#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96CC6	uniprotkb:P01132	intact:EBI-3865223|uniprotkb:Q1W6H2|uniprotkb:Q4TT59|uniprotkb:Q96S34|uniprotkb:Q9H6E1|uniprotkb:Q04842|ensembl:ENSP00000262316	intact:EBI-1782803|uniprotkb:E9QNX6|uniprotkb:Q569W5|uniprotkb:Q6P9J2|ensembl:ENSMUSP00000029653	psi-mi:rhdf1_human(display_long)|uniprotkb:IRHOM1(gene name synonym)|uniprotkb:Rhomboid family member 1(gene name synonym)|uniprotkb:RHBDF1(gene name)|psi-mi:RHBDF1(display_short)|uniprotkb:C16orf8(gene name synonym)|uniprotkb:Rhomboid 5 homolog 1(gene name synonym)|uniprotkb:p100hRho(gene name synonym)|uniprotkb:DIST1(gene name synonym)|uniprotkb:Epidermal growth factor receptor-related protein(gene name synonym)	psi-mi:egf_mouse(display_long)|uniprotkb:Egf(gene name)|psi-mi:Egf(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zettl et al. (2011)	imex:IM-15779|pubmed:21439629	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3865226|imex:IM-15779-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071895.3|refseq:XP_005255551.1|ensembl:ENSG00000007384(gene)|ensembl:ENST00000262316(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019838"(growth factor binding)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952	refseq:NP_034243.2|dip:DIP-5762N|ensembl:ENSMUSG00000028017(gene)|ensembl:ENSMUST00000029653(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01132|rcsb pdb:1A3P|rcsb pdb:1EGF|rcsb pdb:1EPG|rcsb pdb:1EPH|rcsb pdb:1EPI|rcsb pdb:1EPJ|rcsb pdb:1GK5|rcsb pdb:3EGF|reactome:R-MMU-114608|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-177929|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-1963642|reactome:R-MMU-212718|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8863795|reactome:R-MMU-9009391|reactome:R-MMU-9013507	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line)	-	2011/03/31	2014/10/16	rogid:LE4/RJCgut92iUvHPPwAdSs6O7M9606	rogid:Duf+guKALRRb57ZtI1yceGZTz8A10090	intact-crc:93E6BF60BA9DB2D8|rigid:/G/++Gr5Gd/zPQOtM7baVdEqvjI	false	flag tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q80WQ6	uniprotkb:P01132	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	intact:EBI-1782803|uniprotkb:E9QNX6|uniprotkb:Q569W5|uniprotkb:Q6P9J2|ensembl:ENSMUSP00000029653	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:egf_mouse(display_long)|uniprotkb:Egf(gene name)|psi-mi:Egf(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zettl et al. (2011)	imex:IM-15779|pubmed:21439629	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-3865229|imex:IM-15779-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	refseq:NP_034243.2|dip:DIP-5762N|ensembl:ENSMUSG00000028017(gene)|ensembl:ENSMUST00000029653(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0038029"(epidermal growth factor receptor signaling pathway via MAPK cascade)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051048"(negative regulation of secretion)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR016317(Pro-epidermal growth factor)|interpro:IPR018097|mint:P01132|rcsb pdb:1A3P|rcsb pdb:1EGF|rcsb pdb:1EPG|rcsb pdb:1EPH|rcsb pdb:1EPI|rcsb pdb:1EPJ|rcsb pdb:1GK5|rcsb pdb:3EGF|reactome:R-MMU-114608|reactome:R-MMU-1227986|reactome:R-MMU-1236394|reactome:R-MMU-1250196|reactome:R-MMU-1257604|reactome:R-MMU-177929|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-1963642|reactome:R-MMU-212718|reactome:R-MMU-5673001|reactome:R-MMU-6785631|reactome:R-MMU-6811558|reactome:R-MMU-8847993|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8863795|reactome:R-MMU-9009391|reactome:R-MMU-9013507	psi-mi:"MI:0469"(intact)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293e)|taxid:9606(Human HEK293E or 293 c18 cell line)	-	2011/03/31	2014/10/16	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	rogid:Duf+guKALRRb57ZtI1yceGZTz8A10090	intact-crc:7ADD1EC16B2773E4|rigid:HhWKK0DKtOuhE5P4GtQm53b5YYE	false	ha tag:c-c	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)