#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q95SI0	uniprotkb:Q7PLL3	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	intact:EBI-3402022|ensemblmetazoa:FBpp0112403	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:q7pll3_drome(display_long)|uniprotkb:eIF4B(gene name)|psi-mi:eIF4B(display_short)|uniprotkb:eIF-4B(gene name synonym)|uniprotkb:Dm-eIF4B(gene name synonym)|uniprotkb:Dmel\CG10837(gene name synonym)|uniprotkb:EIF-4B(gene name synonym)|uniprotkb:Eif4B(gene name synonym)|uniprotkb:eIF-4B-L(gene name synonym)|uniprotkb:eIF-4B-S(gene name synonym)|uniprotkb:eIF-4b(gene name synonym)|uniprotkb:eIF4B-L(gene name synonym)|uniprotkb:eIF4B-S(gene name synonym)|uniprotkb:eIf4b(gene name synonym)|uniprotkb:Dmel_CG10837(orf name)|uniprotkb:CG10837(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3402018|imex:IM-15286-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	ensemblmetazoa:FBgn0020660(gene)|ensemblmetazoa:FBtr0113680(transcript)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR033107|interpro:IPR035979|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_001015319.1|flybase:FBgn0020660	psi-mi:"MI:0469"(intact)	-	-	comment:alpha-tubulin and actin were also identified but could not be assigned to a single gene product.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	rogid:zNqgtuWkd/j5StL1Dt2o9PK9gog7227	intact-crc:BB8C3AE26035D87F|rigid:3bo1/jkF0Bv4QvdspdJuv1rUiuk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q95SI0	uniprotkb:Q9VG78	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	intact:EBI-138898|ensemblmetazoa:FBpp0082058	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:q9vg78_drome(display_long)|uniprotkb:pps(gene name)|psi-mi:pps(display_short)|uniprotkb:Dmel\CG6525(gene name synonym)|uniprotkb:FBgn0082831(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Spp(gene name synonym)|uniprotkb:spp(gene name synonym)|uniprotkb:Dmel_CG6525(orf name)|uniprotkb:PPS(gene name synonym)|uniprotkb:CG6525(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3402018|imex:IM-15286-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	refseq:NP_650193.1|flybase:FBgn0082831|ensemblmetazoa:FBgn0082831(gene)|ensemblmetazoa:FBtr0082586(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003618(Transcription elongation factor S-II, central region)|interpro:IPR006576(BRK)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012921(Spen paralogue and orthologue C-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036575|interpro:IPR037259|rcsb pdb:5WLE|rcsb pdb:5WLF	psi-mi:"MI:0469"(intact)	-	-	comment:alpha-tubulin and actin were also identified but could not be assigned to a single gene product.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	rogid:eEzr8cIgjmZoHP7Vd82pqaWdtIQ7227	intact-crc:BB8C3AE26035D87F|rigid:3bo1/jkF0Bv4QvdspdJuv1rUiuk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q95SI0	uniprotkb:P23647	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3402018|imex:IM-15286-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	psi-mi:"MI:0469"(intact)	-	-	comment:alpha-tubulin and actin were also identified but could not be assigned to a single gene product.|figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:BB8C3AE26035D87F|rigid:3bo1/jkF0Bv4QvdspdJuv1rUiuk	false	flag tag:?-?	identified peptide:730-739|identified peptide:339-349	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q95SI0	uniprotkb:P23647	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3402051|imex:IM-15286-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 2B, 2G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:80FE7DDE6D9FED2A|rigid:T9hHFSn1m8jha1Ekd3YGMspbsbM	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P23647	uniprotkb:Q95SI0	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3402059|imex:IM-15286-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 2C, 2F, Supp. Fig. 2C|comment:Domain mapping of Tkv showed that the fragment lacking extracellular and transmembrane regions exhibited the strongest binding activity to Fu , although all of the truncation mutants of Tkv interacted with Fu.|caution:Exact coordinates of deletion mutants are not supplied in the publication|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	intact-crc:E6FEF05C7C36AEFA|rigid:T9hHFSn1m8jha1Ekd3YGMspbsbM	false	myc tag:?-?|necessary binding region:1->1	flag tag:?-?|necessary binding region:200..200-509	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q95SI0	uniprotkb:Q9V853	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	intact:EBI-133520|uniprotkb:Q9U3W2|ensemblmetazoa:FBpp0086011|ensemblmetazoa:FBpp0305371	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:smuf1_drome(display_long)|uniprotkb:Smurf(gene name)|psi-mi:Smurf(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Smurf1(gene name synonym)|uniprotkb:Lethal with a checkpoint kinase protein(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1 homolog(gene name synonym)|uniprotkb:Smurf1(gene name synonym)|uniprotkb:lack(gene name synonym)|uniprotkb:CG4943(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405338|imex:IM-15286-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	refseq:NP_523779.1|flybase:FBgn0029006|refseq:NP_001261061.1|ensemblmetazoa:FBgn0029006(gene)|ensemblmetazoa:FBtr0086833(transcript)|ensemblmetazoa:FBtr0333168(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048232"(male gamete generation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035983|interpro:IPR036020|reactome:R-DME-201451|reactome:R-DME-2173788|reactome:R-DME-2173791|reactome:R-DME-2173795|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-5632684|reactome:R-DME-8941858|reactome:R-DME-983168|interpro:IPR035892	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	rogid:y+MepmRUDbeDXaSYafJ8vxu5W4U7227	intact-crc:8AB7E57B22222B4D|rigid:DIm3k326NQdu/I9JXCP5TqG7UjU	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q9V853	uniprotkb:Q95SI0	intact:EBI-133520|uniprotkb:Q9U3W2|ensemblmetazoa:FBpp0086011|ensemblmetazoa:FBpp0305371	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	psi-mi:smuf1_drome(display_long)|uniprotkb:Smurf(gene name)|psi-mi:Smurf(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Smurf1(gene name synonym)|uniprotkb:Lethal with a checkpoint kinase protein(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1 homolog(gene name synonym)|uniprotkb:Smurf1(gene name synonym)|uniprotkb:lack(gene name synonym)|uniprotkb:CG4943(orf name)	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405392|imex:IM-15286-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523779.1|flybase:FBgn0029006|refseq:NP_001261061.1|ensemblmetazoa:FBgn0029006(gene)|ensemblmetazoa:FBtr0086833(transcript)|ensemblmetazoa:FBtr0333168(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048232"(male gamete generation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035983|interpro:IPR036020|reactome:R-DME-201451|reactome:R-DME-2173788|reactome:R-DME-2173791|reactome:R-DME-2173795|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-5632684|reactome:R-DME-8941858|reactome:R-DME-983168|interpro:IPR035892	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:y+MepmRUDbeDXaSYafJ8vxu5W4U7227	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	intact-crc:AB6CECCFD9FCB094|rigid:DIm3k326NQdu/I9JXCP5TqG7UjU	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q9V853	uniprotkb:P23647	intact:EBI-133520|uniprotkb:Q9U3W2|ensemblmetazoa:FBpp0086011|ensemblmetazoa:FBpp0305371	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:smuf1_drome(display_long)|uniprotkb:Smurf(gene name)|psi-mi:Smurf(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Smurf1(gene name synonym)|uniprotkb:Lethal with a checkpoint kinase protein(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1 homolog(gene name synonym)|uniprotkb:Smurf1(gene name synonym)|uniprotkb:lack(gene name synonym)|uniprotkb:CG4943(orf name)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405401|imex:IM-15286-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523779.1|flybase:FBgn0029006|refseq:NP_001261061.1|ensemblmetazoa:FBgn0029006(gene)|ensemblmetazoa:FBtr0086833(transcript)|ensemblmetazoa:FBtr0333168(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048232"(male gamete generation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035983|interpro:IPR036020|reactome:R-DME-201451|reactome:R-DME-2173788|reactome:R-DME-2173791|reactome:R-DME-2173795|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-5632684|reactome:R-DME-8941858|reactome:R-DME-983168|interpro:IPR035892	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 4A, 4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:y+MepmRUDbeDXaSYafJ8vxu5W4U7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:DDA651DEE4B4DBDB|rigid:RqtHS5PoWZHIiwqcj/GxjXOirDA	false	flag tag:?-?|necessary binding region:723..723-1061..1061(IPR000569)	ha tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P23647	uniprotkb:Q9V853	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	intact:EBI-133520|uniprotkb:Q9U3W2|ensemblmetazoa:FBpp0086011|ensemblmetazoa:FBpp0305371	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:smuf1_drome(display_long)|uniprotkb:Smurf(gene name)|psi-mi:Smurf(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Smurf1(gene name synonym)|uniprotkb:Lethal with a checkpoint kinase protein(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1 homolog(gene name synonym)|uniprotkb:Smurf1(gene name synonym)|uniprotkb:lack(gene name synonym)|uniprotkb:CG4943(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3505737|imex:IM-15286-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	refseq:NP_523779.1|flybase:FBgn0029006|refseq:NP_001261061.1|ensemblmetazoa:FBgn0029006(gene)|ensemblmetazoa:FBtr0086833(transcript)|ensemblmetazoa:FBtr0333168(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048232"(male gamete generation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035983|interpro:IPR036020|reactome:R-DME-201451|reactome:R-DME-2173788|reactome:R-DME-2173791|reactome:R-DME-2173795|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-5632684|reactome:R-DME-8941858|reactome:R-DME-983168|interpro:IPR035892	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 4G|comment:Both the N and C terminus of Fu could coimmunoprecipitate with Smurf.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	rogid:y+MepmRUDbeDXaSYafJ8vxu5W4U7227	intact-crc:3C2C9FBF56B086A4|rigid:RqtHS5PoWZHIiwqcj/GxjXOirDA	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q9V853	uniprotkb:P23647	intact:EBI-133520|uniprotkb:Q9U3W2|ensemblmetazoa:FBpp0086011|ensemblmetazoa:FBpp0305371	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	psi-mi:smuf1_drome(display_long)|uniprotkb:Smurf(gene name)|psi-mi:Smurf(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Smurf1(gene name synonym)|uniprotkb:Lethal with a checkpoint kinase protein(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1 homolog(gene name synonym)|uniprotkb:Smurf1(gene name synonym)|uniprotkb:lack(gene name synonym)|uniprotkb:CG4943(orf name)	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405413|imex:IM-15286-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_523779.1|flybase:FBgn0029006|refseq:NP_001261061.1|ensemblmetazoa:FBgn0029006(gene)|ensemblmetazoa:FBtr0086833(transcript)|ensemblmetazoa:FBtr0333168(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048232"(male gamete generation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035983|interpro:IPR036020|reactome:R-DME-201451|reactome:R-DME-2173788|reactome:R-DME-2173791|reactome:R-DME-2173795|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-5632684|reactome:R-DME-8941858|reactome:R-DME-983168|interpro:IPR035892	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 4B|comment:Both the N and C terminus of Fu could coimmunoprecipitate with Smurf.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:y+MepmRUDbeDXaSYafJ8vxu5W4U7227	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	intact-crc:423A516950506AFA|rigid:RqtHS5PoWZHIiwqcj/GxjXOirDA	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P23647	uniprotkb:Q9V853	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	intact:EBI-133520|uniprotkb:Q9U3W2|ensemblmetazoa:FBpp0086011|ensemblmetazoa:FBpp0305371	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:smuf1_drome(display_long)|uniprotkb:Smurf(gene name)|psi-mi:Smurf(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Smurf1(gene name synonym)|uniprotkb:Lethal with a checkpoint kinase protein(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1 homolog(gene name synonym)|uniprotkb:Smurf1(gene name synonym)|uniprotkb:lack(gene name synonym)|uniprotkb:CG4943(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405432|imex:IM-15286-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	refseq:NP_523779.1|flybase:FBgn0029006|refseq:NP_001261061.1|ensemblmetazoa:FBgn0029006(gene)|ensemblmetazoa:FBtr0086833(transcript)|ensemblmetazoa:FBtr0333168(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048232"(male gamete generation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035983|interpro:IPR036020|reactome:R-DME-201451|reactome:R-DME-2173788|reactome:R-DME-2173791|reactome:R-DME-2173795|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-5632684|reactome:R-DME-8941858|reactome:R-DME-983168|interpro:IPR035892	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-ovary)|taxid:7227(Drosophila melanogaster ovary)	-	2011/01/10	2014/10/16	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	rogid:y+MepmRUDbeDXaSYafJ8vxu5W4U7227	intact-crc:C1A25AECA15AE72E|rigid:RqtHS5PoWZHIiwqcj/GxjXOirDA	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23647	uniprotkb:Q95SI0	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405449|imex:IM-15286-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	intact-crc:892AF40AFD6A609A|rigid:qU3UUFEPJywgusNLUtjgJqYBc1A	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P23647	uniprotkb:Q9V853	intact:EBI-165536|ensemblmetazoa:FBpp0074373|uniprotkb:Q26346|uniprotkb:Q26347|uniprotkb:Q27412|uniprotkb:Q9VWR7	intact:EBI-133520|uniprotkb:Q9U3W2|ensemblmetazoa:FBpp0086011|ensemblmetazoa:FBpp0305371	psi-mi:fused_drome(display_long)|uniprotkb:fu(gene name)|psi-mi:fu(display_short)|uniprotkb:CG6551(orf name)	psi-mi:smuf1_drome(display_long)|uniprotkb:Smurf(gene name)|psi-mi:Smurf(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase Smurf1(gene name synonym)|uniprotkb:Lethal with a checkpoint kinase protein(gene name synonym)|uniprotkb:SMAD ubiquitination regulatory factor 1 homolog(gene name synonym)|uniprotkb:Smurf1(gene name synonym)|uniprotkb:lack(gene name synonym)|uniprotkb:CG4943(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Xia et al. (2010)	imex:IM-15286|pubmed:21145463	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-3405449|imex:IM-15286-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0001079(gene)|ensemblmetazoa:FBtr0074602(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007367"(segment polarity determination)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035222"(wing disc pattern formation)|go:"GO:0035301"(Hedgehog signaling complex)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0005119"(smoothened binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6LPH|reactome:R-DME-209159|reactome:R-DME-209190|reactome:R-DME-209214|reactome:R-DME-209338|reactome:R-DME-209360|reactome:R-DME-216119|reactome:R-DME-216217|refseq:NP_477499.1|flybase:FBgn0001079|dip:DIP-492N	refseq:NP_523779.1|flybase:FBgn0029006|refseq:NP_001261061.1|ensemblmetazoa:FBgn0029006(gene)|ensemblmetazoa:FBtr0086833(transcript)|ensemblmetazoa:FBtr0333168(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0040008"(regulation of growth)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048232"(male gamete generation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035983|interpro:IPR036020|reactome:R-DME-201451|reactome:R-DME-2173788|reactome:R-DME-2173791|reactome:R-DME-2173795|reactome:R-DME-4608870|reactome:R-DME-4641257|reactome:R-DME-5632684|reactome:R-DME-8941858|reactome:R-DME-983168|interpro:IPR035892	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2011/01/10	2014/10/16	rogid:5KrFb8xuGHpjwIlFMx4AkeD9/m47227	rogid:y+MepmRUDbeDXaSYafJ8vxu5W4U7227	intact-crc:892AF40AFD6A609A|rigid:qU3UUFEPJywgusNLUtjgJqYBc1A	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)