#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P11799 uniprotkb:Q13085 intact:EBI-8516984|intact:UNK-6024653|uniprotkb:Q549S2|uniprotkb:P19038 intact:EBI-717681|intact:EBI-3962262|uniprotkb:B2ZZ90|uniprotkb:Q6KEV6|uniprotkb:Q6XDA8|uniprotkb:Q7Z2G8|uniprotkb:Q7Z561|uniprotkb:Q7Z563|uniprotkb:Q7Z564|uniprotkb:Q86WB2|uniprotkb:Q86WB3|uniprotkb:B2RP68|ensembl:ENSP00000478547|ensembl:ENSP00000483674 psi-mi:mylk_chick(display_long)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)|uniprotkb:Telokin(gene name synonym) psi-mi:acaca_human(display_long)|uniprotkb:ACACA(gene name)|psi-mi:ACACA(display_short)|uniprotkb:ACAC(gene name synonym)|uniprotkb:ACC1(gene name synonym)|uniprotkb:ACCA(gene name synonym)|uniprotkb:Acetyl-Coenzyme A carboxylase alpha(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Bultot et al. (2009) mint:MINT-6800185|pubmed:19061891|imex:IM-11665|mint:d-08-01940|doi:10.1016/j.febslet.2008.11.022 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517020|mint:MINT-6800252|imex:IM-11665-1 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_015145280.1|interpro:IPR003961(Fibronectin, type III)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015725(Myosin Light Chain Kinase)|mint:P11799|interpro:IPR036116|interpro:IPR036179|go:"GO:0001725"(stress fiber)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0030027"(lamellipodium)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046872"(metal ion binding)|rcsb pdb:1CDL|rcsb pdb:1QS7|rcsb pdb:1QTX|rcsb pdb:1VRK|rcsb pdb:2O5G|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:4OY4|mint:MINT-6800258(identity) refseq:NP_942131.1|refseq:NP_942133.1|refseq:NP_942134.1|refseq:NP_942135.1|refseq:NP_942136.1|refseq:XP_016880044.1|refseq:XP_011523005.1|ensembl:ENSG00000275176(gene)|ensembl:ENSG00000278540(gene)|ensembl:ENST00000613687(transcript)|ensembl:ENST00000614428(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003989"(acetyl-CoA carboxylase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006084"(acetyl-CoA metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019538"(protein metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046949"(fatty-acyl-CoA biosynthetic process)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:2001295"(malonyl-CoA biosynthetic process)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001882(Biotin-binding site)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005481(Carbamoyl phosphate synthase, large subunit, N-terminal)|interpro:IPR005482(Biotin carboxylase, C-terminal)|interpro:IPR011053(Single hybrid motif)|interpro:IPR011054(Rudiment single hybrid motif)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR011762(Acetyl-coenzyme A carboxyltransferase, N-terminal)|interpro:IPR011763(Acetyl-coenzyme A carboxyltransferase, C-terminal)|interpro:IPR011764(Biotin carboxylation region)|interpro:IPR013537(Acetyl-CoA carboxylase, central region)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR029045|interpro:IPR034733|mint:Q13085|rcsb pdb:2YL2|rcsb pdb:3COJ|rcsb pdb:4ASI|rcsb pdb:6G2D|rcsb pdb:6G2H|rcsb pdb:6G2I|reactome:R-HSA-163765|reactome:R-HSA-196780|reactome:R-HSA-200425|reactome:R-HSA-2426168|reactome:R-HSA-3371599|reactome:R-HSA-75105|dip:DIP-36122N|mint:MINT-6800254(identity) - comment:mint|function:Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals - figure legend:F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/11/19 2014/10/16 rogid:1j/+M19fTw8FL9Q4T/TAKPFyq0c9031 rogid:P9d0QlkoP1zrBdF1WOrK68ueGng9606 intact-crc:7D17DB2CCCF1EB36|rigid:fgr5FV3xYywvYyv2p3zT9IPgG6M false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis) uniprotkb:P11799 uniprotkb:P08590 intact:EBI-8516984|intact:UNK-6024653|uniprotkb:Q549S2|uniprotkb:P19038 intact:EBI-3909140|uniprotkb:Q9NRS8|uniprotkb:B2R534|ensembl:ENSP00000292327|ensembl:ENSP00000379210|ensembl:ENSP00000499406|ensembl:ENSP00000499577|ensembl:ENSP00000499624 psi-mi:mylk_chick(display_long)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)|uniprotkb:Telokin(gene name synonym) psi-mi:myl3_human(display_long)|uniprotkb:MYL3(gene name)|psi-mi:MYL3(display_short)|uniprotkb:Cardiac myosin light chain 1(gene name synonym)|uniprotkb:Myosin light chain 1, slow-twitch muscle B/ventricular isoform(gene name synonym)|uniprotkb:Ventricular/slow twitch myosin alkali light chain(gene name synonym)|uniprotkb:Ventricular myosin alkali light chain(gene name synonym)|uniprotkb:Ventricular myosin light chain 1(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Bultot et al. (2009) mint:MINT-6800185|pubmed:19061891|imex:IM-11665|mint:d-08-01940|doi:10.1016/j.febslet.2008.11.022 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8517032|mint:MINT-6800264|imex:IM-11665-2 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_015145280.1|interpro:IPR003961(Fibronectin, type III)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015725(Myosin Light Chain Kinase)|mint:P11799|interpro:IPR036116|interpro:IPR036179|go:"GO:0001725"(stress fiber)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0030027"(lamellipodium)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046872"(metal ion binding)|rcsb pdb:1CDL|rcsb pdb:1QS7|rcsb pdb:1QTX|rcsb pdb:1VRK|rcsb pdb:2O5G|rcsb pdb:3EVU|rcsb pdb:3EVV|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:4OY4|mint:MINT-6800268(identity) refseq:NP_000249.1|ensembl:ENSG00000160808(gene)|ensembl:ENST00000292327(transcript)|ensembl:ENST00000395869(transcript)|ensembl:ENST00000653454(transcript)|ensembl:ENST00000654597(transcript)|ensembl:ENST00000662933(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006942"(regulation of striated muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0030017"(sarcomere)|go:"GO:0031672"(A band)|go:"GO:0031674"(I band)|go:"GO:0032038"(myosin II heavy chain binding)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P08590|rcsb pdb:5TBY|reactome:R-HSA-390522|mint:MINT-6800266(identity) - comment:mint|function:Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals - figure legend:F1A F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/11/19 2014/10/16 rogid:1j/+M19fTw8FL9Q4T/TAKPFyq0c9031 rogid:c6a6WDyl6ICfx4FvSdh2sh8zAaU9606 intact-crc:ACCCEB8A61517C33|rigid:93ewuZdvdS/OpyZ7O58uFTRZIdQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0083"(peptide synthesis)