#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00763	uniprotkb:P50747	intact:EBI-2211739|uniprotkb:A6NK36|uniprotkb:Q16852|uniprotkb:Q1HEC1|uniprotkb:Q6KE87|uniprotkb:Q6KE89|uniprotkb:Q6TY48|intact:EBI-28983570|ensembl:ENSP00000341044|ensembl:ENSP00000367079	intact:EBI-3915568|uniprotkb:B2RAH1|uniprotkb:D3DSG6|uniprotkb:Q99451|ensembl:ENSP00000338387|ensembl:ENSP00000382071|ensembl:ENSP00000479939|ensembl:ENSP00000501750	psi-mi:acacb_human(display_long)|uniprotkb:ACACB(gene name)|psi-mi:ACACB(display_short)|uniprotkb:ACC2(gene name synonym)|uniprotkb:ACCB(gene name synonym)|uniprotkb:ACC-beta(gene name synonym)	psi-mi:bpl1_human(display_long)|uniprotkb:HLCS(gene name)|psi-mi:HLCS(display_short)|uniprotkb:Biotin apo-protein ligase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lee et al. (2010)	pubmed:20085763|imex:IM-15469|mint:MINT-7543048|mint:d-09-02164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7741924|mint:MINT-7543053|imex:IM-15469-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536561.1|refseq:XP_006719430.1|ensembl:ENSP00000341044|ensembl:ENSP00000367079|refseq:NP_001084.3|refseq:XP_005253933.1|dip:DIP-51617N|ensembl:ENSG00000076555(gene)|ensembl:ENST00000338432(transcript)|ensembl:ENST00000377848(transcript)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0097009"(energy homeostasis)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:O00763|rcsb pdb:2DN8|rcsb pdb:2HJW|rcsb pdb:2KCC|rcsb pdb:3FF6|rcsb pdb:3GID|rcsb pdb:3GLK|rcsb pdb:3JRW|rcsb pdb:3JRX|rcsb pdb:3TDC|rcsb pdb:4HQ6|rcsb pdb:5KKN|reactome:R-HSA-163765|reactome:R-HSA-196780|reactome:R-HSA-200425|reactome:R-HSA-2426168|mint:MINT-7543055(identity)	refseq:XP_011527840.1|refseq:XP_011527841.1|refseq:XP_011527843.1|refseq:NP_000402.3|refseq:NP_001229713.1|refseq:NP_001229714.1|refseq:XP_006724057.1|refseq:XP_006724058.1|ensembl:ENSG00000159267(gene)|ensembl:ENST00000336648(transcript)|ensembl:ENST00000399120(transcript)|ensembl:ENST00000612277(transcript)|ensembl:ENST00000675307(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004077"(biotin-[acetyl-CoA-carboxylase] ligase activity)|go:"GO:0004078"(biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity)|go:"GO:0004079"(biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity)|go:"GO:0004080"("biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009305"(protein biotinylation)|go:"GO:0009374"(biotin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016570"(histone modification)|go:"GO:0018271"(biotin-protein ligase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0070781"(response to biotin)|go:"GO:0071110"(histone biotinylation)|interpro:IPR003142(Biotin protein ligase, C-terminal)|interpro:IPR004143(Biotin/lipoate A/B protein ligase)|interpro:IPR004408(Biotin--acetyl-CoA-carboxylase ligase)|interpro:IPR019197|mint:P50747|reactome:R-HSA-196780|reactome:R-HSA-3371599|refseq:XP_005261012.1|refseq:XP_005261013.1|refseq:XP_016883819.1|mint:MINT-7543056(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1b f1c f1d|comment:The ACC75 is biotinylated by 161-HCS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/14	2014/10/16	rogid:P4hgekQx/AZz4InTWHW6u6jpDRA9606	rogid:X8k29PN2JnB6ljCcl4fYCAJ4ahM9606	intact-crc:88065FA66A211BE8|rigid:MKHD1iFkAu+fNrUbHqn2DIPhsvo	false	uncategorized protein modification:929-929(MINT-7543066)|binding-associated region:895-961(MINT-7543064)	binding-associated region:1-160(MINT-7543059)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00763	uniprotkb:P50747	intact:EBI-2211739|uniprotkb:A6NK36|uniprotkb:Q16852|uniprotkb:Q1HEC1|uniprotkb:Q6KE87|uniprotkb:Q6KE89|uniprotkb:Q6TY48|intact:EBI-28983570|ensembl:ENSP00000341044|ensembl:ENSP00000367079	intact:EBI-3915568|uniprotkb:B2RAH1|uniprotkb:D3DSG6|uniprotkb:Q99451|ensembl:ENSP00000338387|ensembl:ENSP00000382071|ensembl:ENSP00000479939|ensembl:ENSP00000501750	psi-mi:acacb_human(display_long)|uniprotkb:ACACB(gene name)|psi-mi:ACACB(display_short)|uniprotkb:ACC2(gene name synonym)|uniprotkb:ACCB(gene name synonym)|uniprotkb:ACC-beta(gene name synonym)	psi-mi:bpl1_human(display_long)|uniprotkb:HLCS(gene name)|psi-mi:HLCS(display_short)|uniprotkb:Biotin apo-protein ligase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lee et al. (2010)	pubmed:20085763|imex:IM-15469|mint:MINT-7543048|mint:d-09-02164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7741999|mint:MINT-7543096|imex:IM-15469-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536561.1|refseq:XP_006719430.1|ensembl:ENSP00000341044|ensembl:ENSP00000367079|refseq:NP_001084.3|refseq:XP_005253933.1|dip:DIP-51617N|ensembl:ENSG00000076555(gene)|ensembl:ENST00000338432(transcript)|ensembl:ENST00000377848(transcript)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0097009"(energy homeostasis)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:O00763|rcsb pdb:2DN8|rcsb pdb:2HJW|rcsb pdb:2KCC|rcsb pdb:3FF6|rcsb pdb:3GID|rcsb pdb:3GLK|rcsb pdb:3JRW|rcsb pdb:3JRX|rcsb pdb:3TDC|rcsb pdb:4HQ6|rcsb pdb:5KKN|reactome:R-HSA-163765|reactome:R-HSA-196780|reactome:R-HSA-200425|reactome:R-HSA-2426168|mint:MINT-7543098(identity)	refseq:XP_011527840.1|refseq:XP_011527841.1|refseq:XP_011527843.1|refseq:NP_000402.3|refseq:NP_001229713.1|refseq:NP_001229714.1|refseq:XP_006724057.1|refseq:XP_006724058.1|ensembl:ENSG00000159267(gene)|ensembl:ENST00000336648(transcript)|ensembl:ENST00000399120(transcript)|ensembl:ENST00000612277(transcript)|ensembl:ENST00000675307(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004077"(biotin-[acetyl-CoA-carboxylase] ligase activity)|go:"GO:0004078"(biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity)|go:"GO:0004079"(biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity)|go:"GO:0004080"("biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009305"(protein biotinylation)|go:"GO:0009374"(biotin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016570"(histone modification)|go:"GO:0018271"(biotin-protein ligase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0070781"(response to biotin)|go:"GO:0071110"(histone biotinylation)|interpro:IPR003142(Biotin protein ligase, C-terminal)|interpro:IPR004143(Biotin/lipoate A/B protein ligase)|interpro:IPR004408(Biotin--acetyl-CoA-carboxylase ligase)|interpro:IPR019197|mint:P50747|reactome:R-HSA-196780|reactome:R-HSA-3371599|refseq:XP_005261012.1|refseq:XP_005261013.1|refseq:XP_016883819.1|mint:MINT-7543104(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f3c f3d f4b f4d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/14	2014/10/16	rogid:P4hgekQx/AZz4InTWHW6u6jpDRA9606	rogid:X8k29PN2JnB6ljCcl4fYCAJ4ahM9606	intact-crc:F69BD25B58D911A1|rigid:MKHD1iFkAu+fNrUbHqn2DIPhsvo	false	binding-associated region:895-961(MINT-7543101)	binding-associated region:1-160(MINT-7543105)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50747	uniprotkb:P50747	intact:EBI-3915568|uniprotkb:B2RAH1|uniprotkb:D3DSG6|uniprotkb:Q99451|ensembl:ENSP00000338387|ensembl:ENSP00000382071|ensembl:ENSP00000479939|ensembl:ENSP00000501750	intact:EBI-3915568|uniprotkb:B2RAH1|uniprotkb:D3DSG6|uniprotkb:Q99451|ensembl:ENSP00000338387|ensembl:ENSP00000382071|ensembl:ENSP00000479939|ensembl:ENSP00000501750	psi-mi:bpl1_human(display_long)|uniprotkb:HLCS(gene name)|psi-mi:HLCS(display_short)|uniprotkb:Biotin apo-protein ligase(gene name synonym)	psi-mi:bpl1_human(display_long)|uniprotkb:HLCS(gene name)|psi-mi:HLCS(display_short)|uniprotkb:Biotin apo-protein ligase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lee et al. (2010)	pubmed:20085763|imex:IM-15469|mint:MINT-7543048|mint:d-09-02164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7742070|mint:MINT-7543113|imex:IM-15469-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011527840.1|refseq:XP_011527841.1|refseq:XP_011527843.1|refseq:NP_000402.3|refseq:NP_001229713.1|refseq:NP_001229714.1|refseq:XP_006724057.1|refseq:XP_006724058.1|ensembl:ENSG00000159267(gene)|ensembl:ENST00000336648(transcript)|ensembl:ENST00000399120(transcript)|ensembl:ENST00000612277(transcript)|ensembl:ENST00000675307(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004077"(biotin-[acetyl-CoA-carboxylase] ligase activity)|go:"GO:0004078"(biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity)|go:"GO:0004079"(biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity)|go:"GO:0004080"("biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009305"(protein biotinylation)|go:"GO:0009374"(biotin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016570"(histone modification)|go:"GO:0018271"(biotin-protein ligase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0070781"(response to biotin)|go:"GO:0071110"(histone biotinylation)|interpro:IPR003142(Biotin protein ligase, C-terminal)|interpro:IPR004143(Biotin/lipoate A/B protein ligase)|interpro:IPR004408(Biotin--acetyl-CoA-carboxylase ligase)|interpro:IPR019197|mint:P50747|reactome:R-HSA-196780|reactome:R-HSA-3371599|refseq:XP_005261012.1|refseq:XP_005261013.1|refseq:XP_016883819.1|mint:MINT-7543119(identity)	refseq:XP_011527840.1|refseq:XP_011527841.1|refseq:XP_011527843.1|refseq:NP_000402.3|refseq:NP_001229713.1|refseq:NP_001229714.1|refseq:XP_006724057.1|refseq:XP_006724058.1|ensembl:ENSG00000159267(gene)|ensembl:ENST00000336648(transcript)|ensembl:ENST00000399120(transcript)|ensembl:ENST00000612277(transcript)|ensembl:ENST00000675307(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004077"(biotin-[acetyl-CoA-carboxylase] ligase activity)|go:"GO:0004078"(biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity)|go:"GO:0004079"(biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity)|go:"GO:0004080"("biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009305"(protein biotinylation)|go:"GO:0009374"(biotin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016570"(histone modification)|go:"GO:0018271"(biotin-protein ligase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0070781"(response to biotin)|go:"GO:0071110"(histone biotinylation)|interpro:IPR003142(Biotin protein ligase, C-terminal)|interpro:IPR004143(Biotin/lipoate A/B protein ligase)|interpro:IPR004408(Biotin--acetyl-CoA-carboxylase ligase)|interpro:IPR019197|mint:P50747|reactome:R-HSA-196780|reactome:R-HSA-3371599|refseq:XP_005261012.1|refseq:XP_005261013.1|refseq:XP_016883819.1|mint:MINT-7543115(identity)	-	-	-	figure legend:f3b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/14	2014/10/16	rogid:X8k29PN2JnB6ljCcl4fYCAJ4ahM9606	rogid:X8k29PN2JnB6ljCcl4fYCAJ4ahM9606	intact-crc:2354D31DAA0B14DF|rigid:xRNeqnyvJRGHM4fyGBq0BDqFDs0	false	binding-associated region:161-726(MINT-7543120)	binding-associated region:1-160(MINT-7543116)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00763	uniprotkb:P50747	intact:EBI-2211739|uniprotkb:A6NK36|uniprotkb:Q16852|uniprotkb:Q1HEC1|uniprotkb:Q6KE87|uniprotkb:Q6KE89|uniprotkb:Q6TY48|intact:EBI-28983570|ensembl:ENSP00000341044|ensembl:ENSP00000367079	intact:EBI-3915568|uniprotkb:B2RAH1|uniprotkb:D3DSG6|uniprotkb:Q99451|ensembl:ENSP00000338387|ensembl:ENSP00000382071|ensembl:ENSP00000479939|ensembl:ENSP00000501750	psi-mi:acacb_human(display_long)|uniprotkb:ACACB(gene name)|psi-mi:ACACB(display_short)|uniprotkb:ACC2(gene name synonym)|uniprotkb:ACCB(gene name synonym)|uniprotkb:ACC-beta(gene name synonym)	psi-mi:bpl1_human(display_long)|uniprotkb:HLCS(gene name)|psi-mi:HLCS(display_short)|uniprotkb:Biotin apo-protein ligase(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Lee et al. (2010)	pubmed:20085763|imex:IM-15469|mint:MINT-7543048|mint:d-09-02164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7742105|mint:MINT-7543129|imex:IM-15469-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536561.1|refseq:XP_006719430.1|ensembl:ENSP00000341044|ensembl:ENSP00000367079|refseq:NP_001084.3|refseq:XP_005253933.1|dip:DIP-51617N|ensembl:ENSG00000076555(gene)|ensembl:ENST00000338432(transcript)|ensembl:ENST00000377848(transcript)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0097009"(energy homeostasis)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:O00763|rcsb pdb:2DN8|rcsb pdb:2HJW|rcsb pdb:2KCC|rcsb pdb:3FF6|rcsb pdb:3GID|rcsb pdb:3GLK|rcsb pdb:3JRW|rcsb pdb:3JRX|rcsb pdb:3TDC|rcsb pdb:4HQ6|rcsb pdb:5KKN|reactome:R-HSA-163765|reactome:R-HSA-196780|reactome:R-HSA-200425|reactome:R-HSA-2426168|mint:MINT-7543131(identity)	refseq:XP_011527840.1|refseq:XP_011527841.1|refseq:XP_011527843.1|refseq:NP_000402.3|refseq:NP_001229713.1|refseq:NP_001229714.1|refseq:XP_006724057.1|refseq:XP_006724058.1|ensembl:ENSG00000159267(gene)|ensembl:ENST00000336648(transcript)|ensembl:ENST00000399120(transcript)|ensembl:ENST00000612277(transcript)|ensembl:ENST00000675307(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004077"(biotin-[acetyl-CoA-carboxylase] ligase activity)|go:"GO:0004078"(biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity)|go:"GO:0004079"(biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity)|go:"GO:0004080"("biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009305"(protein biotinylation)|go:"GO:0009374"(biotin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016570"(histone modification)|go:"GO:0018271"(biotin-protein ligase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0070781"(response to biotin)|go:"GO:0071110"(histone biotinylation)|interpro:IPR003142(Biotin protein ligase, C-terminal)|interpro:IPR004143(Biotin/lipoate A/B protein ligase)|interpro:IPR004408(Biotin--acetyl-CoA-carboxylase ligase)|interpro:IPR019197|mint:P50747|reactome:R-HSA-196780|reactome:R-HSA-3371599|refseq:XP_005261012.1|refseq:XP_005261013.1|refseq:XP_016883819.1|mint:MINT-7543135(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f4a f4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/14	2014/10/16	rogid:P4hgekQx/AZz4InTWHW6u6jpDRA9606	rogid:X8k29PN2JnB6ljCcl4fYCAJ4ahM9606	intact-crc:7108A6E040FC47F9|rigid:MKHD1iFkAu+fNrUbHqn2DIPhsvo	false	binding-associated region:895-961(MINT-7543132)	binding-associated region:161-726(MINT-7543136)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00763	uniprotkb:P50747	intact:EBI-2211739|uniprotkb:A6NK36|uniprotkb:Q16852|uniprotkb:Q1HEC1|uniprotkb:Q6KE87|uniprotkb:Q6KE89|uniprotkb:Q6TY48|intact:EBI-28983570|ensembl:ENSP00000341044|ensembl:ENSP00000367079	intact:EBI-3915568|uniprotkb:B2RAH1|uniprotkb:D3DSG6|uniprotkb:Q99451|ensembl:ENSP00000338387|ensembl:ENSP00000382071|ensembl:ENSP00000479939|ensembl:ENSP00000501750	psi-mi:acacb_human(display_long)|uniprotkb:ACACB(gene name)|psi-mi:ACACB(display_short)|uniprotkb:ACC2(gene name synonym)|uniprotkb:ACCB(gene name synonym)|uniprotkb:ACC-beta(gene name synonym)	psi-mi:bpl1_human(display_long)|uniprotkb:HLCS(gene name)|psi-mi:HLCS(display_short)|uniprotkb:Biotin apo-protein ligase(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Lee et al. (2010)	pubmed:20085763|imex:IM-15469|mint:MINT-7543048|mint:d-09-02164	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7742148|mint:MINT-7543070|imex:IM-15469-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536561.1|refseq:XP_006719430.1|ensembl:ENSP00000341044|ensembl:ENSP00000367079|refseq:NP_001084.3|refseq:XP_005253933.1|dip:DIP-51617N|ensembl:ENSG00000076555(gene)|ensembl:ENST00000338432(transcript)|ensembl:ENST00000377848(transcript)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0009374"(biotin binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060421"(positive regulation of heart growth)|go:"GO:0097009"(energy homeostasis)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:O00763|rcsb pdb:2DN8|rcsb pdb:2HJW|rcsb pdb:2KCC|rcsb pdb:3FF6|rcsb pdb:3GID|rcsb pdb:3GLK|rcsb pdb:3JRW|rcsb pdb:3JRX|rcsb pdb:3TDC|rcsb pdb:4HQ6|rcsb pdb:5KKN|reactome:R-HSA-163765|reactome:R-HSA-196780|reactome:R-HSA-200425|reactome:R-HSA-2426168|mint:MINT-7543072(identity)	refseq:XP_011527840.1|refseq:XP_011527841.1|refseq:XP_011527843.1|refseq:NP_000402.3|refseq:NP_001229713.1|refseq:NP_001229714.1|refseq:XP_006724057.1|refseq:XP_006724058.1|ensembl:ENSG00000159267(gene)|ensembl:ENST00000336648(transcript)|ensembl:ENST00000399120(transcript)|ensembl:ENST00000612277(transcript)|ensembl:ENST00000675307(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004077"(biotin-[acetyl-CoA-carboxylase] ligase activity)|go:"GO:0004078"(biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity)|go:"GO:0004079"(biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity)|go:"GO:0004080"("biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006768"(biotin metabolic process)|go:"GO:0009305"(protein biotinylation)|go:"GO:0009374"(biotin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016570"(histone modification)|go:"GO:0018271"(biotin-protein ligase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0070781"(response to biotin)|go:"GO:0071110"(histone biotinylation)|interpro:IPR003142(Biotin protein ligase, C-terminal)|interpro:IPR004143(Biotin/lipoate A/B protein ligase)|interpro:IPR004408(Biotin--acetyl-CoA-carboxylase ligase)|interpro:IPR019197|mint:P50747|reactome:R-HSA-196780|reactome:R-HSA-3371599|refseq:XP_005261012.1|refseq:XP_005261013.1|refseq:XP_016883819.1|mint:MINT-7543078(identity)	-	-	-	figure legend:f2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2010/01/14	2014/10/16	rogid:P4hgekQx/AZz4InTWHW6u6jpDRA9606	rogid:X8k29PN2JnB6ljCcl4fYCAJ4ahM9606	intact-crc:6B48AB418E0D4978|rigid:MKHD1iFkAu+fNrUbHqn2DIPhsvo	false	uncategorized protein modification:929-929(MINT-7543073)|binding-associated region:895-961(MINT-7543075)	binding-associated region:1-160(MINT-7543079)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)