#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15968	uniprotkb:Q7JQ39	intact:EBI-7997545|intact:MINT-6596654	intact:EBI-7997511|intact:MINT-6596674	psi-mi:o15968_drome(display_long)|uniprotkb:Dad(gene name)|psi-mi:Dad(display_short)|uniprotkb:SMAD family member(gene name synonym)|uniprotkb:CG5201(orf name)	psi-mi:q7jq39_drome(display_long)|uniprotkb:CG1891(orf name)|uniprotkb:sax(gene name)|psi-mi:sax(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kamiya et al. (2008)	pubmed:18588885|imex:IM-9571|mint:MINT-6596644|doi:10.1016/j.febslet.2008.05.052	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7997576|mint:MINT-6596699|imex:IM-9571-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0020493|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016335"(morphogenesis of larval imaginal disc epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048635"(negative regulation of muscle organ development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O15968|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|mint:MINT-6596701(identity)	flybase:FBgn0003317|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008358"(maternal determination of anterior/posterior axis, embryo)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q7JQ39|mint:MINT-6596702(identity)	-	comment:mint	comment:mint	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/06/05	2014/10/16	rogid:HDVJXwJgThB3rrpRzODxWJXyZiA7227	rogid:RIenq7VqWEAKy/31ct7jC/S5zgY7227	intact-crc:3B88715DACE887C5|rigid:InbXf7ZTFlkW12JUchuH/XeuroE	false	flag tag:?-?(MINT-6596710)	ha tag:?-?(MINT-6596714)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O15968	uniprotkb:Q95SI0	intact:EBI-7997545|intact:MINT-6596654	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	psi-mi:o15968_drome(display_long)|uniprotkb:Dad(gene name)|psi-mi:Dad(display_short)|uniprotkb:SMAD family member(gene name synonym)|uniprotkb:CG5201(orf name)	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kamiya et al. (2008)	pubmed:18588885|imex:IM-9571|mint:MINT-6596644|doi:10.1016/j.febslet.2008.05.052	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7997594|mint:MINT-6596719|imex:IM-9571-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0020493|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007443"(Malpighian tubule morphogenesis)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016335"(morphogenesis of larval imaginal disc epithelium)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0035214"(eye-antennal disc development)|go:"GO:0045886"(negative regulation of synaptic assembly at neuromuscular junction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048635"(negative regulation of muscle organ development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0140416"(transcription regulator inhibitor activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O15968|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|mint:MINT-6596725(identity)	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716|mint:MINT-6596721(identity)	-	comment:mint	-	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/06/05	2014/10/16	rogid:HDVJXwJgThB3rrpRzODxWJXyZiA7227	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	intact-crc:D830B6EDA2997D6D|rigid:YukGsoyo+aMZxmrgf+TkCV+CTdk	false	flag tag:?-?(MINT-6596726)	ha tag:?-?(MINT-6596722)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q7JQ39	uniprotkb:O35253	intact:EBI-7997511|intact:MINT-6596674	intact:EBI-5274835|uniprotkb:O88709|ensembl:ENSMUSP00000026999|ensembl:ENSMUSP00000129322	psi-mi:q7jq39_drome(display_long)|uniprotkb:CG1891(orf name)|uniprotkb:sax(gene name)|psi-mi:sax(display_short)	psi-mi:smad7_mouse(display_long)|uniprotkb:Smad7(gene name)|psi-mi:Smad7(display_short)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Madh8(gene name synonym)|uniprotkb:Mothers against decapentaplegic homolog 8(gene name synonym)|uniprotkb:SMAD family member 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kamiya et al. (2008)	pubmed:18588885|imex:IM-9571|mint:MINT-6596644|doi:10.1016/j.febslet.2008.05.052	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7997630|mint:MINT-6596817|imex:IM-9571-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0003317|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008358"(maternal determination of anterior/posterior axis, embryo)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q7JQ39|mint:MINT-6596823(identity)	refseq:NP_001036125.1|refseq:XP_006525766.1|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1903043"(positive regulation of chondrocyte hypertrophy)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000317"(negative regulation of T-helper 17 type immune response)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35253|rcsb pdb:7CD1|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173796|reactome:R-MMU-5689880|ensembl:ENSMUSG00000025880(gene)|ensembl:ENSMUST00000026999(transcript)|ensembl:ENSMUST00000168918(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001657"(ureteric bud development)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034629"|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070411"(I-SMAD binding)|mint:MINT-6596819(identity)	-	comment:mint	-	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/06/05	2014/10/16	rogid:RIenq7VqWEAKy/31ct7jC/S5zgY7227	rogid:3QfaoCXtWp+4BpA6Una+iIPCkEQ10090	intact-crc:B931AEB754E36D07|rigid:JA8fIEqSG+lnZ1BBY5/H1agJLFc	false	ha tag:?-?(MINT-6596824)	flag tag:?-?(MINT-6596820)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q95SI0	uniprotkb:O35253	intact:EBI-3401975|ensemblmetazoa:FBpp0078723	intact:EBI-5274835|uniprotkb:O88709|ensembl:ENSMUSP00000026999|ensembl:ENSMUSP00000129322	psi-mi:q95si0_drome(display_long)|uniprotkb:tkv(gene name)|psi-mi:tkv(display_short)|uniprotkb:Atkv(gene name synonym)|uniprotkb:Atr25D(gene name synonym)|uniprotkb:Brk25D(gene name synonym)|uniprotkb:Brk25D1(gene name synonym)|uniprotkb:Brk25D2(gene name synonym)|uniprotkb:Dmel\CG14026(gene name synonym)|uniprotkb:Dtfr(gene name synonym)|uniprotkb:STK-A(gene name synonym)|uniprotkb:TKV(gene name synonym)|uniprotkb:TKV1(gene name synonym)|uniprotkb:Tkv(gene name synonym)|uniprotkb:dtfr(gene name synonym)|uniprotkb:kv(gene name synonym)|uniprotkb:"l(2)04415"(gene name synonym)|uniprotkb:"l(2)25Da"(gene name synonym)|uniprotkb:str(gene name synonym)|uniprotkb:tkv1(gene name synonym)|uniprotkb:tkva(gene name synonym)|uniprotkb:Dmel_CG14026(orf name)|uniprotkb:CG14026(orf name)	psi-mi:smad7_mouse(display_long)|uniprotkb:Smad7(gene name)|psi-mi:Smad7(display_short)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Madh8(gene name synonym)|uniprotkb:Mothers against decapentaplegic homolog 8(gene name synonym)|uniprotkb:SMAD family member 7(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kamiya et al. (2008)	pubmed:18588885|imex:IM-9571|mint:MINT-6596644|doi:10.1016/j.febslet.2008.05.052	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7997612|mint:MINT-6596805|imex:IM-9571-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0003716(gene)|ensemblmetazoa:FBtr0079089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005769"(early endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007391"(dorsal closure)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007448"(anterior/posterior pattern specification, imaginal disc)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0007488"(histoblast morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008354"(germ cell migration)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0030721"(spectrosome organization)|go:"GO:0035215"(genital disc development)|go:"GO:0042078"(germ-line stem cell division)|go:"GO:0043235"(receptor complex)|go:"GO:0045202"(synapse)|go:"GO:0045570"(regulation of imaginal disc growth)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045705"(negative regulation of salivary gland boundary specification)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0045927"(positive regulation of growth)|go:"GO:0046332"(SMAD binding)|go:"GO:0048100"(wing disc anterior/posterior pattern formation)|go:"GO:0060799"(transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification)|go:"GO:0061327"(anterior Malpighian tubule development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090254"(cell elongation involved in imaginal disc-derived wing morphogenesis)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q95SI0|go:"GO:0001745"(compound eye morphogenesis)|refseq:NP_787992.1|flybase:FBgn0003716|mint:MINT-6596807(identity)	refseq:NP_001036125.1|refseq:XP_006525766.1|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1903043"(positive regulation of chondrocyte hypertrophy)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000317"(negative regulation of T-helper 17 type immune response)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35253|rcsb pdb:7CD1|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173796|reactome:R-MMU-5689880|ensembl:ENSMUSG00000025880(gene)|ensembl:ENSMUST00000026999(transcript)|ensembl:ENSMUST00000168918(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001657"(ureteric bud development)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034629"|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070411"(I-SMAD binding)|mint:MINT-6596811(identity)	-	-	-	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/06/05	2014/10/16	rogid:4hXwFiyKZhXGE8PhO8uLYNxtc2k7227	rogid:3QfaoCXtWp+4BpA6Una+iIPCkEQ10090	intact-crc:7EFD5A61949E4834|rigid:mf6y5ecjqvRZdOxyCc6R1JRMLKg	false	ha tag:?-?(MINT-6596808)	flag tag:?-?(MINT-6596812)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O35253	uniprotkb:A1Z7L9	intact:EBI-5274835|uniprotkb:O88709|ensembl:ENSMUSP00000026999|ensembl:ENSMUSP00000129322	intact:EBI-501109|intact:EBI-2890605|ensemblmetazoa:FBpp0087740	psi-mi:smad7_mouse(display_long)|uniprotkb:Smad7(gene name)|psi-mi:Smad7(display_short)|uniprotkb:Madh7(gene name synonym)|uniprotkb:Madh8(gene name synonym)|uniprotkb:Mothers against decapentaplegic homolog 8(gene name synonym)|uniprotkb:SMAD family member 7(gene name synonym)	psi-mi:a1z7l9_drome(display_long)|uniprotkb:babo(gene name)|psi-mi:babo(display_short)|uniprotkb:BaboA(gene name synonym)|uniprotkb:ATR-1(gene name synonym)|uniprotkb:ATR-I(gene name synonym)|uniprotkb:Atf1(gene name synonym)|uniprotkb:Atr-1(gene name synonym)|uniprotkb:Atr-I(gene name synonym)|uniprotkb:Atr45A(gene name synonym)|uniprotkb:AtrI(gene name synonym)|uniprotkb:BABO(gene name synonym)|uniprotkb:Bab(gene name synonym)|uniprotkb:Babo(gene name synonym)|uniprotkb:Babo-a(gene name synonym)|uniprotkb:Dmel\CG8224(gene name synonym)|uniprotkb:Gprk-3(gene name synonym)|uniprotkb:Gprk3(gene name synonym)|uniprotkb:STK-E(gene name synonym)|uniprotkb:atr-I(gene name synonym)|uniprotkb:"l(2)44Fd"(gene name synonym)|uniprotkb:"l(2)k16912"(gene name synonym)|uniprotkb:CG8224(orf name)|uniprotkb:Dmel_CG8224(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kamiya et al. (2008)	pubmed:18588885|imex:IM-9571|mint:MINT-6596644|doi:10.1016/j.febslet.2008.05.052	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7997648|mint:MINT-6596829|imex:IM-9571-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036125.1|refseq:XP_006525766.1|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1903043"(positive regulation of chondrocyte hypertrophy)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000317"(negative regulation of T-helper 17 type immune response)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:O35253|rcsb pdb:7CD1|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173796|reactome:R-MMU-5689880|ensembl:ENSMUSG00000025880(gene)|ensembl:ENSMUST00000026999(transcript)|ensembl:ENSMUST00000168918(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001657"(ureteric bud development)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0003677"(DNA binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032925"(regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0034629"|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070411"(I-SMAD binding)|mint:MINT-6596835(identity)	refseq:NP_477000.1|flybase:FBgn0011300|ensemblmetazoa:FBgn0011300(gene)|ensemblmetazoa:FBtr0088659(transcript)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007455"(eye-antennal disc morphogenesis)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009411"(response to UV)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016319"(mushroom body development)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0045464"(R8 cell fate specification)|go:"GO:0045572"(positive regulation of imaginal disc growth)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048666"(neuron development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:A1Z7L9|mint:MINT-6596831(identity)	-	-	-	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2008/06/05	2014/10/16	rogid:3QfaoCXtWp+4BpA6Una+iIPCkEQ10090	rogid:EbaVcqs+mWjYzS0Bj0+v8z0EH9E7227	intact-crc:D8BA9194D8DB9697|rigid:19kQS6i9ghRdTFvibSR44E5YtG0	false	flag tag:?-?(MINT-6596836)	ha tag:?-?(MINT-6596832)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)