#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88566	uniprotkb:Q9BV73	intact:EBI-7690990|ensembl:ENSMUSP00000051331|uniprotkb:Q6PFZ9|uniprotkb:Q9QXJ6|intact:MINT-1951339	intact:EBI-1053100|uniprotkb:O14812|uniprotkb:O60588|uniprotkb:Q9H450|uniprotkb:E1P5Q3|ensembl:ENSP00000380661	psi-mi:axin2_mouse(display_long)|uniprotkb:Axin2(gene name)|psi-mi:Axin2(display_short)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)|uniprotkb:Axin-like protein(gene name synonym)	psi-mi:cp250_human(display_long)|uniprotkb:Centrosomal protein 2(gene name synonym)|uniprotkb:Centrosomal Nek2-associated protein 1(gene name synonym)|uniprotkb:CEP250(gene name)|psi-mi:CEP250(display_short)|uniprotkb:CEP2(gene name synonym)|uniprotkb:CNAP1(gene name synonym)|uniprotkb:250 kDa centrosomal protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hadjihannas et al. (2010)	pubmed:20300119|imex:IM-15686|mint:MINT-7718587|doi:10.1038/embor.2010.23	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7866996|mint:MINT-7718819|imex:IM-15686-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000142(gene)|ensembl:ENSMUST00000052915(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008219"(cell death)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O88566|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-5689880|refseq:NP_056547.3|refseq:XP_006532120.1|refseq:XP_006532121.1|refseq:XP_006532122.1|refseq:XP_006532123.1|dip:DIP-42640N|mint:MINT-7718821(identity)	refseq:NP_009117.2|dip:DIP-39406N|refseq:NP_001305148.1|refseq:XP_005260319.1|refseq:XP_006723753.1|refseq:XP_006723754.1|refseq:XP_006723755.1|refseq:XP_006723756.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|mint:Q9BV73|rcsb pdb:6OQA|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000126001(gene)|ensembl:ENST00000397527(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0060271"(cilium assembly)|mint:MINT-7718822(identity)	-	comment:mint|comment:homomint|function:Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2010/03/31	2014/10/16	rogid:pe97ZaMiGSH6OBLnomdG1TmcqwU10090	rogid:We+5inOR7merXjzOl/vRehewlFA9606	intact-crc:A6291AE28E7FA358|rigid:O+ZnW9Uj66WJC13hY6JTi/oX7VY	false	binding-associated region:?-?(MINT-7718829)	myc tag:?-?(MINT-7718824)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O88566	uniprotkb:Q9BV73	intact:EBI-7690990|ensembl:ENSMUSP00000051331|uniprotkb:Q6PFZ9|uniprotkb:Q9QXJ6|intact:MINT-1951339	intact:EBI-1053100|uniprotkb:O14812|uniprotkb:O60588|uniprotkb:Q9H450|uniprotkb:E1P5Q3|ensembl:ENSP00000380661	psi-mi:axin2_mouse(display_long)|uniprotkb:Axin2(gene name)|psi-mi:Axin2(display_short)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)|uniprotkb:Axin-like protein(gene name synonym)	psi-mi:cp250_human(display_long)|uniprotkb:Centrosomal protein 2(gene name synonym)|uniprotkb:Centrosomal Nek2-associated protein 1(gene name synonym)|uniprotkb:CEP250(gene name)|psi-mi:CEP250(display_short)|uniprotkb:CEP2(gene name synonym)|uniprotkb:CNAP1(gene name synonym)|uniprotkb:250 kDa centrosomal protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hadjihannas et al. (2010)	pubmed:20300119|imex:IM-15686|mint:MINT-7718587|doi:10.1038/embor.2010.23	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7867035|mint:MINT-7718851|imex:IM-15686-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000142(gene)|ensembl:ENSMUST00000052915(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008219"(cell death)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O88566|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-5689880|refseq:NP_056547.3|refseq:XP_006532120.1|refseq:XP_006532121.1|refseq:XP_006532122.1|refseq:XP_006532123.1|dip:DIP-42640N|mint:MINT-7718854(identity)	refseq:NP_009117.2|dip:DIP-39406N|refseq:NP_001305148.1|refseq:XP_005260319.1|refseq:XP_006723753.1|refseq:XP_006723754.1|refseq:XP_006723755.1|refseq:XP_006723756.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|mint:Q9BV73|rcsb pdb:6OQA|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000126001(gene)|ensembl:ENST00000397527(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0060271"(cilium assembly)|mint:MINT-7718858(identity)	-	comment:mint|comment:homomint|function:Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B	-	figure legend:sf2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2010/03/31	2014/10/16	rogid:pe97ZaMiGSH6OBLnomdG1TmcqwU10090	rogid:We+5inOR7merXjzOl/vRehewlFA9606	intact-crc:44DCE2162DB1E36B|rigid:O+ZnW9Uj66WJC13hY6JTi/oX7VY	false	green fluorescent protein tag:?-?(MINT-7718855)	myc tag:?-?(MINT-7718859)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O88566	uniprotkb:Q9BV73	intact:EBI-7690990|ensembl:ENSMUSP00000051331|uniprotkb:Q6PFZ9|uniprotkb:Q9QXJ6|intact:MINT-1951339	intact:EBI-1053100|uniprotkb:O14812|uniprotkb:O60588|uniprotkb:Q9H450|uniprotkb:E1P5Q3|ensembl:ENSP00000380661	psi-mi:axin2_mouse(display_long)|uniprotkb:Axin2(gene name)|psi-mi:Axin2(display_short)|uniprotkb:Axis inhibition protein 2(gene name synonym)|uniprotkb:Conductin(gene name synonym)|uniprotkb:Axin-like protein(gene name synonym)	psi-mi:cp250_human(display_long)|uniprotkb:Centrosomal protein 2(gene name synonym)|uniprotkb:Centrosomal Nek2-associated protein 1(gene name synonym)|uniprotkb:CEP250(gene name)|psi-mi:CEP250(display_short)|uniprotkb:CEP2(gene name synonym)|uniprotkb:CNAP1(gene name synonym)|uniprotkb:250 kDa centrosomal protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hadjihannas et al. (2010)	pubmed:20300119|imex:IM-15686|mint:MINT-7718587|doi:10.1038/embor.2010.23	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7867259|mint:MINT-7718832|imex:IM-15686-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000142(gene)|ensembl:ENSMUST00000052915(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003413"(chondrocyte differentiation involved in endochondral bone morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008219"(cell death)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032423"(regulation of mismatch repair)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042476"(odontogenesis)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0061181"(regulation of chondrocyte development)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O88566|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-5689880|refseq:NP_056547.3|refseq:XP_006532120.1|refseq:XP_006532121.1|refseq:XP_006532122.1|refseq:XP_006532123.1|dip:DIP-42640N|mint:MINT-7718838(identity)	refseq:NP_009117.2|dip:DIP-39406N|refseq:NP_001305148.1|refseq:XP_005260319.1|refseq:XP_006723753.1|refseq:XP_006723754.1|refseq:XP_006723755.1|refseq:XP_006723756.1|go:"GO:0070062"(extracellular exosome)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|mint:Q9BV73|rcsb pdb:6OQA|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000126001(gene)|ensembl:ENST00000397527(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050908"(detection of light stimulus involved in visual perception)|go:"GO:0060271"(cilium assembly)|mint:MINT-7718834(identity)	go:"GO:0005813"(centrosome)	comment:mint|comment:homomint|function:Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B	-	figure legend:f1d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2010/03/31	2014/10/16	rogid:pe97ZaMiGSH6OBLnomdG1TmcqwU10090	rogid:We+5inOR7merXjzOl/vRehewlFA9606	intact-crc:9DFFAAF9DAFBF375|rigid:O+ZnW9Uj66WJC13hY6JTi/oX7VY	false	flag tag:?-?(MINT-7718847)	green fluorescent protein tag:?-?(MINT-7718835)	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0396"(predetermined participant)