#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q91713 uniprotkb:B5MFE9 intact:EBI-1997746|uniprotkb:Q6DD60 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1997740|imex:IM-12123-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:4F70B32B7C392DC5|rigid:RR+QpqOrMnFyPaTsjtTcfOq57zQ false - flag tag:c-c|sufficient binding region:127-392(IPR003112) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P98070 uniprotkb:B5MFE9 intact:EBI-1997775 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:bmp1_xenla(display_long)|uniprotkb:bmp1(gene name)|psi-mi:bmp1(display_short) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1997767|imex:IM-12123-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024079|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR034036|interpro:IPR035914|interpro:IPR029837|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008083"(growth factor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0051216"(cartilage development) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 2B, Supp. Fig. 9B|inhibition:"Interaction appears to be inhibited by Szl (O73821) possibly by competing with BMP1 for binding to ONT1"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:hNz/9cBPkEDgp5zSQ6k3Sgg/yfQ8355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:1BF4E66C951A8493|rigid:0CaFQN3zSCDFln3zAoIF72CvVrA false - flag tag:c-c|sufficient binding region:2-126 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P12644 uniprotkb:Q91713 intact:EBI-1998134|uniprotkb:Q9UM80|ensembl:ENSP00000245451|ensembl:ENSP00000394165|ensembl:ENSP00000453485|ensembl:ENSP00000454134 intact:EBI-1997746|uniprotkb:Q6DD60 psi-mi:bmp4_human(display_long)|uniprotkb:BMP4(gene name)|psi-mi:BMP4(display_short)|uniprotkb:BMP2B(gene name synonym)|uniprotkb:DVR4(gene name synonym)|uniprotkb:Bone morphogenetic protein 2B(gene name synonym) psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1998193|imex:IM-12123-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_570911.2|refseq:NP_001193.2|refseq:NP_001334843.1|refseq:NP_001334845.1|refseq:NP_570912.2|dip:DIP-5795N|go:"GO:0072200"(negative regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090191"(negative regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090194"(negative regulation of glomerulus development)|go:"GO:1901964"(positive regulation of cell proliferation involved in outflow tract morphogenesis)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000005"(negative regulation of metanephric S-shaped body morphogenesis)|go:"GO:2000007"(negative regulation of metanephric comma-shaped body morphogenesis)|go:"GO:2000137"(negative regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000125378(gene)|ensembl:ENST00000245451(transcript)|ensembl:ENST00000417573(transcript)|ensembl:ENST00000558984(transcript)|ensembl:ENST00000559087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003014"(renal system process)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010159"(specification of animal organ position)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0021537"(telencephalon development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035990"(tendon cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048392"(intermediate mesodermal cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055020"(positive regulation of cardiac muscle fiber development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060197"(cloacal septation)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060438"(trachea development)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060503"(bud dilation involved in lung branching)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060592"(mammary gland formation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061149"(BMP signaling pathway involved in ureter morphogenesis)|go:"GO:0061151"(BMP signaling pathway involved in renal system segmentation)|go:"GO:0061155"(pulmonary artery endothelial tube morphogenesis)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071893"(BMP signaling pathway involved in nephric duct formation)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072097"(negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)|go:"GO:0072101"(specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0072192"(ureter epithelial cell differentiation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072198"(mesenchymal cell proliferation involved in ureter development) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) psi-mi:"MI:0469"(intact) - - figure legend:Supp. Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:HQjZUJQMMkLov0JIQOQVh7NN7zM9606 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 intact-crc:38041254A308D1FC|rigid:8rUVXgngJzhFve8KwVgKvJ1cMdg false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91713 uniprotkb:Q91597 intact:EBI-1997746|uniprotkb:Q6DD60 intact:EBI-1998255 psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:q91597_xenla(display_long)|uniprotkb:admp.S(gene name)|psi-mi:admp.S(display_short)|uniprotkb:LOC398053(gene name synonym)|uniprotkb:admp(gene name synonym)|uniprotkb:XELAEV_18009898mg(orf name) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1998267|imex:IM-12123-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) interpro:IPR001839(Transforming growth factor beta)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|refseq:NP_001081792.1|interpro:IPR029034|go:"GO:0005576"(extracellular region)|go:"GO:0008083"(growth factor activity) psi-mi:"MI:0469"(intact) - - figure legend:Supp. Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 rogid:Hr3iE2w61CloHTQCngFvhWhryZc8355 intact-crc:9133249AB47C8CB7|rigid:EBBqSIv5VJwxlds3yoar0foDstA false flag tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91713 uniprotkb:B5MFE9 intact:EBI-1997746|uniprotkb:Q6DD60 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1998273|imex:IM-12123-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:3AB2A80436CE332C|rigid:RR+QpqOrMnFyPaTsjtTcfOq57zQ false sufficient binding region:?-?(IPR001007) flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8JI28 uniprotkb:B5MFE9 intact:EBI-1997794 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:tll1_xenla(display_long)|uniprotkb:tll1(gene name)|psi-mi:tll1(display_short)|uniprotkb:xlr(gene name synonym)|uniprotkb:Xenopus tolloid-like protein 1(gene name synonym)|uniprotkb:Metalloprotease xolloid-like(gene name synonym)|uniprotkb:Xlr(gene name synonym) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1997814|imex:IM-12123-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001083894.1|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024079|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR034036|interpro:IPR035914|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 2C|caution:Coordinates of ONT1 region not given in paper so have been inferredf from the UniProt sequence|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:j9w3fYh2r6PV7OUXNNUns9E2uaI8355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:DCF90ED9925460BC|rigid:qJJ5ECjp9kCuo+3T/wMCPmSDPVE false myc tag:?-? flag tag:c-c|sufficient binding region:2-126 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q91713 uniprotkb:B5MFE9 intact:EBI-1997746|uniprotkb:Q6DD60 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1997842|imex:IM-12123-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:D6895CF366AE8CBB|rigid:RR+QpqOrMnFyPaTsjtTcfOq57zQ false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P98070 uniprotkb:B5MFE9 intact:EBI-1997775 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:bmp1_xenla(display_long)|uniprotkb:bmp1(gene name)|psi-mi:bmp1(display_short) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1997848|imex:IM-12123-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024079|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR034036|interpro:IPR035914|interpro:IPR029837|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008083"(growth factor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0051216"(cartilage development) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 2F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:hNz/9cBPkEDgp5zSQ6k3Sgg/yfQ8355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:0E409E466F13088B|rigid:0CaFQN3zSCDFln3zAoIF72CvVrA false - flag tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91713 uniprotkb:Q8JI28 intact:EBI-1997746|uniprotkb:Q6DD60 intact:EBI-1997794 psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:tll1_xenla(display_long)|uniprotkb:tll1(gene name)|psi-mi:tll1(display_short)|uniprotkb:xlr(gene name synonym)|uniprotkb:Xenopus tolloid-like protein 1(gene name synonym)|uniprotkb:Metalloprotease xolloid-like(gene name synonym)|uniprotkb:Xlr(gene name synonym) psi-mi:"MI:0435"(protease assay) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-1997893|imex:IM-12123-2 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) refseq:NP_001083894.1|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024079|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR034036|interpro:IPR035914|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation) go:"GO:0008237"(metallopeptidase activity) - - figure legend:Fig. 4E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 rogid:j9w3fYh2r6PV7OUXNNUns9E2uaI8355 intact-crc:E87996B2E7DC01E3|rigid:L4EWcSQEYgzSOQUogf+AJ+bJ+pA false his tag:?-?|v5 tag:?-? flag tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91713 uniprotkb:B5MFE9 intact:EBI-1997746|uniprotkb:Q6DD60 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0435"(protease assay) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-1997927|imex:IM-12123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0840"(stimulator) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) go:"GO:0008237"(metallopeptidase activity) - - figure legend:Sup. Fig. 4E|comment:At low concentration, ONT1 stimulates TLL1 activity, at higher concentrations it acts as an inhibitor. When a low molecular weight substrate was used in place of chordin, ONT1 had no effect on enzyme rate.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:64C0B349BD45BDD5|rigid:lA23Z5+FKQBgHMvZpvb4XtQadNQ false his tag:?-?|v5 tag:?-? his tag:c-c|flag tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91713 uniprotkb:Q8JI28 intact:EBI-1997746|uniprotkb:Q6DD60 intact:EBI-1997794 psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:tll1_xenla(display_long)|uniprotkb:tll1(gene name)|psi-mi:tll1(display_short)|uniprotkb:xlr(gene name synonym)|uniprotkb:Xenopus tolloid-like protein 1(gene name synonym)|uniprotkb:Metalloprotease xolloid-like(gene name synonym)|uniprotkb:Xlr(gene name synonym) psi-mi:"MI:0435"(protease assay) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0570"(protein cleavage) psi-mi:"MI:0469"(IntAct) intact:EBI-1997927|imex:IM-12123-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) refseq:NP_001083894.1|interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024079|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR034036|interpro:IPR035914|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation) go:"GO:0008237"(metallopeptidase activity) - - figure legend:Sup. Fig. 4E|comment:At low concentration, ONT1 stimulates TLL1 activity, at higher concentrations it acts as an inhibitor. When a low molecular weight substrate was used in place of chordin, ONT1 had no effect on enzyme rate.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 rogid:j9w3fYh2r6PV7OUXNNUns9E2uaI8355 intact-crc:64C0B349BD45BDD5|rigid:lA23Z5+FKQBgHMvZpvb4XtQadNQ false his tag:?-?|v5 tag:?-? flag tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B5MFE9 uniprotkb:Q91713 intact:EBI-1997734|uniprotkb:Q5U5B5 intact:EBI-1997746|uniprotkb:Q6DD60 psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1997951|imex:IM-12123-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 4I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 intact-crc:52666B1D89C80E06|rigid:l+25lTAWOzrMLCG+Xd5JYGTmK/w false his tag:?-?|v5 tag:?-? his tag:?-?|v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B5MFE9 uniprotkb:P98070 intact:EBI-1997734|uniprotkb:Q5U5B5 intact:EBI-1997775 psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:bmp1_xenla(display_long)|uniprotkb:bmp1(gene name)|psi-mi:bmp1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1997951|imex:IM-12123-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) interpro:IPR015446(Bone morphogenetic protein 1/tolloid-like protein)|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR024079|interpro:IPR001506(Peptidase M12A, astacin)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR034036|interpro:IPR035914|interpro:IPR029837|go:"GO:0001503"(ossification)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008083"(growth factor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0051216"(cartilage development) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 4I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 rogid:hNz/9cBPkEDgp5zSQ6k3Sgg/yfQ8355 intact-crc:52666B1D89C80E06|rigid:l+25lTAWOzrMLCG+Xd5JYGTmK/w false his tag:?-?|v5 tag:?-? flag tag:?-?|his tag:?-?|mutation:253-253 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B5MFE9 uniprotkb:Q91713 intact:EBI-1997734|uniprotkb:Q5U5B5 intact:EBI-1997746|uniprotkb:Q6DD60 psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:chrd_xenla(display_long)|uniprotkb:chrd(gene name)|psi-mi:chrd(display_short)|uniprotkb:Organizer-specific secreted-dorsalizing factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1998316|imex:IM-12123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) interpro:IPR016353(Chordin)|interpro:IPR010895(CHRD)|interpro:IPR001007(von Willebrand factor, type C)|refseq:NP_001081778.1|go:"GO:0005576"(extracellular region)|go:"GO:0008201"(heparin binding)|go:"GO:0009798"(axis specification)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0045545"(syndecan binding)|go:"GO:0048793"(pronephros development) psi-mi:"MI:0469"(intact) - - figure legend:Supp. Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 rogid:FikBgTrSAqd5YAJYoIYPSyJSGIA8355 intact-crc:76E33AD026C679D5|rigid:hu1c5OHkO1EujGihBYBWWscSjm0 false flag tag:?-? his tag:?-?|v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B5MFE9 uniprotkb:P12644 intact:EBI-1997734|uniprotkb:Q5U5B5 intact:EBI-1998134|uniprotkb:Q9UM80|ensembl:ENSP00000245451|ensembl:ENSP00000394165|ensembl:ENSP00000453485|ensembl:ENSP00000454134 psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:bmp4_human(display_long)|uniprotkb:BMP4(gene name)|psi-mi:BMP4(display_short)|uniprotkb:BMP2B(gene name synonym)|uniprotkb:DVR4(gene name synonym)|uniprotkb:Bone morphogenetic protein 2B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1998316|imex:IM-12123-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) refseq:NP_570911.2|refseq:NP_001193.2|refseq:NP_001334843.1|refseq:NP_001334845.1|refseq:NP_570912.2|dip:DIP-5795N|go:"GO:0072200"(negative regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090191"(negative regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090194"(negative regulation of glomerulus development)|go:"GO:1901964"(positive regulation of cell proliferation involved in outflow tract morphogenesis)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000005"(negative regulation of metanephric S-shaped body morphogenesis)|go:"GO:2000007"(negative regulation of metanephric comma-shaped body morphogenesis)|go:"GO:2000137"(negative regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000125378(gene)|ensembl:ENST00000245451(transcript)|ensembl:ENST00000417573(transcript)|ensembl:ENST00000558984(transcript)|ensembl:ENST00000559087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003014"(renal system process)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010159"(specification of animal organ position)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0021537"(telencephalon development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035990"(tendon cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048392"(intermediate mesodermal cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055020"(positive regulation of cardiac muscle fiber development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060197"(cloacal septation)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060438"(trachea development)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060503"(bud dilation involved in lung branching)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060592"(mammary gland formation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061149"(BMP signaling pathway involved in ureter morphogenesis)|go:"GO:0061151"(BMP signaling pathway involved in renal system segmentation)|go:"GO:0061155"(pulmonary artery endothelial tube morphogenesis)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071893"(BMP signaling pathway involved in nephric duct formation)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072097"(negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)|go:"GO:0072101"(specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0072192"(ureter epithelial cell differentiation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072198"(mesenchymal cell proliferation involved in ureter development) psi-mi:"MI:0469"(intact) - - figure legend:Supp. Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/09/25 2014/10/16 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 rogid:HQjZUJQMMkLov0JIQOQVh7NN7zM9606 intact-crc:76E33AD026C679D5|rigid:hu1c5OHkO1EujGihBYBWWscSjm0 false flag tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B5MFE9 uniprotkb:B5MFE9 intact:EBI-1997734|uniprotkb:Q5U5B5 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1998012|imex:IM-12123-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) go:"GO:0042803"(protein homodimerization activity) - - comment:Homodimerisation identified by molecular weight under non-reducing conditions|figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/09/25 2014/10/16 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:CE1E9EC0CDFD8B8B|rigid:Iy+EV4EtVWPf7R1cPQbSahGxNJE false - - 2 0 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B5MFE9 uniprotkb:B5MFE9 intact:EBI-1997734|uniprotkb:Q5U5B5 intact:EBI-1997734|uniprotkb:Q5U5B5 psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:olfl3_xenla(display_long)|uniprotkb:olfml3(gene name)|psi-mi:olfml3(display_short)|uniprotkb:ont1(gene name synonym)|uniprotkb:Olfactomedin-noelin-tiarin factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Inomata et al. (2008) imex:IM-12123|pubmed:18775317 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1998035|imex:IM-12123-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) interpro:IPR031230|interpro:IPR003112(Olfactomedin-like)|refseq:NP_001088445.1|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding) go:"GO:0042803"(protein homodimerization activity) - - comment:Homodimerisation identified by molecular weight under non-reducing conditions|figure legend:Supp. Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:8355(xenla-embryo)|taxid:8355(Xenopus laevis embryo) - 2008/09/25 2014/10/16 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 rogid:oLPLR66d6ExCvsWsQMX2ou066p48355 intact-crc:A9E9F3EF8ED6CC20|rigid:Iy+EV4EtVWPf7R1cPQbSahGxNJE false - - 2 0 psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)