#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P05771-2 uniprotkb:O60346 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-7750591|mint:MINT-8297217 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297220(identity) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2|mint:MINT-8297219(identity) - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660. - figure legend:F1A|comment:mint|causality statement:O60346 is required for dephosphorylation of P05771-2|causality statement:O60346 increases degradation at protein level of P05771-2|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/11/30 2014/10/16 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:18E4288FE5157D77|rigid:v9nD/nwNakjIHyFaNTis/iLqRV0 false his tag:?-? glutathione s tranferase tag:?-?|sufficient binding region:1165-1418(IPR001932) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P05771-2 uniprotkb:O60346 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0027"(cosedimentation) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7750675|mint:MINT-8297228 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297230(identity) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2|mint:MINT-8297231(identity) - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660.|comment:"Resulting Phenotypic qualities properties)[PATO]: PATO:0002263 (dephosphorylated)" - figure legend:F1B|comment:mint|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2011/11/30 2017/11/15 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:99D5F0CDFF1005D6|rigid:v9nD/nwNakjIHyFaNTis/iLqRV0 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P05771-2 uniprotkb:Q6ZVD8 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0027"(cosedimentation) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7750936|mint:MINT-8297301 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297304(identity) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418|mint:MINT-8297303(identity) - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660.|comment:"Resulting Phenotypic qualities properties)[PATO]: PATO:0002263 (dephosphorylated)" - figure legend:F4A|comment:mint|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2011/11/30 2017/11/15 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 intact-crc:217C00C43E96ED52|rigid:Mm7v6BkC4Y58BqP0tqupiYjOEy4 false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P35813 uniprotkb:P05771-2 intact:EBI-989143|uniprotkb:O75551|uniprotkb:B5BU11|uniprotkb:J3KNM0|ensembl:ENSP00000378514 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 psi-mi:ppm1a_human(display_long)|uniprotkb:Protein phosphatase 2C isoform alpha(gene name synonym)|uniprotkb:PPM1A(gene name)|psi-mi:PPM1A(display_short)|uniprotkb:PPPM1A(gene name synonym)|uniprotkb:Protein phosphatase IA(gene name synonym) psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7750745|mint:MINT-8297248 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011535181.1|refseq:XP_011535180.1|refseq:NP_066283.1|refseq:NP_808820.1|refseq:NP_808821.2|refseq:XP_011535182.1|refseq:XP_011535183.1|refseq:XP_011535184.1|refseq:XP_011535185.1|refseq:XP_011535186.1|refseq:XP_005267836.1|refseq:XP_005267838.1|refseq:XP_016876873.1|refseq:XP_016876874.1|refseq:XP_016876875.1|refseq:XP_016876876.1|ensembl:ENSG00000100614(gene)|ensembl:ENST00000395076(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:P35813|rcsb pdb:1A6Q|rcsb pdb:3FXJ|rcsb pdb:3FXK|rcsb pdb:3FXM|rcsb pdb:3FXO|rcsb pdb:4RA2|rcsb pdb:4RAF|rcsb pdb:4RAG|rcsb pdb:6B67|rcsb pdb:3FXL|reactome:R-HSA-2173795|reactome:R-HSA-380972|mint:MINT-8297250(identity) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297251(identity) - - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660. figure legend:F2A|comment:mint|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2011/11/30 2017/11/15 rogid:6Bhsr96yCyS7GN3SgN64RrNJTWk9606 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 intact-crc:C71ACB55DB747928|rigid:NSvkHLJRIfoDmFDqmOcOf/wMBxE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P05771-2 uniprotkb:O60346 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7750722|mint:MINT-8297241 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297244(identity) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2|mint:MINT-8297243(identity) - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660. - comment:mint|figure legend:F2A; F3B,C|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2011/11/30 2014/10/16 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:F89148FFDA583677|rigid:v9nD/nwNakjIHyFaNTis/iLqRV0 false - mutation decreasing interaction:513-658(IPR001849)|ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P05771-2 uniprotkb:Q6ZVD8 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7750753|mint:MINT-8297321 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297324(identity) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418|mint:MINT-8297323(identity) - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660. - figure legend:F4B|comment:mint|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2011/11/30 2017/11/15 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 intact-crc:5CAA0827F0008682|rigid:Mm7v6BkC4Y58BqP0tqupiYjOEy4 false - ha tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P05771-2 uniprotkb:O60346 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7750847|mint:MINT-8297257 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297260(identity) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2|mint:MINT-8297259(identity) - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660. - figure legend:F2B|comment:mint|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/11/30 2014/10/16 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:A8BC07F08BFB58CF|rigid:v9nD/nwNakjIHyFaNTis/iLqRV0 false sufficient binding region:32-111(IPR002219)|sufficient binding region:296-673(IPR002290)|glutathione s tranferase tag:?-? ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P05771-2 uniprotkb:O60346 intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gao et al. (2008) doi:10.1074/jbc.M707319200|pubmed:18162466|mint:MINT-8296472 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7750890|mint:MINT-8297270 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)|mint:MINT-8297273(identity) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2|mint:MINT-8297272(identity) - isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660. - figure legend:F2C|comment:mint|dataset:IBD - Inflammatory bowel disease|partial coverage:partial coverage|curation depth:rapid curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2011/11/30 2014/10/16 rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:17C9D38993F83308|rigid:v9nD/nwNakjIHyFaNTis/iLqRV0 false - sufficient binding region:1165-1418(IPR001932)|sufficient binding region:513-658(IPR001849)|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)