#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O60494	uniprotkb:P27352	intact:EBI-3953632|uniprotkb:B0YIZ4|uniprotkb:Q5VTA6|uniprotkb:Q96RU9|ensembl:ENSP00000367064	intact:EBI-3953638|uniprotkb:B2RAN8|uniprotkb:B4DVZ1|ensembl:ENSP00000257248	psi-mi:cubn_human(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Intestinal intrinsic factor receptor(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:if_human(display_long)|uniprotkb:CBLIF(gene name)|psi-mi:CBLIF(display_short)|uniprotkb:GIF(gene name synonym)|uniprotkb:Gastric intrinsic factor(gene name synonym)|uniprotkb:IFMH(gene name synonym)|uniprotkb:Intrinsic factor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Andersen et al. (2010)	pubmed:20237569|imex:IM-15209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-3953631|pdbe:3KQ4|imex:IM-15209-1|dip:DIP-185656E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001072.2|ensembl:ENSG00000107611(gene)|ensembl:ENST00000377833(transcript)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR024731|interpro:IPR028876|interpro:IPR035914|rcsb pdb:3KQ4|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-196791|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011|dip:DIP-58583N	refseq:NP_005133.2|dip:DIP-46206N|ensembl:ENSG00000134812(gene)|ensembl:ENST00000257248(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005902"(microvillus)|go:"GO:0006824"(cobalt ion transport)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0043202"(lysosomal lumen)|interpro:IPR002157("Cobalamin (vitamin B12)-binding transporter, eukaryotic")|interpro:IPR027954|rcsb pdb:2CKT|rcsb pdb:2PMV|rcsb pdb:3KQ4|reactome:R-HSA-196741|reactome:R-HSA-3359457|reactome:R-HSA-3359462|reactome:R-HSA-3359463	psi-mi:"MI:0465"(dip)	-	-	3d-r-factors:R value 0.211  R free 0.243|3d-resolution:3.3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/26	2017/06/30	rogid:YvJJjMkqNOU+Ktis0SvKbGUU46w9606	rogid:jrYXRaI1wGOMD2oYJ9CqM8XH4IU9606	intact-crc:2ABF0121F5D9480C|rigid:SFMS98nbc1VoUiAcwBb6vBTDPLY	false	sufficient binding region:932-1388	sufficient binding region:25-417	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60494	uniprotkb:O60494	intact:EBI-3953632|uniprotkb:B0YIZ4|uniprotkb:Q5VTA6|uniprotkb:Q96RU9|ensembl:ENSP00000367064	intact:EBI-3953632|uniprotkb:B0YIZ4|uniprotkb:Q5VTA6|uniprotkb:Q96RU9|ensembl:ENSP00000367064	psi-mi:cubn_human(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Intestinal intrinsic factor receptor(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:cubn_human(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Intestinal intrinsic factor receptor(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Andersen et al. (2010)	pubmed:20237569|imex:IM-15209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-3953733|imex:IM-15209-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001072.2|ensembl:ENSG00000107611(gene)|ensembl:ENST00000377833(transcript)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR024731|interpro:IPR028876|interpro:IPR035914|rcsb pdb:3KQ4|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-196791|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011|dip:DIP-58583N	refseq:NP_001072.2|ensembl:ENSG00000107611(gene)|ensembl:ENST00000377833(transcript)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR024731|interpro:IPR028876|interpro:IPR035914|rcsb pdb:3KQ4|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-196791|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011|dip:DIP-58583N	-	-	-	figure legend:supplementary figure 9|comment:dimer and trimer according to authors, higher oligomers also possible.  The complex contains also AMN, according to authors, but this cannot be seen in the experiment|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/26	2017/06/30	rogid:YvJJjMkqNOU+Ktis0SvKbGUU46w9606	rogid:YvJJjMkqNOU+Ktis0SvKbGUU46w9606	intact-crc:86381F847D6CD799|rigid:wy/J6EqIKRiXjAQjxhl7DrIYnEI	false	-	-	-	-	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:O70244	uniprotkb:O70244	intact:EBI-3954161	intact:EBI-3954161	psi-mi:cubn_rat(display_long)|uniprotkb:Cubn(gene name)|psi-mi:Cubn(display_short)|uniprotkb:Ifcr(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Glycoprotein 280(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:cubn_rat(display_long)|uniprotkb:Cubn(gene name)|psi-mi:Cubn(display_short)|uniprotkb:Ifcr(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Glycoprotein 280(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Andersen et al. (2010)	pubmed:20237569|imex:IM-15209	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-3954178|imex:IM-15209-2|dip:DIP-185657E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035914|rgd:68355|refseq:NP_445784.1|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024731|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030135"(coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042366"(cobalamin catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028876|reactome:R-RNO-196741|reactome:R-RNO-196791|reactome:R-RNO-8964011	interpro:IPR035914|rgd:68355|refseq:NP_445784.1|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024731|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030135"(coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042366"(cobalamin catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028876|reactome:R-RNO-196741|reactome:R-RNO-196791|reactome:R-RNO-8964011	psi-mi:"MI:0465"(dip)	-	-	figure legend:supplementary fig 9b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/26	2017/06/30	rogid:ZhOYCS0px5AdqzMx3LmANRwaeog10116	rogid:ZhOYCS0px5AdqzMx3LmANRwaeog10116	intact-crc:1F37897E95D8F943|rigid:axcmMA0/bZwPM3PCT6QB9voW2cU	false	sufficient binding region:89-469|mutation disrupting interaction strength:110-110,117-117	sufficient binding region:89-469|mutation disrupting interaction strength:110-110,117-117	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70244	uniprotkb:O70244	intact:EBI-3954161	intact:EBI-3954161	psi-mi:cubn_rat(display_long)|uniprotkb:Cubn(gene name)|psi-mi:Cubn(display_short)|uniprotkb:Ifcr(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Glycoprotein 280(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:cubn_rat(display_long)|uniprotkb:Cubn(gene name)|psi-mi:Cubn(display_short)|uniprotkb:Ifcr(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Glycoprotein 280(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Andersen et al. (2010)	pubmed:20237569|imex:IM-15209	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-3954160|imex:IM-15209-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035914|rgd:68355|refseq:NP_445784.1|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024731|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030135"(coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042366"(cobalamin catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028876|reactome:R-RNO-196741|reactome:R-RNO-196791|reactome:R-RNO-8964011|imex:IM-15209-4(imex-primary)|dip:DIP-185657E(identity)|psi-mi:"MI:0465"(dip)	interpro:IPR035914|rgd:68355|refseq:NP_445784.1|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024731|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030135"(coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042366"(cobalamin catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028876|reactome:R-RNO-196741|reactome:R-RNO-196791|reactome:R-RNO-8964011|imex:IM-15209-4(imex-primary)|dip:DIP-185657E(identity)|psi-mi:"MI:0465"(dip)	-	-	-	figure legend:supplementary fig 9c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/26	2017/06/30	rogid:ZhOYCS0px5AdqzMx3LmANRwaeog10116	rogid:ZhOYCS0px5AdqzMx3LmANRwaeog10116	intact-crc:363AF86138570D4A|rigid:gdFeUUyNFZvJQ2LNdgcowJXYlnE	false	sufficient binding region:69-449	sufficient binding region:69-449	3	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60494	uniprotkb:P27352	intact:EBI-3953632|uniprotkb:B0YIZ4|uniprotkb:Q5VTA6|uniprotkb:Q96RU9|ensembl:ENSP00000367064	intact:EBI-3953638|uniprotkb:B2RAN8|uniprotkb:B4DVZ1|ensembl:ENSP00000257248	psi-mi:cubn_human(display_long)|uniprotkb:CUBN(gene name)|psi-mi:CUBN(display_short)|uniprotkb:IFCR(gene name synonym)|uniprotkb:460 kDa receptor(gene name synonym)|uniprotkb:Intestinal intrinsic factor receptor(gene name synonym)|uniprotkb:Intrinsic factor-cobalamin receptor(gene name synonym)|uniprotkb:Intrinsic factor-vitamin B12 receptor(gene name synonym)	psi-mi:if_human(display_long)|uniprotkb:CBLIF(gene name)|psi-mi:CBLIF(display_short)|uniprotkb:GIF(gene name synonym)|uniprotkb:Gastric intrinsic factor(gene name synonym)|uniprotkb:IFMH(gene name synonym)|uniprotkb:Intrinsic factor(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Andersen et al. (2010)	pubmed:20237569|imex:IM-15209	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-25591897|imex:IM-15209-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001072.2|ensembl:ENSG00000107611(gene)|ensembl:ENST00000377833(transcript)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009617"(response to bacterium)|go:"GO:0010008"(endosome membrane)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0031526"(brush border membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043235"(receptor complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR024731|interpro:IPR028876|interpro:IPR035914|rcsb pdb:3KQ4|rcsb pdb:6GJE|reactome:R-HSA-196741|reactome:R-HSA-196791|reactome:R-HSA-3359462|reactome:R-HSA-3359463|reactome:R-HSA-8964011|dip:DIP-58583N	refseq:NP_005133.2|dip:DIP-46206N|ensembl:ENSG00000134812(gene)|ensembl:ENST00000257248(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005902"(microvillus)|go:"GO:0006824"(cobalt ion transport)|go:"GO:0015889"(cobalamin transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031419"(cobalamin binding)|go:"GO:0043202"(lysosomal lumen)|interpro:IPR002157("Cobalamin (vitamin B12)-binding transporter, eukaryotic")|interpro:IPR027954|rcsb pdb:2CKT|rcsb pdb:2PMV|rcsb pdb:3KQ4|reactome:R-HSA-196741|reactome:R-HSA-3359457|reactome:R-HSA-3359462|reactome:R-HSA-3359463	psi-mi:"MI:0465"(dip)	-	-	3d-r-factors:R value 0.211  R free 0.243|3d-resolution:3.3A|figure legend:Supp. Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/05/26	2020/04/29	rogid:YvJJjMkqNOU+Ktis0SvKbGUU46w9606	rogid:jrYXRaI1wGOMD2oYJ9CqM8XH4IU9606	rigid:SFMS98nbc1VoUiAcwBb6vBTDPLY	false	sufficient binding region:932-1388	sufficient binding region:25-417	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)|psi-mi:"MI:2287"(identification by structure determination)