#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99708	uniprotkb:P38398	intact:EBI-745715|uniprotkb:A6NKN2|ensembl:ENSP00000323050|ensembl:ENSP00000382628|intact:EBI-1263531|uniprotkb:A8K8W6|uniprotkb:E7ETY1|uniprotkb:O75371|uniprotkb:Q8NHQ3	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	psi-mi:ctip_human(display_long)|uniprotkb:RBBP8(gene name)|psi-mi:RBBP8(display_short)|uniprotkb:CTIP(gene name synonym)|uniprotkb:CtBP-interacting protein(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 8(gene name synonym)|uniprotkb:Retinoblastoma-interacting protein and myosin-like(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2 homolog(gene name synonym)	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wong et al. (1998)	pubmed:9811458|imex:IM-18866|mint:MINT-6548316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1803170|imex:IM-18866-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011524434.1|ensembl:ENSG00000101773(gene)|ensembl:ENST00000327155(transcript)|ensembl:ENST00000399722(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070336"(flap-structured DNA binding)|interpro:IPR013882(DNA repair protein Sae2)|interpro:IPR019518|interpro:IPR033316|interpro:IPR033594|mint:Q99708|rcsb pdb:2L4Z|rcsb pdb:4D2H|rcsb pdb:7BGF|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|refseq:NP_002885.1|refseq:NP_976036.1|refseq:NP_976037.1|refseq:XP_006722582.1|refseq:XP_006722583.1|refseq:XP_006722584.1|dip:DIP-24244N	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	-	-	-	comment:A weak self-activation of BRCA1 in the Gal4p-DNA-binding fusion was detected in the reporter assay, hence additional directed two-hybrid assays have been performed.|figure legend:no fig|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/08/15	2014/10/16	rogid:4oYHOQGiavaE9TTzRbHyOZtL28E9606	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	intact-crc:12B115A385B00879|rigid:Uh1GQEEAsZ7vzXcQNXGVaS6LcKQ	false	-	sufficient binding region:1602-1863	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99708	uniprotkb:P38398	intact:EBI-745715|uniprotkb:A6NKN2|ensembl:ENSP00000323050|ensembl:ENSP00000382628|intact:EBI-1263531|uniprotkb:A8K8W6|uniprotkb:E7ETY1|uniprotkb:O75371|uniprotkb:Q8NHQ3	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	psi-mi:ctip_human(display_long)|uniprotkb:RBBP8(gene name)|psi-mi:RBBP8(display_short)|uniprotkb:CTIP(gene name synonym)|uniprotkb:CtBP-interacting protein(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 8(gene name synonym)|uniprotkb:Retinoblastoma-interacting protein and myosin-like(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2 homolog(gene name synonym)	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wong et al. (1998)	pubmed:9811458|imex:IM-18866|mint:MINT-6548316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1803179|imex:IM-18866-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011524434.1|ensembl:ENSG00000101773(gene)|ensembl:ENST00000327155(transcript)|ensembl:ENST00000399722(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070336"(flap-structured DNA binding)|interpro:IPR013882(DNA repair protein Sae2)|interpro:IPR019518|interpro:IPR033316|interpro:IPR033594|mint:Q99708|rcsb pdb:2L4Z|rcsb pdb:4D2H|rcsb pdb:7BGF|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|refseq:NP_002885.1|refseq:NP_976036.1|refseq:NP_976037.1|refseq:XP_006722582.1|refseq:XP_006722583.1|refseq:XP_006722584.1|dip:DIP-24244N	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/08/15	2014/10/16	rogid:4oYHOQGiavaE9TTzRbHyOZtL28E9606	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	intact-crc:ABF680A5E5D58ACB|rigid:Uh1GQEEAsZ7vzXcQNXGVaS6LcKQ	false	-	necessary binding region:1853-1863	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38398	uniprotkb:Q99708	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-745715|uniprotkb:A6NKN2|ensembl:ENSP00000323050|ensembl:ENSP00000382628|intact:EBI-1263531|uniprotkb:A8K8W6|uniprotkb:E7ETY1|uniprotkb:O75371|uniprotkb:Q8NHQ3	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:ctip_human(display_long)|uniprotkb:RBBP8(gene name)|psi-mi:RBBP8(display_short)|uniprotkb:CTIP(gene name synonym)|uniprotkb:CtBP-interacting protein(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 8(gene name synonym)|uniprotkb:Retinoblastoma-interacting protein and myosin-like(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2 homolog(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wong et al. (1998)	pubmed:9811458|imex:IM-18866|mint:MINT-6548316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1803185|imex:IM-18866-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	refseq:XP_011524434.1|ensembl:ENSG00000101773(gene)|ensembl:ENST00000327155(transcript)|ensembl:ENST00000399722(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070336"(flap-structured DNA binding)|interpro:IPR013882(DNA repair protein Sae2)|interpro:IPR019518|interpro:IPR033316|interpro:IPR033594|mint:Q99708|rcsb pdb:2L4Z|rcsb pdb:4D2H|rcsb pdb:7BGF|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|refseq:NP_002885.1|refseq:NP_976036.1|refseq:NP_976037.1|refseq:XP_006722582.1|refseq:XP_006722583.1|refseq:XP_006722584.1|dip:DIP-24244N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/08/15	2014/10/16	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:4oYHOQGiavaE9TTzRbHyOZtL28E9606	intact-crc:9E4D384C52047269|rigid:Uh1GQEEAsZ7vzXcQNXGVaS6LcKQ	false	necessary binding region:1853-1863	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99708	uniprotkb:P38398	intact:EBI-745715|uniprotkb:A6NKN2|ensembl:ENSP00000323050|ensembl:ENSP00000382628|intact:EBI-1263531|uniprotkb:A8K8W6|uniprotkb:E7ETY1|uniprotkb:O75371|uniprotkb:Q8NHQ3	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	psi-mi:ctip_human(display_long)|uniprotkb:RBBP8(gene name)|psi-mi:RBBP8(display_short)|uniprotkb:CTIP(gene name synonym)|uniprotkb:CtBP-interacting protein(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 8(gene name synonym)|uniprotkb:Retinoblastoma-interacting protein and myosin-like(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2 homolog(gene name synonym)	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wong et al. (1998)	pubmed:9811458|imex:IM-18866|mint:MINT-6548316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1803191|imex:IM-18866-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011524434.1|ensembl:ENSG00000101773(gene)|ensembl:ENST00000327155(transcript)|ensembl:ENST00000399722(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070336"(flap-structured DNA binding)|interpro:IPR013882(DNA repair protein Sae2)|interpro:IPR019518|interpro:IPR033316|interpro:IPR033594|mint:Q99708|rcsb pdb:2L4Z|rcsb pdb:4D2H|rcsb pdb:7BGF|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|refseq:NP_002885.1|refseq:NP_976036.1|refseq:NP_976037.1|refseq:XP_006722582.1|refseq:XP_006722583.1|refseq:XP_006722584.1|dip:DIP-24244N	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	-	-	-	figure legend:fig 2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/08/15	2014/10/16	rogid:4oYHOQGiavaE9TTzRbHyOZtL28E9606	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	intact-crc:D4633DA5DE2D64A0|rigid:Uh1GQEEAsZ7vzXcQNXGVaS6LcKQ	false	35s radiolabel:?-?|binding-associated region:312-712	necessary binding region:1853-1863|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38398	uniprotkb:Q99708	intact:EBI-349905|uniprotkb:Q3LRJ0|uniprotkb:O15129|uniprotkb:Q7KYU9|ensembl:ENSP00000350283|uniprotkb:E9PFZ0|uniprotkb:Q3LRJ6|uniprotkb:Q6IN79|uniprotkb:Q1RMC1	intact:EBI-745715|uniprotkb:A6NKN2|ensembl:ENSP00000323050|ensembl:ENSP00000382628|intact:EBI-1263531|uniprotkb:A8K8W6|uniprotkb:E7ETY1|uniprotkb:O75371|uniprotkb:Q8NHQ3	psi-mi:brca1_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short)|uniprotkb:RNF53(gene name synonym)|uniprotkb:RING finger protein 53(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRCA1(gene name synonym)	psi-mi:ctip_human(display_long)|uniprotkb:RBBP8(gene name)|psi-mi:RBBP8(display_short)|uniprotkb:CTIP(gene name synonym)|uniprotkb:CtBP-interacting protein(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 8(gene name synonym)|uniprotkb:Retinoblastoma-interacting protein and myosin-like(gene name synonym)|uniprotkb:Sporulation in the absence of SPO11 protein 2 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wong et al. (1998)	pubmed:9811458|imex:IM-18866|mint:MINT-6548316	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1803203|imex:IM-18866-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009225.1|refseq:NP_009228.2|refseq:NP_009229.2|refseq:NP_009231.2|ensembl:ENSG00000012048(gene)|ensembl:ENST00000357654(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000800"(lateral element)|go:"GO:0000931"(gamma-tubulin large complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015631"(tubulin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035067"(negative regulation of histone acetylation)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070512"(positive regulation of histone H4-K20 methylation)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|go:"GO:2000620"(positive regulation of histone H4-K16 acetylation)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011364(BRCA1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR025994|interpro:IPR031099|interpro:IPR036420|mint:P38398|rcsb pdb:1JM7|rcsb pdb:1JNX|rcsb pdb:1N5O|rcsb pdb:1OQA|rcsb pdb:1T15|rcsb pdb:1T29|rcsb pdb:1T2U|rcsb pdb:1T2V|rcsb pdb:1Y98|rcsb pdb:2ING|rcsb pdb:3COJ|rcsb pdb:3K0H|rcsb pdb:3K0K|rcsb pdb:3K15|rcsb pdb:3K16|rcsb pdb:3PXA|rcsb pdb:3PXB|rcsb pdb:3PXC|rcsb pdb:3PXD|rcsb pdb:3PXE|rcsb pdb:4IFI|rcsb pdb:4IGK|rcsb pdb:4JLU|rcsb pdb:4OFB|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|rcsb pdb:6G2I|reactome:R-HSA-1221632|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689901|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|reactome:R-HSA-9663199|reactome:R-HSA-9699150|refseq:NP_009230.2|dip:DIP-5971N	refseq:XP_011524434.1|ensembl:ENSG00000101773(gene)|ensembl:ENST00000327155(transcript)|ensembl:ENST00000399722(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070336"(flap-structured DNA binding)|interpro:IPR013882(DNA repair protein Sae2)|interpro:IPR019518|interpro:IPR033316|interpro:IPR033594|mint:Q99708|rcsb pdb:2L4Z|rcsb pdb:4D2H|rcsb pdb:7BGF|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-8953750|reactome:R-HSA-912446|refseq:NP_002885.1|refseq:NP_976036.1|refseq:NP_976037.1|refseq:XP_006722582.1|refseq:XP_006722583.1|refseq:XP_006722584.1|dip:DIP-24244N	-	-	-	figure legend:fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/08/15	2014/10/16	rogid:Tx+5uS8dERqc0lhPZ0ZIKQaifXM9606	rogid:4oYHOQGiavaE9TTzRbHyOZtL28E9606	intact-crc:9FFA705D1D9156D4|rigid:Uh1GQEEAsZ7vzXcQNXGVaS6LcKQ	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|binding-associated region:324-584	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)