#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865399|imex:IM-15780-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, 1C, 6B, 6D, 6E|comment:"DRB1*04:01 was used in combination with DRA to assemble HLA-DR2, which then interacted with the MBP peptide. Interaction is disrupted by the presence of HLA-DM, which is made up of HLA-DMA and HLA-DMB."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:7084733B57F53150|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c|mutation decreasing interaction:98-98|mutation disrupting interaction:98-98,194-194	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865399|imex:IM-15780-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, 1C, 6B, 6D, 6E|comment:"DRB1*04:01 was used in combination with DRA to assemble HLA-DR2, which then interacted with the MBP peptide. Interaction is disrupted by the presence of HLA-DM, which is made up of HLA-DMA and HLA-DMB."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:7084733B57F53150|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c|mutation decreasing interaction:98-98|mutation disrupting interaction:98-98,194-194	mutation disrupting interaction:53-53|mutation decreasing interaction:53-53|mutation increasing interaction:49-49	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865399|imex:IM-15780-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, 1C, 6B, 6D, 6E|comment:"DRB1*04:01 was used in combination with DRA to assemble HLA-DR2, which then interacted with the MBP peptide. Interaction is disrupted by the presence of HLA-DM, which is made up of HLA-DMA and HLA-DMB."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:7084733B57F53150|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c|mutation decreasing interaction:98-98|mutation disrupting interaction:98-98,194-194	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P02686	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865399|imex:IM-15780-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, 1C, 6B, 6D, 6E|comment:"DRB1*04:01 was used in combination with DRA to assemble HLA-DR2, which then interacted with the MBP peptide. Interaction is disrupted by the presence of HLA-DM, which is made up of HLA-DMA and HLA-DMB."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:7084733B57F53150|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c|mutation decreasing interaction:98-98|mutation disrupting interaction:98-98,194-194	alexa 488 label:?-?|sufficient binding region:85-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01903	uniprotkb:P01911	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865433|imex:IM-15780-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:"Fig. 1A (black line)"|comment:"DRB1*04:01 was used in combination with DRA to assemble HLA-DR2, which then interacted with the MBP peptide."|antagonist:Interaction is disrupted by the presence of HLA-DM, which is made up of HLA-DMA and HLA-DMB.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:9B8A93E45F2F9FCA|rigid:xPiCdA3FOglEJcRvxVQx5RNKDQA	false	mutation disrupting interaction:53-53|mutation decreasing interaction:53-53|mutation increasing interaction:49-49	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01903	uniprotkb:P02686	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865433|imex:IM-15780-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:"Fig. 1A (black line)"|comment:"DRB1*04:01 was used in combination with DRA to assemble HLA-DR2, which then interacted with the MBP peptide."|antagonist:Interaction is disrupted by the presence of HLA-DM, which is made up of HLA-DMA and HLA-DMB.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:9B8A93E45F2F9FCA|rigid:xPiCdA3FOglEJcRvxVQx5RNKDQA	false	mutation disrupting interaction:53-53|mutation decreasing interaction:53-53|mutation increasing interaction:49-49	alexa 488 label:?-?|sufficient binding region:85-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865585|imex:IM-15780-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D, 2A, 2B, 2C, 2D, 6C, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of free CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:73736663F5A7762B|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865585|imex:IM-15780-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D, 2A, 2B, 2C, 2D, 6C, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of free CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:73736663F5A7762B|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865585|imex:IM-15780-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D, 2A, 2B, 2C, 2D, 6C, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of free CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:73736663F5A7762B|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	mutation decreasing interaction:68-68	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865585|imex:IM-15780-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D, 2A, 2B, 2C, 2D, 6C, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of free CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:73736663F5A7762B|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865585|imex:IM-15780-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D, 2A, 2B, 2C, 2D, 6C, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of free CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:73736663F5A7762B|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:A0A1V1IGJ9	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-25339774	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865469|imex:IM-15780-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:	figure legend:Fig. 1B, 1E, 2E, 2F|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 caused disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606	intact-crc:6539022E0CE5B40F|rigid:pHW+fopbraoS3Dmj9cm0WrB6ogs	false	biotin tag:c-c|mutation decreasing interaction:220-220,124-124|mutation decreasing interaction:124-124	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865469|imex:IM-15780-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B, 1E, 2E, 2F|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 caused disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:6539022E0CE5B40F|rigid:pHW+fopbraoS3Dmj9cm0WrB6ogs	false	biotin tag:c-c|mutation decreasing interaction:220-220,124-124|mutation decreasing interaction:124-124	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P02686	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865469|imex:IM-15780-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B, 1E, 2E, 2F|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 caused disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:6539022E0CE5B40F|rigid:pHW+fopbraoS3Dmj9cm0WrB6ogs	false	biotin tag:c-c|mutation decreasing interaction:220-220,124-124|mutation decreasing interaction:124-124	mutation decreasing interaction:89-89|sufficient binding region:85-99|mutation decreasing interaction:89-89|mutation decreasing interaction:85-85|mutation decreasing interaction:89-89	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865469|imex:IM-15780-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B, 1E, 2E, 2F|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 caused disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:6539022E0CE5B40F|rigid:pHW+fopbraoS3Dmj9cm0WrB6ogs	false	biotin tag:c-c|mutation decreasing interaction:220-220,124-124|mutation decreasing interaction:124-124	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865469|imex:IM-15780-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B, 1E, 2E, 2F|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 caused disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:6539022E0CE5B40F|rigid:pHW+fopbraoS3Dmj9cm0WrB6ogs	false	biotin tag:c-c|mutation decreasing interaction:220-220,124-124|mutation decreasing interaction:124-124	biotin tag:c-c|sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865647|imex:IM-15780-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, S1|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:1E3160C5212AB495|rigid:gL2YPpji3WKD7OR4BGJ6EwmG3nI	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865647|imex:IM-15780-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, S1|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:1E3160C5212AB495|rigid:gL2YPpji3WKD7OR4BGJ6EwmG3nI	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865647|imex:IM-15780-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, S1|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:1E3160C5212AB495|rigid:gL2YPpji3WKD7OR4BGJ6EwmG3nI	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865675|imex:IM-15780-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:11F29B9047D87AA1|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	sufficient binding region:87-101	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865675|imex:IM-15780-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:11F29B9047D87AA1|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865675|imex:IM-15780-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:11F29B9047D87AA1|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865675|imex:IM-15780-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:11F29B9047D87AA1|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865675|imex:IM-15780-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A|inhibition:injection of CLIP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:11F29B9047D87AA1|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:98-98|biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865540|imex:IM-15780-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B, 1D, 6C, 6F, S2, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:461CAB8163BE3BAE|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865540|imex:IM-15780-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B, 1D, 6C, 6F, S2, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:461CAB8163BE3BAE|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	mutation increasing interaction:49-49|mutation disrupting interaction:53-53|mutation disrupting interaction:53-53|mutation decreasing interaction:43-43	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:A0A1V1IGJ9	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-25339774	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865540|imex:IM-15780-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:	figure legend:Fig. 1B, 1D, 6C, 6F, S2, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606	intact-crc:461CAB8163BE3BAE|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865540|imex:IM-15780-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B, 1D, 6C, 6F, S2, S9|comment:CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:461CAB8163BE3BAE|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865829|imex:IM-15780-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3E|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:FCC9E913302625BD|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865829|imex:IM-15780-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3E|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:FCC9E913302625BD|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865829|imex:IM-15780-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3E|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:FCC9E913302625BD|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865829|imex:IM-15780-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3E|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:FCC9E913302625BD|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865694|imex:IM-15780-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B, 3E, 3F, 4D, 4E, 4F, 5A, 5B, 7A, 7B, 7C, 7D, 7E, 7F, 7G, S8|comment:"Fig. 3E, 3F used HLA-DR preloaded with HA (306-318). Fig. 4D, 4E, 4F, 5A, 5B, 7B, 7D, 7E used HLA-DR linked with HA6 or HA3 peptides"|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:B8F38E9375A05E94|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	mutation:112-113,115-115,107-107	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865694|imex:IM-15780-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B, 3E, 3F, 4D, 4E, 4F, 5A, 5B, 7A, 7B, 7C, 7D, 7E, 7F, 7G, S8|comment:"Fig. 3E, 3F used HLA-DR preloaded with HA (306-318). Fig. 4D, 4E, 4F, 5A, 5B, 7B, 7D, 7E used HLA-DR linked with HA6 or HA3 peptides"|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:B8F38E9375A05E94|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865694|imex:IM-15780-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B, 3E, 3F, 4D, 4E, 4F, 5A, 5B, 7A, 7B, 7C, 7D, 7E, 7F, 7G, S8|comment:"Fig. 3E, 3F used HLA-DR preloaded with HA (306-318). Fig. 4D, 4E, 4F, 5A, 5B, 7B, 7D, 7E used HLA-DR linked with HA6 or HA3 peptides"|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:B8F38E9375A05E94|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865694|imex:IM-15780-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B, 3E, 3F, 4D, 4E, 4F, 5A, 5B, 7A, 7B, 7C, 7D, 7E, 7F, 7G, S8|comment:"Fig. 3E, 3F used HLA-DR preloaded with HA (306-318). Fig. 4D, 4E, 4F, 5A, 5B, 7B, 7D, 7E used HLA-DR linked with HA6 or HA3 peptides"|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:B8F38E9375A05E94|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866128|imex:IM-15780-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S3|comment:DNP-CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:FD120960246ACBE2|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	sufficient binding region:103-117|tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866128|imex:IM-15780-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S3|comment:DNP-CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:FD120960246ACBE2|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	mutation increasing interaction:74-74|mutation disrupting interaction:78-78|mutation decreasing interaction:68-68	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:A0A1V1IGJ9	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-25339774	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:a0a1v1igj9_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866128|imex:IM-15780-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR000353(MHC class II, beta chain, N-terminal)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:	figure legend:Fig. S3|comment:DNP-CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:t0oiEebDmTMAhQ97YLbgIkwvFek9606	intact-crc:FD120960246ACBE2|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866128|imex:IM-15780-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S3|comment:DNP-CLIP 15mer is convalently attached via thrombin-cleavable linker at the n' of HLA-DRB|inhibition:injection of MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:FD120960246ACBE2|rigid:8KEbgqb3JV+flj0O9QEGoe4S6ck	false	mutation decreasing interaction:124-124,220-220|mutation decreasing interaction:124-124|biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P02686	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866158|imex:IM-15780-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:injection of free MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:56AA2FEAA7F31C38|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	sufficient binding region:85-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866158|imex:IM-15780-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:injection of free MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:56AA2FEAA7F31C38|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866158|imex:IM-15780-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:injection of free MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:56AA2FEAA7F31C38|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866158|imex:IM-15780-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:injection of free MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:56AA2FEAA7F31C38|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866158|imex:IM-15780-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S4|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:injection of free MBP peptide at stage 3 cause disassembly of the quaternary complex|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:56AA2FEAA7F31C38|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P02686	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865808|imex:IM-15780-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free MBP(85-99) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:F748DFC46B4229E2|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	sufficient binding region:85-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865808|imex:IM-15780-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free MBP(85-99) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:F748DFC46B4229E2|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P02686	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865808|imex:IM-15780-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free MBP(85-99) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:F748DFC46B4229E2|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	sufficient binding region:85-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865808|imex:IM-15780-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free MBP(85-99) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:F748DFC46B4229E2|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865808|imex:IM-15780-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free MBP(85-99) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:F748DFC46B4229E2|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865790|imex:IM-15780-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:A6A5572DFEE27843|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	sufficient binding region:87-101	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P02686	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865790|imex:IM-15780-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:A6A5572DFEE27843|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	sufficient binding region:85-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865790|imex:IM-15780-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:A6A5572DFEE27843|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865790|imex:IM-15780-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:A6A5572DFEE27843|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865790|imex:IM-15780-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:A6A5572DFEE27843|rigid:YAMfB7T/aXK6RM6VO3kzmMGrHzc	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865769|imex:IM-15780-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:9540C3318B5E73D4|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865769|imex:IM-15780-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:9540C3318B5E73D4|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P02686	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-947410|uniprotkb:A4FU54|uniprotkb:Q15337|uniprotkb:Q15338|uniprotkb:Q15339|uniprotkb:A8MY86|uniprotkb:A8MYL4|uniprotkb:A6NI84|uniprotkb:Q15340|uniprotkb:Q59GX3|uniprotkb:Q65ZS4|uniprotkb:Q6AI64|uniprotkb:Q6FH37|uniprotkb:Q6FI04|uniprotkb:Q6PK23|uniprotkb:B3KY66|uniprotkb:B7ZKS2|uniprotkb:B7ZKS4|ensembl:ENSP00000348273|ensembl:ENSP00000462223	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:mbp_human(display_long)|uniprotkb:MBP(gene name)|psi-mi:MBP(display_short)|uniprotkb:Myelin A1 protein(gene name synonym)|uniprotkb:Myelin membrane encephalitogenic protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865769|imex:IM-15780-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020252.1|refseq:NP_001020261.1|refseq:NP_001020263.1|refseq:NP_001020271.1|refseq:NP_001020272.1|refseq:NP_002376.1|refseq:XP_016881269.1|dip:DIP-36624N|ensembl:ENSG00000197971(gene)|ensembl:ENST00000355994(transcript)|ensembl:ENST00000580402(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002020"(protease binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008366"(axon ensheathment)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0019911"(structural constituent of myelin sheath)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033269"(internode region of axon)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042552"(myelination)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0045202"(synapse)|go:"GO:0061024"(membrane organization)|go:"GO:0071944"(cell periphery)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000548(Myelin basic protein)|mint:P02686|rcsb pdb:1BX2|rcsb pdb:1FV1|rcsb pdb:1HQR|rcsb pdb:1K2D|rcsb pdb:1QCL|rcsb pdb:1YMM|rcsb pdb:1ZGL|reactome:R-HSA-9619665	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:ebDCekUqLVlpi0vmYj/WZjha+AQ9606	intact-crc:9540C3318B5E73D4|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	sufficient binding region:85-99	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865769|imex:IM-15780-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with MBP peptide"|inhibition:"injection of free CLIP (87-101) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:9540C3318B5E73D4|rigid:Sbb30Ra2DHNDPAymZOpi+nKglHA	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865750|imex:IM-15780-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S7A|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:1B67A866D9BBC2B7|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	sufficient binding region:87-101	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865750|imex:IM-15780-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S7A|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:1B67A866D9BBC2B7|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865750|imex:IM-15780-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S7A|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:1B67A866D9BBC2B7|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865750|imex:IM-15780-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S7A|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:1B67A866D9BBC2B7|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865750|imex:IM-15780-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S7A|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:1B67A866D9BBC2B7|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865715|imex:IM-15780-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S4, S7A, S7B|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:B9003C8D7D4D9039|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865715|imex:IM-15780-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S4, S7A, S7B|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:B9003C8D7D4D9039|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865715|imex:IM-15780-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S4, S7A, S7B|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:B9003C8D7D4D9039|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3865715|imex:IM-15780-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C, S4, S7A, S7B|comment:"HLA-DR2 (HLA-DRA :: HLA-DRB1) is preloaded with CLIP (103-117) peptide"|inhibition:"injection of free CLIP (87-101) or HA (306-318) peptide at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:B9003C8D7D4D9039|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P04233	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866112|imex:IM-15780-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G|comment:"HLA-DR4 (HLA-DRA :: HLA-DRB4) was preloaded with CLIP peptide"|inhibition:"injection of free HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	intact-crc:6EBCD43ED6E1D6A9|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	sufficient binding region:103-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866112|imex:IM-15780-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G|comment:"HLA-DR4 (HLA-DRA :: HLA-DRB4) was preloaded with CLIP peptide"|inhibition:"injection of free HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:6EBCD43ED6E1D6A9|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866112|imex:IM-15780-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G|comment:"HLA-DR4 (HLA-DRA :: HLA-DRB4) was preloaded with CLIP peptide"|inhibition:"injection of free HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:6EBCD43ED6E1D6A9|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866112|imex:IM-15780-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G|comment:"HLA-DR4 (HLA-DRA :: HLA-DRB4) was preloaded with CLIP peptide"|inhibition:"injection of free HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:6EBCD43ED6E1D6A9|rigid:2jir73x94PrzSq3BNflffMSvOb0	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01911	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1033104|uniprotkb:O19717|uniprotkb:O19739|uniprotkb:P13759|uniprotkb:Q29875|uniprotkb:Q30145|uniprotkb:Q9GIX9|uniprotkb:Q9GIY4|uniprotkb:Q9MY13|uniprotkb:Q9XRY5|uniprotkb:Q0PQ39|uniprotkb:Q14280|uniprotkb:Q14QT2|uniprotkb:Q155F7|uniprotkb:Q19AF2|uniprotkb:Q19K86|uniprotkb:Q1AP33|uniprotkb:Q1G0Z9|uniprotkb:Q1JRP3|uniprotkb:Q1KLJ6|uniprotkb:Q27PR6|uniprotkb:Q27PR7|uniprotkb:Q29673|uniprotkb:Q29720|uniprotkb:Q29722|uniprotkb:Q29734|uniprotkb:Q29770|uniprotkb:Q29771|uniprotkb:A0MWF2|uniprotkb:A0N0W1|uniprotkb:A2ICT1|uniprotkb:A2TGX3|uniprotkb:A4F5N0|uniprotkb:A4ZXA5|uniprotkb:A4ZXA6|uniprotkb:A4ZY86|uniprotkb:A5H000|ensembl:ENSP00000353099|uniprotkb:A5HKN8|uniprotkb:A7DZP9|uniprotkb:A7LA26|uniprotkb:A7UHG2|uniprotkb:A7X5B1|uniprotkb:A7X5B7|uniprotkb:A7X5E0|uniprotkb:A7X5E6|uniprotkb:A7X5H8|uniprotkb:A7X5J4|uniprotkb:A7X5K7|uniprotkb:A8K098|uniprotkb:A8YQE9|uniprotkb:A9JPG0|uniprotkb:B0BK85|uniprotkb:B1GWE7|uniprotkb:B2CR03|uniprotkb:B0LUZ6|uniprotkb:B0UYW1|uniprotkb:Q768U2|uniprotkb:Q29772|uniprotkb:Q29790|uniprotkb:Q29792|uniprotkb:Q29800|uniprotkb:Q29806|uniprotkb:Q29833|uniprotkb:Q29874|uniprotkb:Q29886|uniprotkb:Q29968|uniprotkb:Q29974|uniprotkb:Q29975|uniprotkb:Q2A120|uniprotkb:Q2HZE5|uniprotkb:Q2L9H4|uniprotkb:Q2LE76|uniprotkb:Q2MF40|uniprotkb:Q2MJA6|uniprotkb:Q2MZ92|uniprotkb:Q2VQU1|uniprotkb:Q2YHQ2|uniprotkb:Q30006|uniprotkb:Q30108|uniprotkb:Q30112|uniprotkb:Q30115|uniprotkb:Q30116|uniprotkb:Q30117|uniprotkb:Q30120|uniprotkb:Q30134|uniprotkb:Q30142|uniprotkb:Q30149|uniprotkb:Q30159|uniprotkb:Q30166|uniprotkb:Q30167|uniprotkb:Q30200|uniprotkb:Q307W5|uniprotkb:Q31636|uniprotkb:Q32MY7|uniprotkb:Q3HUP9|uniprotkb:Q3KTM1|uniprotkb:Q3LA84|uniprotkb:Q3LA87|uniprotkb:Q3LA88|uniprotkb:Q3LA89|uniprotkb:Q3LA90|uniprotkb:Q3LA91|uniprotkb:Q3LA92|uniprotkb:Q3LA93|uniprotkb:Q3LA94|uniprotkb:Q3LA95|uniprotkb:Q3LA96|uniprotkb:Q3LA97|uniprotkb:Q3LA98|uniprotkb:Q3LA99|uniprotkb:Q3LAA0|uniprotkb:Q3LAA1|uniprotkb:Q3LAA2|uniprotkb:Q3MQ60|uniprotkb:Q3T919|uniprotkb:Q4PRC3|uniprotkb:Q4PRC5|uniprotkb:Q4VZY7|uniprotkb:Q53IG1|uniprotkb:Q56FN9|uniprotkb:Q56FP1|uniprotkb:Q56FP2|uniprotkb:Q56FP3|uniprotkb:Q58F52|uniprotkb:Q5BM92|uniprotkb:Q5EER6|uniprotkb:Q5K3W2|uniprotkb:Q5NDB9|uniprotkb:Q5U9W6|uniprotkb:Q5UBA2|uniprotkb:Q5UT58|uniprotkb:Q5W3L4|uniprotkb:Q5Y7A7|uniprotkb:Q5Y7B0|uniprotkb:Q5Y7B9|uniprotkb:Q5Y7E9|uniprotkb:Q5Y7G0|uniprotkb:Q683P7|uniprotkb:Q6REE2|uniprotkb:Q6T865|uniprotkb:Q6U387|uniprotkb:Q701T1|uniprotkb:Q70GL2|uniprotkb:Q70Q85|uniprotkb:Q768U4|uniprotkb:Q7M2H4|uniprotkb:Q7YNY9|uniprotkb:Q7YP03|uniprotkb:Q7YP04|uniprotkb:Q7YQ26|uniprotkb:Q7YQA3|uniprotkb:Q7YQA5|uniprotkb:Q860D8|uniprotkb:Q860D9|uniprotkb:Q860E5|uniprotkb:Q860H8|uniprotkb:Q860S0|uniprotkb:Q860Z3|uniprotkb:Q861G6|uniprotkb:Q861H0|uniprotkb:Q861H4|uniprotkb:Q861H5|uniprotkb:Q861H7|uniprotkb:Q861H8|uniprotkb:Q8HWQ6|uniprotkb:Q8MH59|uniprotkb:Q8MH60|uniprotkb:Q8WLU3|uniprotkb:Q8WMA0|uniprotkb:Q95348|uniprotkb:Q95383|uniprotkb:Q95389|uniprotkb:Q95461|uniprotkb:Q95HK1|uniprotkb:Q95HL0|uniprotkb:Q95HL1|uniprotkb:Q95IE3|uniprotkb:Q95IG2|uniprotkb:Q95IT6|uniprotkb:Q96HZ9|uniprotkb:Q9BCL7|uniprotkb:Q9BCP0|uniprotkb:Q9BCP1|uniprotkb:Q9BCP2|uniprotkb:Q9BCP5|uniprotkb:Q9BD21|uniprotkb:Q9BD33|uniprotkb:Q9BD40|uniprotkb:Q9GIK5|uniprotkb:Q9GIL5|uniprotkb:Q9GIL6|uniprotkb:Q9GIP3|uniprotkb:Q9GIX8|uniprotkb:Q9GIY0|uniprotkb:Q9GIY1|uniprotkb:Q9GIY2|uniprotkb:B2LVF9|uniprotkb:B2NJ29|uniprotkb:B2ZCY1|uniprotkb:B3VTP8|uniprotkb:B3VTQ3|uniprotkb:B5A8Y2|uniprotkb:B5A8Y3|uniprotkb:C0LAB5|uniprotkb:B5B8U0|uniprotkb:B5B9V5|uniprotkb:B5B9V6|uniprotkb:B5LZ25|uniprotkb:B5QSK8|uniprotkb:B6VCX2|uniprotkb:B6VEL9|uniprotkb:B7UDB2|uniprotkb:B9VRA4|uniprotkb:B9X248|uniprotkb:Q0PGR5|uniprotkb:O02876|uniprotkb:O02930|uniprotkb:O19585|uniprotkb:O19718|uniprotkb:O19788|uniprotkb:O46699|uniprotkb:O46793|uniprotkb:O46872|uniprotkb:O62869|uniprotkb:O62889|uniprotkb:O77969|uniprotkb:O78047|uniprotkb:O78210|uniprotkb:O98212|uniprotkb:P01912|uniprotkb:P01914|uniprotkb:P04229|uniprotkb:P13758|uniprotkb:P13760|uniprotkb:P13761|uniprotkb:P20039|uniprotkb:P79545|uniprotkb:Q06662|intact:EBI-3866098|intact:EBI-13953066|uniprotkb:Q9GIY3|uniprotkb:Q9GJ25|uniprotkb:Q9GJ56|uniprotkb:Q9GJ57|uniprotkb:Q9GJ58|uniprotkb:Q9GJ60|uniprotkb:Q9GJF8|uniprotkb:Q9GJF9|uniprotkb:Q9GJG0|uniprotkb:Q9MXZ0|uniprotkb:Q9MXZ5|uniprotkb:Q9MY45|uniprotkb:Q9MY56|uniprotkb:Q9MYF5|uniprotkb:Q9TPB6|uniprotkb:Q9TPW1|uniprotkb:Q9TPW3|uniprotkb:Q9TPW9|uniprotkb:Q9TPX4|uniprotkb:Q9TQ37|uniprotkb:Q9TQ91|uniprotkb:Q9TQE0|uniprotkb:Q9UBY1|uniprotkb:Q9UIM9|uniprotkb:Q9UIN0|uniprotkb:Q9XRX1|uniprotkb:Q9XRY4|uniprotkb:Q9Y453|uniprotkb:Q9Y4H7|intact:EBI-13953170|intact:EBI-2877159	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:drb1_human(display_long)|uniprotkb:HLA-DRB1(gene name)|psi-mi:HLA-DRB1(display_short)|uniprotkb:Human leukocyte antigen DRB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866101|imex:IM-15780-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002115.2|ensembl:ENSG00000196126(gene)|ensembl:ENST00000360004(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001772"(immunological synapse)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032673"(regulation of interleukin-4 production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051262"(protein tetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FYT|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:1KLU|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:1R5I|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:1T5X|rcsb pdb:1YMM|rcsb pdb:2FSE|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:2SEB|rcsb pdb:2WBJ|rcsb pdb:2XN9|rcsb pdb:3L6F|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6HBY|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V0Y|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|refseq:XP_011546040.1|refseq:NP_001230894.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|comment:"HLA-DR4 (HLA-DRA :: HLA-DRB4) was preloaded with HA(306-318) peptide"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:YdQX0KNIxO5tYjgm6hdRRZfNlk49606	intact-crc:98BB98D6142074A8|rigid:gL2YPpji3WKD7OR4BGJ6EwmG3nI	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P01903	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-1030473|uniprotkb:Q30160|uniprotkb:Q6IAZ1|uniprotkb:Q861I2|uniprotkb:Q9TP70|uniprotkb:A2BET4|ensembl:ENSP00000372608|ensembl:ENSP00000372746|ensembl:ENSP00000378786|ensembl:ENSP00000402951|ensembl:ENSP00000404533|ensembl:ENSP00000405295|ensembl:ENSP00000410443|ensembl:ENSP00000479287	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dra_human(display_long)|uniprotkb:HLA-DRA(gene name)|psi-mi:HLA-DRA(display_short)|uniprotkb:MHC class II antigen DRA(gene name synonym)|uniprotkb:HLA-DRA1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866101|imex:IM-15780-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_061984.2|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002469"(myeloid dendritic cell antigen processing and presentation)|go:"GO:0002491"(antigen processing and presentation of endogenous peptide antigen via MHC class II)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|ensembl:ENST00000416883(transcript)|go:"GO:0023026"(MHC class II protein complex binding)|ensembl:ENST00000442960(transcript)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0032588"(trans-Golgi network membrane)|ensembl:ENST00000613328(transcript)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045622"(regulation of T-helper cell differentiation)|go:"GO:0050890"(cognition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000516"(positive regulation of CD4-positive, alpha-beta T cell activation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|go:"GO:0001772"(immunological synapse)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1A6A|rcsb pdb:1AQD|rcsb pdb:1BX2|rcsb pdb:1D5M|rcsb pdb:1D5X|rcsb pdb:1D5Z|rcsb pdb:1D6E|rcsb pdb:1DLH|rcsb pdb:1FV1|rcsb pdb:1FYT|rcsb pdb:1H15|rcsb pdb:1HQR|rcsb pdb:1HXY|rcsb pdb:1J8H|rcsb pdb:1JWM|rcsb pdb:1JWS|rcsb pdb:1JWU|rcsb pdb:1KG0|rcsb pdb:1KLG|rcsb pdb:2G9H|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2ICW|rcsb pdb:2IPK|rcsb pdb:2OJE|rcsb pdb:1KLU|rcsb pdb:2Q6W|rcsb pdb:2SEB|rcsb pdb:1LO5|rcsb pdb:1PYW|rcsb pdb:2WBJ|rcsb pdb:1R5I|rcsb pdb:2XN9|rcsb pdb:3C5J|rcsb pdb:3L6F|rcsb pdb:1SEB|rcsb pdb:1SJE|rcsb pdb:3O6F|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|rcsb pdb:3QXA|rcsb pdb:3QXD|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4C56|rcsb pdb:4E41|rcsb pdb:4FQX|rcsb pdb:4GBX|rcsb pdb:4H1L|rcsb pdb:4H25|rcsb pdb:4H26|rcsb pdb:4I5B|rcsb pdb:4IS6|rcsb pdb:1SJH|rcsb pdb:1T5W|rcsb pdb:4MCY|rcsb pdb:4MCZ|rcsb pdb:4MD0|rcsb pdb:4MD4|rcsb pdb:1T5X|rcsb pdb:4MD5|rcsb pdb:4MDI|rcsb pdb:4MDJ|rcsb pdb:4OV5|rcsb pdb:1YMM|rcsb pdb:4X5W|rcsb pdb:4X5X|rcsb pdb:4Y19|rcsb pdb:4Y1A|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5V4M|rcsb pdb:5V4N|rcsb pdb:6ATF|rcsb pdb:6ATI|rcsb pdb:6ATZ|rcsb pdb:1ZGL|rcsb pdb:6BIJ|rcsb pdb:6BIL|rcsb pdb:6BIN|rcsb pdb:6BIR|rcsb pdb:6BIV|rcsb pdb:6BIX|rcsb pdb:6BIY|rcsb pdb:6BIZ|rcsb pdb:2FSE|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6CQR|rcsb pdb:6NIX|rcsb pdb:6QZA|rcsb pdb:6QZC|rcsb pdb:6QZD|rcsb pdb:6R0E|rcsb pdb:6V13|rcsb pdb:6V15|rcsb pdb:6V18|rcsb pdb:6V19|rcsb pdb:6V1A|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-2132295|reactome:R-HSA-389948|reactome:R-HSA-877300|rcsb pdb:6V0Y|ensembl:ENSG00000204287(gene)|ensembl:ENSG00000206308(gene)|ensembl:ENSG00000226260(gene)|ensembl:ENSG00000227993(gene)|ensembl:ENSG00000228987(gene)|ensembl:ENSG00000230726(gene)|ensembl:ENSG00000234794(gene)|ensembl:ENSG00000277263(gene)|ensembl:ENST00000383127(transcript)|ensembl:ENST00000383259(transcript)|ensembl:ENST00000395388(transcript)|ensembl:ENST00000411524(transcript)|ensembl:ENST00000414698(transcript)|dip:DIP-6063N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|comment:"HLA-DR4 (HLA-DRA :: HLA-DRB4) was preloaded with HA(306-318) peptide"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:NCr/6W1ldQuOhlyWUW4aTnhmKKY9606	intact-crc:98BB98D6142074A8|rigid:gL2YPpji3WKD7OR4BGJ6EwmG3nI	false	biotin tag:c-c	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Anders et al. (2011)	pubmed:21131964|imex:IM-15780	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-3866101|imex:IM-15780-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3G|inhibition:"injection of HA peptide(306-318) at stage 3 cause disassembly of the quaternary complex"|comment:"HLA-DR4 (HLA-DRA :: HLA-DRB4) was preloaded with HA(306-318) peptide"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/03/31	2021/02/11	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	intact-crc:98BB98D6142074A8|rigid:gL2YPpji3WKD7OR4BGJ6EwmG3nI	false	biotin tag:c-c	tag:19..19-218..218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)