#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QXZ0	uniprotkb:G1T8E2	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	intact:EBI-3833365|intact:EBI-9845140|ensembl:ENSOCUP00000012837	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:g1t8e2_rabit(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Wu et al. (2011)	pubmed:21295697|imex:IM-15769	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3832591|imex:IM-15769-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	ensembl:ENSOCUG00000014932(gene)|ensembl:ENSOCUT00000014932(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0048511"(rhythmic process)|go:"GO:0050321"(tau-protein kinase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	comment:Similar to P49841	figure legend:Fig. 2B|resulting-ptm:Phosphorylation of Macf1|caution:Exact coordinates of MACF1 C-terminal domain not given and has been inferred from the information in the text.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/14	2020/01/07	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rogid:kbUTKOUdarFmb5RGV5t35+WH78w9986	intact-crc:1C3B7DDA686C33DF|rigid:c0x0JplidveIlk8XJ3Qxh4olSjY	false	sufficient binding region:7077..7077-7354	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WV60	uniprotkb:Q9QXZ0	intact:EBI-400793|ensembl:ENSMUSP00000023507	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	psi-mi:gsk3b_mouse(display_long)|uniprotkb:Gsk3b(gene name)|psi-mi:Gsk3b(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wu et al. (2011)	pubmed:21295697|imex:IM-15769	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3832003|imex:IM-15769-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062801.1|dip:DIP-32446N|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006983"(ER overload response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014043"(negative regulation of neuron maturation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0034452"(dynactin binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:Q9WV60|rcsb pdb:4NU1|rcsb pdb:5AIR|rcsb pdb:6AE3|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-3371453|reactome:R-MMU-399956|reactome:R-MMU-4641262|reactome:R-MMU-5250924|reactome:R-MMU-5610785|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044027"(hypermethylation of CpG island)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046849"(bone remodeling)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090290"(positive regulation of osteoclast proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0106027"(neuron projection organization)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000171"(negative regulation of dendrite development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|ensembl:ENSMUSG00000022812(gene)|ensembl:ENSMUST00000023507(transcript)|go:"GO:0000320"(re-entry into mitotic cell cycle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-som_stem_cell)|taxid:10090(Mouse somatic stem cell)	-	2011/03/14	2014/10/16	rogid:FKe0WkOBBYU0vIJLmcFNMJ+KVHA10090	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	intact-crc:4AC5ADAA1D8377E7|rigid:T4Ipx+OjTw4AgF4A5EUWYjEUqAk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)