#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0096"(pull down)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447145|mint:MINT-8084992|imex:IM-15292-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8084994(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8084998(identity)	-	-	-	figure legend:f1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:6BCE66DE4F4CCA5B|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	-	tandem tag:?-?(MINT-8084999)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0018"(two hybrid)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447186|mint:MINT-8084886|imex:IM-15292-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8084888(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8084889(identity)	-	-	-	comment:homomint|comment:mint|figure legend:Sf1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:B68A5151610C5C4F|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	fusion protein:?-?(MINT-8084894)	fusion protein:?-?(MINT-8084898)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H2X6	uniprotkb:P61962	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447230|mint:MINT-8084902|imex:IM-15292-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8084908(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8084904(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:86A813E638067FC1|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	ha tag:?-?(MINT-8084909)	flag tag:?-?(MINT-8084905)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447248|mint:MINT-8084962|imex:IM-15292-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8084964(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8084968(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:A94DB7BD69C5A541|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	flag tag:?-?(MINT-8084965)	ha tag:?-?(MINT-8084969)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61962	uniprotkb:Q13233	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447343|mint:MINT-8085134|imex:IM-15292-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085136(identity)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085140(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f4a sf8a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:BB18FF41BAE9016F|rigid:yhNVCOkaU+AYpHC/Wq2pdppp2Yc	false	myc tag:?-?(MINT-8085137)	ha tag:?-?(MINT-8085141)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13233	uniprotkb:Q9H2X6	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447362|mint:MINT-8085171|imex:IM-15292-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085177(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8085182(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f4a sf11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:1838C9284850AF52|rigid:7Usl+LDXR+RCyfYUfICWMfkKQ44	false	ha tag:?-?(MINT-8085178)	flag tag:?-?(MINT-8085183)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13233	uniprotkb:P61962	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447362|mint:MINT-8085171|imex:IM-15292-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085177(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085173(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f4a sf11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:1838C9284850AF52|rigid:7Usl+LDXR+RCyfYUfICWMfkKQ44	false	ha tag:?-?(MINT-8085178)	myc tag:?-?(MINT-8085174)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13233	uniprotkb:P61962	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447403|mint:MINT-8085187|imex:IM-15292-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085193(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085189(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:248A19A9A39903CF|rigid:ZhKILWc/0cOwAB5vgXoLAMarUxU	false	ha tag:?-?(MINT-8085194)	myc tag:?-?(MINT-8085190)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13233	uniprotkb:Q13627	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-1053596|uniprotkb:O60769|uniprotkb:Q92582|uniprotkb:Q92810|uniprotkb:Q9UNM5|ensembl:ENSP00000381932|ensembl:ENSP00000494544	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:dyr1a_human(display_long)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:HP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:DYRK1A(gene name)|psi-mi:DYRK1A(display_short)|uniprotkb:DYRK(gene name synonym)|uniprotkb:MNB(gene name synonym)|uniprotkb:MNBH(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447403|mint:MINT-8085187|imex:IM-15292-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085193(identity)	refseq:NP_001387.2|refseq:NP_567824.1|refseq:NP_569120.1|refseq:NP_569122.1|refseq:XP_011527785.1|refseq:XP_006724039.1|refseq:XP_006724040.1|refseq:XP_006724041.1|ensembl:ENSG00000157540(gene)|ensembl:ENST00000398960(transcript)|ensembl:ENST00000644942(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q13627|rcsb pdb:2VX3|rcsb pdb:2WO6|rcsb pdb:3ANQ|rcsb pdb:3ANR|rcsb pdb:4AZE|rcsb pdb:4MQ1|rcsb pdb:4MQ2|rcsb pdb:4NCT|rcsb pdb:4YLJ|rcsb pdb:4YLK|rcsb pdb:4YLL|rcsb pdb:4YU2|rcsb pdb:5A3X|rcsb pdb:5A4E|rcsb pdb:5A4L|rcsb pdb:5A4Q|rcsb pdb:5A4T|rcsb pdb:5A54|rcsb pdb:5AIK|rcsb pdb:6A1G|rcsb pdb:6EIF|rcsb pdb:6EIJ|rcsb pdb:6EIL|rcsb pdb:6EIP|rcsb pdb:6EIQ|rcsb pdb:6EIR|rcsb pdb:6EIS|rcsb pdb:6EIV|rcsb pdb:6EJ4|rcsb pdb:6QU2|rcsb pdb:6S11|rcsb pdb:6S14|rcsb pdb:6S17|rcsb pdb:6S1B|rcsb pdb:6S1H|rcsb pdb:6S1I|rcsb pdb:6S1J|rcsb pdb:6T6A|rcsb pdb:6UIP|rcsb pdb:6UWY|rcsb pdb:6YF8|rcsb pdb:7A4O|rcsb pdb:7A4R|rcsb pdb:7A4S|rcsb pdb:7A4W|rcsb pdb:7A4Z|rcsb pdb:7A51|rcsb pdb:7A52|rcsb pdb:7A53|rcsb pdb:7A55|rcsb pdb:7A5B|rcsb pdb:7A5D|rcsb pdb:7A5L|rcsb pdb:7A5N|rcsb pdb:7AJ2|rcsb pdb:7AJ4|rcsb pdb:7AJ5|rcsb pdb:7AJ7|rcsb pdb:7AJ8|rcsb pdb:7AJA|rcsb pdb:7AJM|rcsb pdb:7AJS|rcsb pdb:7AJV|rcsb pdb:7AJW|rcsb pdb:7AJY|rcsb pdb:7AK2|rcsb pdb:7AKA|rcsb pdb:7AKB|rcsb pdb:7AKE|rcsb pdb:7AKL|reactome:R-HSA-1538133|rcsb pdb:6A1F|refseq:XP_016883773.1|refseq:NP_001334650.1|refseq:NP_001334651.1|dip:DIP-39750N|mint:MINT-8085197(identity)	-	-	-	figure legend:f4b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:1Y5lOF9SszLsUVauAnydhzUh7fM9606	intact-crc:248A19A9A39903CF|rigid:ZhKILWc/0cOwAB5vgXoLAMarUxU	false	ha tag:?-?(MINT-8085194)	flag tag:?-?(MINT-8085198)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447498|mint:MINT-8085240|imex:IM-15292-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085242(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8085246(identity)	-	-	-	figure legend:sf2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:4FCB8018F350C13C|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	myc tag:?-?(MINT-8085243)	flag tag:c-c(MINT-8085247)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447545|mint:MINT-8085254|imex:IM-15292-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085256(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8085260(identity)	-	-	-	figure legend:sf2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:A8F5F72FA600D7DB|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	myc tag:?-?(MINT-8085257)	flag tag:c-c(MINT-8085261)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13233	uniprotkb:P61962	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447457|mint:MINT-8085204|imex:IM-15292-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085210(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085206(identity)	-	-	-	figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:187DC94878EED530|rigid:RLe3kgqm/I8NnnE9P9FkdZln7FA	false	ha tag:?-?(MINT-8085211)	myc tag:?-?(MINT-8085207)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13233	uniprotkb:Q9Y463	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447457|mint:MINT-8085204|imex:IM-15292-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085210(identity)	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)|mint:MINT-8085214(identity)	-	-	-	figure legend:f4c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2011/01/11	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:187DC94878EED530|rigid:RLe3kgqm/I8NnnE9P9FkdZln7FA	false	ha tag:?-?(MINT-8085211)	flag tag:?-?(MINT-8085215)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13627	uniprotkb:P61962	intact:EBI-1053596|uniprotkb:O60769|uniprotkb:Q92582|uniprotkb:Q92810|uniprotkb:Q9UNM5|ensembl:ENSP00000381932|ensembl:ENSP00000494544	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:dyr1a_human(display_long)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:HP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:DYRK1A(gene name)|psi-mi:DYRK1A(display_short)|uniprotkb:DYRK(gene name synonym)|uniprotkb:MNB(gene name synonym)|uniprotkb:MNBH(gene name synonym)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447626|mint:MINT-8085104|imex:IM-15292-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001387.2|refseq:NP_567824.1|refseq:NP_569120.1|refseq:NP_569122.1|refseq:XP_011527785.1|refseq:XP_006724039.1|refseq:XP_006724040.1|refseq:XP_006724041.1|ensembl:ENSG00000157540(gene)|ensembl:ENST00000398960(transcript)|ensembl:ENST00000644942(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q13627|rcsb pdb:2VX3|rcsb pdb:2WO6|rcsb pdb:3ANQ|rcsb pdb:3ANR|rcsb pdb:4AZE|rcsb pdb:4MQ1|rcsb pdb:4MQ2|rcsb pdb:4NCT|rcsb pdb:4YLJ|rcsb pdb:4YLK|rcsb pdb:4YLL|rcsb pdb:4YU2|rcsb pdb:5A3X|rcsb pdb:5A4E|rcsb pdb:5A4L|rcsb pdb:5A4Q|rcsb pdb:5A4T|rcsb pdb:5A54|rcsb pdb:5AIK|rcsb pdb:6A1G|rcsb pdb:6EIF|rcsb pdb:6EIJ|rcsb pdb:6EIL|rcsb pdb:6EIP|rcsb pdb:6EIQ|rcsb pdb:6EIR|rcsb pdb:6EIS|rcsb pdb:6EIV|rcsb pdb:6EJ4|rcsb pdb:6QU2|rcsb pdb:6S11|rcsb pdb:6S14|rcsb pdb:6S17|rcsb pdb:6S1B|rcsb pdb:6S1H|rcsb pdb:6S1I|rcsb pdb:6S1J|rcsb pdb:6T6A|rcsb pdb:6UIP|rcsb pdb:6UWY|rcsb pdb:6YF8|rcsb pdb:7A4O|rcsb pdb:7A4R|rcsb pdb:7A4S|rcsb pdb:7A4W|rcsb pdb:7A4Z|rcsb pdb:7A51|rcsb pdb:7A52|rcsb pdb:7A53|rcsb pdb:7A55|rcsb pdb:7A5B|rcsb pdb:7A5D|rcsb pdb:7A5L|rcsb pdb:7A5N|rcsb pdb:7AJ2|rcsb pdb:7AJ4|rcsb pdb:7AJ5|rcsb pdb:7AJ7|rcsb pdb:7AJ8|rcsb pdb:7AJA|rcsb pdb:7AJM|rcsb pdb:7AJS|rcsb pdb:7AJV|rcsb pdb:7AJW|rcsb pdb:7AJY|rcsb pdb:7AK2|rcsb pdb:7AKA|rcsb pdb:7AKB|rcsb pdb:7AKE|rcsb pdb:7AKL|reactome:R-HSA-1538133|rcsb pdb:6A1F|refseq:XP_016883773.1|refseq:NP_001334650.1|refseq:NP_001334651.1|dip:DIP-39750N|mint:MINT-8085110(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085106(identity)	-	-	-	figure legend:f1e|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:1Y5lOF9SszLsUVauAnydhzUh7fM9606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:92861F511FBD0F39|rigid:1pg80t6DifoBEwfwlvV002nyLyM	false	flag tag:?-?(MINT-8085111)	ha tag:?-?(MINT-8085107)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61962	uniprotkb:Q13233	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447608|mint:MINT-8085083|imex:IM-15292-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085085(identity)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8085089(identity)	-	-	-	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:57B1CBD2CF75BCB4|rigid:yhNVCOkaU+AYpHC/Wq2pdppp2Yc	false	ha tag:?-?(MINT-8085086)	tag:?-?(MINT-8085090)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447572|mint:MINT-8084976|imex:IM-15292-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8084978(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8084982(identity)	-	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:BF1E9FD10A72779C|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	ha tag:?-?(MINT-8084979)	flag tag:?-?(MINT-8084983)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y463	uniprotkb:P61962	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447644|mint:MINT-8085121|imex:IM-15292-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)|mint:MINT-8085127(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085123(identity)	-	-	-	figure legend:f1f|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:04FFAD10E94B9CB6|rigid:gtgZu3b5/jCi1CTvbArwpJjwpv4	false	flag tag:?-?(MINT-8085128)	ha tag:?-?(MINT-8085124)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447679|mint:MINT-8085226|imex:IM-15292-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085228(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8085232(identity)	-	-	-	comment:homomint|figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:118BEDBF492A6D06|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	ha tag:?-?(MINT-8085229)	flag tag:c-c(MINT-8085233)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H2X6	uniprotkb:P61962	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447725|mint:MINT-8085008|imex:IM-15292-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8085014(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085010(identity)	go:"GO:0016607"(nuclear speck)	-	-	figure legend:f2c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/01/11	2014/10/16	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:C8C41E243FDA973E|rigid:njLFQSmLx91CWPYskWSybzcme8k	false	flag tag:?-?(MINT-8085015)	green fluorescent protein tag:?-?(MINT-8085011)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q13627	uniprotkb:P61962	intact:EBI-1053596|uniprotkb:O60769|uniprotkb:Q92582|uniprotkb:Q92810|uniprotkb:Q9UNM5|ensembl:ENSP00000381932|ensembl:ENSP00000494544	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	psi-mi:dyr1a_human(display_long)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:HP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:DYRK1A(gene name)|psi-mi:DYRK1A(display_short)|uniprotkb:DYRK(gene name synonym)|uniprotkb:MNB(gene name synonym)|uniprotkb:MNBH(gene name synonym)	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447744|mint:MINT-8085026|imex:IM-15292-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001387.2|refseq:NP_567824.1|refseq:NP_569120.1|refseq:NP_569122.1|refseq:XP_011527785.1|refseq:XP_006724039.1|refseq:XP_006724040.1|refseq:XP_006724041.1|ensembl:ENSG00000157540(gene)|ensembl:ENST00000398960(transcript)|ensembl:ENST00000644942(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q13627|rcsb pdb:2VX3|rcsb pdb:2WO6|rcsb pdb:3ANQ|rcsb pdb:3ANR|rcsb pdb:4AZE|rcsb pdb:4MQ1|rcsb pdb:4MQ2|rcsb pdb:4NCT|rcsb pdb:4YLJ|rcsb pdb:4YLK|rcsb pdb:4YLL|rcsb pdb:4YU2|rcsb pdb:5A3X|rcsb pdb:5A4E|rcsb pdb:5A4L|rcsb pdb:5A4Q|rcsb pdb:5A4T|rcsb pdb:5A54|rcsb pdb:5AIK|rcsb pdb:6A1G|rcsb pdb:6EIF|rcsb pdb:6EIJ|rcsb pdb:6EIL|rcsb pdb:6EIP|rcsb pdb:6EIQ|rcsb pdb:6EIR|rcsb pdb:6EIS|rcsb pdb:6EIV|rcsb pdb:6EJ4|rcsb pdb:6QU2|rcsb pdb:6S11|rcsb pdb:6S14|rcsb pdb:6S17|rcsb pdb:6S1B|rcsb pdb:6S1H|rcsb pdb:6S1I|rcsb pdb:6S1J|rcsb pdb:6T6A|rcsb pdb:6UIP|rcsb pdb:6UWY|rcsb pdb:6YF8|rcsb pdb:7A4O|rcsb pdb:7A4R|rcsb pdb:7A4S|rcsb pdb:7A4W|rcsb pdb:7A4Z|rcsb pdb:7A51|rcsb pdb:7A52|rcsb pdb:7A53|rcsb pdb:7A55|rcsb pdb:7A5B|rcsb pdb:7A5D|rcsb pdb:7A5L|rcsb pdb:7A5N|rcsb pdb:7AJ2|rcsb pdb:7AJ4|rcsb pdb:7AJ5|rcsb pdb:7AJ7|rcsb pdb:7AJ8|rcsb pdb:7AJA|rcsb pdb:7AJM|rcsb pdb:7AJS|rcsb pdb:7AJV|rcsb pdb:7AJW|rcsb pdb:7AJY|rcsb pdb:7AK2|rcsb pdb:7AKA|rcsb pdb:7AKB|rcsb pdb:7AKE|rcsb pdb:7AKL|reactome:R-HSA-1538133|rcsb pdb:6A1F|refseq:XP_016883773.1|refseq:NP_001334650.1|refseq:NP_001334651.1|dip:DIP-39750N|mint:MINT-8085033(identity)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8085029(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f2c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/01/11	2014/10/16	rogid:1Y5lOF9SszLsUVauAnydhzUh7fM9606	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	intact-crc:C8DBA897A6AD2CAF|rigid:1pg80t6DifoBEwfwlvV002nyLyM	false	flag tag:?-?(MINT-8085034)	green fluorescent protein tag:?-?(MINT-8085030)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9H2X6	uniprotkb:Q9Y463	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	intact:EBI-634187|uniprotkb:O75258|uniprotkb:O75788|uniprotkb:O75789|ensembl:ENSP00000312789|ensembl:ENSP00000469863|ensembl:ENSP00000485915|ensembl:ENSP00000486377	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:dyr1b_human(display_long)|uniprotkb:Mirk protein kinase(gene name synonym)|uniprotkb:Minibrain-related kinase(gene name synonym)|uniprotkb:DYRK1B(gene name)|psi-mi:DYRK1B(display_short)|uniprotkb:MIRK(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447800|mint:MINT-8085067|imex:IM-15292-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8085070(identity)	refseq:NP_004705.1|refseq:NP_006474.1|refseq:NP_006475.1|refseq:XP_005259455.1|ensembl:ENSG00000105204(gene)|ensembl:ENSG00000281320(gene)|ensembl:ENST00000323039(transcript)|ensembl:ENST00000593685(transcript)|ensembl:ENST00000625757(transcript)|ensembl:ENST00000631090(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007520"(myoblast fusion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q9Y463|go:"GO:0106310"(protein serine kinase activity)|mint:MINT-8085074(identity)	go:"GO:0016607"(nuclear speck)	-	-	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/01/11	2014/10/16	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	rogid:MaG/ZUw0KMo5JxQdeIhMu0DebXI9606	intact-crc:CAC4AAF7FFC3186B|rigid:x4TOGeczTElGIvYbACT0N9R01Qk	false	flag tag:?-?(MINT-8085071)	green fluorescent protein tag:?-?(MINT-8085075)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q13627	uniprotkb:Q9H2X6	intact:EBI-1053596|uniprotkb:O60769|uniprotkb:Q92582|uniprotkb:Q92810|uniprotkb:Q9UNM5|ensembl:ENSP00000381932|ensembl:ENSP00000494544	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dyr1a_human(display_long)|uniprotkb:Protein kinase minibrain homolog(gene name synonym)|uniprotkb:HP86(gene name synonym)|uniprotkb:Dual specificity YAK1-related kinase(gene name synonym)|uniprotkb:DYRK1A(gene name)|psi-mi:DYRK1A(display_short)|uniprotkb:DYRK(gene name synonym)|uniprotkb:MNB(gene name synonym)|uniprotkb:MNBH(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447763|mint:MINT-8085045|imex:IM-15292-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001387.2|refseq:NP_567824.1|refseq:NP_569120.1|refseq:NP_569122.1|refseq:XP_011527785.1|refseq:XP_006724039.1|refseq:XP_006724040.1|refseq:XP_006724041.1|ensembl:ENSG00000157540(gene)|ensembl:ENST00000398960(transcript)|ensembl:ENST00000644942(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015631"(tubulin binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043621"(protein self-association)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0090312"(positive regulation of protein deacetylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028318|interpro:IPR044131|mint:Q13627|rcsb pdb:2VX3|rcsb pdb:2WO6|rcsb pdb:3ANQ|rcsb pdb:3ANR|rcsb pdb:4AZE|rcsb pdb:4MQ1|rcsb pdb:4MQ2|rcsb pdb:4NCT|rcsb pdb:4YLJ|rcsb pdb:4YLK|rcsb pdb:4YLL|rcsb pdb:4YU2|rcsb pdb:5A3X|rcsb pdb:5A4E|rcsb pdb:5A4L|rcsb pdb:5A4Q|rcsb pdb:5A4T|rcsb pdb:5A54|rcsb pdb:5AIK|rcsb pdb:6A1G|rcsb pdb:6EIF|rcsb pdb:6EIJ|rcsb pdb:6EIL|rcsb pdb:6EIP|rcsb pdb:6EIQ|rcsb pdb:6EIR|rcsb pdb:6EIS|rcsb pdb:6EIV|rcsb pdb:6EJ4|rcsb pdb:6QU2|rcsb pdb:6S11|rcsb pdb:6S14|rcsb pdb:6S17|rcsb pdb:6S1B|rcsb pdb:6S1H|rcsb pdb:6S1I|rcsb pdb:6S1J|rcsb pdb:6T6A|rcsb pdb:6UIP|rcsb pdb:6UWY|rcsb pdb:6YF8|rcsb pdb:7A4O|rcsb pdb:7A4R|rcsb pdb:7A4S|rcsb pdb:7A4W|rcsb pdb:7A4Z|rcsb pdb:7A51|rcsb pdb:7A52|rcsb pdb:7A53|rcsb pdb:7A55|rcsb pdb:7A5B|rcsb pdb:7A5D|rcsb pdb:7A5L|rcsb pdb:7A5N|rcsb pdb:7AJ2|rcsb pdb:7AJ4|rcsb pdb:7AJ5|rcsb pdb:7AJ7|rcsb pdb:7AJ8|rcsb pdb:7AJA|rcsb pdb:7AJM|rcsb pdb:7AJS|rcsb pdb:7AJV|rcsb pdb:7AJW|rcsb pdb:7AJY|rcsb pdb:7AK2|rcsb pdb:7AKA|rcsb pdb:7AKB|rcsb pdb:7AKE|rcsb pdb:7AKL|reactome:R-HSA-1538133|rcsb pdb:6A1F|refseq:XP_016883773.1|refseq:NP_001334650.1|refseq:NP_001334651.1|dip:DIP-39750N|mint:MINT-8085048(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8085052(identity)	go:"GO:0016607"(nuclear speck)	-	-	figure legend:f3c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/01/11	2014/10/16	rogid:1Y5lOF9SszLsUVauAnydhzUh7fM9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:78C582326F0997FB|rigid:06mxhTU9+3x6tPVdGDY63Tj6egQ	false	green fluorescent protein tag:?-?(MINT-8085049)	flag tag:?-?(MINT-8085053)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P61962	uniprotkb:Q9H2X6	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447819|mint:MINT-8088896|imex:IM-15292-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8088899(identity)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N|mint:MINT-8088903(identity)	go:"GO:0016607"(nuclear speck)	-	-	comment:homomint|comment:mint|figure legend:f8e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	intact-crc:1465489FD9C1C1F0|rigid:7Usl+LDXR+RCyfYUfICWMfkKQ44	false	green fluorescent protein tag:?-?(MINT-8088900)	flag tag:?-?(MINT-8088904)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P61962	uniprotkb:Q13233	intact:EBI-359808|uniprotkb:O15491|uniprotkb:Q9DAE4|uniprotkb:D3DU14|ensembl:ENSP00000402312|ensembl:ENSP00000483236|uniprotkb:B4E039	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:dcaf7_human(display_long)|uniprotkb:DCAF7(gene name)|psi-mi:DCAF7(display_short)|uniprotkb:HAN11(gene name synonym)|uniprotkb:WD repeat-containing protein An11 homolog(gene name synonym)|uniprotkb:WDR68(gene name synonym)|uniprotkb:WD repeat-containing protein 68(gene name synonym)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Ritterhoff et al. (2010)	pubmed:20940704|imex:IM-15292|mint:MINT-8084776|doi:10.1038/emboj.2010.251	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8447819|mint:MINT-8088896|imex:IM-15292-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005819.3|ensembl:ENSG00000136485(gene)|ensembl:ENST00000431926(transcript)|ensembl:ENST00000614556(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:P61962|reactome:R-HSA-390471|reactome:R-HSA-8951664|dip:DIP-40363N|mint:MINT-8088899(identity)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-8088909(identity)	go:"GO:0016607"(nuclear speck)	-	-	comment:homomint|comment:mint|figure legend:f8e|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2011/01/11	2014/10/16	rogid:wDucyMrZBaqRcL25mMGhB4KXQtI9606	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:1465489FD9C1C1F0|rigid:7Usl+LDXR+RCyfYUfICWMfkKQ44	false	green fluorescent protein tag:?-?(MINT-8088900)	ha tag:?-?(MINT-8088915)	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0707"(anti tag immunostaining)