#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q93794	uniprotkb:P14585	intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1	intact:EBI-326049|ensemblmetazoa:R107.8.1	psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym)	psi-mi:lin12_caeel(display_long)|uniprotkb:lin-12(gene name)|psi-mi:lin-12(display_short)|uniprotkb:Abnormal cell lineage protein 12(gene name synonym)|uniprotkb:Notch-like protein lin-12(gene name synonym)|uniprotkb:R107.8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hubbard et al. (1997)	pubmed:9389650|imex:IM-19389	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1571699|imex:IM-19389-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322	refseq:NP_499007.1|wormbase:R107.8|ensemblmetazoa:R107.8.1(transcript)|ensemblmetazoa:WBGene00003001(gene)|go:"GO:0001708"(cell fate specification)|go:"GO:0002119"(nematode larval development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018991"(oviposition)|go:"GO:0040025"(vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043054"(dauer exit)|go:"GO:0045168"(cell-cell signaling involved in cell fate commitment)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|dip:DIP-25208N|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR035993|interpro:IPR036770|rcsb pdb:2FO1|rcsb pdb:3BRD|rcsb pdb:3BRF	-	-	-	figure legend:Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/01/07	2014/10/16	rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239	rogid:s+lJ4eptcr8dmCYg+ZxLxPCPX1c6239	intact-crc:401C9D3804FD517F|rigid:By8KapoxVisSzg2BzKze79mc43k	false	sufficient binding region:13-587|myc tag:n-n	sufficient binding region:939-1429|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q93794	uniprotkb:P14585	intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1	intact:EBI-326049|ensemblmetazoa:R107.8.1	psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym)	psi-mi:lin12_caeel(display_long)|uniprotkb:lin-12(gene name)|psi-mi:lin-12(display_short)|uniprotkb:Abnormal cell lineage protein 12(gene name synonym)|uniprotkb:Notch-like protein lin-12(gene name synonym)|uniprotkb:R107.8(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hubbard et al. (1997)	pubmed:9389650|imex:IM-19389	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1571711|imex:IM-19389-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322	refseq:NP_499007.1|wormbase:R107.8|ensemblmetazoa:R107.8.1(transcript)|ensemblmetazoa:WBGene00003001(gene)|go:"GO:0001708"(cell fate specification)|go:"GO:0002119"(nematode larval development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018991"(oviposition)|go:"GO:0040025"(vulval development)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042661"(regulation of mesodermal cell fate specification)|go:"GO:0043054"(dauer exit)|go:"GO:0045168"(cell-cell signaling involved in cell fate commitment)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|dip:DIP-25208N|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR035993|interpro:IPR036770|rcsb pdb:2FO1|rcsb pdb:3BRD|rcsb pdb:3BRF	-	-	-	figure legend:Fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/01/07	2014/10/16	rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239	rogid:s+lJ4eptcr8dmCYg+ZxLxPCPX1c6239	intact-crc:3C4C3198636A0E88|rigid:By8KapoxVisSzg2BzKze79mc43k	false	sufficient binding region:13-587|myc tag:n-n	sufficient binding region:939-1429|ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q93794	uniprotkb:P31695	intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1	intact:EBI-643670|uniprotkb:O35442|uniprotkb:O88314|uniprotkb:O88316|uniprotkb:Q62389|uniprotkb:Q62390|uniprotkb:Q9R1W9|uniprotkb:Q9R1X0|ensembl:ENSMUSP00000015612|uniprotkb:A2CG28	psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym)	psi-mi:notc4_mouse(display_long)|uniprotkb:Notch4(gene name)|psi-mi:Notch4(display_short)|uniprotkb:Int3(gene name synonym)|uniprotkb:Int-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hubbard et al. (1997)	pubmed:9389650|imex:IM-19389	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1571723|imex:IM-19389-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322	refseq:NP_035059.2|ensembl:ENSMUSG00000015468(gene)|ensembl:ENSMUST00000015612(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030879"(mammary gland development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022355|interpro:IPR035993|interpro:IPR036770|reactome:R-MMU-1912420|reactome:R-MMU-350054|reactome:R-MMU-9013700|reactome:R-MMU-9604323	-	-	-	figure legend:Fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/01/07	2019/04/15	rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239	rogid:VJKBo9EopPR5o/YNqRqsKIMH4T410090	intact-crc:EB52D3EDE5EDADD6|rigid:lYb61RN48Ofc2Lt5UfFw6DP8i5s	false	sufficient binding region:13-587|ha tag:n-n	sufficient binding region:1411-1964	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P31695	uniprotkb:Q93794	intact:EBI-643670|uniprotkb:O35442|uniprotkb:O88314|uniprotkb:O88316|uniprotkb:Q62389|uniprotkb:Q62390|uniprotkb:Q9R1W9|uniprotkb:Q9R1X0|ensembl:ENSMUSP00000015612|uniprotkb:A2CG28	intact:EBI-323098|uniprotkb:O44083|uniprotkb:Q95ZT0|ensemblmetazoa:F55B12.3a.1	psi-mi:notc4_mouse(display_long)|uniprotkb:Notch4(gene name)|psi-mi:Notch4(display_short)|uniprotkb:Int3(gene name synonym)|uniprotkb:Int-3(gene name synonym)	psi-mi:sel10_caeel(display_long)|uniprotkb:sel-10(gene name)|psi-mi:sel-10(display_short)|uniprotkb:F55B12.3(orf name)|uniprotkb:Suppressor/enhancer of lin-12 protein 10(gene name synonym)|uniprotkb:Egg laying defective protein 41(gene name synonym)|uniprotkb:egl-41(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hubbard et al. (1997)	pubmed:9389650|imex:IM-19389	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1571733|imex:IM-19389-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035059.2|ensembl:ENSMUSG00000015468(gene)|ensembl:ENSMUST00000015612(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030879"(mammary gland development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022355|interpro:IPR035993|interpro:IPR036770|reactome:R-MMU-1912420|reactome:R-MMU-350054|reactome:R-MMU-9013700|reactome:R-MMU-9604323	refseq:NP_001023975.1|refseq:NP_506421.1|wormbase:F55B12.3a|wormbase:F55B12.3b|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR020472|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|ensemblmetazoa:F55B12.3a.1(transcript)|ensemblmetazoa:WBGene00004767(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0010826"(negative regulation of centrosome duplication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0046660"(female sex differentiation)|go:"GO:0031647"(regulation of protein stability)|interpro:IPR036047|interpro:IPR036322	-	-	-	figure legend:Fig 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/01/07	2019/04/15	rogid:VJKBo9EopPR5o/YNqRqsKIMH4T410090	rogid:g0ot7MHRd+isjIPmH2xt4HEUUvM6239	intact-crc:F5E43323FD922A13|rigid:lYb61RN48Ofc2Lt5UfFw6DP8i5s	false	sufficient binding region:1411-1964	sufficient binding region:13-587|ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)