#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:28931"	uniprotkb:O14936	intact:EBI-1778566	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	psi-mi:adenosine 3'-monophosphate(display_short)|psi-mi:"CHEBI:28931"(display_long)	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1778575|wwpdb:3C0I|wwpdb:3C0G|imex:IM-11961-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	-	-	-	3d-resolution:1.85A|3d-r-factors:working 20.2%, free 26.7%|figure legend:Fig. 1, Table S1, Supp. Fig. 3|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/03	2014/10/16	-	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	intact-crc:5F93FB4D836CFC02	false	-	sufficient binding region:1-337	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:47785"	uniprotkb:O14936	intact:EBI-1554642	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	psi-mi:amp-pnp(display_short)|psi-mi:"CHEBI:47785"(display_long)	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1778588|wwpdb:3C0G|imex:IM-11961-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	-	-	-	3d-resolution:2.19A|3d-r-factors:working 20.2%, free 25.7%|figure legend:Fig. 1B, 2B, Table S1, Supp. Fig. 2|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/03	2014/10/16	-	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	intact-crc:8E61E7127BFCF9CE	false	-	sufficient binding region:1-337	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50104"	uniprotkb:O14936	intact:EBI-1778619	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	psi-mi:tnp-atp(display_short)|psi-mi:"CHEBI:50104"(display_long)	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1778621|imex:IM-11961-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	-	comment:ChEBI entry requested	-	figure legend:Fig. 3A-D|comment:"ATP titrations revealed that a 500-fold excess of ATP reduced the TNP-ATP fluorescence by 50% (KiATP = 0.365 mM), consistent with competitive binding of ATP and TNP-ATP to a single site that exhibits a much higher affinity for TNP-ATP than for ATP. Divalent cations could also inhibit this interaction, but the authors speculate that this was by complexing with ATP rather than by binding to the enzyme. EDTA stimulates the interaction, presumably by chelating divalent cations."|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/03	2014/10/16	-	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	intact-crc:236671882FBE5A45	false	-	sufficient binding region:1-337	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14936	-	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	-	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1779307|imex:IM-11961-1	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	kinetics:KmATP of =0.563 mM, Vmax = 4.9 nmol/umol enzyme/min|kinetics:KiMg2+ = 61 uM|figure legend:Figs. 4A-D, Supp. Fig. S11A|resulting-ptm:Phosphorylation of Ser-151 and Ser-155 identified by mass spectrometry|comment:Mg2+ and other divalent cations inhibited but did not abolish the autophosphorylation of CASK, presumably by reducing its ATP affinity|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/03	2014/10/16	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	-	intact-crc:8AB7F427AD246694	false	sufficient binding region:1-337|mutation decreasing interaction:24-24,26-26	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:O14936	uniprotkb:Q63373	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	intact:EBI-1780696	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:nrx1b_rat(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-beta(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780733|imex:IM-11961-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	rgd:628659|dip:DIP-40508N|go:"GO:0001525"(angiogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009986"(cell surface)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042297"(vocal learning)|go:"GO:0042551"(neuron maturation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090126"(protein-containing complex assembly involved in synapse maturation)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:1C4R|rcsb pdb:2R1B|rcsb pdb:2R1D|rcsb pdb:2WQZ|rcsb pdb:2XB6	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	kinetics:"KmATP of neurexin-1 phosphorylation by CASK (=748.7 uM, Vmax = 159.4 nmol/umol enzyme/min"|figure legend:Fig. 5, Supp. Figs. 10, 11B|resulting-ptm:Phosphorylation of Nrxn1 identified by mass spectrometry|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/03	2014/10/16	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	rogid:pd7OfT32rDvttEtlEt1ZEdtxPlI10116	intact-crc:84D50C2DC9D00BDE|rigid:bFY/fryip6XG3YM5p7VplFkGoRg	false	sufficient binding region:1-337|mutation decreasing interaction:26-26,24-24	sufficient binding region:412-468|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
chebi:"CHEBI:15422"	uniprotkb:O14936	intact:EBI-1108845|chebi:"CHEBI:40938"|chebi:"CHEBI:10841"|chebi:"CHEBI:10789"|chebi:"CHEBI:2359"|chebi:"CHEBI:13236"|chebi:"CHEBI:22249"	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	psi-mi:atp(display_short)|psi-mi:"CHEBI:15422"(display_long)|intact:Adenosine 5'-triphosphate(synonym)|intact:Adenosine triphosphate(synonym)|intact:ADENOSINE-5'-TRIPHOSPHATE(synonym)|intact:Adephos(synonym)|intact:Adetol(synonym)|intact:Adynol(synonym)|intact:Atipi(synonym)|intact:ATP(synonym)|intact:Atriphos(synonym)|intact:Cardenosine(synonym)|intact:Fosfobion(synonym)|intact:Glucobasin(synonym)|intact:H4atp(synonym)|intact:Myotriphos(synonym)|intact:Triadenyl(synonym)|intact:Triphosphaden(synonym)|intact:"adenosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1780972|imex:IM-11961-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	-	-	-	figure legend:Supp. Fig. 6A|inhibition:ATP binding is inhibited by Mg2+ but not by Na+.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/03	2014/10/16	-	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	intact-crc:1023FBC97A1D94EE	false	-	sufficient binding region:1-337	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14936	uniprotkb:Q63373	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	intact:EBI-1780696	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:nrx1b_rat(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-beta(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1781013|imex:IM-11961-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	rgd:628659|dip:DIP-40508N|go:"GO:0001525"(angiogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009986"(cell surface)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042297"(vocal learning)|go:"GO:0042551"(neuron maturation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090126"(protein-containing complex assembly involved in synapse maturation)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:1C4R|rcsb pdb:2R1B|rcsb pdb:2R1D|rcsb pdb:2WQZ|rcsb pdb:2XB6	go:"GO:0005886"(plasma membrane)	-	-	figure legend:Supp. Fig. S8A|resulting-ptm:coexpression of a CASK-EGFP fusion protein with neurexin-1β in HEK293 cells recruits CASK from the cytosol to the plasma membrane|delivery method:Q63373; O14936 transfection|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2008/06/03	2014/10/16	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	rogid:pd7OfT32rDvttEtlEt1ZEdtxPlI10116	intact-crc:B824C971C4E7AA3D|rigid:bFY/fryip6XG3YM5p7VplFkGoRg	false	enhanced green fluorescent protein tag:?-?	sufficient binding region:412-468|tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q63373	uniprotkb:O14936	intact:EBI-1780696	intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405	psi-mi:nrx1b_rat(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-beta(gene name synonym)	psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mukherjee et al. (2008)	imex:IM-11961|pubmed:18423203	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1781100|imex:IM-11961-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:628659|dip:DIP-40508N|go:"GO:0001525"(angiogenesis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009986"(cell surface)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0021707"(cerebellar granule cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042297"(vocal learning)|go:"GO:0042551"(neuron maturation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090126"(protein-containing complex assembly involved in synapse maturation)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097117"(guanylate kinase-associated protein clustering)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905520"(positive regulation of presynaptic active zone assembly)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:1C4R|rcsb pdb:2R1B|rcsb pdb:2R1D|rcsb pdb:2WQZ|rcsb pdb:2XB6	refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 9A|comment:Binding does not appear to be dependent on adenine-nucleotides|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/03	2014/10/16	rogid:pd7OfT32rDvttEtlEt1ZEdtxPlI10116	rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606	intact-crc:C83D42254D9AF685|rigid:bFY/fryip6XG3YM5p7VplFkGoRg	false	sufficient binding region:412-468|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)