#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8VCR8	uniprotkb:Q8CFN5	intact:EBI-8663937|ensembl:ENSMUSP00000028970|uniprotkb:A2APB9|intact:UNK-5526977	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	psi-mi:mylk2_mouse(display_long)|uniprotkb:Mylk2(gene name)|psi-mi:Mylk2(display_short)	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Al et al. (2011)	mint:MINT-8189000|pubmed:21556048|imex:IM-15440|doi:10.1038/emboj.2011.153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8663931|mint:MINT-8189015|imex:IM-15440-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042717|go:"GO:0048489"(synaptic vesicle transport)|ensembl:ENSMUSG00000027470(gene)|ensembl:ENSMUST00000028970(transcript)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006833"(water transport)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|refseq:NP_001074513.2|mint:MINT-8189018(identity)	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N|mint:MINT-8189017(identity)	-	comment:mint|function:Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2011/06/23	2014/10/16	rogid:9c+K7aRSZ/k2JAnX4sawAM7wA1M10090	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	intact-crc:DF35F55FB54FD7B5|rigid:YgFfM3tdnGTEHjaOa6xGs6p8JDU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H1R3	uniprotkb:Q06413	intact:EBI-356910|uniprotkb:Q569L1|uniprotkb:Q96I84|ensembl:ENSP00000365152|ensembl:ENSP00000365162	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	psi-mi:mylk2_human(display_long)|uniprotkb:MYLK2(gene name)|psi-mi:MYLK2(display_short)	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Al et al. (2011)	mint:MINT-8189000|pubmed:21556048|imex:IM-15440|doi:10.1038/emboj.2011.153	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8664065|mint:MINT-8189024|imex:IM-15440-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_149109.1|ensembl:ENSP00000365152|ensembl:ENSP00000365162|ensembl:ENSG00000101306(gene)|ensembl:ENST00000375985(transcript)|ensembl:ENST00000375994(transcript)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030017"(sarcomere)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042717|rcsb pdb:2LV6|rcsb pdb:3KF9|mint:MINT-8189026(identity)	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|mint:MINT-8189027(identity)	-	-	-	figure legend:f2b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/06/23	2014/10/16	rogid:VfJn/QlOkBjTcPHsi+5EkEQY3/c9606	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	intact-crc:88DBB3D7CAD2EF33|rigid:ljSUb5ruZVHg9tyVdzMVLizxUd8	false	binding-associated region:296-596(MINT-8189600)|his tag:?-?(MINT-8189029)	flag tag:?-?(MINT-8189033)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q09472	uniprotkb:Q06413	intact:EBI-447295|intact:EBI-3908041|uniprotkb:B1AKC2|intact:EBI-28987257|ensembl:ENSP00000263253	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	psi-mi:ep300_human(display_long)|uniprotkb:Histone butyryltransferase p300(gene name synonym)|uniprotkb:Histone crotonyltransferase p300(gene name synonym)|uniprotkb:Protein propionyltransferase p300(gene name synonym)|uniprotkb:EP300(gene name)|psi-mi:EP300(display_short)|uniprotkb:P300(gene name synonym)|uniprotkb:E1A-associated protein p300(gene name synonym)|uniprotkb:Protein 2-hydroxyisobutyryltransferase p300(gene name synonym)|uniprotkb:Protein lactyltransferas p300(gene name synonym)	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:"MI:0096"(pull down)	Al et al. (2011)	mint:MINT-8189000|pubmed:21556048|imex:IM-15440|doi:10.1038/emboj.2011.153	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8664086|mint:MINT-8189037|imex:IM-15440-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001420.2|ensembl:ENSP00000263253|dip:DIP-257N|go:"GO:0140068"(histone crotonyltransferase activity)|go:"GO:0140069"(histone butyryltransferase activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1905636"(positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR000197(Zinc finger, TAZ-type)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001487(Bromodomain)|interpro:IPR003101(Coactivator CBP, KIX)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010303(Protein of unknown function DUF902, CREBbp)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013178(H3K56 histone acetylation protein, RTT109)|interpro:IPR014744(Nuclear receptor coactivator, CREB-bp-like, interlocking)|interpro:IPR018359|interpro:IPR031162|interpro:IPR035898|interpro:IPR036427|interpro:IPR036529|interpro:IPR037073|interpro:IPR038547|interpro:IPR043145|mint:Q09472|rcsb pdb:1L3E|rcsb pdb:1P4Q|rcsb pdb:2K8F|rcsb pdb:2MH0|rcsb pdb:2MZD|rcsb pdb:3BIY|rcsb pdb:3I3J|rcsb pdb:3IO2|go:"GO:0140067"(peptidyl-lysine butyrylation)|rcsb pdb:3P57|rcsb pdb:3T92|rcsb pdb:4PZR|rcsb pdb:4PZS|rcsb pdb:4PZT|rcsb pdb:5BT3|rcsb pdb:5KJ2|rcsb pdb:5LKT|rcsb pdb:5LKU|rcsb pdb:5LKX|rcsb pdb:5LKZ|rcsb pdb:5LPK|rcsb pdb:5LPM|rcsb pdb:5NU5|rcsb pdb:5XZC|rcsb pdb:6DS6|rcsb pdb:6FGN|rcsb pdb:6FGS|rcsb pdb:6GYR|rcsb pdb:6GYT|rcsb pdb:6K4N|rcsb pdb:6PF1|rcsb pdb:6PGU|rcsb pdb:6V8B|rcsb pdb:6V8K|rcsb pdb:6V8N|rcsb pdb:6V90|rcsb pdb:7LJE|reactome:R-HSA-1234158|reactome:R-HSA-1368082|reactome:R-HSA-156711|reactome:R-HSA-1912408|reactome:R-HSA-1989781|reactome:R-HSA-201722|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2197563|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3134973|reactome:R-HSA-3214847|reactome:R-HSA-3371568|reactome:R-HSA-381340|reactome:R-HSA-3899300|reactome:R-HSA-400253|reactome:R-HSA-5250924|reactome:R-HSA-5617472|reactome:R-HSA-5621575|reactome:R-HSA-5689901|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-6804758|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-8866907|reactome:R-HSA-8936459|reactome:R-HSA-8939243|reactome:R-HSA-8941856|reactome:R-HSA-8941858|reactome:R-HSA-8951936|reactome:R-HSA-9013508|reactome:R-HSA-9013695|reactome:R-HSA-9018519|reactome:R-HSA-9029569|reactome:R-HSA-9031628|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-9614657|reactome:R-HSA-9616222|reactome:R-HSA-9617629|reactome:R-HSA-9707616|rcsb pdb:4BHW|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|ensembl:ENSG00000100393(gene)|ensembl:ENST00000263253(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001756"(somitogenesis)|go:"GO:0001966"(thigmotaxis)|go:"GO:0002039"(p53 binding)|go:"GO:0002209"(behavioral defense response)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0004468"(lysine N-acetyltransferase activity, acting on acetyl phosphate as donor)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007611"(learning or memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018076"(N-terminal peptidyl-lysine acetylation)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030324"(lung development)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0034644"(cellular response to UV)|go:"GO:0006473"(protein acetylation)|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0006915"(apoptotic process)|go:"GO:0036268"(swimming)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043627"(response to estrogen)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043969"(histone H2B acetylation)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0061920"(protein propionyltransferase activity)|go:"GO:0061921"(peptidyl-lysine propionylation)|go:"GO:0090043"(regulation of tubulin deacetylation)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:0097677"(STAT family protein binding)|go:"GO:0106226"(peptide 2-hydroxyisobutyryltransferase activity)|go:"GO:0120301"(histone lactyltransferase activity)|go:"GO:0140065"(peptide butyryltransferase activity)|go:"GO:0140066"(peptidyl-lysine crotonylation)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|mint:MINT-8189039(identity)	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|mint:MINT-8189043(identity)	-	-	-	figure legend:f7b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/06/23	2014/10/16	rogid:7XzMU6kWdFN0GiLox7RamD9pZeM9606	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	intact-crc:1C10830F03698767|rigid:gb3n8M2Q4oe39t2ukucQqciMnQs	false	-	flag tag:?-?(MINT-8189044)|mutation decreasing interaction:80-80(MINT-8189049)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q06413	uniprotkb:Q9H1R3	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	intact:EBI-356910|uniprotkb:Q569L1|uniprotkb:Q96I84|ensembl:ENSP00000365152|ensembl:ENSP00000365162	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:mylk2_human(display_long)|uniprotkb:MYLK2(gene name)|psi-mi:MYLK2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Al et al. (2011)	mint:MINT-8189000|pubmed:21556048|imex:IM-15440|doi:10.1038/emboj.2011.153	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8664114|mint:MINT-8189066|imex:IM-15440-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|mint:MINT-8189072(identity)	refseq:NP_149109.1|ensembl:ENSP00000365152|ensembl:ENSP00000365162|ensembl:ENSG00000101306(gene)|ensembl:ENST00000375985(transcript)|ensembl:ENST00000375994(transcript)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030017"(sarcomere)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042717|rcsb pdb:2LV6|rcsb pdb:3KF9|mint:MINT-8189068(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2c f2e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/06/23	2014/10/16	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	rogid:VfJn/QlOkBjTcPHsi+5EkEQY3/c9606	intact-crc:A34E067AFBA5FCAA|rigid:ljSUb5ruZVHg9tyVdzMVLizxUd8	false	phosphorylated residue:80-80(MINT-8189080)|his tag:?-?(MINT-8189073)	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8VCR8	uniprotkb:Q06413	intact:EBI-8663937|ensembl:ENSMUSP00000028970|uniprotkb:A2APB9|intact:UNK-5526977	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	psi-mi:mylk2_mouse(display_long)|uniprotkb:Mylk2(gene name)|psi-mi:Mylk2(display_short)	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Al et al. (2011)	mint:MINT-8189000|pubmed:21556048|imex:IM-15440|doi:10.1038/emboj.2011.153	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8664142|mint:MINT-8189103|imex:IM-15440-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042717|go:"GO:0048489"(synaptic vesicle transport)|ensembl:ENSMUSG00000027470(gene)|ensembl:ENSMUST00000028970(transcript)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006833"(water transport)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031448"(positive regulation of fast-twitch skeletal muscle fiber contraction)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032971"(regulation of muscle filament sliding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|refseq:NP_001074513.2|mint:MINT-8189105(identity)	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|mint:MINT-8189107(identity)	-	comment:mint|function:Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain	-	comment:homomint|comment:mint|figure legend:sf1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-p19)|taxid:10090(Mus musculus embryonic teratocarcinoma cell line,  epithelial-like, induced by retinoic acid)	-	2011/06/23	2014/10/16	rogid:9c+K7aRSZ/k2JAnX4sawAM7wA1M10090	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	intact-crc:75A5C5D5BEE888A1|rigid:pSwBTKWzL5VkA/MwNwVQkAe2Ki4	false	-	calmodulin binding peptide plus protein a tag:?-?(MINT-8189108)	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0113"(western blot)