#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13131	uniprotkb:P49593	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Voss et al. (2011)	pubmed:20801214|mint:MINT-8288067|doi:10.1016/j.cellsig.2010.08.010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178696|mint:MINT-8288084	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N|mint:MINT-8288087(identity)	refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|mint:MINT-8288088(identity)	-	-	-	figure legend:f4c|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/11/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606	intact-crc:8EE23D5B299D6881|rigid:RMcNBOtG160Nu1Df1J342+SGxaE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13131	uniprotkb:P54646	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	intact:EBI-1383852|uniprotkb:Q9H1E8|uniprotkb:Q9UD43|ensembl:ENSP00000360290	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:aapk2_human(display_long)|uniprotkb:PRKAA2(gene name)|psi-mi:PRKAA2(display_short)|uniprotkb:AMPK(gene name synonym)|uniprotkb:AMPK2(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Voss et al. (2011)	pubmed:20801214|mint:MINT-8288067|doi:10.1016/j.cellsig.2010.08.010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178696|mint:MINT-8288084	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N|mint:MINT-8288087(identity)	refseq:NP_006243.2|dip:DIP-39796N|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0030424"(axon)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028783|interpro:IPR032270|interpro:IPR039148|mint:P54646|rcsb pdb:2H6D|rcsb pdb:3AQV|rcsb pdb:2LTU|rcsb pdb:2YZA|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6BX6|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|ensembl:ENSG00000162409(gene)|ensembl:ENST00000371244(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|mint:MINT-8288086(identity)	-	-	-	figure legend:f4c|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/11/07	2014/10/16	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	rogid:2t/qHlT6HwqoLLbMjjbhOaCZ1Ow9606	intact-crc:8EE23D5B299D6881|rigid:RMcNBOtG160Nu1Df1J342+SGxaE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54646	uniprotkb:P49593	intact:EBI-1383852|uniprotkb:Q9H1E8|uniprotkb:Q9UD43|ensembl:ENSP00000360290	intact:EBI-719945|uniprotkb:Q96PM2|uniprotkb:A8K6G3|uniprotkb:B7Z2C3|ensembl:ENSP00000263212	psi-mi:aapk2_human(display_long)|uniprotkb:PRKAA2(gene name)|psi-mi:PRKAA2(display_short)|uniprotkb:AMPK(gene name synonym)|uniprotkb:AMPK2(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:ppm1f_human(display_long)|uniprotkb:"Ca(2+)/calmodulin-dependent protein kinase phosphatase"(gene name synonym)|uniprotkb:Partner of PIX 2(gene name synonym)|uniprotkb:PPM1F(gene name)|psi-mi:PPM1F(display_short)|uniprotkb:KIAA0015(gene name synonym)|uniprotkb:POPX2(gene name synonym)|uniprotkb:Protein fem-2 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Voss et al. (2011)	pubmed:20801214|mint:MINT-8288067|doi:10.1016/j.cellsig.2010.08.010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178707|mint:MINT-8288092	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006243.2|dip:DIP-39796N|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0030424"(axon)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028783|interpro:IPR032270|interpro:IPR039148|mint:P54646|rcsb pdb:2H6D|rcsb pdb:3AQV|rcsb pdb:2LTU|rcsb pdb:2YZA|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6BX6|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|ensembl:ENSG00000162409(gene)|ensembl:ENST00000371244(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|mint:MINT-8288094(identity)	refseq:NP_055449.1|ensembl:ENSG00000100034(gene)|ensembl:ENST00000263212(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035690"|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903827"|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:P49593|reactome:R-HSA-9617324|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|mint:MINT-8288096(identity)	-	-	-	figure legend:f4c|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/11/07	2014/10/16	rogid:2t/qHlT6HwqoLLbMjjbhOaCZ1Ow9606	rogid:G2Zr0KQjJ8rebVMjL+Wf+OuY6rU9606	intact-crc:E019DCEFFA01E1BD|rigid:RMcNBOtG160Nu1Df1J342+SGxaE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P54646	uniprotkb:Q13131	intact:EBI-1383852|uniprotkb:Q9H1E8|uniprotkb:Q9UD43|ensembl:ENSP00000360290	intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317	psi-mi:aapk2_human(display_long)|uniprotkb:PRKAA2(gene name)|psi-mi:PRKAA2(display_short)|uniprotkb:AMPK(gene name synonym)|uniprotkb:AMPK2(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Voss et al. (2011)	pubmed:20801214|mint:MINT-8288067|doi:10.1016/j.cellsig.2010.08.010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8178707|mint:MINT-8288092	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006243.2|dip:DIP-39796N|go:"GO:0030425"(dendrite)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048511"(rhythmic process)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0030424"(axon)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028783|interpro:IPR032270|interpro:IPR039148|mint:P54646|rcsb pdb:2H6D|rcsb pdb:3AQV|rcsb pdb:2LTU|rcsb pdb:2YZA|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6BX6|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-163680|reactome:R-HSA-200425|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9613354|reactome:R-HSA-9619483|ensembl:ENSG00000162409(gene)|ensembl:ENST00000371244(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|mint:MINT-8288094(identity)	refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N|mint:MINT-8288095(identity)	-	-	-	figure legend:f4c|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2011/11/07	2014/10/16	rogid:2t/qHlT6HwqoLLbMjjbhOaCZ1Ow9606	rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606	intact-crc:E019DCEFFA01E1BD|rigid:RMcNBOtG160Nu1Df1J342+SGxaE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)