#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UHD9 uniprotkb:P54725 intact:EBI-947187|uniprotkb:O94798|uniprotkb:Q9H3W6|uniprotkb:Q9HAZ4|uniprotkb:Q5D027|intact:EBI-28967571|ensembl:ENSP00000345195 intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024 psi-mi:ubql2_human(display_long)|uniprotkb:UBQLN2(gene name)|psi-mi:UBQLN2(display_short)|uniprotkb:PLIC2(gene name synonym)|uniprotkb:HRIHFB2157(orf name)|uniprotkb:N4BP4(gene name synonym)|uniprotkb:Protein linking IAP with cytoskeleton 2(gene name synonym)|uniprotkb:Ubiquitin-like product Chap1/Dsk2(gene name synonym)|uniprotkb:DSK2 homolog(gene name synonym)|uniprotkb:Chap1(gene name synonym) psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Kang et al. (2007) pubmed:17098253|imex:IM-17271 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-4292820|imex:IM-17271-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000345195|refseq:NP_038472.2|dip:DIP-42116N|ensembl:ENSG00000188021(gene)|ensembl:ENST00000338222(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028430|interpro:IPR029071|mint:Q9UHD9|rcsb pdb:1J8C|rcsb pdb:2NBV|rcsb pdb:6MUN|reactome:R-HSA-8856825 refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395 - - - figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/06/28 2014/10/16 rogid:tElcz7gHFkKFVDTz3PXeNcaBP7U9606 rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606 intact-crc:506A83952E88E1DD|rigid:jlyIyNPIA48+evspZsmfY9Szugk false sufficient binding region:574-624(IPR015496)|glutathione s tranferase tag:?-? sufficient binding region:1-81(IPR000626) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54725 uniprotkb:Q9UHD9 intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024 intact:EBI-947187|uniprotkb:O94798|uniprotkb:Q9H3W6|uniprotkb:Q9HAZ4|uniprotkb:Q5D027|intact:EBI-28967571|ensembl:ENSP00000345195 psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short) psi-mi:ubql2_human(display_long)|uniprotkb:UBQLN2(gene name)|psi-mi:UBQLN2(display_short)|uniprotkb:PLIC2(gene name synonym)|uniprotkb:HRIHFB2157(orf name)|uniprotkb:N4BP4(gene name synonym)|uniprotkb:Protein linking IAP with cytoskeleton 2(gene name synonym)|uniprotkb:Ubiquitin-like product Chap1/Dsk2(gene name synonym)|uniprotkb:DSK2 homolog(gene name synonym)|uniprotkb:Chap1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Kang et al. (2007) pubmed:17098253|imex:IM-17271 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0486"(UniProt) intact:EBI-4303153|imex:IM-17271-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395 ensembl:ENSP00000345195|refseq:NP_038472.2|dip:DIP-42116N|ensembl:ENSG00000188021(gene)|ensembl:ENST00000338222(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028430|interpro:IPR029071|mint:Q9UHD9|rcsb pdb:1J8C|rcsb pdb:2NBV|rcsb pdb:6MUN|reactome:R-HSA-8856825 - - - figure legend:1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2011/06/28 2014/10/16 rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606 rogid:tElcz7gHFkKFVDTz3PXeNcaBP7U9606 intact-crc:DCB8FD148A1EF89E|rigid:jlyIyNPIA48+evspZsmfY9Szugk false sufficient binding region:319-363(IPR015940) sufficient binding region:26-103(IPR000626)|glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P54725 uniprotkb:Q9UHD9 intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024 intact:EBI-947187|uniprotkb:O94798|uniprotkb:Q9H3W6|uniprotkb:Q9HAZ4|uniprotkb:Q5D027|intact:EBI-28967571|ensembl:ENSP00000345195 psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short) psi-mi:ubql2_human(display_long)|uniprotkb:UBQLN2(gene name)|psi-mi:UBQLN2(display_short)|uniprotkb:PLIC2(gene name synonym)|uniprotkb:HRIHFB2157(orf name)|uniprotkb:N4BP4(gene name synonym)|uniprotkb:Protein linking IAP with cytoskeleton 2(gene name synonym)|uniprotkb:Ubiquitin-like product Chap1/Dsk2(gene name synonym)|uniprotkb:DSK2 homolog(gene name synonym)|uniprotkb:Chap1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kang et al. (2007) pubmed:17098253|imex:IM-17271 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-4292831|imex:IM-17271-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395 ensembl:ENSP00000345195|refseq:NP_038472.2|dip:DIP-42116N|ensembl:ENSG00000188021(gene)|ensembl:ENST00000338222(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904021"(negative regulation of G protein-coupled receptor internalization)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028430|interpro:IPR029071|mint:Q9UHD9|rcsb pdb:1J8C|rcsb pdb:2NBV|rcsb pdb:6MUN|reactome:R-HSA-8856825 - - - figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2011/06/28 2014/10/16 rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606 rogid:tElcz7gHFkKFVDTz3PXeNcaBP7U9606 intact-crc:912A3B639E3D7566|rigid:jlyIyNPIA48+evspZsmfY9Szugk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)