#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92542	uniprotkb:P49768-PRO_0000025591	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	intact:EBI-2606326	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:p49768-pro_0000025591(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606334|imex:IM-20429-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	intact:EBI-297277(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:298	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	rogid:LkOs+b4Ke5mtyCo4IXRVHUf25/M9606	intact-crc:674036DA0BBA69D4|rigid:eZSDzrpZKD0kuFsq+ykGaUQrFvg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92542	uniprotkb:Q96BI3	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	intact:EBI-2606935|uniprotkb:Q5TB23|uniprotkb:Q969R6|uniprotkb:Q9BVG0|uniprotkb:Q9Y386|ensembl:ENSP00000358105|uniprotkb:Q5TB22|uniprotkb:B4DQK0	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:aph1a_human(display_long)|uniprotkb:APH1A(gene name)|psi-mi:APH1A(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Aph-1alpha(gene name synonym)|uniprotkb:Presenilin-stabilization factor(gene name synonym)|uniprotkb:CGI-78(orf name)|uniprotkb:UNQ579/PRO1141(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606334|imex:IM-20429-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	refseq:NP_001071096.1|refseq:NP_057106.2|ensembl:ENSG00000117362(gene)|ensembl:ENST00000369109(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR009294(Aph-1)|mint:Q96BI3|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|reactome:R-HSA-977225|reactome:R-HSA-1251985|refseq:NP_001230700.1|refseq:NP_001230701.1|dip:DIP-44671N	-	-	-	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	rogid:QsBXByp3aPY99/oP5uQ77SZ7Tls9606	intact-crc:674036DA0BBA69D4|rigid:eZSDzrpZKD0kuFsq+ykGaUQrFvg	false	-	myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92542	uniprotkb:Q96BI3-1	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	intact:EBI-2606967|ensembl:ENSP00000358105	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:q96bi3-1(display_long)|uniprotkb:APH1A(gene name)|psi-mi:APH1A(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Aph-1alpha(gene name synonym)|uniprotkb:Presenilin-stabilization factor(gene name synonym)|uniprotkb:CGI-78(orf name)|uniprotkb:UNQ579/PRO1141(orf name)|uniprotkb:L(isoform synonym)|uniprotkb:Aph-alpha1(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606339|imex:IM-20429-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	intact:EBI-2606935(isoform-parent)|ensembl:ENSG00000117362(gene)|ensembl:ENST00000369109(transcript)	-	-	-	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	rogid:QsBXByp3aPY99/oP5uQ77SZ7Tls9606	intact-crc:8749A2A07A690C66|rigid:DqvUGe4lRjmr9oiCUG/bBsUEmCs	false	-	his tag:c-c|myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92542	uniprotkb:P49768-PRO_0000025591	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	intact:EBI-2606326	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:p49768-pro_0000025591(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606339|imex:IM-20429-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	intact:EBI-297277(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:298	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	rogid:LkOs+b4Ke5mtyCo4IXRVHUf25/M9606	intact-crc:8749A2A07A690C66|rigid:DqvUGe4lRjmr9oiCUG/bBsUEmCs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92542	uniprotkb:P49810-PRO_0000025603	intact:EBI-998440|uniprotkb:Q86VV5|uniprotkb:Q5T207|ensembl:ENSP00000294785|uniprotkb:Q5T208	intact:EBI-2606342	psi-mi:nica_human(display_long)|uniprotkb:NCSTN(gene name)|psi-mi:NCSTN(display_short)|uniprotkb:KIAA0253(gene name synonym)|uniprotkb:UNQ1874/PRO4317(orf name)	psi-mi:p49810-pro_0000025603(display_long)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606339|imex:IM-20429-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|rcsb pdb:6LQG|reactome:R-HSA-977225|ensembl:ENSG00000162736(gene)|ensembl:ENST00000294785(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:Q92542|rcsb pdb:2N7Q|rcsb pdb:2N7R|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|refseq:NP_056146.1|refseq:NP_001277113.1|refseq:NP_001277115.1|dip:DIP-36336N	intact:EBI-2010251(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:297	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:Lf6xGDVDkOQXMUuG3Yn0tayAjF89606	rogid:1HfXVsJL5GR98sYU5JLpg6lfHh09606	intact-crc:8749A2A07A690C66|rigid:DqvUGe4lRjmr9oiCUG/bBsUEmCs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49768-PRO_0000025592	uniprotkb:P49768-PRO_0000025591	intact:EBI-2606356	intact:EBI-2606326	psi-mi:p49768-pro_0000025592(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:p49768-pro_0000025591(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606353|imex:IM-20429-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-297277(chain-parent)	intact:EBI-297277(chain-parent)	-	chain-seq-start:299|chain-seq-end:467	chain-seq-start:1|chain-seq-end:298	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:xG27cmMbn5XEzF1wFo+iVIp3Kx09606	rogid:LkOs+b4Ke5mtyCo4IXRVHUf25/M9606	intact-crc:E7E0B7F177962856|rigid:DoOhkJ27jjNjAlwZZWLuGVBQYe0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49768-PRO_0000025592	uniprotkb:Q96BI3-1	intact:EBI-2606356	intact:EBI-2606967|ensembl:ENSP00000358105	psi-mi:p49768-pro_0000025592(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:q96bi3-1(display_long)|uniprotkb:APH1A(gene name)|psi-mi:APH1A(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Aph-1alpha(gene name synonym)|uniprotkb:Presenilin-stabilization factor(gene name synonym)|uniprotkb:CGI-78(orf name)|uniprotkb:UNQ579/PRO1141(orf name)|uniprotkb:L(isoform synonym)|uniprotkb:Aph-alpha1(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606353|imex:IM-20429-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-297277(chain-parent)	intact:EBI-2606935(isoform-parent)|ensembl:ENSG00000117362(gene)|ensembl:ENST00000369109(transcript)	-	chain-seq-start:299|chain-seq-end:467	-	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2010/03/01	2014/10/16	rogid:xG27cmMbn5XEzF1wFo+iVIp3Kx09606	rogid:QsBXByp3aPY99/oP5uQ77SZ7Tls9606	intact-crc:E7E0B7F177962856|rigid:DoOhkJ27jjNjAlwZZWLuGVBQYe0	false	-	myc tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96BI3-1	uniprotkb:P49810-PRO_0000025603	intact:EBI-2606967|ensembl:ENSP00000358105	intact:EBI-2606342	psi-mi:q96bi3-1(display_long)|uniprotkb:APH1A(gene name)|psi-mi:APH1A(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Aph-1alpha(gene name synonym)|uniprotkb:Presenilin-stabilization factor(gene name synonym)|uniprotkb:CGI-78(orf name)|uniprotkb:UNQ579/PRO1141(orf name)|uniprotkb:L(isoform synonym)|uniprotkb:Aph-alpha1(isoform synonym)	psi-mi:p49810-pro_0000025603(display_long)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606431|imex:IM-20429-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2606935(isoform-parent)|ensembl:ENSG00000117362(gene)|ensembl:ENST00000369109(transcript)	intact:EBI-2010251(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:297	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/01	2014/10/16	rogid:QsBXByp3aPY99/oP5uQ77SZ7Tls9606	rogid:1HfXVsJL5GR98sYU5JLpg6lfHh09606	intact-crc:39251CF613E34D85|rigid:bNnm1NYV5JheDzkJsliaZmgwvT0	false	myc tag:c-c|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96BI3-1	uniprotkb:P49768-PRO_0000025591	intact:EBI-2606967|ensembl:ENSP00000358105	intact:EBI-2606326	psi-mi:q96bi3-1(display_long)|uniprotkb:APH1A(gene name)|psi-mi:APH1A(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Aph-1alpha(gene name synonym)|uniprotkb:Presenilin-stabilization factor(gene name synonym)|uniprotkb:CGI-78(orf name)|uniprotkb:UNQ579/PRO1141(orf name)|uniprotkb:L(isoform synonym)|uniprotkb:Aph-alpha1(isoform synonym)	psi-mi:p49768-pro_0000025591(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606431|imex:IM-20429-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2606935(isoform-parent)|ensembl:ENSG00000117362(gene)|ensembl:ENST00000369109(transcript)	intact:EBI-297277(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:298	figure legend:fig 2A|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/01	2014/10/16	rogid:QsBXByp3aPY99/oP5uQ77SZ7Tls9606	rogid:LkOs+b4Ke5mtyCo4IXRVHUf25/M9606	intact-crc:39251CF613E34D85|rigid:bNnm1NYV5JheDzkJsliaZmgwvT0	false	myc tag:c-c|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97887-PRO_0000025600	uniprotkb:P97887-PRO_0000025599	intact:EBI-2606447	intact:EBI-2606464	psi-mi:p97887-pro_0000025600(display_long)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Psnl1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:p97887-pro_0000025599(display_long)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Psnl1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606470|imex:IM-20429-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2878956(chain-parent)	intact:EBI-2878956(chain-parent)	-	chain-seq-start:299|chain-seq-end:468	chain-seq-start:1|chain-seq-end:298	figure legend:fig 3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2010/03/01	2014/10/16	rogid:EprRK8FVKmA6/nJupLX6InAf0jc10116	rogid:S8wSdbFAa+PNwz9XFt3qf34BN4810116	intact-crc:67D099494C69EBEC|rigid:XzCLics5brBoR/jzR9B5r8vovzE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97887-PRO_0000025600	uniprotkb:Q5PQQ3	intact:EBI-2606447	intact:EBI-2606456|ensembl:ENSRNOP00000053129	psi-mi:p97887-pro_0000025600(display_long)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Psnl1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:q5pqq3_rat(display_long)|uniprotkb:Aph1a(gene name)|psi-mi:Aph1a(display_short)|uniprotkb:rCG_52020(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606470|imex:IM-20429-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2878956(chain-parent)	rgd:1311546|refseq:NP_001014277.1|ensembl:ENSRNOG00000023816(gene)|ensembl:ENSRNOT00000056289(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0016485"(protein processing)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR009294(Aph-1)	-	chain-seq-start:299|chain-seq-end:468	-	figure legend:fig 3B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2010/03/01	2014/10/16	rogid:EprRK8FVKmA6/nJupLX6InAf0jc10116	rogid:ZkAGA4FGUoxkjSykhwrJk+ped9U10116	intact-crc:67D099494C69EBEC|rigid:XzCLics5brBoR/jzR9B5r8vovzE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97887-PRO_0000025600	uniprotkb:Q8CGU6	intact:EBI-2606447	intact:EBI-919483|uniprotkb:Q8CH12|ensembl:ENSRNOP00000008150	psi-mi:p97887-pro_0000025600(display_long)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Psnl1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:nica_rat(display_long)|uniprotkb:Ncstn(gene name)|psi-mi:Ncstn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606475|imex:IM-20429-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2878956(chain-parent)	rgd:631418|refseq:NP_777353.1|refseq:XP_008767955.1|ensembl:ENSRNOG00000005355(gene)|ensembl:ENSRNOT00000008150(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045202"(synapse)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0070997"(neuron death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|reactome:R-RNO-1251985|reactome:R-RNO-193692|reactome:R-RNO-205043|reactome:R-RNO-3928665|reactome:R-RNO-6798695|reactome:R-RNO-9013507|reactome:R-RNO-9017802	-	chain-seq-start:299|chain-seq-end:468	-	figure legend:fig 3C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2010/03/01	2014/10/16	rogid:EprRK8FVKmA6/nJupLX6InAf0jc10116	rogid:i7mLB/dG+pTidsJNUywhbvAzjDs10116	intact-crc:C611F9A3174894B7|rigid:pEVJQfK/F1Sv5WAghS2FEyKz120	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5PQQ3	uniprotkb:Q8CGU6	intact:EBI-2606456|ensembl:ENSRNOP00000053129	intact:EBI-919483|uniprotkb:Q8CH12|ensembl:ENSRNOP00000008150	psi-mi:q5pqq3_rat(display_long)|uniprotkb:Aph1a(gene name)|psi-mi:Aph1a(display_short)|uniprotkb:rCG_52020(orf name)	psi-mi:nica_rat(display_long)|uniprotkb:Ncstn(gene name)|psi-mi:Ncstn(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606480|imex:IM-20429-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1311546|refseq:NP_001014277.1|ensembl:ENSRNOG00000023816(gene)|ensembl:ENSRNOT00000056289(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0016485"(protein processing)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR009294(Aph-1)	rgd:631418|refseq:NP_777353.1|refseq:XP_008767955.1|ensembl:ENSRNOG00000005355(gene)|ensembl:ENSRNOT00000008150(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045202"(synapse)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0070997"(neuron death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|reactome:R-RNO-1251985|reactome:R-RNO-193692|reactome:R-RNO-205043|reactome:R-RNO-3928665|reactome:R-RNO-6798695|reactome:R-RNO-9013507|reactome:R-RNO-9017802	-	-	-	figure legend:fig 3C|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2010/03/01	2014/10/16	rogid:ZkAGA4FGUoxkjSykhwrJk+ped9U10116	rogid:i7mLB/dG+pTidsJNUywhbvAzjDs10116	intact-crc:92C0F87497106DAF|rigid:a28NXld0ymEkpSQmwEmE3gQpp+E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97887-PRO_0000025600	uniprotkb:Q5PQQ3	intact:EBI-2606447	intact:EBI-2606456|ensembl:ENSRNOP00000053129	psi-mi:p97887-pro_0000025600(display_long)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Psnl1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:q5pqq3_rat(display_long)|uniprotkb:Aph1a(gene name)|psi-mi:Aph1a(display_short)|uniprotkb:rCG_52020(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606485|imex:IM-20429-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2878956(chain-parent)	rgd:1311546|refseq:NP_001014277.1|ensembl:ENSRNOG00000023816(gene)|ensembl:ENSRNOT00000056289(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0016485"(protein processing)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR009294(Aph-1)	-	chain-seq-start:299|chain-seq-end:468	-	figure legend:fig 3D|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2010/03/01	2014/10/16	rogid:EprRK8FVKmA6/nJupLX6InAf0jc10116	rogid:ZkAGA4FGUoxkjSykhwrJk+ped9U10116	intact-crc:E4E600D9F864826A|rigid:EBv/4IbaINKyew67AwJv604+uhY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8WW43	uniprotkb:P49810-PRO_0000025603	intact:EBI-2606497|uniprotkb:Q6UWQ1|uniprotkb:Q9H0S0|uniprotkb:A8K589|ensembl:ENSP00000261879|uniprotkb:Q564N3	intact:EBI-2606342	psi-mi:aph1b_human(display_long)|uniprotkb:APH1B(gene name)|psi-mi:APH1B(display_short)|uniprotkb:PSFL(gene name synonym)|uniprotkb:Aph-1beta(gene name synonym)|uniprotkb:Presenilin-stabilization factor-like(gene name synonym)|uniprotkb:UNQ688/PRO1328(orf name)	psi-mi:p49810-pro_0000025603(display_long)|uniprotkb:AD3LP(gene name synonym)|uniprotkb:AD5(gene name synonym)|uniprotkb:E5-1(gene name synonym)|uniprotkb:STM-2(gene name synonym)|uniprotkb:PSEN2(gene name)|psi-mi:PSEN2(display_short)|uniprotkb:AD4(gene name synonym)|uniprotkb:PS2(gene name synonym)|uniprotkb:PSNL2(gene name synonym)|uniprotkb:STM2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Sheu-Fen et al. (2002)	pubmed:12297508|imex:IM-20429	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2606507|imex:IM-20429-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112591.2|ensembl:ENSG00000138613(gene)|ensembl:ENST00000261879(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010008"(endosome membrane)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0030133"(transport vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070765"(gamma-secretase complex)|interpro:IPR009294(Aph-1)|mint:Q8WW43|reactome:R-HSA-1251985|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|reactome:R-HSA-977225|refseq:NP_001139118.1	intact:EBI-2010251(chain-parent)	-	-	chain-seq-start:1|chain-seq-end:297	figure legend:fig 2B|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Alzheimers - Interactions investigated in the context of Alzheimers disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2010/03/01	2014/10/16	rogid:w8GOGnbWB3OPYAAfOxy/YCzlXPo9606	rogid:1HfXVsJL5GR98sYU5JLpg6lfHh09606	intact-crc:1E36E469DC9700BB|rigid:FbgfalhRoUTHXnm9rRyzMxCSCnQ	false	myc tag:c-c|his tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)