#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08393	uniprotkb:P30281	intact:EBI-6148881	intact:EBI-375013|uniprotkb:Q5T8J0|uniprotkb:Q96F49|uniprotkb:B2RD63|uniprotkb:Q6FG62|ensembl:ENSP00000362082|uniprotkb:B3KQ22|uniprotkb:E9PAS4|uniprotkb:E9PB36|intact:EBI-10979075|intact:EBI-11132276	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:ccnd3_human(display_long)|uniprotkb:CCND3(gene name)|psi-mi:CCND3(display_short)	psi-mi:"MI:0018"(two hybrid)	Kawaguchi et al. (1997)	mint:MINT-6692494|pubmed:9311810	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8621523|mint:MINT-6741276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6741279(identity)|uniprotkb:P08393(P08393)	refseq:NP_001129489.1|refseq:NP_001129597.1|refseq:NP_001129598.1|refseq:NP_001751.1|reactome:R-HSA-9661069|ensembl:ENSG00000112576(gene)|ensembl:ENST00000372991(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P30281|rcsb pdb:3G33|reactome:R-HSA-381340|reactome:R-HSA-5687128|reactome:R-HSA-69231|reactome:R-HSA-8934593|refseq:NP_001274356.1|refseq:NP_001274363.1|dip:DIP-31734N|mint:MINT-6741277(identity)|uniprotkb:P30281(P30281)	-	-	-	figure legend:NFA|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/29	2015/08/27	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:y9i4nI+f/p5JWQAOnSbKr/As7gQ9606	intact-crc:AE73210834FC5AB1|rigid:OgXBwF1COZdm/9DMFmywD9Bz4dY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:P30281	intact:EBI-6148881	intact:EBI-375013|uniprotkb:Q5T8J0|uniprotkb:Q96F49|uniprotkb:B2RD63|uniprotkb:Q6FG62|ensembl:ENSP00000362082|uniprotkb:B3KQ22|uniprotkb:E9PAS4|uniprotkb:E9PB36|intact:EBI-10979075|intact:EBI-11132276	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:ccnd3_human(display_long)|uniprotkb:CCND3(gene name)|psi-mi:CCND3(display_short)	psi-mi:"MI:0096"(pull down)	Kawaguchi et al. (1997)	mint:MINT-6692494|pubmed:9311810	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8621546|mint:MINT-6741283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6741286(identity)|uniprotkb:P08393(P08393)	refseq:NP_001129489.1|refseq:NP_001129597.1|refseq:NP_001129598.1|refseq:NP_001751.1|reactome:R-HSA-9661069|ensembl:ENSG00000112576(gene)|ensembl:ENST00000372991(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P30281|rcsb pdb:3G33|reactome:R-HSA-381340|reactome:R-HSA-5687128|reactome:R-HSA-69231|reactome:R-HSA-8934593|refseq:NP_001274356.1|refseq:NP_001274363.1|dip:DIP-31734N|mint:MINT-6741284(identity)|uniprotkb:P30281(P30281)	-	-	-	figure legend:F6|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/29	2015/08/27	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:y9i4nI+f/p5JWQAOnSbKr/As7gQ9606	intact-crc:42D01F046807D87C|rigid:OgXBwF1COZdm/9DMFmywD9Bz4dY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:P30281	intact:EBI-6148881	intact:EBI-375013|uniprotkb:Q5T8J0|uniprotkb:Q96F49|uniprotkb:B2RD63|uniprotkb:Q6FG62|ensembl:ENSP00000362082|uniprotkb:B3KQ22|uniprotkb:E9PAS4|uniprotkb:E9PB36|intact:EBI-10979075|intact:EBI-11132276	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:ccnd3_human(display_long)|uniprotkb:CCND3(gene name)|psi-mi:CCND3(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Kawaguchi et al. (1997)	mint:MINT-6692494|pubmed:9311810	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8621569|mint:MINT-6741290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6741293(identity)|uniprotkb:P08393(P08393)	refseq:NP_001129489.1|refseq:NP_001129597.1|refseq:NP_001129598.1|refseq:NP_001751.1|reactome:R-HSA-9661069|ensembl:ENSG00000112576(gene)|ensembl:ENST00000372991(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051301"(cell division)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR015451(Cyclin D)|interpro:IPR036915|interpro:IPR039361|mint:P30281|rcsb pdb:3G33|reactome:R-HSA-381340|reactome:R-HSA-5687128|reactome:R-HSA-69231|reactome:R-HSA-8934593|refseq:NP_001274356.1|refseq:NP_001274363.1|dip:DIP-31734N|mint:MINT-6741291(identity)|uniprotkb:P30281(P30281)	-	-	-	figure legend:F7|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/29	2015/08/27	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:y9i4nI+f/p5JWQAOnSbKr/As7gQ9606	intact-crc:C4F4E3E45C127EE1|rigid:OgXBwF1COZdm/9DMFmywD9Bz4dY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)