#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UER7	uniprotkb:O43918	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320380|imex:IM-17203-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	-	-	-	figure legend:Fig 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2011/08/03	2014/10/16	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:24608CE4AB5DA30C|rigid:Iko8Ll5wH2Eo9eNqR4GM8WMkiy8	false	-	necessary binding region:1-11|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43918	intact:EBI-4320389	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	-	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:daxx_cerae_protein(display_short)|psi-mi:EBI-4320389(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320399|imex:IM-17203-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	-	-	-	comment:Similar to O35613	figure legend:Fig 2C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2011/08/03	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	-	intact-crc:E6D225B465EBEACD	false	v5 tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UER7	uniprotkb:O43918	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320404|imex:IM-17203-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2011/08/03	2014/10/16	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:D6CE350FC2D2A4FB|rigid:Iko8Ll5wH2Eo9eNqR4GM8WMkiy8	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O43918	intact:EBI-4320428	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	-	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:hdac1_cerae_protein(display_short)|psi-mi:EBI-4320428(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320431|imex:IM-17203-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	-	-	-	comment:Similar to O09106	figure legend:Fig. 8|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2011/08/03	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	-	intact-crc:FDD724298392C391	false	ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43918	intact:EBI-4320430	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	-	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:hdac2_cerae_protein(display_short)|psi-mi:EBI-4320430(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320447|imex:IM-17203-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	-	-	-	-	figure legend:Fig. 8|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2011/08/03	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	-	intact-crc:80E5A9B8AF1D806F	false	ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O43918	uniprotkb:Q9UER7	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320363|imex:IM-17203-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	-	-	-	figure legend:Fig. 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/08/03	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	intact-crc:25FF52591653AF81|rigid:Iko8Ll5wH2Eo9eNqR4GM8WMkiy8	false	sufficient binding region:1-517	sufficient binding region:629-740	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UER7	uniprotkb:O43918	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320237|imex:IM-17203-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	-	-	-	figure legend:Fig. 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/08/03	2014/10/16	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:02CC26E3F2860459|rigid:Iko8Ll5wH2Eo9eNqR4GM8WMkiy8	false	-	necessary binding region:1-11,101-161|mutation decreasing interaction:78-78	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43918	uniprotkb:Q9UER7	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320319|imex:IM-17203-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2011/08/03	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	intact-crc:7D798B120C281F0A|rigid:Iko8Ll5wH2Eo9eNqR4GM8WMkiy8	false	sufficient binding region:1-517	sufficient binding region:629-740	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O43918	uniprotkb:O43918	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	intact:EBI-1753081|uniprotkb:O43922|uniprotkb:O43932|uniprotkb:O75745|uniprotkb:B2RP50|ensembl:ENSP00000291582	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:aire_human(display_long)|uniprotkb:AIRE(gene name)|psi-mi:AIRE(display_short)|uniprotkb:APECED(gene name synonym)|uniprotkb:Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Meloni et al. (2010)	pubmed:20185822|imex:IM-17203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-4320420|imex:IM-17203-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	refseq:NP_000374.1|dip:DIP-47504N|ensembl:ENSG00000160224(gene)|ensembl:ENST00000291582(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002458"(peripheral T cell tolerance induction)|go:"GO:0002509"(central tolerance induction to self antigen)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097536"(thymus epithelium morphogenesis)|go:"GO:2000410"(regulation of thymocyte migration)|interpro:IPR000770(SAND)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR004865(Sp100)|interpro:IPR008087(Autoimmune regulator, AIRE)|interpro:IPR010919(SAND-like)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR042580|mint:O43918|rcsb pdb:1XWH|rcsb pdb:2KE1|rcsb pdb:2KFT|rcsb pdb:2LRI	-	-	-	figure legend:Fig 6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2011/08/03	2014/10/16	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	rogid:ofG1NBODk8hM2KlMCg/x3NY8QWg9606	intact-crc:DD06456B0561F321|rigid:C3bXsl1h9kuWQRjW7NsPjL467y4	false	v5 tag:?-?	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)