#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Z2R9	-	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	-	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559792|mint:MINT-8082615	-	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0503"(self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082617(identity)	-	-	-	-	comment:mint|figure legend:fs2|intra-molecular:true	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	-	intact-crc:C267BD8091699F3A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	-
uniprotkb:Q9Z2R9	uniprotkb:Q6ZWX6	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	intact:EBI-1202234|uniprotkb:Q3TIQ0|ensembl:ENSMUSP00000071214	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:if2a_mouse(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559773|mint:MINT-8082577	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082579(identity)	refseq:NP_080390.1|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|ensembl:ENSMUSG00000021116(gene)|ensembl:ENSMUST00000071230(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|mint:MINT-8082580(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3 sf2 f4 sf5	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10090	intact-crc:D6AB7A746C7D0D22|rigid:N62m/f79ocSJvQWAFwv0ZjAKbhI	false	mutation decreasing interaction:120-120(MINT-8082591)|mutation decreasing interaction:119-119(MINT-8082588)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9Z2R9	uniprotkb:Q6ZWX6	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	intact:EBI-1202234|uniprotkb:Q3TIQ0|ensembl:ENSMUSP00000071214	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:if2a_mouse(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559830|mint:MINT-8082651	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082653(identity)	refseq:NP_080390.1|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|ensembl:ENSMUSG00000021116(gene)|ensembl:ENSMUST00000071230(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|mint:MINT-8082657(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3 sf2 f4 sf5a	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10090	intact-crc:94EB5FE8CB862228|rigid:N62m/f79ocSJvQWAFwv0ZjAKbhI	false	mutation disrupting interaction:490-490(MINT-8082654)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9Z2R9	uniprotkb:Q6ZWX6	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	intact:EBI-1202234|uniprotkb:Q3TIQ0|ensembl:ENSMUSP00000071214	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:if2a_mouse(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559815|mint:MINT-8082638	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082640(identity)	refseq:NP_080390.1|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|ensembl:ENSMUSG00000021116(gene)|ensembl:ENSMUST00000071230(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|mint:MINT-8082644(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3 sf2 f4 sf5c	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10090	intact-crc:E9C327C5A8FAFFB1|rigid:N62m/f79ocSJvQWAFwv0ZjAKbhI	false	mutation disrupting interaction:502-502(MINT-8082641)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q6ZWX6	uniprotkb:Q9Z2R9	intact:EBI-1202234|uniprotkb:Q3TIQ0|ensembl:ENSMUSP00000071214	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	psi-mi:if2a_mouse(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559800|mint:MINT-8082625	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080390.1|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|ensembl:ENSMUSG00000021116(gene)|ensembl:ENSMUST00000071230(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|mint:MINT-8082633(identity)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082627(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3 sf2 f4 sf5	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10090	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	intact-crc:A5A5D41B7D092D4B|rigid:N62m/f79ocSJvQWAFwv0ZjAKbhI	false	-	mutation disrupting interaction:196-196(MINT-8082630)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z2R9	uniprotkb:Q6ZWX6	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	intact:EBI-1202234|uniprotkb:Q3TIQ0|ensembl:ENSMUSP00000071214	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:if2a_mouse(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559860|mint:MINT-8082675	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082677(identity)	refseq:NP_080390.1|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|ensembl:ENSMUSG00000021116(gene)|ensembl:ENSMUST00000071230(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|mint:MINT-8082681(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3 sf2 f4 sf5a	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10090	intact-crc:CED7EA046D92CD4D|rigid:N62m/f79ocSJvQWAFwv0ZjAKbhI	false	mutation decreasing interaction:485-485(MINT-8082678)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q6ZWX6	uniprotkb:Q9Z2R9	intact:EBI-1202234|uniprotkb:Q3TIQ0|ensembl:ENSMUSP00000071214	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	psi-mi:if2a_mouse(display_long)|uniprotkb:Eif2s1(gene name)|psi-mi:Eif2s1(display_short)|uniprotkb:Eif2a(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2 subunit alpha(gene name synonym)	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559845|mint:MINT-8082664	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080390.1|go:"GO:0006412"(translation)|go:"GO:0007568"(aging)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043022"(ribosome binding)|go:"GO:0043558"(regulation of translational initiation in response to stress)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0044207"(translation initiation ternary complex)|go:"GO:0045202"(synapse)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0097451"(glial limiting end-foot)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:2000676"(positive regulation of type B pancreatic cell apoptotic process)|interpro:IPR003029(S1, RNA binding)|interpro:IPR011488(Eukaryotic translation initiation factor 2, alpha subunit)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR024054|interpro:IPR024055|interpro:IPR044126|reactome:R-MMU-156827|reactome:R-MMU-381042|reactome:R-MMU-382556|reactome:R-MMU-72649|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706|reactome:R-MMU-72731|go:"GO:0005851"(eukaryotic translation initiation factor 2B complex)|ensembl:ENSMUSG00000021116(gene)|ensembl:ENSMUST00000071230(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005850"(eukaryotic translation initiation factor 2 complex)|mint:MINT-8082670(identity)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082666(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3 sf2 f4 sf5a	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:FKeyVi3QK42ZWZl8m/PyPoleIDQ10090	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	intact-crc:3CF49A22511520CA|rigid:N62m/f79ocSJvQWAFwv0ZjAKbhI	false	-	mutation decreasing interaction:193-193(MINT-8082667)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z2R9	uniprotkb:Q9Z2R9	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:"MI:0096"(pull down)	Igarashi et al. (2011)	mint:MINT-8082572|pubmed:21223507|mint:fj-10-0855.r1|doi:10.1111/j.1742-4658.2011.08007	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8559884|mint:MINT-8082598	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082601(identity)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)|mint:MINT-8082600(identity)	-	-	-	figure legend:f2|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/05	2014/10/16	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	intact-crc:BF2A7846BD0A7C1C|rigid:M5cgQ5OEWmqfa3qsXwqvGmQTKdk	false	binding-associated region:?-?(MINT-8082612)	binding-associated region:1-138(MINT-8082608)|his tag:?-?(MINT-8082605)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)