#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9DBB1	uniprotkb:P63085	intact:EBI-7812384|ensembl:ENSMUSP00000020118|intact:UNK-5544408|uniprotkb:Q9D7L4|uniprotkb:Q542I5	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:dus6_mouse(display_long)|uniprotkb:Dusp6(gene name)|psi-mi:Dusp6(display_short)|uniprotkb:Mkp3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase phosphatase 3(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tárrega et al. (2005)	pubmed:16148006|mint:MINT-8209392|doi:10.1074/jbc.M504366200	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7812434|mint:MINT-8209403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000019960(gene)|ensembl:ENSMUST00000020118(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051409"(response to nitrosative stress)|go:"GO:0060420"(regulation of heart growth)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|reactome:R-MMU-112409|reactome:R-MMU-202670|reactome:R-MMU-5675221|go:"GO:0042493"|refseq:NP_080544.1|mint:MINT-8209405(identity)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772|mint:MINT-8209406(identity)	-	comment:mint|function:Inactivates MAP kinases. Has a specificity for the ERK family	-	figure legend:f4b|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2011/09/30	2014/10/16	rogid:X9QpkZZQte15H0lr4cTZUZ5mzYA10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:4FD27353C509568F|rigid:wyx/ZwWefIw+0LBpjyWg15MOq8E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62132	uniprotkb:P63085	intact:EBI-6954051|ensembl:ENSMUSP00000064392|uniprotkb:Q64491|uniprotkb:Q9QUH9|intact:MINT-99987|uniprotkb:Q64492	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:ptprr_mouse(display_long)|uniprotkb:Ptprr(gene name)|psi-mi:Ptprr(display_short)|uniprotkb:Ptp13(gene name synonym)|uniprotkb:Phosphotyrosine phosphatase 13(gene name synonym)|uniprotkb:Protein-tyrosine-phosphatase SL(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Tárrega et al. (2005)	pubmed:16148006|mint:MINT-8209392|doi:10.1074/jbc.M504366200	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7812448|mint:MINT-8209414	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020151(gene)|ensembl:ENSMUST00000063470(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008356(Protein-tyrosine phosphatase, KIM-containing)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016334(Protein-tyrosine phosphatase, receptor type R/non-receptor type 5)|interpro:IPR029021|rcsb pdb:1JLN|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:NP_001155311.1|refseq:NP_035347.1|refseq:NP_001155312.1|refseq:NP_001155309.1|refseq:NP_001155310.1|mint:MINT-8209416(identity)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772|mint:MINT-8209417(identity)	-	comment:mint|function:"Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton"	-	figure legend:f4b|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2011/09/30	2014/10/16	rogid:xzLOLSS+hrBdcqZeAjUo6k+B9Ag10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:C14AD9FFD6153FF9|rigid:ZyujgRuS4xlLiw99ndvKBykpLBc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62132	uniprotkb:P63085	intact:EBI-6954051|ensembl:ENSMUSP00000064392|uniprotkb:Q64491|uniprotkb:Q9QUH9|intact:MINT-99987|uniprotkb:Q64492	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:ptprr_mouse(display_long)|uniprotkb:Ptprr(gene name)|psi-mi:Ptprr(display_short)|uniprotkb:Ptp13(gene name synonym)|uniprotkb:Phosphotyrosine phosphatase 13(gene name synonym)|uniprotkb:Protein-tyrosine-phosphatase SL(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Tárrega et al. (2005)	pubmed:16148006|mint:MINT-8209392|doi:10.1074/jbc.M504366200	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7812468|mint:MINT-8209605	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020151(gene)|ensembl:ENSMUST00000063470(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008356(Protein-tyrosine phosphatase, KIM-containing)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016334(Protein-tyrosine phosphatase, receptor type R/non-receptor type 5)|interpro:IPR029021|rcsb pdb:1JLN|go:"GO:0004725"(protein tyrosine phosphatase activity)|refseq:NP_001155311.1|refseq:NP_035347.1|refseq:NP_001155312.1|refseq:NP_001155309.1|refseq:NP_001155310.1|mint:MINT-8209608(identity)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772|mint:MINT-8209607(identity)	-	comment:mint|function:"Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton"	-	figure legend:f5|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/30	2014/10/16	rogid:xzLOLSS+hrBdcqZeAjUo6k+B9Ag10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:F113433A23F347E7|rigid:ZyujgRuS4xlLiw99ndvKBykpLBc	false	-	mutation disrupting interaction:79-79(MINT-8209614)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9DBB1	uniprotkb:P63085	intact:EBI-7812384|ensembl:ENSMUSP00000020118|intact:UNK-5544408|uniprotkb:Q9D7L4|uniprotkb:Q542I5	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:dus6_mouse(display_long)|uniprotkb:Dusp6(gene name)|psi-mi:Dusp6(display_short)|uniprotkb:Mkp3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase phosphatase 3(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0434"(phosphatase assay)	Tárrega et al. (2005)	pubmed:16148006|mint:MINT-8209392|doi:10.1074/jbc.M504366200	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7812501|mint:MINT-8209618	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000019960(gene)|ensembl:ENSMUST00000020118(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051409"(response to nitrosative stress)|go:"GO:0060420"(regulation of heart growth)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|reactome:R-MMU-112409|reactome:R-MMU-202670|reactome:R-MMU-5675221|go:"GO:0042493"|refseq:NP_080544.1|mint:MINT-8209624(identity)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772|mint:MINT-8209620(identity)	-	comment:mint|function:Inactivates MAP kinases. Has a specificity for the ERK family	-	figure legend:f5|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2011/09/30	2014/10/16	rogid:X9QpkZZQte15H0lr4cTZUZ5mzYA10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:2C634820DC5C01FC|rigid:wyx/ZwWefIw+0LBpjyWg15MOq8E	false	-	mutation disrupting interaction:79-79(MINT-8209621)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)