#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:62878"	uniprotkb:P27694	intact:EBI-4398436	intact:EBI-621389|ensembl:ENSP00000254719|uniprotkb:Q59ES9|uniprotkb:A8K0Y9	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:rfa1_human(display_long)|uniprotkb:Replication factor A protein 1(gene name synonym)|uniprotkb:Single-stranded DNA-binding protein(gene name synonym)|uniprotkb:RPA1(gene name)|psi-mi:RPA1(display_short)|uniprotkb:REPA1(gene name synonym)|uniprotkb:RPA70(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398654|imex:IM-16356-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000132383(gene)|ensembl:ENST00000254719(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016605"(PML body)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0090734"(site of DNA damage)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004591(Replication factor-a protein 1 Rpa1)|interpro:IPR007199(Replication factor-A protein 1, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013955(Replication factor-A, C-terminal)|interpro:IPR031657|go:"GO:0006268"(DNA unwinding involved in DNA replication)|mint:P27694|rcsb pdb:1EWI|rcsb pdb:1FGU|rcsb pdb:1JMC|rcsb pdb:1L1O|rcsb pdb:2B29|rcsb pdb:2B3G|rcsb pdb:4IJH|rcsb pdb:4IJL|rcsb pdb:4IPC|rcsb pdb:4IPD|rcsb pdb:4IPG|rcsb pdb:4IPH|rcsb pdb:4LUO|rcsb pdb:4LUV|rcsb pdb:4LUZ|rcsb pdb:4LW1|rcsb pdb:4LWC|rcsb pdb:4NB3|rcsb pdb:4O0A|rcsb pdb:4R4C|rcsb pdb:4R4I|rcsb pdb:4R4O|rcsb pdb:4R4Q|rcsb pdb:4R4T|rcsb pdb:5E7N|rcsb pdb:5EAY|rcsb pdb:5N85|rcsb pdb:5N8A|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-3108214|refseq:NP_002936.1|dip:DIP-24189N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:DRZpMUlGyS0Qa5XFEtx71k0iPig9606	intact-crc:D59DA2ED0A2A36B5	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:Q9BTM1	intact:EBI-4398436	intact:EBI-4398590|uniprotkb:Q9NV63|ensembl:ENSP00000373730|ensembl:ENSP00000438553	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:h2aj_human(display_long)|uniprotkb:H2AJ(gene name)|psi-mi:H2AJ(display_short)|uniprotkb:H2AFJ(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398588|imex:IM-16356-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_808760.1|ensembl:ENSG00000246705(gene)|ensembl:ENST00000389078(transcript)|ensembl:ENST00000544848(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:4EDU|rcsb pdb:6K60|rcsb pdb:6KVD|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-8939236	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:g6br63FeM17yJRfQI3GnmoM0vbc9606	intact-crc:82F807701B5AF20D	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:P12956	intact:EBI-4398436	intact:EBI-353208|ensembl:ENSP00000352257|ensembl:ENSP00000353192|ensembl:ENSP00000384257|intact:EBI-2843064|uniprotkb:Q6FG89|uniprotkb:Q9UCQ2|uniprotkb:Q9UCQ3|intact:EBI-8456785|intact:MINT-8429298|uniprotkb:B1AHC8	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:xrcc6_human(display_long)|uniprotkb:XRCC6(gene name)|psi-mi:XRCC6(display_short)|uniprotkb:G22P1(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 70 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p70(gene name synonym)|uniprotkb:70 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 75 kDa subunit(gene name synonym)|uniprotkb:DNA repair protein XRCC6(gene name synonym)|uniprotkb:X-ray repair complementing defective repair in Chinese hamster cells 6(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 1(gene name synonym)|uniprotkb:5'-deoxyribose-5-phosphate lyase Ku70(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398644|imex:IM-16356-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0051575"(5'-deoxyribose-5-phosphate lyase activity)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR006165(DNA helicase, ATP-dependent, Ku70 subunit)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR027388|interpro:IPR036361|interpro:IPR036465|mint:P12956|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1JJR|rcsb pdb:3RZX|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZHA|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|rcsb pdb:6ZHE|rcsb pdb:7AXZ|interpro:IPR003034(DNA-binding SAP)|rcsb pdb:7K0Y|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|ensembl:ENSG00000196419(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006266"(DNA ligation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|ensembl:ENST00000359308(transcript)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|ensembl:ENST00000360079(transcript)|ensembl:ENST00000405878(transcript)|go:"GO:0016020"(membrane)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030332"(cyclin binding)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|refseq:NP_001460.1|refseq:NP_001275906.1|refseq:NP_001275905.1|dip:DIP-24188N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:45wj3HmNJ4dfVgw0zc2r3AUZ0Dw9606	intact-crc:3C88C30D5926DACB	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:O75531	intact:EBI-4398436	intact:EBI-1055977|uniprotkb:O60558|uniprotkb:Q6FGG7|ensembl:ENSP00000310275|ensembl:ENSP00000416128|ensembl:ENSP00000432867|ensembl:ENSP00000433760	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:baf_human(display_long)|uniprotkb:BANF1(gene name)|psi-mi:BANF1(display_short)|uniprotkb:BAF(gene name synonym)|uniprotkb:BCRG1(gene name synonym)|uniprotkb:Breakpoint cluster region protein 1(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398619|imex:IM-16356-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001137457.1|refseq:NP_003851.1|ensembl:ENST00000445560(transcript)|ensembl:ENST00000527348(transcript)|ensembl:ENST00000533166(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009615"(response to virus)|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0097726"(LEM domain binding)|interpro:IPR004122(Barrier to autointegration factor, BAF)|interpro:IPR036617|mint:O75531|rcsb pdb:1CI4|rcsb pdb:1QCK|rcsb pdb:2BZF|rcsb pdb:2EZX|rcsb pdb:2EZY|rcsb pdb:2EZZ|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:6UNT|rcsb pdb:6URE|rcsb pdb:6URJ|rcsb pdb:6URK|rcsb pdb:6URL|rcsb pdb:6URN|rcsb pdb:6URR|rcsb pdb:6URZ|rcsb pdb:6US0|rcsb pdb:6US1|rcsb pdb:6US7|rcsb pdb:6USB|rcsb pdb:6USD|rcsb pdb:6USI|rcsb pdb:7NDY|ensembl:ENSG00000175334(gene)|ensembl:ENST00000312175(transcript)|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|reactome:R-HSA-2980766|reactome:R-HSA-2995383|refseq:XP_016874003.1|refseq:XP_016874004.1|dip:DIP-50395N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:JSfPqQhIXIFEXNQn1+I8v5zG+Hw9606	intact-crc:5E3B04C4F40F6D57	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:Q08945	intact:EBI-4398436	intact:EBI-353771|uniprotkb:Q5BJG8|ensembl:ENSP00000278412	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:ssrp1_human(display_long)|uniprotkb:SSRP1(gene name)|psi-mi:SSRP1(display_short)|uniprotkb:FACT80(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex subunit SSRP1(gene name synonym)|uniprotkb:Facilitates chromatin transcription complex 80 kDa subunit(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 80 kDa subunit(gene name synonym)|uniprotkb:Structure-specific recognition protein 1(gene name synonym)|uniprotkb:Recombination signal sequence recognition protein 1(gene name synonym)|uniprotkb:T160(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398609|imex:IM-16356-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003137.1|ensembl:ENSG00000149136(gene)|ensembl:ENST00000278412(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031491"(nucleosome binding)|go:"GO:0035101"(FACT complex)|go:"GO:0042393"(histone binding)|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|go:"GO:1902275"(regulation of chromatin organization)|interpro:IPR000969(Structure-specific recognition protein)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR024954|interpro:IPR035417|interpro:IPR036910|interpro:IPR038167|mint:Q08945|rcsb pdb:4IFS|rcsb pdb:5UMR|rcsb pdb:5UMS|rcsb pdb:5VWE|rcsb pdb:6L1E|rcsb pdb:6L1R|rcsb pdb:6L34|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|dip:DIP-169N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:WmdGVZadHdcS6Nk9SI41xKm+OrU9606	intact-crc:87205597E517F43B	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:O60547	intact:EBI-4398436	intact:EBI-746373|uniprotkb:O75357|uniprotkb:Q5T954|uniprotkb:Q6FH09|uniprotkb:Q9UGZ3|uniprotkb:Q9UJK9|ensembl:ENSP00000370194|intact:EBI-10968896|uniprotkb:E9PI88	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:gmds_human(display_long)|uniprotkb:GDP-D-mannose dehydratase(gene name synonym)|uniprotkb:GMDS(gene name)|psi-mi:GMDS(display_short)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398432|imex:IM-16356-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001491.1|ensembl:ENSG00000112699(gene)|ensembl:ENST00000380815(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008446"(GDP-mannose 4,6-dehydratase activity)|go:"GO:0019673"(GDP-mannose metabolic process)|go:"GO:0042351"('de novo' GDP-L-fucose biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070401"(NADP+ binding)|interpro:IPR006368(GDP-mannose 4,6-dehydratase)|interpro:IPR016040("NAD(P)-binding")|interpro:IPR036291|rcsb pdb:1T2A|rcsb pdb:5IN4|rcsb pdb:5IN5|rcsb pdb:6GPJ|rcsb pdb:6GPK|rcsb pdb:6GPL|rcsb pdb:6Q94|reactome:R-HSA-6787639|refseq:NP_001240775.1	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:phGw3/m75gYQcBlRP3OXK4mQvhM9606	intact-crc:8A2673826F50E470	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:P35244	intact:EBI-4398436	intact:EBI-621428|ensembl:ENSP00000223129|ensembl:ENSP00000379914|uniprotkb:Q549U6|intact:EBI-1058317	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:rfa3_human(display_long)|uniprotkb:Replication factor A protein 3(gene name synonym)|uniprotkb:RPA3(gene name)|psi-mi:RPA3(display_short)|uniprotkb:REPA3(gene name synonym)|uniprotkb:RPA14(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398578|imex:IM-16356-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0035861"(site of double-strand break)|ensembl:ENSG00000106399(gene)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013970(Replication factor A protein 3)|mint:P35244|rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|ensembl:ENST00000223129(transcript)|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|ensembl:ENST00000396682(transcript)|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|refseq:NP_002938.1|dip:DIP-24190N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:hHO7MxGGHUjz30HXSBZd9cXOq6I9606	intact-crc:9E46F1262489705B	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:Q9H2K2	intact:EBI-4398436	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398573|imex:IM-16356-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:4213F2429B632F7A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:O60232	intact:EBI-4398436	intact:EBI-741415|ensembl:ENSP00000312318	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:znrd2_human(display_long)|uniprotkb:ZNRD2(gene name)|psi-mi:ZNRD2(display_short)|uniprotkb:Autoantigen p27(gene name synonym)|uniprotkb:SSSCA1(gene name synonym)|uniprotkb:Sjoegren syndrome/scleroderma autoantigen 1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398664|imex:IM-16356-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006387.1|ensembl:ENSG00000173465(gene)|ensembl:ENST00000309328(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0051301"(cell division)|interpro:IPR009563(Sjogrens syndrome scleroderma autoantigen 1)|rcsb pdb:6HCZ	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:Uou80pZneoL39/0YYzb1TAbiB2I9606	intact-crc:3EF171531B9F188B	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:O95271	intact:EBI-4398436	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398659|imex:IM-16356-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:DB62C74CCA79E8F5	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:P15927	intact:EBI-4398436	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398649|imex:IM-16356-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	intact-crc:FF07291F7085DF91	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:P09874	intact:EBI-4398436	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398634|imex:IM-16356-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:CC03A6F9743A692A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:P13010	intact:EBI-4398436	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398629|imex:IM-16356-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:1B760E3EB2D36C00	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:Q9Y5B9	intact:EBI-4398436	intact:EBI-1046849|uniprotkb:Q6GMT8|uniprotkb:Q6P2F1|uniprotkb:Q6PJM1|uniprotkb:Q9NRX0|ensembl:ENSP00000216297	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:sp16h_human(display_long)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:SUPT16H(gene name)|psi-mi:SUPT16H(display_short)|uniprotkb:FACT140(gene name synonym)|uniprotkb:FACTP140(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398583|imex:IM-16356-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000092201(gene)|ensembl:ENST00000216297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|interpro:IPR029148|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|mint:Q9Y5B9|rcsb pdb:4Z2M|rcsb pdb:4Z2N|rcsb pdb:5E5B|rcsb pdb:5UMT|rcsb pdb:5UMU|rcsb pdb:5XM2|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|refseq:NP_009123.1|dip:DIP-42757N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:jLK5dOF3mEyI0UbZhcNgtdlG+WI9606	intact-crc:FBF38CCFCB07C18D	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:P62805	intact:EBI-4398436	intact:EBI-302023|ensembl:ENSP00000244537|ensembl:ENSP00000347168|ensembl:ENSP00000350767|ensembl:ENSP00000366974|ensembl:ENSP00000366956|ensembl:ENSP00000462667|ensembl:ENSP00000367034|ensembl:ENSP00000478519|ensembl:ENSP00000478786|ensembl:ENSP00000443017|ensembl:ENSP00000462355|ensembl:ENSP00000479106|ensembl:ENSP00000479461|uniprotkb:A2VCL0|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:Q6DRA9|uniprotkb:Q6FGB8|uniprotkb:Q6NWP7|ensembl:ENSP00000479794|ensembl:ENSP00000480960|ensembl:ENSP00000481343|ensembl:ENSP00000481486|ensembl:ENSP00000481507|ensembl:ENSP00000482412|ensembl:ENSP00000484789|ensembl:ENSP00000489319|ensembl:ENSP00000489567	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:h4_human(display_long)|uniprotkb:H4-16(gene name)|psi-mi:H4-16(display_short)|uniprotkb:H4C1(gene name)|psi-mi:H4C1(display_short)|uniprotkb:H4C11(gene name)|psi-mi:H4C11(display_short)|uniprotkb:H4C12(gene name)|psi-mi:H4C12(display_short)|uniprotkb:H4C13(gene name)|psi-mi:H4C13(display_short)|uniprotkb:H4C14(gene name)|psi-mi:H4C14(display_short)|uniprotkb:H4C15(gene name)|psi-mi:H4C15(display_short)|uniprotkb:H4C2(gene name)|psi-mi:H4C2(display_short)|uniprotkb:H4C3(gene name)|psi-mi:H4C3(display_short)|uniprotkb:H4C4(gene name)|psi-mi:H4C4(display_short)|uniprotkb:H4C5(gene name)|psi-mi:H4C5(display_short)|uniprotkb:H4C6(gene name)|psi-mi:H4C6(display_short)|uniprotkb:H4C8(gene name)|psi-mi:H4C8(display_short)|uniprotkb:H4C9(gene name)|psi-mi:H4C9(display_short)|uniprotkb:H4/A(gene name synonym)|uniprotkb:H4/B(gene name synonym)|uniprotkb:H4/C(gene name synonym)|uniprotkb:H4/D(gene name synonym)|uniprotkb:H4/E(gene name synonym)|uniprotkb:H4/G(gene name synonym)|uniprotkb:H4/H(gene name synonym)|uniprotkb:H4/I(gene name synonym)|uniprotkb:H4/J(gene name synonym)|uniprotkb:H4/K(gene name synonym)|uniprotkb:H4/M(gene name synonym)|uniprotkb:H4/N(gene name synonym)|uniprotkb:H4/O(gene name synonym)|uniprotkb:H4F2(gene name synonym)|uniprotkb:H4FA(gene name synonym)|uniprotkb:H4FB(gene name synonym)|uniprotkb:H4FC(gene name synonym)|uniprotkb:H4FD(gene name synonym)|uniprotkb:H4FE(gene name synonym)|uniprotkb:H4FG(gene name synonym)|uniprotkb:H4FH(gene name synonym)|uniprotkb:H4FI(gene name synonym)|uniprotkb:H4FJ(gene name synonym)|uniprotkb:H4FK(gene name synonym)|uniprotkb:H4FM(gene name synonym)|uniprotkb:H4FN(gene name synonym)|uniprotkb:H4FO(gene name synonym)|uniprotkb:HIST1H4A(gene name synonym)|uniprotkb:HIST1H4B(gene name synonym)|uniprotkb:HIST1H4C(gene name synonym)|uniprotkb:HIST1H4D(gene name synonym)|uniprotkb:HIST1H4E(gene name synonym)|uniprotkb:HIST1H4F(gene name synonym)|uniprotkb:HIST1H4H(gene name synonym)|uniprotkb:HIST1H4I(gene name synonym)|uniprotkb:HIST1H4J(gene name synonym)|uniprotkb:HIST1H4K(gene name synonym)|uniprotkb:HIST1H4L(gene name synonym)|uniprotkb:HIST2H4(gene name synonym)|uniprotkb:HIST2H4A(gene name synonym)|uniprotkb:HIST2H4B(gene name synonym)|uniprotkb:HIST4H4(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398614|imex:IM-16356-15	-	-	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000197061(gene)|ensembl:ENSG00000276180(gene)|ensembl:ENSG00000197238(gene)|ensembl:ENSG00000276966(gene)|ensembl:ENSG00000277157(gene)|ensembl:ENSG00000270276(gene)|ensembl:ENSG00000197837(gene)|ensembl:ENSG00000270882(gene)|ensembl:ENSG00000278637(gene)|ensembl:ENSG00000273542(gene)|ensembl:ENSG00000274618(gene)|ensembl:ENSG00000278705(gene)|ensembl:ENSG00000275126(gene)|ensembl:ENSG00000158406(gene)|dip:DIP-33079N|ensembl:ENST00000244537(transcript)|ensembl:ENST00000355057(transcript)|ensembl:ENST00000358064(transcript)|ensembl:ENST00000377727(transcript)|ensembl:ENST00000377745(transcript)|ensembl:ENST00000377803(transcript)|ensembl:ENST00000539745(transcript)|ensembl:ENST00000578186(transcript)|ensembl:ENST00000579512(transcript)|ensembl:ENST00000611927(transcript)|ensembl:ENST00000612061(transcript)|ensembl:ENST00000613412(transcript)|ensembl:ENST00000614247(transcript)|ensembl:ENST00000614272(transcript)|ensembl:ENST00000615164(transcript)|ensembl:ENST00000615353(transcript)|ensembl:ENST00000617569(transcript)|ensembl:ENST00000618193(transcript)|ensembl:ENST00000618305(transcript)|ensembl:ENST00000621520(transcript)|ensembl:ENST00000634560(transcript)|ensembl:ENST00000634956(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0005576"(extracellular region)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AYW|rcsb pdb:3AZJ|rcsb pdb:3AZK|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:3F9W|rcsb pdb:3F9X|rcsb pdb:3F9Y|rcsb pdb:3F9Z|rcsb pdb:3IJ1|rcsb pdb:3JPX|rcsb pdb:3NQJ|rcsb pdb:3NQU|rcsb pdb:3O36|rcsb pdb:3QBY|rcsb pdb:3QZS|rcsb pdb:3QZT|rcsb pdb:3QZV|rcsb pdb:3R45|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3WTP|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:4GQB|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:4M38|rcsb pdb:4N3W|rcsb pdb:4N4F|rcsb pdb:4QUT|rcsb pdb:4QUU|rcsb pdb:4QYD|rcsb pdb:4U9W|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4YY6|rcsb pdb:4YYD|rcsb pdb:4YYG|rcsb pdb:4YYH|rcsb pdb:4YYI|rcsb pdb:4YYJ|rcsb pdb:4YYK|rcsb pdb:4YYM|rcsb pdb:4YYN|rcsb pdb:4Z2M|rcsb pdb:4Z5T|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5AY8|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B2J|rcsb pdb:5B31|rcsb pdb:5B32|rcsb pdb:5B33|rcsb pdb:5B40|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5CPI|interpro:IPR019809|interpro:IPR035425|mint:P62805|rcsb pdb:1ZKK|rcsb pdb:2BQZ|rcsb pdb:2CV5|rcsb pdb:2IG0|rcsb pdb:2KWN|rcsb pdb:2KWO|rcsb pdb:2LVM|rcsb pdb:2QQS|rcsb pdb:2RJE|rcsb pdb:2RNY|interpro:IPR009072(Histone-fold)|rcsb pdb:2RS9|rcsb pdb:3A6N|rcsb pdb:3AFA|rcsb pdb:3AN2|rcsb pdb:3AV1|rcsb pdb:3AV2|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5GXQ|rcsb pdb:5JA4|rcsb pdb:5JRG|rcsb pdb:5KDM|rcsb pdb:5TEG|rcsb pdb:5X7X|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5YE3|rcsb pdb:5YE4|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:5ZBX|rcsb pdb:5ZGC|rcsb pdb:5CPJ|rcsb pdb:6A5L|rcsb pdb:6A5O|rcsb pdb:5CPK|rcsb pdb:6A5P|rcsb pdb:5FA5|rcsb pdb:6A5R|rcsb pdb:6A5T|rcsb pdb:6A5U|rcsb pdb:6ACP|rcsb pdb:6BUZ|rcsb pdb:6C0W|rcsb pdb:6E0C|rcsb pdb:6E0P|rcsb pdb:6FML|rcsb pdb:6HKT|rcsb pdb:6HTS|rcsb pdb:6INQ|rcsb pdb:6IR9|rcsb pdb:6J4W|rcsb pdb:6J4X|rcsb pdb:6J4Y|rcsb pdb:6J4Z|rcsb pdb:6J50|rcsb pdb:6J51|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6KXV|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:5FFW|rcsb pdb:5FWE|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MLC|rcsb pdb:6MUO|rcsb pdb:6MUP|rcsb pdb:6O1D|rcsb pdb:6R0C|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|refseq:NP_001029249.1|refseq:NP_003486.1|refseq:NP_003529.1|refseq:NP_003530.1|refseq:NP_003531.1|refseq:NP_003532.1|refseq:NP_003533.1|refseq:NP_003534.1|refseq:NP_003535.1|refseq:NP_003536.1|refseq:NP_003537.1|refseq:NP_003539.1|rcsb pdb:6R92|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6RNY|rcsb pdb:6RXS|rcsb pdb:6SE0|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2K|rcsb pdb:6V92|rcsb pdb:6VO5|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6YOV|rcsb pdb:7A08|rcsb pdb:7BWD|rcsb pdb:7BXT|rcsb pdb:7BY0|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:7CCR|rcsb pdb:7CIZ|rcsb pdb:7CJ0|rcsb pdb:7D1Z|rcsb pdb:7D20|rcsb pdb:7DBP|rcsb pdb:7JO9|rcsb pdb:7JOA|rcsb pdb:7JZV|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7LMK|rcsb pdb:7LMM|rcsb pdb:7LYC|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-4551638|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5693565|refseq:NP_068803.1|refseq:NP_778224.1|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA9606	intact-crc:CD784B88E39154D5	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:Q9UGN5	intact:EBI-4398436	intact:EBI-2795348|uniprotkb:Q8TEU4|uniprotkb:Q9NUV2|uniprotkb:Q9UMR4|uniprotkb:Q9Y6C8|ensembl:ENSP00000250416	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:parp2_human(display_long)|uniprotkb:PARP2(gene name)|psi-mi:PARP2(display_short)|uniprotkb:ADPRT2(gene name synonym)|uniprotkb:ADPRTL2(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 2"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 2(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 2(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP2(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398639|imex:IM-16356-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036083.1|refseq:NP_005475.2|ensembl:ENSG00000129484(gene)|ensembl:ENST00000250416(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016570"(histone modification)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0031491"(nucleosome binding)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036616|go:"GO:0005634"(nucleus)|interpro:IPR036930|mint:Q9UGN5|rcsb pdb:3KCZ|rcsb pdb:3KJD|rcsb pdb:4PJV|rcsb pdb:4TVJ|rcsb pdb:4ZZX|rcsb pdb:4ZZY|rcsb pdb:5D5K|rcsb pdb:5DSY|rcsb pdb:6F1K|rcsb pdb:6F5B|rcsb pdb:6F5F|rcsb pdb:6TX3|rcsb pdb:6USJ|rcsb pdb:6X0L|rcsb pdb:6X0M|rcsb pdb:6X0N|rcsb pdb:7AEO|reactome:R-HSA-110362|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|dip:DIP-48934N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:0sLs7K5dQNmmhUwnGT9UIvparjU9606	intact-crc:AAF6FE3C8A943146	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:Q71DI3	intact:EBI-4398436	intact:EBI-750650|uniprotkb:A2BDF6|uniprotkb:A6NFS4|uniprotkb:Q6B053|ensembl:ENSP00000333277|ensembl:ENSP00000358154|ensembl:ENSP00000385479	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:h32_human(display_long)|uniprotkb:H3C13(gene name)|psi-mi:H3C13(display_short)|uniprotkb:H3C14(gene name)|psi-mi:H3C14(display_short)|uniprotkb:H3C15(gene name)|psi-mi:H3C15(display_short)|uniprotkb:H3-clustered histone 13(gene name synonym)|uniprotkb:H3-clustered histone 14(gene name synonym)|uniprotkb:H3-clustered histone 15(gene name synonym)|uniprotkb:H3F2(gene name synonym)|uniprotkb:H3FM(gene name synonym)|uniprotkb:HIST2H3A(gene name synonym)|uniprotkb:HIST2H3C(gene name synonym)|uniprotkb:HIST2H3D(gene name synonym)|uniprotkb:Histone H3/m(gene name synonym)|uniprotkb:Histone H3/o(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398624|imex:IM-16356-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001005464.1|refseq:NP_001116847.1|refseq:NP_066403.2|dip:DIP-48606N|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|rcsb pdb:7BU9|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214858|reactome:R-HSA-3247509|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9710421|reactome:R-HSA-977225|reactome:R-HSA-983231|rcsb pdb:7JZV|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|ensembl:ENSG00000183598(gene)|ensembl:ENSG00000203811(gene)|ensembl:ENSG00000203852(gene)|ensembl:ENST00000331491(transcript)|ensembl:ENST00000369158(transcript)|ensembl:ENST00000403683(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|mint:Q71DI3|rcsb pdb:2IIJ|rcsb pdb:2X4W|rcsb pdb:2X4X|rcsb pdb:2X4Y|rcsb pdb:3AV1|rcsb pdb:3DB3|rcsb pdb:3MO8|rcsb pdb:3QO2|rcsb pdb:3R93|rcsb pdb:4MZF|rcsb pdb:4MZG|rcsb pdb:4MZH|rcsb pdb:4OUC|rcsb pdb:5B0Y|rcsb pdb:5B0Z|rcsb pdb:5B40|rcsb pdb:5BO0|rcsb pdb:5CIU|rcsb pdb:5VAC|rcsb pdb:6ACE|rcsb pdb:6FML|rcsb pdb:6T79|rcsb pdb:6T7A|rcsb pdb:6T7B|rcsb pdb:6T7C|rcsb pdb:6T7D|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:6Y5D|rcsb pdb:6Y5E|rcsb pdb:7BQZ	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:2TuVqWkeAnhHR4nrl0GNyUj1N3o9606	intact-crc:D7330A09FC4B4559	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:P50402	intact:EBI-4398436	intact:EBI-489887|uniprotkb:Q6FI02|ensembl:ENSP00000358857|ensembl:ENSP00000507533	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:emd_human(display_long)|uniprotkb:EDMD(gene name synonym)|uniprotkb:STA(gene name synonym)|uniprotkb:EMD(gene name)|psi-mi:EMD(display_short)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398669|imex:IM-16356-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000108.1|ensembl:ENSP00000358857|ensembl:ENSP00000507533|ensembl:ENSG00000102119(gene)|ensembl:ENST00000369842(transcript)|ensembl:ENST00000683627(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR011015(LEM-like fold)|interpro:IPR034989|interpro:IPR035004|mint:P50402|rcsb pdb:1JEI|rcsb pdb:2ODC|rcsb pdb:2ODG|rcsb pdb:6GHD|rcsb pdb:6RPR|rcsb pdb:7NDY|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-4419969|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609523|interpro:IPR003887(Lamino-associated polypeptide 2/emerin)|dip:DIP-34638N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:hqH2sFjAGwjIGtGX/rjVVFgaYsE9606	intact-crc:3E2D93066D39C25A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
chebi:"CHEBI:62878"	uniprotkb:Q9UGN5	intact:EBI-4398436	intact:EBI-2795348|uniprotkb:Q8TEU4|uniprotkb:Q9NUV2|uniprotkb:Q9UMR4|uniprotkb:Q9Y6C8|ensembl:ENSP00000250416	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:parp2_human(display_long)|uniprotkb:PARP2(gene name)|psi-mi:PARP2(display_short)|uniprotkb:ADPRT2(gene name synonym)|uniprotkb:ADPRTL2(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 2"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 2(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 2(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP2(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398679|imex:IM-16356-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036083.1|refseq:NP_005475.2|ensembl:ENSG00000129484(gene)|ensembl:ENST00000250416(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016570"(histone modification)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0031491"(nucleosome binding)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036616|go:"GO:0005634"(nucleus)|interpro:IPR036930|mint:Q9UGN5|rcsb pdb:3KCZ|rcsb pdb:3KJD|rcsb pdb:4PJV|rcsb pdb:4TVJ|rcsb pdb:4ZZX|rcsb pdb:4ZZY|rcsb pdb:5D5K|rcsb pdb:5DSY|rcsb pdb:6F1K|rcsb pdb:6F5B|rcsb pdb:6F5F|rcsb pdb:6TX3|rcsb pdb:6USJ|rcsb pdb:6X0L|rcsb pdb:6X0M|rcsb pdb:6X0N|rcsb pdb:7AEO|reactome:R-HSA-110362|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|dip:DIP-48934N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:0sLs7K5dQNmmhUwnGT9UIvparjU9606	intact-crc:1984B997C0513B5D	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:62878"	uniprotkb:P09874	intact:EBI-4398436	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398674|imex:IM-16356-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	-	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:B0EA7E6255595F8E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:62878"	uniprotkb:Q9H2K2	intact:EBI-4398436	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398927|imex:IM-16356-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.093x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:156E1540C698A405	false	cy5 label:?-?	glutathione s tranferase tag:?-?|sufficient binding region:959..959-1166(IPR012317)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:62878"	uniprotkb:O95271	intact:EBI-4398436	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398859|imex:IM-16356-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.099x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:384D96486C79738B	false	cy5 label:?-?	sufficient binding region:1112..1112-1317..1317|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:62878"	uniprotkb:P09874	intact:EBI-4398436	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4398985|imex:IM-16356-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 2c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.2x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:2E28663F4FC96CCA	false	cy5 label:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15846"	uniprotkb:Q9H2K2	intact:EBI-4399035	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399019|imex:IM-16356-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig 3H, 5C.|resulting-ptm:Auto-poly ADP ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.093x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:4810D440CD0EE4A7	false	biotin tag:?-?	sufficient binding region:872-1166(IPR012317)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:15846"	chebi:"CHEBI:62878"	intact:EBI-4399035	intact:EBI-4398436	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399019|imex:IM-16356-32	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	figure legend:Fig 3H, 5C.|resulting-ptm:Auto-poly ADP ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.093x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:4810D440CD0EE4A7	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:15846"	uniprotkb:Q9H2K2	intact:EBI-4399035	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400568|imex:IM-16356-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig S3i|resulting-ptm:Auto-poly ADP ribosylation of TNKS2.|comment:IWR-1-endo and XAV939 inhibit  the auto-poly ADP ribosylation of TNKS2.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:00189410D4687513	false	biotin tag:?-?	his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:15846"	chebi:"CHEBI:62878"	intact:EBI-4399035	intact:EBI-4398436	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400568|imex:IM-16356-46	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	figure legend:Fig S3i|resulting-ptm:Auto-poly ADP ribosylation of TNKS2.|comment:IWR-1-endo and XAV939 inhibit  the auto-poly ADP ribosylation of TNKS2.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	-	-	intact-crc:00189410D4687513	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:15846"	uniprotkb:O35625	intact:EBI-4399035	intact:EBI-2365912	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400506|imex:IM-16356-3|dip:DIP-187509E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	go:"GO:0070212"(protein poly-ADP-ribosylation)|psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 5C|resulting-ptm:Poly ADP ribosylation of Axin-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	-	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	intact-crc:09D8F7DE876A84E1	false	biotin tag:?-?	glutathione s tranferase tag:?-?|necessary binding region:1-280	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:O35625	uniprotkb:Q9H2K2	intact:EBI-2365912	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400506|imex:IM-16356-3|dip:DIP-187509E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)|psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 5C|resulting-ptm:Poly ADP ribosylation of Axin-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:09D8F7DE876A84E1	false	glutathione s tranferase tag:?-?|necessary binding region:1-280	his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:62878"	uniprotkb:O35625	intact:EBI-4398436	intact:EBI-2365912	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400506|imex:IM-16356-3|dip:DIP-187509E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	go:"GO:0070212"(protein poly-ADP-ribosylation)|psi-mi:"MI:0465"(dip)	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	-	figure legend:Fig 5C|resulting-ptm:Poly ADP ribosylation of Axin-1.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	-	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	intact-crc:09D8F7DE876A84E1	false	-	glutathione s tranferase tag:?-?|necessary binding region:1-280	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:62882"	chebi:"CHEBI:15846"	intact:EBI-4399767	intact:EBI-4399035	psi-mi:iwr-1-endo(display_short)|psi-mi:"CHEBI:62882"(display_long)	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400584|imex:IM-16356-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig S3i|resulting-ptm:Auto-poly-adp ribosylation of TNKS2.|comment:IWR-1-endo and XAV939 inhibit  the auto-poly ADP ribosylation of TNKS2.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	-	-	intact-crc:B892B6260A3E0721	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:62882"	uniprotkb:Q9H2K2	intact:EBI-4399767	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:iwr-1-endo(display_short)|psi-mi:"CHEBI:62882"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400584|imex:IM-16356-47	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig S3i|resulting-ptm:Auto-poly-adp ribosylation of TNKS2.|comment:IWR-1-endo and XAV939 inhibit  the auto-poly ADP ribosylation of TNKS2.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:B892B6260A3E0721	false	-	his tag:n-n	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
chebi:"CHEBI:62883"	chebi:"CHEBI:15846"	intact:EBI-4399768	intact:EBI-4399035	psi-mi:iwr-1-exo(display_short)|psi-mi:"CHEBI:62883"(display_long)	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399869|imex:IM-16356-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.056x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:F66F8050A54CA5E4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:62883"	uniprotkb:Q9H2K2	intact:EBI-4399768	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:iwr-1-exo(display_short)|psi-mi:"CHEBI:62883"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399869|imex:IM-16356-43	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.056x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:F66F8050A54CA5E4	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:Q9H2K2	intact:EBI-4399035	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399769|imex:IM-16356-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.004x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:5BD90FC0C052CAE8	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62880"	intact:EBI-4399035	intact:EBI-4399766	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:veliparib/abt-888(display_short)|psi-mi:"CHEBI:62880"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399769|imex:IM-16356-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.004x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:5BD90FC0C052CAE8	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:62882"	chebi:"CHEBI:15846"	intact:EBI-4399767	intact:EBI-4399035	psi-mi:iwr-1-endo(display_short)|psi-mi:"CHEBI:62882"(display_long)	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399858|imex:IM-16356-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.5x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:02FDFADF79B97F1F	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:62882"	uniprotkb:Q9H2K2	intact:EBI-4399767	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:iwr-1-endo(display_short)|psi-mi:"CHEBI:62882"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399858|imex:IM-16356-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:6.5x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:02FDFADF79B97F1F	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:Q9UGN5	intact:EBI-4399035	intact:EBI-2795348|uniprotkb:Q8TEU4|uniprotkb:Q9NUV2|uniprotkb:Q9UMR4|uniprotkb:Q9Y6C8|ensembl:ENSP00000250416	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:parp2_human(display_long)|uniprotkb:PARP2(gene name)|psi-mi:PARP2(display_short)|uniprotkb:ADPRT2(gene name synonym)|uniprotkb:ADPRTL2(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 2"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 2(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 2(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP2(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399811|imex:IM-16356-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036083.1|refseq:NP_005475.2|ensembl:ENSG00000129484(gene)|ensembl:ENST00000250416(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016570"(histone modification)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0031491"(nucleosome binding)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036616|go:"GO:0005634"(nucleus)|interpro:IPR036930|mint:Q9UGN5|rcsb pdb:3KCZ|rcsb pdb:3KJD|rcsb pdb:4PJV|rcsb pdb:4TVJ|rcsb pdb:4ZZX|rcsb pdb:4ZZY|rcsb pdb:5D5K|rcsb pdb:5DSY|rcsb pdb:6F1K|rcsb pdb:6F5B|rcsb pdb:6F5F|rcsb pdb:6TX3|rcsb pdb:6USJ|rcsb pdb:6X0L|rcsb pdb:6X0M|rcsb pdb:6X0N|rcsb pdb:7AEO|reactome:R-HSA-110362|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|dip:DIP-48934N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.011x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:0sLs7K5dQNmmhUwnGT9UIvparjU9606	intact-crc:C405AC1C0CE72DB9	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62880"	intact:EBI-4399035	intact:EBI-4399766	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:veliparib/abt-888(display_short)|psi-mi:"CHEBI:62880"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399811|imex:IM-16356-40	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.011x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:C405AC1C0CE72DB9	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:Q9UGN5	intact:EBI-4399035	intact:EBI-2795348|uniprotkb:Q8TEU4|uniprotkb:Q9NUV2|uniprotkb:Q9UMR4|uniprotkb:Q9Y6C8|ensembl:ENSP00000250416	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:parp2_human(display_long)|uniprotkb:PARP2(gene name)|psi-mi:PARP2(display_short)|uniprotkb:ADPRT2(gene name synonym)|uniprotkb:ADPRTL2(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 2"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 2(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 2(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP2(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399737|imex:IM-16356-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001036083.1|refseq:NP_005475.2|ensembl:ENSG00000129484(gene)|ensembl:ENST00000250416(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016570"(histone modification)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0031491"(nucleosome binding)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR036616|go:"GO:0005634"(nucleus)|interpro:IPR036930|mint:Q9UGN5|rcsb pdb:3KCZ|rcsb pdb:3KJD|rcsb pdb:4PJV|rcsb pdb:4TVJ|rcsb pdb:4ZZX|rcsb pdb:4ZZY|rcsb pdb:5D5K|rcsb pdb:5DSY|rcsb pdb:6F1K|rcsb pdb:6F5B|rcsb pdb:6F5F|rcsb pdb:6TX3|rcsb pdb:6USJ|rcsb pdb:6X0L|rcsb pdb:6X0M|rcsb pdb:6X0N|rcsb pdb:7AEO|reactome:R-HSA-110362|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|dip:DIP-48934N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.011x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:0sLs7K5dQNmmhUwnGT9UIvparjU9606	intact-crc:B53B241B1F5CA411	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62878"	intact:EBI-4399035	intact:EBI-4398436	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399737|imex:IM-16356-35	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.011x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:B53B241B1F5CA411	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:62882"	chebi:"CHEBI:15846"	intact:EBI-4399767	intact:EBI-4399035	psi-mi:iwr-1-endo(display_short)|psi-mi:"CHEBI:62882"(display_long)	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399849|imex:IM-16356-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:FF7A260E2B1B5225	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:62882"	uniprotkb:O95271	intact:EBI-4399767	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:iwr-1-endo(display_short)|psi-mi:"CHEBI:62882"(display_long)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399849|imex:IM-16356-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:FF7A260E2B1B5225	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:P09874	intact:EBI-4399035	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399746|imex:IM-16356-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.2x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:D9035E1DDD162341	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62878"	intact:EBI-4399035	intact:EBI-4398436	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399746|imex:IM-16356-36	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.2x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:D9035E1DDD162341	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:O95271	intact:EBI-4399035	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399725|imex:IM-16356-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:15.0x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:A65C031192F0E7D2	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62880"	intact:EBI-4399035	intact:EBI-4399766	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:veliparib/abt-888(display_short)|psi-mi:"CHEBI:62880"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399725|imex:IM-16356-34	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:15.0x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:A65C031192F0E7D2	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:Q9H2K2	intact:EBI-4399035	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399702|imex:IM-16356-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.0x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:AB11B70FF60D7AE6	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62878"	intact:EBI-4399035	intact:EBI-4398436	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399702|imex:IM-16356-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:4.0x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:AB11B70FF60D7AE6	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:P09874	intact:EBI-4399035	intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399802|imex:IM-16356-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.008x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606	intact-crc:A83DD61ACEADAAE9	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62880"	intact:EBI-4399035	intact:EBI-4399766	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:veliparib/abt-888(display_short)|psi-mi:"CHEBI:62880"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399802|imex:IM-16356-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of PARP1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.008x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:A83DD61ACEADAAE9	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	uniprotkb:O95271	intact:EBI-4399035	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399792|imex:IM-16356-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.004x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:56966BDEA4AF57DC	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:15846"	chebi:"CHEBI:62878"	intact:EBI-4399035	intact:EBI-4398436	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:xav939(display_short)|psi-mi:"CHEBI:62878"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399792|imex:IM-16356-38	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	comment:"chebi details to be added when available    Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluorom  ethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one"	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.004x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:56966BDEA4AF57DC	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:62883"	chebi:"CHEBI:15846"	intact:EBI-4399768	intact:EBI-4399035	psi-mi:iwr-1-exo(display_short)|psi-mi:"CHEBI:62883"(display_long)	psi-mi:nad+(display_short)|psi-mi:"CHEBI:15846"(display_long)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399878|imex:IM-16356-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0580"(electron acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-6(molar)	2011/09/08	2017/06/30	-	-	intact-crc:0BE85C81F7EE88DE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
chebi:"CHEBI:62883"	uniprotkb:O95271	intact:EBI-4399768	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:iwr-1-exo(display_short)|psi-mi:"CHEBI:62883"(display_long)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0557"(adp ribosylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-4399878|imex:IM-16356-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	go:"GO:0070212"(protein poly-ADP-ribosylation)	-	-	figure legend:Fig  3I.|resulting-ptm:Auto-poly-ADP-ribosylation of TNKS1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.13x10^-6(molar)	2011/09/08	2017/06/30	-	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:0BE85C81F7EE88DE	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9Y2T1	uniprotkb:Q9H2K2	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400023|imex:IM-16356-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	-	-	-	figure legend:Fig 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sw480)|taxid:9606(Human SW480 adenocarcinoma cell line)	-	2011/09/08	2017/06/30	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:1D32F07B3ED22295|rigid:V7dq1nSFH1eb2F9cTY8jlRUDHmM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y2T1	uniprotkb:O95271	intact:EBI-4400025|uniprotkb:Q3MJ88|uniprotkb:Q9H3M6|uniprotkb:Q9UH84|ensembl:ENSP00000302625	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:axin2_human(display_long)|uniprotkb:AXIN2(gene name)|psi-mi:AXIN2(display_short)|uniprotkb:Axin-like protein(gene name synonym)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400023|imex:IM-16356-45	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004646.3|dip:DIP-59293N|ensembl:ENSG00000168646(gene)|ensembl:ENST00000307078(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:Q9Y2T1|reactome:R-HSA-201681|reactome:R-HSA-4411364|reactome:R-HSA-4641257|reactome:R-HSA-5689880	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	-	-	-	figure legend:Fig 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sw480)|taxid:9606(Human SW480 adenocarcinoma cell line)	-	2011/09/08	2017/06/30	rogid:Tz6ggQ7gnpx/kUUmlEUumOQjJvI9606	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:1D32F07B3ED22295|rigid:V7dq1nSFH1eb2F9cTY8jlRUDHmM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15169	uniprotkb:P49841	intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28	intact:EBI-373586|uniprotkb:Q9BWH3|uniprotkb:Q9UL47|uniprotkb:D3DN89|ensembl:ENSP00000264235	psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym)	psi-mi:gsk3b_human(display_long)|uniprotkb:GSK3B(gene name)|psi-mi:GSK3B(display_short)|uniprotkb:Serine/threonine-protein kinase GSK3B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400268|imex:IM-16356-2|dip:DIP-69582E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N	refseq:NP_001139628.1|refseq:NP_002084.2|ensembl:ENSG00000082701(gene)|ensembl:ENST00000264235(transcript)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006983"(ER overload response)|go:"GO:0007165"(signal transduction)|go:"GO:0007212"(dopamine receptor signaling pathway)|rcsb pdb:2JDO|rcsb pdb:2JDR|rcsb pdb:2JLD|rcsb pdb:2O5K|rcsb pdb:2OW3|rcsb pdb:2UW9|rcsb pdb:2X39|rcsb pdb:2XH5|rcsb pdb:3CQU|rcsb pdb:3CQW|rcsb pdb:3DU8|rcsb pdb:3E87|rcsb pdb:3E88|rcsb pdb:3E8D|rcsb pdb:3F7Z|rcsb pdb:3F88|rcsb pdb:3GB2|rcsb pdb:3I4B|rcsb pdb:3L1S|rcsb pdb:3M1S|rcsb pdb:3MV5|rcsb pdb:3OW4|rcsb pdb:3PUP|rcsb pdb:3Q3B|rcsb pdb:3QKK|rcsb pdb:3SAY|rcsb pdb:3SD0|rcsb pdb:3ZDI|rcsb pdb:3ZRK|rcsb pdb:3ZRL|rcsb pdb:3ZRM|rcsb pdb:4ACC|rcsb pdb:4ACD|rcsb pdb:4ACG|rcsb pdb:4ACH|rcsb pdb:4AFJ|rcsb pdb:4B7T|rcsb pdb:4DIT|rcsb pdb:4EKK|rcsb pdb:4IQ6|rcsb pdb:4J1R|rcsb pdb:4PTE|rcsb pdb:4PTG|rcsb pdb:5F94|rcsb pdb:5F95|rcsb pdb:5HLN|rcsb pdb:5HLP|rcsb pdb:5K5N|rcsb pdb:5KPK|rcsb pdb:5KPL|rcsb pdb:5KPM|rcsb pdb:5OY4|rcsb pdb:5T31|rcsb pdb:6B8J|rcsb pdb:6BUU|rcsb pdb:6GJO|rcsb pdb:6GN1|rcsb pdb:6H0U|rcsb pdb:6HK3|rcsb pdb:6HK4|rcsb pdb:6HK7|rcsb pdb:6NPZ|rcsb pdb:6TCU|rcsb pdb:6V6L|rcsb pdb:6Y9R|rcsb pdb:6Y9S|rcsb pdb:7B6F|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198323|reactome:R-HSA-3371453|reactome:R-HSA-399956|reactome:R-HSA-4641262|reactome:R-HSA-5250924|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5674400|reactome:R-HSA-75815|reactome:R-HSA-8939902|rcsb pdb:4J71|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4PTC|reactome:R-HSA-9682706|reactome:R-HSA-9683610|reactome:R-HSA-9694631|reactome:R-HSA-9694686|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019082"(viral protein processing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034452"(dynactin binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048156"(tau protein binding)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071109"(superior temporal gyrus development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106027"(neuron projection organization)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0106311"|go:"GO:0150101"(regulation of microtubule anchoring at centrosome)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1904886"(beta-catenin destruction complex disassembly)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000077"(negative regulation of type B pancreatic cell development)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000466"("negative regulation of glycogen (starch) synthase activity")|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033573|interpro:IPR039192|mint:P49841|rcsb pdb:1GNG|rcsb pdb:1H8F|rcsb pdb:1I09|rcsb pdb:1J1B|rcsb pdb:1J1C|rcsb pdb:1O6K|rcsb pdb:1O6L|rcsb pdb:1O9U|rcsb pdb:1PYX|rcsb pdb:1Q3D|rcsb pdb:1Q3W|rcsb pdb:1Q41|rcsb pdb:1Q4L|rcsb pdb:1Q5K|rcsb pdb:1R0E|rcsb pdb:1UV5|go:"GO:0106310"(protein serine kinase activity)|dip:DIP-878N	psi-mi:"MI:0465"(dip)	-	-	figure legend:S1B|agonist:XAV939|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sw480)|taxid:9606(Human SW480 adenocarcinoma cell line)	-	2011/09/08	2017/06/30	rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606	rogid:dhXyRv7fPByw6we1Rbmh8pYS05o9606	intact-crc:6130271AC8C69BE9|rigid:m32pJ7YUONUDrgnUZe2m7Lj8KJ4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95271	uniprotkb:O35625	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	intact:EBI-2365912	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400085|imex:IM-16356-1|dip:DIP-187506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	imex:"MI:0465"(imex source)	-	-	figure legend:Fig 4B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2011/09/08	2017/06/30	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	intact-crc:3F16B104FD685128|rigid:GRFAaNAtM0rj3bXZVjXNgOiy7fY	false	-	necessary binding region:19-30	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35625	uniprotkb:O95271	intact:EBI-2365912	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4422214|imex:IM-16356-4|dip:DIP-187506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	psi-mi:"MI:0465"(dip)	-	-	figure legend:Supplementary Fig. 6a.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2011/09/08	2017/06/30	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:5CC3594EDBDEFFFC|rigid:GRFAaNAtM0rj3bXZVjXNgOiy7fY	false	-	sufficient binding region:668-1010(IPR002110)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95271	uniprotkb:O35625	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	intact:EBI-2365912	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:"MI:0096"(pull down)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400101|imex:IM-16356-8|dip:DIP-187506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/08	2017/06/30	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	intact-crc:8666EE582BCDD8ED|rigid:GRFAaNAtM0rj3bXZVjXNgOiy7fY	false	flag tag:?-?	necessary binding region:19-30|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35625	uniprotkb:O95271	intact:EBI-2365912	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym)	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Huang et al. (2009)	pubmed:19759537|imex:IM-16356	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-4400210|imex:IM-16356-6|dip:DIP-187506E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	psi-mi:"MI:0465"(dip)	-	-	figure legend:Fig 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2011/09/08	2017/06/30	rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	intact-crc:F15B25ED4F4AE525|rigid:GRFAaNAtM0rj3bXZVjXNgOiy7fY	false	green fluorescent protein tag:?-?|necessary binding region:19-30	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)