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/10/12 2014/10/16 rogid:rBIu0nHHyVgNhLmPsQ4pTFy0Xj89606 rogid:KAqdqIVvc4LUwx7y0KRMc87FsUM9606 intact-crc:AAEB5B18B3081D45|rigid:HkiOh+RYj3XHqwdCornuT/P0fTA false fusion protein:?-?(MINT-8214610) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)